LOCUS       NM_001010968            2888 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus endoglin (Eng), mRNA.
ACCESSION   NM_001010968
VERSION     NM_001010968.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2888)
  AUTHORS   Szczepanski,J., Spencer,S.K., Griffin,A., Bowles,T., Williams,J.M.,
            Kyle,P.B., Dumas,J.P., Araji,S. and Wallace,K.
  TITLE     Acute kidney injury during pregnancy leads to increased sFlt-1 and
            sEng and decreased renal T regulatory cells in pregnant rats with
            HELLP syndrome
  JOURNAL   Biol Sex Differ 11 (1), 54 (2020)
   PUBMED   32972452
  REMARK    GeneRIF: Acute kidney injury during pregnancy leads to increased
            sFlt-1 and sEng and decreased renal T regulatory cells in pregnant
            rats with HELLP syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2888)
  AUTHORS   Badmus,O.O., Michael,O.S., Rabiu,S. and Olatunji,L.A.
  TITLE     Gestational glucocorticoid exposure disrupts glucose homeostasis
            that is accompanied by increased endoglin and DPP-4 activity
            instead of GSK-3 in rats
  JOURNAL   Environ Toxicol Pharmacol 60, 66-75 (2018)
   PUBMED   29677638
  REMARK    GeneRIF: Study demonstrates that gestational glucocorticoid (GC)
            exposure during late pregnancy induced impaired glucose homeostasis
            that is accompanied by increased endoglin levels, atherogenic
            dyslipidemia and pancreatic beta cell dysfunction, increased DPP-4
            activity and altered foetal outcome. Therefore, GC-induced glucose
            deregulation and inflammation during late gestation is through
            endoglin-/DPP-4-dependent pathway.
REFERENCE   3  (bases 1 to 2888)
  AUTHORS   Somashekar,S.T., Sammour,I., Huang,J., Dominguez-Bendala,J.,
            Pastori,R., Alvarez-Cubela,S., Torres,E., Wu,S. and Young,K.C.
  TITLE     Intra-Amniotic Soluble Endoglin Impairs Lung Development in
            Neonatal Rats
  JOURNAL   Am J Respir Cell Mol Biol 57 (4), 468-476 (2017)
   PUBMED   28590142
  REMARK    GeneRIF: findings demonstrate that intrauterine exposure to an
            adenovirus overexpressing sENG disrupts lung development by
            impairing Smad1/5-eNOS signaling. We speculate that sENG-mediated
            dysregulation of Smad1/5-eNOS signaling contributes to impaired
            lung development and potentially primes the developing lung for
            further postnatal insults.
REFERENCE   4  (bases 1 to 2888)
  AUTHORS   Hlushchuk,R., Styp-Rekowska,B., Dzambazi,J., Wnuk,M., Huynh-Do,U.,
            Makanya,A. and Djonov,V.
  TITLE     Endoglin inhibition leads to intussusceptive angiogenesis via
            activation of factors related to COUP-TFII signaling pathway
  JOURNAL   PLoS One 12 (8), e0182813 (2017)
   PUBMED   28859090
  REMARK    GeneRIF: In this study, we have shown that ENG inhibition and at
            the same time up-regulation of COUP-TFII expression promotes
            intussusceptive angiogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2888)
  AUTHORS   Saito,T., Bokhove,M., Croci,R., Zamora-Caballero,S., Han,L.,
            Letarte,M., de Sanctis,D. and Jovine,L.
  TITLE     Structural Basis of the Human Endoglin-BMP9 Interaction: Insights
            into BMP Signaling and HHT1
  JOURNAL   Cell Rep 19 (9), 1917-1928 (2017)
   PUBMED   28564608
REFERENCE   6  (bases 1 to 2888)
  AUTHORS   McAllister,K.A., Grogg,K.M., Johnson,D.W., Gallione,C.J.,
            Baldwin,M.A., Jackson,C.E., Helmbold,E.A., Markel,D.S.,
            McKinnon,W.C., Murrell,J. et al.
  TITLE     Endoglin, a TGF-beta binding protein of endothelial cells, is the
            gene for hereditary haemorrhagic telangiectasia type 1
  JOURNAL   Nat Genet 8 (4), 345-351 (1994)
   PUBMED   7894484
REFERENCE   7  (bases 1 to 2888)
  AUTHORS   St-Jacques,S., Cymerman,U., Pece,N. and Letarte,M.
  TITLE     Molecular characterization and in situ localization of murine
            endoglin reveal that it is a transforming growth factor-beta
            binding protein of endothelial and stromal cells
  JOURNAL   Endocrinology 134 (6), 2645-2657 (1994)
   PUBMED   8194490
REFERENCE   8  (bases 1 to 2888)
  AUTHORS   Cheifetz,S., Bellon,T., Cales,C., Vera,S., Bernabeu,C., Massague,J.
            and Letarte,M.
  TITLE     Endoglin is a component of the transforming growth factor-beta
            receptor system in human endothelial cells
  JOURNAL   J Biol Chem 267 (27), 19027-19030 (1992)
   PUBMED   1326540
REFERENCE   9  (bases 1 to 2888)
  AUTHORS   Lastres,P., Bellon,T., Cabanas,C., Sanchez-Madrid,F., Acevedo,A.,
            Gougos,A., Letarte,M. and Bernabeu,C.
  TITLE     Regulated expression on human macrophages of endoglin, an
            Arg-Gly-Asp-containing surface antigen
  JOURNAL   Eur J Immunol 22 (2), 393-397 (1992)
   PUBMED   1537377
REFERENCE   10 (bases 1 to 2888)
  AUTHORS   Gougos,A. and Letarte,M.
  TITLE     Biochemical characterization of the 44G4 antigen from the HOON
            pre-B leukemic cell line
  JOURNAL   J Immunol 141 (6), 1934-1940 (1988)
   PUBMED   3262645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001010968.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY562420.1, SRR26643297.10891.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               JAXUCZ010000003.1  36332279-36332632
            355-506             JAXUCZ010000003.1  36342839-36342990
            507-647             JAXUCZ010000003.1  36356423-36356563
            648-810             JAXUCZ010000003.1  36358532-36358694
            811-976             JAXUCZ010000003.1  36359406-36359571
            977-1097            JAXUCZ010000003.1  36360121-36360241
            1098-1269           JAXUCZ010000003.1  36360537-36360708
            1270-1412           JAXUCZ010000003.1  36361628-36361770
            1413-1550           JAXUCZ010000003.1  36365514-36365651
            1551-1589           JAXUCZ010000003.1  36365876-36365914
            1590-1706           JAXUCZ010000003.1  36366387-36366503
            1707-1958           JAXUCZ010000003.1  36366804-36367055
            1959-2013           JAXUCZ010000003.1  36368350-36368404
            2014-2115           JAXUCZ010000003.1  36369302-36369403
            2116-2888           JAXUCZ010000003.1  36369551-36370323
FEATURES             Location/Qualifiers
     source          1..2888
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..2888
                     /gene="Eng"
                     /note="endoglin"
                     /db_xref="GeneID:497010"
                     /db_xref="RGD:1593188"
     exon            1..354
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..2240
                     /gene="Eng"
                     /codon_start=1
                     /product="endoglin precursor"
                     /protein_id="NP_001010968.1"
                     /db_xref="GeneID:497010"
                     /db_xref="RGD:1593188"
                     /translation="MDRSMLPLVITLLLVIYSFVPTSLAERVGCDLQRVDSTRGEVTY
                     TTSQVSEGCVAQVANAAHEVHVLFLNLSRRKSEVELTLQASKQNGTETREVFLVFISN
                     ENVLVKLQAPEIPLHLVYNSSLEVFKGPKVNSTPLPSFTSKTQILDWAATKGTITSIA
                     ALDDPKSIVLRLGQDPKAPPFCFPEAQKDMGVTLEWQPRTQTPVQGCHLEGVTGHKEA
                     YVLRIRSGSEAGPRTVTVTVKLSCTSGDAVLILQGPPYVSWLIDTNHNMQIWTTGEYS
                     IKIFPENNIKGFELPDTPQGLIGEARKLNASIVTFVEIPLTSDVSLTVSSCGGGLQTS
                     PAPVVTTPPKDTCSPELLMSLIQPKCGNDVMTLALNKKLVQTLQCTITGLAFWDSSCQ
                     AKDQDGHLVLSSTYSSCGMKVTDHVISNEVIINLPSGLPPLRKKVQCIDMDSLSFQLG
                     LYLSPHFLQASNTIELGQQGFVQVSMSPLTSEVTVQLDSCHLDLGPEGDMVELIQSRA
                     AKGSCVSLLSPSPEGDPRFSFLLRVYMVPTPAAGTLSCNLALHPSTLSQEVYKTVSMR
                     LNIVSPDLSGKGLVLPSVLGITFGAFLIGALLTAALWYIYSHTRAPSKREPVVAVAAP
                     ASSESSSTNHSIGSTQSTPCSTSSMA"
     exon            355..506
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     exon            507..647
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     exon            648..810
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     exon            811..976
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1097
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1269
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1412
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1550
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1589
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1706
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1958
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2013
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2115
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2888
                     /gene="Eng"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtcccgtc cccaggccag gaccgtcgtc cgctgccgtc ccaaagagcc cagtgtctct
       61 ttctcaccat ccagtcagct agagacccct gccctgcttt gagtctccag cccacttctc
      121 ctgacttctc cgccgccacc tcagaaggct ggagcaggga cgtggtcgct ccggctgcct
      181 gctcccttcg gatccccgtg cgaacccacg caggccccgg cgcccaccag cagccctgcc
      241 tctggacacc ggataaggcc cagcgcacag actcccgggt ggacagcatg gaccgtagca
      301 tgctccctct ggtcattacc ctgctgttgg tcatctatag cttcgtgccc acaagtcttg
      361 cagaaagagt cggttgtgat ctacagcgtg tggactccac aaggggtgag gtgacataca
      421 ccaccagcca ggtctctgag ggctgtgtag ctcaggttgc caacgctgcg catgaagtcc
      481 acgttctctt cctgaatctt tccagaagga agtccgaggt ggagttgact cttcaagcat
      541 ccaagcaaaa tggcactgag actcgggagg tgtttctggt cttcatttcg aacgagaatg
      601 tcttggtgaa gctccaggcc ccagaaatcc cactgcactt ggtctacaac tccagcctcg
      661 aggtcttcaa aggaccaaaa gtcaacagca caccactacc atcctttacc tccaagacac
      721 agatcctcga ctgggcagcc accaagggca ccattacctc catagcagca ctggatgacc
      781 ccaaaagcat tgtcctccgg ctgggccaag acccaaaggc accacccttc tgcttcccag
      841 aagctcagaa ggacatgggc gtcacacttg aatggcaacc acgaacccag acaccagtcc
      901 aaggctgcca cttggaaggt gtgactggac acaaggaggc ctatgtcctg aggattcgat
      961 caggttctga ggccgggccc cggacagtga cggtaacggt gaaactgagt tgcacatctg
     1021 gggatgccgt tctcatcctg cagggtcccc cgtacgtctc ctggctcatc gataccaacc
     1081 acaatatgca gatctggacc acaggtgaat actccatcaa gatctttcca gaaaacaaca
     1141 tcaaaggctt cgagctccca gacacacccc aaggcctgat cggggaggcc cgcaagctca
     1201 atgccagcat agtaaccttt gtagagatcc ctctgaccag tgatgtctcc ctgacggtct
     1261 ccagctgcgg tggtgggctc cagacctccc ctgcaccagt tgtgaccaca cctcccaagg
     1321 acacgtgcag ccctgagcta ctcatgtccc tgattcagcc aaagtgtggc aatgacgtca
     1381 tgactctggc actcaataaa aaactcgtgc agactctaca gtgcaccatc acaggcctgg
     1441 ctttctggga ctccagctgc caggctaaag accaggacgg ccaccttgtc ctgagtagca
     1501 cctactccag ctgcggcatg aaagtgacag atcatgtgat cagcaacgag gtgatcatca
     1561 atttgccatc aggcttacca ccacttcgga aaaaggtaca gtgcatcgac atggacagcc
     1621 tctccttcca gctgggcctc tacctcagcc cgcacttcct ccaggcatcc aacaccatag
     1681 agctaggcca gcagggcttc gtacaggtga gcatgtctcc attgacctct gaggtcacag
     1741 tccagctaga cagctgccat ctggatttgg ggccagaagg tgacatggtg gaactcatcc
     1801 agagtcgagc agccaagggc agctgtgtga gcttgctgtc cccaagccct gagggcgacc
     1861 cacgtttcag ctttctcctc cgtgtctaca tggtgcccac acccgcagct ggcaccctca
     1921 gttgcaactt agccctgcac cctagcacct tgtcccagga agtctacaag actgtctcca
     1981 tgcgcctgaa catcgtcagt cctgacctgt ctggcaaagg cctcgtcctg ccctctgtac
     2041 tgggcatcac ctttggtgcc ttcctcattg gggccctgct cacagctgca ctctggtaca
     2101 tctattctca cacacgtgcc cctagcaagc gggagcccgt ggtggcagtg gctgccccgg
     2161 cctcctctga gagcagcagt accaaccaca gcatcgggag cacccagagc accccctgct
     2221 ccaccagcag catggcatag tacccagcct ggagccttgg ggagcccccc agccagccct
     2281 tgccctgcag gagaggcgga gcagccacaa gctgggaacc atcggccatg aacttgtccc
     2341 ctcagccaag gatggagcgt cctcctgtac ctgctcctca tgcctccccc gcagaggctt
     2401 gttgccagta gagactccaa cttggaacac cttgggatct cctcacccca ctttacctgc
     2461 ccaacccagg ggccctggga tatggctgcc tgggactaca gaaagacacc gcactgctgt
     2521 gaacatccgt gctgctgtgg aaccctaatc ccctgccttc aagctggatc ctgtgctgat
     2581 gaactgggca gggtgggagg ctaggactca agacacgcgc ctggcctagc ccagagccac
     2641 ctgcatctgg ctggccccag gagcctcctc accttgacta gcacaatttt ggtcggggaa
     2701 acagaggctg aggggtgctc agctcattgg cctagaagat ggcaagaagg gtgggttggg
     2761 ggagcccagc ccctccccag agatctcctc ccagcccatc cattgagctg gcagcaggag
     2821 ggtagtggcc aggtggctgg tcctgggcca agcccatata tttaccaata aatcagacat
     2881 gaaaccag
//
