LOCUS       NM_001034938             929 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus endonuclease G (Endog), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001034938
VERSION     NM_001034938.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 929)
  AUTHORS   Dos Santos Pereira RT, Porto CS and Abdalla FMF.
  TITLE     Ovariectomy and 17beta-estradiol replacement play a role on the
            expression of Endonuclease-G and phosphorylated cyclic AMP response
            element-binding (CREB) protein in hippocampus
  JOURNAL   Mol Cell Endocrinol 382 (1), 227-233 (2014)
   PUBMED   24121025
  REMARK    GeneRIF: The aim of the present study was to investigate the
            effects of ovariectomy and 17beta-estradiol (E2) replacement on the
            expression of Cytochrome C, apoptosis inducing factor (AIF) and
            Endonuclease-G (Endo-G) and CREB in hippocampus of the adult female
            rats.
REFERENCE   2  (bases 1 to 929)
  AUTHORS   Kapoor R, Rizvi F and Kakkar P.
  TITLE     Naringenin prevents high glucose-induced mitochondria-mediated
            apoptosis involving AIF, Endo-G and caspases
  JOURNAL   Apoptosis 18 (1), 9-27 (2013)
   PUBMED   23192364
REFERENCE   3  (bases 1 to 929)
  AUTHORS   Liu W, Fan Z, Han Y, Zhang D, Li J and Wang H.
  TITLE     Intranuclear localization of apoptosis-inducing factor and
            endonuclease G involves in peroxynitrite-induced apoptosis of
            spiral ganglion neurons
  JOURNAL   Neurol Res 34 (10), 915-922 (2012)
   PUBMED   23006905
  REMARK    GeneRIF: Peroxynitrite can trigger apoptosis in spiral ganglion
            neurons associated with mitochondrial AIF and endonuclease G
            intranuclear localization.
REFERENCE   4  (bases 1 to 929)
  AUTHORS   Singh BK, Tripathi M, Chaudhari BP, Pandey PK and Kakkar P.
  TITLE     Natural terpenes prevent mitochondrial dysfunction, oxidative
            stress and release of apoptotic proteins during
            nimesulide-hepatotoxicity in rats
  JOURNAL   PLoS One 7 (4), e34200 (2012)
   PUBMED   22509279
REFERENCE   5  (bases 1 to 929)
  AUTHORS   McDermott-Roe C, Ye J, Ahmed R, Sun XM, Serafin A, Ware J, Bottolo
            L, Muckett P, Canas X, Zhang J, Rowe GC, Buchan R, Lu H,
            Braithwaite A, Mancini M, Hauton D, Marti R, Garcia-Arumi E, Hubner
            N, Jacob H, Serikawa T, Zidek V, Papousek F, Kolar F, Cardona M,
            Ruiz-Meana M, Garcia-Dorado D, Comella JX, Felkin LE, Barton PJ,
            Arany Z, Pravenec M, Petretto E, Sanchis D and Cook SA.
  TITLE     Endonuclease G is a novel determinant of cardiac hypertrophy and
            mitochondrial function
  JOURNAL   Nature 478 (7367), 114-118 (2011)
   PUBMED   21979051
  REMARK    GeneRIF: present study has further established the link between
            mitochondrial dysfunction, reactive oxygen species and heart
            disease and has uncovered a role for Endog in maladaptive cardiac
            hypertrophy
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 929)
  AUTHORS   Ishihara Y and Shimamoto N.
  TITLE     Involvement of endonuclease G in nucleosomal DNA fragmentation
            under sustained endogenous oxidative stress
  JOURNAL   J Biol Chem 281 (10), 6726-6733 (2006)
   PUBMED   16407272
REFERENCE   7  (bases 1 to 929)
  AUTHORS   Leeuwenburgh C, Gurley CM, Strotman BA and Dupont-Versteegden EE.
  TITLE     Age-related differences in apoptosis with disuse atrophy in soleus
            muscle
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 288 (5), R1288-R1296 (2005)
   PUBMED   15650125
REFERENCE   8  (bases 1 to 929)
  AUTHORS   Zhang J, Dong M, Li L, Fan Y, Pathre P, Dong J, Lou D, Wells JM,
            Olivares-Villagomez D, Van Kaer L, Wang X and Xu M.
  TITLE     Endonuclease G is required for early embryogenesis and normal
            apoptosis in mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (26), 15782-15787 (2003)
   PUBMED   14663139
REFERENCE   9  (bases 1 to 929)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 929)
  AUTHORS   Davies AM, Hershman S, Stabley GJ, Hoek JB, Peterson J and Cahill
            A.
  TITLE     A Ca2+-induced mitochondrial permeability transition causes
            complete release of rat liver endonuclease G activity from its
            exclusive location within the mitochondrial intermembrane space.
            Identification of a novel endo-exonuclease activity residing within
            the mitochondrial matrix
  JOURNAL   Nucleic Acids Res 31 (4), 1364-1373 (2003)
   PUBMED   12582256
  REMARK    Erratum:[Nucleic Acids Res. 2003 Apr 1;31(7):2024]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB221075.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB221075.1, FQ232745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..929
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..929
                     /gene="Endog"
                     /note="endonuclease G"
                     /db_xref="GeneID:362100"
                     /db_xref="RGD:1310763"
     exon            1..516
                     /gene="Endog"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..909
                     /gene="Endog"
                     /function="nuclease activity"
                     /note="endonuclease G, mitochondrial"
                     /codon_start=1
                     /product="endonuclease G, mitochondrial precursor"
                     /protein_id="NP_001030110.1"
                     /db_xref="GeneID:362100"
                     /db_xref="RGD:1310763"
                     /translation="MRALRAGLTLALGAGLGAAAEHWRRREGKGPGLLGRVPVLPVVA
                     ADLPALPGGPAGSTGELAKYGLPGVAQLRSRESYVLSYDPRTRGALWVLEQLRPERLR
                     GDGDRRACDFHEDDSVHAYHRATNADYRGSGFDRGHLAAAANHRWSQRAMDDTFYLSN
                     VAPQVPHLNQHAWNNLEKYSRSLTRTYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKN
                     HVAVPTHFFKVLILEAASGQIELRSYVMPNAPVDETLPLERFLVPIESIERASGLLFV
                     PNILARAGNLKAITAGSK"
     exon            517..626
                     /gene="Endog"
                     /inference="alignment:Splign:2.1.0"
     exon            627..929
                     /gene="Endog"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagcgcgctg gtcctccggt aggcatgcgc gcgctacggg ccggtttgac cctggcgctg
       61 ggcgccggcc tgggcgccgc ggcagagcat tggcggcggc gagagggtaa agggccgggg
      121 ctgctgggcc gagtgccagt gttgccggtt gtcgcggccg atcttcccgc gctgccgggg
      181 ggaccggctg gcagcaccgg agagttggcc aagtacgggc tgcccggcgt ggcgcagctc
      241 cggagccgcg agtcctacgt gctgagctac gacccgcgca cgcgcggtgc gctctgggtg
      301 ttggagcagc tgaggccaga gcggctccgt ggcgatgggg accgtcgcgc ctgcgacttc
      361 cacgaggacg attctgtgca cgcgtaccac cgcgccacca atgcggacta ccgcggcagt
      421 ggctttgacc gcggccactt ggcggccgcc gccaatcacc gctggagtca gcgggccatg
      481 gacgacacct tctacctgag caacgtagcg cctcaggtgc cacacctcaa ccagcatgcc
      541 tggaacaacc ttgagaagta cagccgcagc ttgactcgaa cttaccaaaa cgtttatgtc
      601 tgcacagggc ctcttttcct gcccaggacc gaggctgatg ggaagtccta tgtgaagtac
      661 caggttattg ggaagaacca cgtggcagtg cccacacact tcttcaaggt gttgatcctg
      721 gaggcagcca gtgggcaaat cgagctgcgt tcctatgtga tgcccaatgc cccggtggat
      781 gagactctcc ctttggagcg cttcctagtg cccatcgaga gcatcgagcg ggcctcggga
      841 ttgctcttcg tgcccaatat tctggctcga gctggaaacc tcaaggccat cactgctggt
      901 agcaagtgat ggagtaggac tcactcaag
//
