LOCUS       NM_001003401            4617 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ectodermal-neural cortex 1 (Enc1), mRNA.
ACCESSION   NM_001003401 XM_215453
VERSION     NM_001003401.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4617)
  AUTHORS   Lei,H., Li,J., Zhao,Z. and Liu,L.
  TITLE     Inhibition of Ectodermal-Neural Cortex 1 Protects Neural Cells from
            Apoptosis Induced by Hypoxia and Hypoglycemia
  JOURNAL   J Mol Neurosci 59 (1), 126-134 (2016)
   PUBMED   27039095
  REMARK    GeneRIF: Knockdown of Enc1 protects neurons from apoptosis induced
            by oxygen-glucose deprivation associated with Nrf2 and HO-1.
REFERENCE   2  (bases 1 to 4617)
  AUTHORS   Degaki,T.L., Demasi,M.A. and Sogayar,M.C.
  TITLE     Overexpression of Nrp/b (nuclear restrict protein in brain)
            suppresses the malignant phenotype in the C6/ST1 glioma cell line
  JOURNAL   J Steroid Biochem Mol Biol 117 (4-5), 107-116 (2009)
   PUBMED   19682578
  REMARK    GeneRIF: show that overexpression of the Nrp/b cDNA in C6/ST1 cells
            suppresses anchorage independence in vitro and tumorigenicity in
            vivo, altering their malignant nature towards a more benign
            phenotype.
REFERENCE   3  (bases 1 to 4617)
  AUTHORS   Kim,S.G., Jang,S.J., Soh,J., Lee,K., Park,J.K., Chang,W.K.,
            Park,E.W. and Chun,S.Y.
  TITLE     Expression of ectodermal neural cortex 1 and its association with
            actin during the ovulatory process in the rat
  JOURNAL   Endocrinology 150 (8), 3800-3806 (2009)
   PUBMED   19372205
  REMARK    GeneRIF: The study further shows the physical association of ENC1
            and F-actin, implicating the role of ENC1 in cytoskeletal
            reorganization during the differentiation of granulosa cells.
REFERENCE   4  (bases 1 to 4617)
  AUTHORS   Wang,X.J. and Zhang,D.D.
  TITLE     Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational
            level
  JOURNAL   PLoS One 4 (5), e5492 (2009)
   PUBMED   19424503
REFERENCE   5  (bases 1 to 4617)
  AUTHORS   Zhang,D.D., Lo,S.C., Sun,Z., Habib,G.M., Lieberman,M.W. and
            Hannink,M.
  TITLE     Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for
            Cul3, targets Keap1 for degradation by a proteasome-independent
            pathway
  JOURNAL   J Biol Chem 280 (34), 30091-30099 (2005)
   PUBMED   15983046
REFERENCE   6  (bases 1 to 4617)
  AUTHORS   Kim,T.A., Lim,J., Ota,S., Raja,S., Rogers,R., Rivnay,B., Avraham,H.
            and Avraham,S.
  TITLE     NRP/B, a novel nuclear matrix protein, associates with p110(RB) and
            is involved in neuronal differentiation
  JOURNAL   J Cell Biol 141 (3), 553-566 (1998)
   PUBMED   9566959
REFERENCE   7  (bases 1 to 4617)
  AUTHORS   Hernandez,M.C., Andres-Barquin,P.J., Martinez,S., Bulfone,A.,
            Rubenstein,J.L. and Israel,M.A.
  TITLE     ENC-1: a novel mammalian kelch-related gene specifically expressed
            in the nervous system encodes an actin-binding protein
  JOURNAL   J Neurosci 17 (9), 3038-3051 (1997)
   PUBMED   9096139
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_001003401.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY669396.1, DQ282125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               JAXUCZ010000002.1  30285274-30285558
            286-2099            JAXUCZ010000002.1  30289060-30290873
            2100-4617           JAXUCZ010000002.1  30294677-30297194
FEATURES             Location/Qualifiers
     source          1..4617
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..4617
                     /gene="Enc1"
                     /gene_synonym="Nrpb"
                     /note="ectodermal-neural cortex 1"
                     /db_xref="GeneID:294674"
                     /db_xref="RGD:1303152"
     exon            1..285
                     /gene="Enc1"
                     /gene_synonym="Nrpb"
                     /inference="alignment:Splign:2.1.0"
     exon            286..2099
                     /gene="Enc1"
                     /gene_synonym="Nrpb"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..2068
                     /gene="Enc1"
                     /gene_synonym="Nrpb"
                     /note="nuclear restrict protein in brain"
                     /codon_start=1
                     /product="ectoderm-neural cortex protein 1"
                     /protein_id="NP_001003401.1"
                     /db_xref="GeneID:294674"
                     /db_xref="RGD:1303152"
                     /translation="MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRL
                     FTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLL
                     DYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQ
                     CTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAMNWI
                     SYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKI
                     LQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFS
                     ACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYV
                     VGGHTAATGCLPASPSVSLKQVEQYDPTTNKWTMVAPLREGVSNAAVVSAKLKLFAFG
                     GTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSA
                     YKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWN
                     SITTVPYSLIPTAFVSTWKHLPS"
     exon            2100..4617
                     /gene="Enc1"
                     /gene_synonym="Nrpb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgccgc aggctcactc tcccctggct aggcgagcgc ccgcagacgc ttggcccggc
       61 cggggcgcca ggtccgtagc tgctgatcgg gagaccgaga tcagctgcct gccggagccg
      121 gcctgagagc cactacccgg gacgccatcg cctcccttcc cggcgctctt ttctccccgg
      181 cgatcgccac cgcttcctgg aacagagacg cctttcttcg gctccctgcg ggtgaccgag
      241 gcaagaaccc cagccggttg tgtgcggagg ccagtcgcca ctactgagtt gaaacaaaat
      301 gtccgtcagc gtgcatgaga accgcaagtc cagggccagc agcggctcca tcaacatcta
      361 cctgtttcat aagtcttcct atgccgacag tgttctcact cacttgaacc ttctgcgtca
      421 gcagaggctc tttacagacg tcctccttca tgcgggaaac aggaccttcc cttgccaccg
      481 ggcagtgttg gctgcctgca gccgctactt cgaagccatg ttcagtggtg gcctgaaaga
      541 gagccaggac agtgaggtga acttcgacaa ttccatccac ccagaagtct tagagctgct
      601 tctggactac gcatactcct cccgggtcat catcaatgaa gaaaatgctg agtccctcct
      661 ggaggctggt gacatgctgg agtttcagga catcagggat gcatgtgcag aattcctgga
      721 gaagaacctg catcccacca actgcttagg gatgctgctg ctgtctgacg cccaccagtg
      781 caccaagctg tacgaactct cctggagaat gtgtctgagc aacttccaaa ccatccggaa
      841 gaatgaagat tttctccagt tgccccagga catggtggtg cagctcctgt ccagcgaaga
      901 actggagaca gaagacgaaa ggctggtgta tgagtctgca atgaactgga ttagctatga
      961 cctgaagaaa cgctactgtt acctcccaga actgttgcag acagtgaggc tggccctcct
     1021 tcctgccatc tatctcatgg agaacgtggc aatggaagaa ctcatcacca agcagagaaa
     1081 gagtaaggag attgtggaag aggccatccg gtgcaaacta aaaatcttac agaatgacgg
     1141 cgtggtcacc agtctctgtg ctcgccctcg gaaaactggc cacgccctgt tcctcctggg
     1201 agggcagact ttcatgtgtg acaaactgta cttggtagac cagaaggcta aagaaatcat
     1261 tcccaaggct gacattccca gcccgaggaa agagttcagt gcgtgtgcga ttggctgcaa
     1321 agtgtatatt actggggggc ggggatcaga gaacggagtc tcaaaagatg tctgggttta
     1381 tgataccctg catgaggaat ggtccaaggc tgcccccatg ctggtggcca ggtttggcca
     1441 tggatcagcc gaactgaagc actgcctgta tgtggtcggt gggcacacag ctgcaactgg
     1501 ctgcctccca gcctctcctt cagtctctct aaagcaagta gaacaatatg accccacaac
     1561 caacaaatgg accatggtag ccccactccg agaaggtgtc agcaatgctg ctgtagtgag
     1621 cgccaagctc aagctgttcg ctttcggagg taccagcgta agccacgaca agcttcctaa
     1681 ggttcagtgt tatgaccagt gtgaaaacag atggacagtt ccagccacct gtccccagcc
     1741 ctggcgttac acagccgcag ctgtgctggg gaaccagatt tttatcatgg gtggggatac
     1801 agaattctca gcctgctctg cttacaagtt caacagtgaa acttaccagt ggaccaaggt
     1861 aggagacgtg acagccaagc gcatgagctg ccatgccgtg gcctccggga acaagcttta
     1921 cgtggttgga ggatacttcg gcattcagcg ctgcaagacg ttggactgtt acgatccgac
     1981 tttagatgtg tggaacagca taaccacggt tccctactct ctgatcccta ccgcgttcgt
     2041 cagcacctgg aaacacctgc cttcctaatg cagagcaaac caaggagagc acgagtgagc
     2101 tcactctgac acacacgaga tgtcgtttct gctctgaaga aggcaagttt aatgaagaga
     2161 aagaaaaaaa acaggagcag ttgctactaa actcctcgaa taccattggc tgcaccttgt
     2221 gaacactctt taagtggaca tgaaggaagg ggtgggggag ggggcgggtt tttttttttc
     2281 ccccaatgta agtagcacat ggtttaaata tgaatgactg aacttgtgat ctagtccttg
     2341 tctggtaatt gtggattaat gtcagcgtta atcagcccct caaagggaga gagaagctgg
     2401 gcttttccct tgttgtacct cattcagctt ctgatttcca cggccccacc atttatgtgc
     2461 aagatttgaa atggttgtca gcttcctctg aggactgagc ttgaagcctc tcttccagct
     2521 gctgttagag atgcagagcc gagcaagggt caggagggaa gctgacctgg ctgactgaat
     2581 aagggggaac cccaggactc tccactcatc tccaagactt gtggtcccca ggaacgtctg
     2641 gaaacaatgg ggacattgtt ggtcggctgt ttggtagatg ctatttataa gtgactttaa
     2701 accttctctt ggctgttaag aaatgtgttc tagatttagc tatttattgt ttgcggcctg
     2761 catgctgaaa cagtgcttac gttgttgtct ccacgtgtat gggcctgtgg agacggtcgt
     2821 atgttttgca catttcgtag ctgttggtgt gctttgccgt gtgcgtgcac gcagacacac
     2881 aaaaagaaaa ctttgggact ataatttgga ggataagtaa agggtgggtg ggggaagggt
     2941 gcatttttga agtgtccgga cagagacaga ttctgagatg gaaacttaaa ttacatccca
     3001 gaggcaggga aactatgaag tcaccgttcc tagaccaccc cttactgagg ttccacggtc
     3061 acactgacgg caggacccac aagggcaggg tattggtctg ccctcctttc tcctgtctgt
     3121 ctgacttacc taactttggt ctcggctgct gacacttgga aaggaccaaa ttacttgata
     3181 gtatttcccc ctgtttgtgt aatagcctga aaccttggag aggttccaga atacttctgt
     3241 atatagggca caggtgaaga cattgtccaa agcttattta tttatctatt tatttaccct
     3301 ggctgagtaa ccacaccagt agggggaaaa ctaaaatgtg ttgagtgtaa acaaagtcac
     3361 cagcctggct agaaattctc cctggaaaac atccattttg atacaatgta aacgttagtg
     3421 ttcaccctta gatacatgtt gaaagagagc tttggtacgc ggaagtggca tctttggtca
     3481 cacaccatgc caaagtgaag aggtggccag tggaggtctt ccggtcctgt cgggatcatt
     3541 tgtgaataca ttctttgccc ctcttaagta cttgtttact aaacatgtgc agtggtaggt
     3601 attagtgtta gatcacagtg ggcacttccc tggggatctg gggaagacca gagcttgcaa
     3661 ctctgcctgt tttgatccct atttctcaca gtgctgtatt aaaaaaaata ggatttaaga
     3721 cagataacca cctttacatt gtgagtgtgt ttgccttgtc taacgacaga taattcctta
     3781 acatttctct tcaccttagt actttaggct aattatacac gtctgtctat gccatgagta
     3841 agtggactgt agtcggacca aaagaaaaca aatgagccgt tggaccattt gtgcagtcag
     3901 tttctggtcc ttagatgtat cctaagcagt aagtgtctga ttgtaccctg gtggtatgat
     3961 cagttgtctc gtagctgtct cagctccaca gtttacaatg caaatctgtc tcaagatctt
     4021 cacgtcactg ctgctgagag cagggagaat tctctgcagc tgtttcaaag ttgtggcccg
     4081 gccttgaatc ctctgttaat tactgtgtga gccagaggga gctgcccagc aagggtgggc
     4141 ccccagccgg caggggaact ttctagactc cccgctcatt caattgatct aggcattcgg
     4201 gcctgctact tgaccattct cgccctgtga aatgtcccac actttgaagc aaatacaatt
     4261 cacagcacag tacacacaaa aaccctggca taagacaggg gaggttcttc ttattttgtg
     4321 agccggttgc cctggaaacg gataacaaag ggcagccttc cacttctggc ataatggtgg
     4381 agcctctttt ctcaggcttg acacctgtct gaataagagt gattagagcc gcataatatc
     4441 cctctcttgg ctattgaata tgtggttcac ataccaaacc ctgtagaagt tagaagacgg
     4501 tcgtgttcgt atgttgtttg cttccactac atttttgagg ttttgtaaaa ctgttatttt
     4561 ttttcacgat gtgaaactga aggtcaataa attattagag attttctctt cattgta
//
