LOCUS       NM_001401377           12349 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus ENAH, actin regulator (Enah), transcript variant
            1, mRNA.
ACCESSION   NM_001401377 XM_039090927
VERSION     NM_001401377.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12349)
  AUTHORS   Deng,G., Luo,Y., Zhang,Y., Zhang,J. and He,Z.
  TITLE     Enabled homolog (ENAH) regulated by RNA binding protein splicing
            factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion
            and migration of hepatocellular carcinoma cells via Notch signaling
            pathway
  JOURNAL   Bioengineered 13 (2), 2194-2206 (2022)
   PUBMED   35030977
REFERENCE   2  (bases 1 to 12349)
  AUTHORS   Wang,D.D., Chen,Y.B., Zhao,J.J., Zhang,X.F., Zhu,G.C., Weng,D.S.,
            Pan,K., Lv,L., Pan,Q.Z., Jiang,S.S., Wang,L.L. and Xia,J.C.
  TITLE     TES functions as a Mena-dependent tumor suppressor in gastric
            cancer carcinogenesis and metastasis
  JOURNAL   Cancer Commun (Lond) 39 (1), 3 (2019)
   PUBMED   30728082
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12349)
  AUTHORS   Riquelme,D.N., Meyer,A.S., Barzik,M., Keating,A. and Gertler,F.B.
  TITLE     Selectivity in subunit composition of Ena/VASP tetramers
  JOURNAL   Biosci Rep 35 (5), e00246 (2015)
   PUBMED   26221026
  REMARK    GeneRIF: The tetramerization domain (TD) at the C-termini of
            enabled/VASP proteins conferred the observed selectivity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12349)
  AUTHORS   Ram,R., Wescott,A.P., Varandas,K., Dirksen,R.T. and Blaxall,B.C.
  TITLE     Mena associates with Rac1 and modulates connexin 43 remodeling in
            cardiomyocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 306 (1), H154-H159 (2014)
   PUBMED   24186093
  REMARK    GeneRIF: Mena is associated with active Rac1 in cardiomyocytes.
            Knockdown of Mena increased Rac1 activity, connexin43 expression
            and localization.
REFERENCE   5  (bases 1 to 12349)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 12349)
  AUTHORS   Giesemann,T., Schwarz,G., Nawrotzki,R., Berhorster,K.,
            Rothkegel,M., Schluter,K., Schrader,N., Schindelin,H., Mendel,R.R.,
            Kirsch,J. and Jockusch,B.M.
  TITLE     Complex formation between the postsynaptic scaffolding protein
            gephyrin, profilin, and Mena: a possible link to the microfilament
            system
  JOURNAL   J Neurosci 23 (23), 8330-8339 (2003)
   PUBMED   12967995
REFERENCE   7  (bases 1 to 12349)
  AUTHORS   Tani,K., Sato,S., Sukezane,T., Kojima,H., Hirose,H., Hanafusa,H.
            and Shishido,T.
  TITLE     Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian
            enabled (Mena) by c-Abl kinase
  JOURNAL   J Biol Chem 278 (24), 21685-21692 (2003)
   PUBMED   12672821
REFERENCE   8  (bases 1 to 12349)
  AUTHORS   Lanier,L.M., Gates,M.A., Witke,W., Menzies,A.S., Wehman,A.M.,
            Macklis,J.D., Kwiatkowski,D., Soriano,P. and Gertler,F.B.
  TITLE     Mena is required for neurulation and commissure formation
  JOURNAL   Neuron 22 (2), 313-325 (1999)
   PUBMED   10069337
REFERENCE   9  (bases 1 to 12349)
  AUTHORS   Yamabhai,M. and Kay,B.K.
  TITLE     Examining the specificity of Src homology 3 domain--ligand
            interactions with alkaline phosphatase fusion proteins
  JOURNAL   Anal Biochem 247 (1), 143-151 (1997)
   PUBMED   9126384
REFERENCE   10 (bases 1 to 12349)
  AUTHORS   Gertler,F.B., Niebuhr,K., Reinhard,M., Wehland,J. and Soriano,P.
  TITLE     Mena, a relative of VASP and Drosophila Enabled, is implicated in
            the control of microfilament dynamics
  JOURNAL   Cell 87 (2), 227-239 (1996)
   PUBMED   8861907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Feb 10, 2022 this sequence version replaced XM_039090927.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-401               JAXUCZ010000013.1  96269396-96269796   c
            402-567             JAXUCZ010000013.1  96211471-96211636   c
            568-745             JAXUCZ010000013.1  96206002-96206179   c
            746-802             JAXUCZ010000013.1  96187601-96187657   c
            803-887             JAXUCZ010000013.1  96183046-96183130   c
            888-1174            JAXUCZ010000013.1  96176329-96176615   c
            1175-2008           JAXUCZ010000013.1  96174448-96175281   c
            2009-2313           JAXUCZ010000013.1  96172545-96172849   c
            2314-2459           JAXUCZ010000013.1  96171690-96171835   c
            2460-2517           JAXUCZ010000013.1  96171487-96171544   c
            2518-2566           JAXUCZ010000013.1  96170587-96170635   c
            2567-2633           JAXUCZ010000013.1  96166714-96166780   c
            2634-2712           JAXUCZ010000013.1  96161430-96161508   c
            2713-2770           JAXUCZ010000013.1  96159477-96159534   c
            2771-12349          JAXUCZ010000013.1  96149437-96159015   c
FEATURES             Location/Qualifiers
     source          1..12349
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..12349
                     /gene="Enah"
                     /note="ENAH, actin regulator"
                     /db_xref="GeneID:360891"
                     /db_xref="RGD:1307666"
     exon            1..401
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     CDS             397..2808
                     /gene="Enah"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein enabled homolog"
                     /codon_start=1
                     /product="protein enabled homolog isoform 1"
                     /protein_id="NP_001388306.1"
                     /db_xref="GeneID:360891"
                     /db_xref="RGD:1307666"
                     /translation="MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNN
                     TFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFAS
                     AMMHALEVLNSQEAAQSKVTATQDSTNLRCIFCGPTLPRQNSQLPAQVQNGPSQEEME
                     IQRRQLQEQQRQKELERERMERERLERERLERERLERERLEQEQLERQRQEREHVERL
                     ERERLERLERERQDRERERERLEQLEREQVEWERERRMSNAAPSSDSSLYSAPLPEYS
                     SCQPPSAPPPSYAKVISAPVSDAAPDYAVVTALPPTSTPPTPPLRHSATRFATSLGSA
                     FHPVLPHYATVPRPLNRNSRPSSPVNTPSSQPPAAKSCAWPTSNFSPLPPSPPIMISS
                     PPGKATGPRPVLPVCVSSPVPQMPPSPTAPNGSLDSVTYPVSPPPTSGPAAPPPPPPP
                     PPPPPPPPPPPPLPPLASLSHCGSQASPPPGTPLASTPSSKPSVLPSPSAAAPASVET
                     PLNPELGDSSASEPGLQAASQPAETPAPQGHVLGPPAPPPPPPLPSGPAYASALPPPP
                     GPPPPPPLPSAGPPPPPPPPPPLPNQVPPPPPPPPAPPLPASGIFSGSMSEDNRPLTG
                     LAAAIAGAKLRKVSRVEDGSFPSGGNTVSVNLASSKTDSGRGNGPLPLGGSGLMEEMS
                     ALLARRRRIAEKGSTIETEQKEDRSEDAEPVTSKAASTSTPEPTRKPWERTNTMNGSK
                     SPVISRPKSTPSSQPSANGVQTEGLDYDRLKQDILDEMRKELAKLKEELIDAIRQELS
                     KSNTA"
     exon            402..567
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     exon            568..745
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     exon            746..802
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     exon            803..887
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1174
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..2008
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2313
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2459
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2517
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2566
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2633
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2712
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2770
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..12349
                     /gene="Enah"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcctcaggg cttcggcggc ggcggcggcg gcggcggcgc acttggagcg gcctctggag
       61 cggcgggcgg gcgaacggac gggcgcgcgg ccccggtggc tcccgtctga ggcagcggac
      121 gaagctcggc gggtaggagg cggcgacgca ggcggaggag gcggcggccg ccggggaccc
      181 gctcggcgcc tcggccccgc gctccctcct cagcccgtgg tcgctcgcgc tcggcgggcc
      241 ggcgcctcgc ctctgcgcgc ggagatggtg tagcccggcc gccggagccg gagccgcctc
      301 tgctcgtgcg tccccgcggc gtccgcctcc ccgcctgaga agagaccctc cgctcggcgt
      361 ctcccgcgcc ggagaagcct cggcgccgcc ggcaccatga gtgaacagag tatctgtcag
      421 gcaagagctg ctgtgatggt ttatgatgat gccaataaga aatgggtgcc agctggtggc
      481 tcaaccgggt tcagcagagt acatatatat caccatacag gcaacaacac attcagagtg
      541 gtgggcagaa agattcaaga ccatcaggtt gtgataaact gtgccattcc taaaggactg
      601 aagtacaatc aagctacaca gactttccac caatggcggg atgctagaca ggtgtatggt
      661 ctcaactttg gcagcaaaga ggatgccaat gtcttcgcaa gtgccatgat gcatgcctta
      721 gaagtgttaa attcacagga agcagcccag agcaaggtta ctgctaccca ggacagcact
      781 aatttgcgat gtattttctg tgggccaaca ttgcctagac agaattcaca gctacctgct
      841 caagttcaaa atggcccatc ccaagaagag atggaaatcc agagaaggca actgcaagag
      901 cagcagcgac agaaggagct ggagagggag cgaatggaga gggaaaggtt ggagagagaa
      961 cgactagaac gagagaggct agagagggag cgcctggaac aggagcagct ggagcggcag
     1021 aggcaggaga gggagcacgt ggagcgcctg gaaagggagc gcctggagcg gctggagaga
     1081 gagaggcaag accgagagcg agagcgcgag cgcctggaac agctggagcg agagcaagtg
     1141 gagtgggaga gagagcgcag aatgtccaat gctgctccat cttcagacag ctccctgtat
     1201 agcgctccac ttcctgagta ttccagttgc cagcctcctt cagcacctcc tccatcatac
     1261 gctaaagtca tctcagctcc ggtgtcagac gccgctcctg attatgctgt agtgactgct
     1321 ttgccaccta cttccacacc ccctacacca ccactgcgac actcagcgac acgttttgca
     1381 acatctctag gttcagcctt ccaccctgtt cttccccatt acgccacagt tcctcgtcct
     1441 ctgaacagaa actctcgacc ttcttctcct gtgaacacac cctcttctca gcctccagct
     1501 gcgaagtcct gtgcctggcc tacttccaat ttctcgcccc tccctccatc tcctccaata
     1561 atgattagca gcccccctgg caaagctact ggcccacggc ctgtccttcc cgtttgtgtc
     1621 tcctctcctg tgccccaaat gcctccgtca ccaacagcac ccaatgggtc gctagactct
     1681 gtaacatacc cagtgtctcc accgcctacc tcagggccag cagcgccacc tccgccgcca
     1741 ccgccaccgc cgccaccacc accaccaccg ccaccgccgc cgctgcctcc cctcgcctca
     1801 ctctcacact gtggatcaca ggcttctcct cctccaggca cccctcttgc ctcaactccc
     1861 tcatccaagc ccagtgttct cccttctccc tctgcagctg cccctgcctc tgtggagacc
     1921 cctctaaatc ctgagctggg agactcctct gcttccgagc caggcttgca ggcagcctct
     1981 cagccggccg agacgccagc cccacagggc catgtcttgg gaccacctgc acctccacca
     2041 ccaccccccc taccatcagg ccctgcctat gcttcagcac ttccccctcc tcctggaccc
     2101 cctccaccac ctccactgcc atccgctgga cctcctcctc caccgcctcc accaccccct
     2161 cttcctaatc aagttcctcc ccctcctcca ccacctcctg cccctcccct ccccgcatct
     2221 ggaattttct ctggatccat gtcagaagac aatcgccctt taactggact tgcagctgca
     2281 atcgcgggag caaaacttag gaaagtgtct cgggtggagg atggctcttt cccaagtgga
     2341 ggaaatactg tgagtgtgaa cttggcctca tccaaaacag attctggtcg tggcaatgga
     2401 ccccttcctc tagggggcag tggcttaatg gaagaaatga gtgccctgct ggccaggagg
     2461 agaagaattg ctgagaaggg atcaacaata gaaacagaac aaaaagaaga cagaagtgaa
     2521 gatgcagagc ctgtaacttc taaggcagca tcaacaagta cacctgaacc aaccagaaaa
     2581 ccttgggaaa gaacaaacac aatgaacggc agtaagtcac ctgtcatctc cagacccaaa
     2641 tccacacctt cctcacagcc aagtgccaat ggggtccaga cagaagggct tgactatgac
     2701 aggctgaagc aggacatttt agatgaaatg agaaaagaac ttgcaaagct gaaggaggag
     2761 ctcattgatg caatcaggca ggaactgagc aagtcgaata ctgcataaag aagcaaacta
     2821 aggagggaca ggacttgaat ctggagaaaa acaaaaattc ctacaaacaa ctgttaacaa
     2881 cccccaaaat ttttaagctg taagaagaaa atggatacac agtcaggagg gaaaaccgcc
     2941 aacctctgga agccttcaga cacagtgact ctggcgatca gctgttccct cagtgtgctg
     3001 cttttattct gacctttacc acaggatgga gaattatatt tgagttccct tagcagtact
     3061 aaacccgtca ggcaagatca ccgtgcactg aaatattttc atgtctagat gaatctgcac
     3121 gttttccata atccattgct aaaataaaga cgaaaaaggc ttaagaggtt tttttcagag
     3181 ggcgctgatg aagaatttaa tttagtaagt tctgctgttg cattgtaaac gtttctctca
     3241 ggtttgtctt cctatcatat tcgatattcc gtgcatagtt aagaccataa gtatggaaca
     3301 aatgggattg tatgtgcttt caaagggtgg tgtctgtaag gaaggtccta aaatgtttag
     3361 cccactggag gaattttaga atgataggaa gcctctcggg ttagccttca tgcaattttg
     3421 tagtttaaaa cataaagtcc gtccagaaat taaagattta gatgccttcc taaattgtta
     3481 caatgcttta ccaaatctat gacttctata taaccaacag tggtcaaatg taaaacattc
     3541 tattatagat ttactgtagg ttttcaacct tttttagaca tatgcatgtg gacattttta
     3601 taatgtaatt acaatcacca cacagttagc ttttttaatt acagacaata atgcacgtca
     3661 cactaatatg tagtggccct ttcaaggcct agtcccaggg aaaacatttt gtagaatata
     3721 gggaagtggg aggaagggaa ggaatcattt ttttatttaa agttaatttc tgcactatcc
     3781 ttttttcttc aattatctgc atgaattata agagagatac tttgtgactt taatcagtaa
     3841 acatgttaac aagaccaagc acttacatct tttacatcat gtcttcaact atttgtattt
     3901 taaccaacaa tttcaacgcc ctgaaacatg attctgattt cacatgaatt acgtctcact
     3961 gtggaactcc aacgtctgat ccctgaattt ggcagatatt gtcactaggt tcccacagtg
     4021 ctgcggtgtc tgggtgcctg ctcctggctt tgaagcactc ctgacctttg ttgtgctgaa
     4081 gtacaagaaa tgtcagtggt ggccgcaacc agggtcacag aagtcactag ggagagggaa
     4141 cctgtgaggg tttggcagtt tccttttaat aaaactaaag tgaggcttaa gtggtaggaa
     4201 gtgtccgatg ctgttacacc ctgagcacgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4261 gtgtgtgtgt gtgagagaga gagagagaga gagagagagc gcacatgtga tagatatgtt
     4321 ccaccccttt attgaaattt ataattggca agattaaaat aagggaggga ttctgtgttg
     4381 tagtgttagc tttttagaaa atctaggaaa tcaaagattc tcctggctct ccatcatggt
     4441 ctatgcttga gttattaatg tgccatattt gctttggaat ctttggttat caacttttac
     4501 taaaacatag aatccacttt gatttgcttt ctagatttca tgtgtctcag ctgtaaagcg
     4561 aaccttgatg agagtagttt tctacatcct gcagtctgca gttgacaccg ctgcagagat
     4621 gtttgaaaga ggagttttta ctggtttttt attgttgtta agagtttctg tttctgtaga
     4681 aacttacttc atttttagat taaagtgtga gggacgagct gttgtaatcc aactctggct
     4741 gtttttctgc cccttctaca ttgtcttgca gacatagtaa aggcattaaa gatgcagcaa
     4801 gcttgtcagt tgttctcgaa aagaggtagg catctcattt gctgccgaac ttttgattat
     4861 gcaactactt tgatagtgta aatgtgtcat atcccttaca gatctgatca aaagtcactt
     4921 ttctttttgt tgctaaggtt aagtagtctg tagtaggtag agtactggtt ataaatggtc
     4981 caaagtgaga cagaaagcta aggtcaaatg ctaagtccta aaagaagctg gtttatgcac
     5041 taaacgtttt gtgccttggt ctaatattta acacaatgtc tgtaaaatga caaaaaaaga
     5101 aaaaaaaaag aaaaacgaaa aagaaccgct gttgactcat gctgtatccg taccctccat
     5161 cgtattgcgt tgtcccacat gactacacgt gctctgccct ggaggcttac gtggactctt
     5221 ctgtacattc actgtcacac agcaggagag tcctgcgtgt cattgttaga gatttcagtg
     5281 actcaaatgg gaaacacaag ctcgagttac tttcccagaa ctgtccccct ggaaccatac
     5341 tgtgacgatg ggttcttgct tctgtgtgct gaatgtcttc agctgaggac agtttaggga
     5401 ttctctctaa tgacaggaag gcactgctct cctcaacact gtgatctgac ctgcgacaat
     5461 tctacaatac actctgtgaa tggctagcaa gtccatagca aacaaactga atgtacaagc
     5521 cttagcgtgg tgctgaaatc ccttcagagt agtaaccgtg atctcaaagt ctgtttaaaa
     5581 tctacgagca tcatgtgtca atcggaacta aagatgaaac actgatgaat gttcaatcct
     5641 catgctgcag gtgtggttcc tgtttagctt ttcagttctc tgctgttacc accgtaactg
     5701 ttccatttaa atctcctaca cggcgacttc atctgtgcgg ttaaaataaa attgcagtgt
     5761 atactgtttc tggtttgtga cactacatgg tcttctgaaa gaatgtgtta attctaaacc
     5821 atgaaacaag caccttataa agcccaaggc gtcactgttt acagtttaca catcacgtca
     5881 ctgttcttta aagatttcat ccaagtcagg aatagtgaat gacacaacgg ggatgcatgg
     5941 tgatctctgc cttctgactg caggaagtgc catgcgttcc ttctgtctta cattccttct
     6001 gtctcagttc agcctgacag tgtcttttaa gtcaagatgg tgggaaatgg cttactccat
     6061 tttttgttcc ataacacgga tcacatatag ttcacctcat ttacacagtt catttttctt
     6121 tgtgtgattt tcatattaaa gaatattgcc aagtaattga ctttaaatgt agcagtctgt
     6181 accatctaca gtgatctttt taaattggct ttatgtgtat atgcctcagc acgtttgtct
     6241 atattataaa gtgtcgtttt tgagtttatt ttcaaactgt aatgtcatta gaagtacaac
     6301 aatcgtgtgg ggtgtgggtg tgtttctctg tgtatgttgt gtgtgtgtgt gtgtgtatgt
     6361 atgtatgtat ataattgtgt atatgtgtgt ttgtgtgttt atgtgtgtac atctctgcat
     6421 atgtgtgtat atgtctgtgt gtatgtttct gtgcatgtgt atgtatgttt gtgtgtatat
     6481 atgtatgtgt gtatatctct gtatgcatgt gtatgtatgt ctgtgtgtat gtacatgtgt
     6541 gtatgtatgt gtatatatgt gagtgtgtgt gtgtgtgtgt gtgtgtgtag tgtgtgtttg
     6601 tgtgcccccc gcccccttaa gcagacccca gtctctatct cgggcctctg catcctctgt
     6661 gtacttcctg ttcctggtac tgattggcgt ttgtaaccac tctattgccc actgatgtga
     6721 aaacaacagc tggtttttct tttcatttgc ctggctaaaa ttactatctc ttaactttta
     6781 tccatctttt tagtgatgct gagaactcgt gcttttatgg ttcaggtctt gcaaaggtga
     6841 acttcagaac gtgttggcat ttcttctcgt tgccataaga attgttaagc cctttacgat
     6901 ggtctcttgt cctgtggatg tacctgtaag ccggcatcct agagacagaa acaggaggat
     6961 tgtggatctg aggtcaggct gggatgcata gagaaacttt gtctaaagca aaccagtaaa
     7021 gtgctgcagg tcatacacat aatactgaca ccatgtctca gagtgtaaag gaactcgagt
     7081 atagagggac acaaatgcag atcgtaaagg gggcacctgt ccctttgtca tgctagaaaa
     7141 cccactgttc ctaaagacag tctagttttc acttccaaac tcaaacctgt tcctgagtgc
     7201 gccatttttt gttttcaata caattggtat ctgatcatct ccccagagct ctgagaaata
     7261 gaaaaggatc ctaagaattt actggagttg atacctctga ctttctggtt agagccattt
     7321 actccttcat aagttcagtt ttgttttgtt ttgttttttc tttaagtcaa aacttgctgt
     7381 attttaaaga accgcagtta ctctggtcag taacttatgt gaagatcgca gagaacatgt
     7441 acttagagga attgtttttt gttaagcata caactgtttg actaagaagc taaaattagc
     7501 aatctctcaa gagaagccat ttatttatgc caaatattct tggggttgag ggtggggata
     7561 ggatacaatc tttctgttcc taacatcaaa ataggctgtg gactaaatct tgttctctta
     7621 ggtttctcgt aatggttttt tgaagtacca agattctttt taaaacctct ttgtggatga
     7681 ataagatgag tatatccctg tagaaaccag tgttcaacct tgacgcccat gtcctttgag
     7741 acagggccac aaattcagcc agtgagtctc cgggatcctc ctgtctctgt tgcctgctgc
     7801 tgggtgtact ggcttgtacc accacaccca gcatttttgc atgggttctg ggatctaact
     7861 ggtgaccttg tgcttgcaat ggaagcgtgc ttccaattta gctggctttc taggcctgcc
     7921 ccccattttg tcttaatatc ttaatgttgg aacagtgaaa cattgcacgt tcgaactgta
     7981 agattgatga gttaattaga agagaaagta aagtgaaaca gtgagttcac agggttatgg
     8041 gacaggtgcc ttctgtcagt attctactaa tgaatagtca ccttgcagaa gggaaactgg
     8101 gctttggggt aaaaatgtga gcttgaaagt ctttccaagc gtgaactgtg ttcatttgta
     8161 aagcagcagt cactgaatga aagggtagaa agtgacttgg tcattgtgac ttgattaaat
     8221 agaacgttct acagtcgttg gttgtatctg ttgaaagcta aaagtctgga tcatgtgagg
     8281 aggagacgtt tgggaaatgg ttttcccttc tgctagagat gctctgttgt ataaaccctg
     8341 gtaggtttcc agtgcttgct cattaaacgt gtagaataag tgaaaactga agcttgggtt
     8401 aaatgtttga accagagatc agtcaccgtt ccctagtttc tgaagcttac tgggtattcc
     8461 aatagagaac ttctagaatt ttctggccta gaatcctagg attcctggat ataggaggaa
     8521 cttgattagg gacctaggca agaactgaga ggtagcagag tccatgactc acttgaatta
     8581 gggaactcaa gagtattgcc aagttcacca aactaggcct tttctaaaac atgtactaag
     8641 ctaagagaga acagggctgt ctgtgctgat aaaatcagaa atgtctgtgt gcttcatttc
     8701 tctcagtctg ttttacctgt ccccttttga ttccaggaag atttccttag caatagataa
     8761 cagactcctt caaaagaaaa agaaaaaaag acaggtgtct aatacaggca gtaaatggtg
     8821 ttgtcagtag atatggctaa tatggtgtac atattttcta gctctggggg catctcagtt
     8881 gcggtgggat tgcatagtat gtatggggat tggtccctac cactgaaaaa tcaaaatgca
     8941 gtttttacca ggaggtgaat gtaacacatg gaccgttttc aagtacctaa gaaaacaaaa
     9001 ttcaatcgtt agtcagttct gtctacacag ccttccttta aagtttttct gttgtttgtt
     9061 tgttgtttta agatttttaa acttgtttta ggagagacat acaagactgt catcccacca
     9121 ccaagtttca cctagattaa caggcaagtt ttgacatttg atattttaac ttgtgggatt
     9181 tccccgaata ttttttgatt ctcaaattct gaggtctgtc tgttctgggg gattgtctaa
     9241 caatcttaaa accacaagtc ctacctgatg ccgaagccac caggcctctc ttgtgtatca
     9301 ggagaaaaac aaccaagctg gcttagccct ttggggacca acctggtacc agctttgcac
     9361 tttgcctggg agaactatat ctcagaggaa ggtaattggg ggggaaagca ggttaaaatc
     9421 tagatacgat ttctgtttac tgcaggggca gagaacagtt tcaggagttt gtctacttac
     9481 tcaggacacc aagttcctaa cagtgaactt gggcatctat ggttcctgcg agacatctca
     9541 gatgtgtatc tgttctctgt gctcctgctt tactctaaat gtgagtcctg aggcagccag
     9601 ccgttgactt ggggccctgt gccaggttac tcgtatatca ggtcccctct gcttctgaca
     9661 tctagttgtt tcttcacccc ctatcctcta gctatgatca gtgtgtattt cacccaagaa
     9721 acagaattat tttttttatg catatgggtg ttttacctgc atatctttac accacacatg
     9781 tgcctgctgc ctttggaggt tgaagaagag catcagatcc cctggaactg gagtcataga
     9841 cagtagtgag ctgccctttg tatgctggag cctctgcaaa taaataaaaa gtgctgttag
     9901 tggctgagcc atttctccag cccccttctc tctgatctta aagagcagct tttcaatgtt
     9961 taaagttgct agatcatgat tggtgaaatt cttctattta tgaataaaga ggtaagagca
    10021 gatggtctgt cattctgaga tcaggcattg gtcgttagct gtgtgctttc ataagctgaa
    10081 acactgggga caacttggtg gcttcagtac aagcatgtgc ggtcagaaag acccgtgttc
    10141 tccgggggtt gtttttcaga cctgtgctcc agtgagctag gtagaaagtc ccatgtattc
    10201 tcatgctttg tgagccgttt ctaggctagc tgattgctga gctgctgtga gcgctatctt
    10261 accctcctct ttgcctaggg agaatgcacc tcagcggcgt ttgtgaatgc ttgtttcctg
    10321 tgagccagct gtgtactgtg tcactagcag cttgaaactg acaaaaggtg acagtacacg
    10381 cccccctcta ccctttttat tatacaaagt acgatccttc cttgcctccg ttttaaactc
    10441 cagctttact gcaattaatt gacaggcccc cctctgatac tgtttaagtg ttctgatccc
    10501 tcatttactg tctttttttt tttttttttt tttaaaaggc aggatttctc cgtatagcct
    10561 tgggtatctt agaactctgt agaccaggct agcctggaag tcagaggtcc acctgcctct
    10621 gactcctgag caccgggatt aaaggcgtgt gcgccacaac cacctgcccc gttgcttgct
    10681 ttttaagata ggtgcctaga tgatacgttt gggcattttg acctactagt gtactttttc
    10741 tcagaatctt tcttggtttg tgtgtggaca tccatttctt gttgacaaga cttgcttttc
    10801 catttctaca ggtgtctgta gtcgatacaa aatatttata taatacatgt ttataacaga
    10861 ggcctggggt acttttgagg caacctgtaa tctgtagcca cccactgaac ctccggggtc
    10921 cccattggaa gataaaaggc cgctgcatct gtggttcatc cagaacagaa cttcagacag
    10981 ttgactaagg attccagcta gaagcacttc agggcctgac ccatgagaga aggtccaacc
    11041 cgatgcgagc cagctgcttc ctttgtgctt tccggaaagg ctctggcagt cagaatgaat
    11101 aggccagtgt gtgacttgaa agctgttttt aacattgatt ggtttgtctg tttttctttt
    11161 gagaggtttt tctttgtttt ggttttgagt tttggtaggt tggttttggt ggggtttttt
    11221 gtttttttga gcccttagga attcagtgat gaccctttct ggctaaagaa ccagatttag
    11281 gtccttaaat agattttcct tctcagacct caacttgata ttaccaaaaa acacactaga
    11341 atagcacagt gggtgggatt agaacagtcc gtcttagaga tcagatgtat catcggagcc
    11401 cttttcttac agaacactct gaacttttcg tctcatgtcc tcttcctttg tggcagatac
    11461 tggaaatacg cacttacgtc ctttagacat gcccagatct gctctccttg gtaaaggatg
    11521 ataaatattt gcagtctgcc aactgggact tagatactct aaagtcaggt gtggcggcag
    11581 cttcactgag gtcagacttc tagaagtcaa gttttattct acatcacttg ctagctacag
    11641 ccttgtgtac cttatctcag tgaatcttac ggattatagg ccttgctaga atccaggaga
    11701 gaggaaactg gccacaactt actgtagatt tcataactta ttgtaagttt ttgcctgatt
    11761 gactgaaata attttgaaag tctgtataaa atacgatttc gtcatcaagt aacaccgtca
    11821 tccaagcttg gcacatgctt taagaggggg aaacagaaga gagggcgaga aggcaagatg
    11881 ggtggcttag taggatcagg tagcgccaga gcttggcacc aaagtttcta atgatttcac
    11941 gtggaggacc acttgtgatc caccctagga agacttgcca gaacgtagcg gtttctgcta
    12001 cacaatacag tgccttccaa tgatgttatg tgtgaattgc atgcaatctc atgtaaccct
    12061 ggaatataac atgtatgtgc atgatctgtc cagaatgtgc aaagctagga ttcagcagaa
    12121 agggctgagc cctgttgctg atgggtcagc aagctgctgg agttgaactt gtgacttagg
    12181 cttttagcct tggatcctgg ggtttgcact aaaatgattt tgtcacccaa tcagatctgt
    12241 ctccctttta gctcctttcc tactttgcag ctttgctgat tttaactgct tcattcttct
    12301 gcttcttggt atctttcttt tgaaataaaa agacacaata cctaaccca
//
