LOCUS       NM_001109214            2713 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus engrailed homeobox 2 (En2), mRNA.
ACCESSION   NM_001109214 XM_001058797 XM_575315
VERSION     NM_001109214.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2713)
  AUTHORS   Sgado P, Alberi L, Gherbassi D, Galasso SL, Ramakers GM, Alavian
            KN, Smidt MP, Dyck RH and Simon HH.
  TITLE     Slow progressive degeneration of nigral dopaminergic neurons in
            postnatal Engrailed mutant mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (41), 15242-15247 (2006)
   PUBMED   17015829
REFERENCE   2  (bases 1 to 2713)
  AUTHORS   Simon HH, Scholz C and O'Leary DD.
  TITLE     Engrailed genes control developmental fate of serotonergic and
            noradrenergic neurons in mid- and hindbrain in a gene
            dose-dependent manner
  JOURNAL   Mol Cell Neurosci 28 (1), 96-105 (2005)
   PUBMED   15607945
REFERENCE   3  (bases 1 to 2713)
  AUTHORS   Simon HH, Thuret S and Alberi L.
  TITLE     Midbrain dopaminergic neurons: control of their cell fate by the
            engrailed transcription factors
  JOURNAL   Cell Tissue Res 318 (1), 53-61 (2004)
   PUBMED   15340832
  REMARK    Review article
REFERENCE   4  (bases 1 to 2713)
  AUTHORS   Alberi L, Sgado P and Simon HH.
  TITLE     Engrailed genes are cell-autonomously required to prevent apoptosis
            in mesencephalic dopaminergic neurons
  JOURNAL   Development 131 (13), 3229-3236 (2004)
   PUBMED   15175251
REFERENCE   5  (bases 1 to 2713)
  AUTHORS   Simon HH, Saueressig H, Wurst W, Goulding MD and O'Leary DD.
  TITLE     Fate of midbrain dopaminergic neurons controlled by the engrailed
            genes
  JOURNAL   J Neurosci 21 (9), 3126-3134 (2001)
   PUBMED   11312297
REFERENCE   6  (bases 1 to 2713)
  AUTHORS   Joliot A, Trembleau A, Raposo G, Calvet S, Volovitch M and
            Prochiantz A.
  TITLE     Association of Engrailed homeoproteins with vesicles presenting
            caveolae-like properties
  JOURNAL   Development 124 (10), 1865-1875 (1997)
   PUBMED   9169834
REFERENCE   7  (bases 1 to 2713)
  AUTHORS   Kury P, Schaeren-Wiemers N and Monard D.
  TITLE     Protease nexin-1 is expressed at the mouse met-/mesencephalic
            junction and FGF signaling regulates its promoter activity in
            primary met-/mesencephalic cells
  JOURNAL   Development 124 (6), 1251-1262 (1997)
   PUBMED   9102311
REFERENCE   8  (bases 1 to 2713)
  AUTHORS   Hanks M, Wurst W, Anson-Cartwright L, Auerbach AB and Joyner AL.
  TITLE     Rescue of the En-1 mutant phenotype by replacement of En-1 with
            En-2
  JOURNAL   Science 269 (5224), 679-682 (1995)
   PUBMED   7624797
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474057.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575315.2, XM_001058797.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO400332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2713
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..2713
                     /gene="En2"
                     /gene_synonym="RGD1561842"
                     /note="engrailed homeobox 2"
                     /db_xref="GeneID:499964"
                     /db_xref="RGD:1561842"
     exon            1..702
                     /gene="En2"
                     /gene_synonym="RGD1561842"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1019
                     /gene="En2"
                     /gene_synonym="RGD1561842"
                     /note="engrailed 2"
                     /codon_start=1
                     /product="homeobox protein engrailed-2"
                     /protein_id="NP_001102684.1"
                     /db_xref="GeneID:499964"
                     /db_xref="RGD:1561842"
                     /translation="MEEKDSKSSETAAEAQRQPEPSPGGGSGGGSSPSDSDTGRRRAL
                     MLPAVLQAPGNHQHPHRITNFFIDNILRPEFGRRKDAGTCCAGAGGARGGEGGAGSTE
                     GGGGADGAEQILGARESRPNPACAPSAGGPLSGASGDPAADGEGGSKTLSLHGGAKKP
                     GDPGGSLDGALKARGLGGGDLSVSSDSDSSQASATLGAQPMLWPAWVYCTRYSDRPSS
                     GPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNES
                     QIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHSTTAKEGKSDSE"
     exon            703..2713
                     /gene="En2"
                     /gene_synonym="RGD1561842"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttggaggtg ggccggtgaa gaggcggttt gggattttct gtaaagcatg gaggagaagg
       61 attccaagtc cagcgagacg gcggcggagg cgcagcggca gccggaaccc agccccggcg
      121 gcggctccgg aggcggcagc agcccgagcg actcggacac cggccgccgg cgtgctctga
      181 tgttgcccgc ggtcctgcag gcgccaggca accaccagca tccgcatcgc atcaccaact
      241 tcttcatcga taacatccta cgaccggagt tcggccgccg aaaggatgcg gggacttgct
      301 gtgccggcgc gggcggagcc aggggaggcg aaggcggcgc tggcagtacg gagggaggcg
      361 gcggcgcaga cggagccgag cagatcctgg gcgccaggga gtcccgaccg aaccctgcgt
      421 gcgcacccag tgcaggaggg ccgctctccg gtgcctccgg cgaccctgcg gccgatggag
      481 aaggcggctc caagacgctg tcgctgcacg gtggtgctaa aaaacccgga gacccggggg
      541 gttccttgga tggagcgctc aaggcccggg gcttgggcgg aggtgacctg tcggtgagct
      601 ccgactcgga cagctctcaa gccagcgcca ccctgggcgc gcagcccatg ctctggccgg
      661 cttgggtcta ctgcacacgt tactctgacc ggccttcttc aggccccagg tctcgaaaac
      721 caaagaagaa gaacccgaac aaagaggaca agaggccgcg caccgccttc actgctgagc
      781 agctgcagag gctcaaagct gagtttcaga ccaacaggta cctgacggag cagaggcgcc
      841 aaagtcttgc gcaggagctc agcctcaacg agtcccagat caagatctgg ttccagaaca
      901 agcgggccaa aatcaagaaa gccacgggca acaagaacac tttggcggtg cacctcatgg
      961 cgcagggcct gtacaaccat tccaccaccg ccaaggaggg caagtcggac agcgagtagg
     1021 gcgagcaggg cgggcgggcc gaccggccag gtcttaggac cgcgcaaaac aatgcaataa
     1081 tttaaaaaac cgtgaacaaa gggccagtgt ataaagatta taccagcatt atctgtgaaa
     1141 aacccgtgta ttagctatgg ttctacaata atctatgtac atataattta cagatggtgt
     1201 ataatccaaa aaaactgact ataaaatatt tttgaggttt tttttgtgct taagaggtta
     1261 tgctaatttg ttattatttt tctgcaaagg gggctgtttc ttttcttttt cttttccccc
     1321 ttgtttaatc tcctaagctc cactttggga cattggacac cctccccccc ccccgaaaga
     1381 aaaaaaatta aaacaacttg ctgaagtcca aagattttta ttgctgcatt tcacaggact
     1441 gtgaaccaat aaatagctcc tatttggtct gtgggctctg ccgcttgctt tgtgctggct
     1501 cggacagcgc tgtaggaagc gccagcgtgg tgatggagag ctctggtggg gagagagggc
     1561 acagttcttt tgctgaggtc tgaggaagtc cattcaggcc atcgatcctc ccagcccctc
     1621 tccacttctg cctcctactg cctcacttcc caaccaccgc agaggccctt gctggcagcc
     1681 accgagtgtc tgcgtctgtg tctatgaccc ctgtccccgc cacagtcccg tagcgactgc
     1741 cagcgccaac tctcccgcgg ctgtgggcag gcagcgcttg gggcctgggg agcagtgcga
     1801 gtgtaccctg aaggcttgaa ggctgctagg acagctcgcc ctgatccaaa agcccccgcc
     1861 gaggtgggtc ttggggcctg gcagagcaag ttggcatcgt cttccctttc cttttcttcc
     1921 tctttttttc tttttcactt atttttgaat ggtacataca tgtttgtgta catacttgtg
     1981 tatgcatgtg cacgcacacc ccaggcctgt gtgaagctgg ggttctggag ctcgaagcta
     2041 ccttgacttt caaaggaact cgaatcctcc tgaatctaaa ggacatgtgt aaataatcat
     2101 ttcttatcac gttttgtctt ttttgttttt ttaaagaaaa tatacatttt atttttgaag
     2161 gtgtggtact gtgtaaatta aatatattca atatattcct caccaagtac atatatatat
     2221 aagcaaacac attatatata actccacaat gtcttctgtt tagtgtatgg gaaaaaggtg
     2281 tccaaatgtc cacctggggc cagcacagtg gcaagggtgt tctcagctga gctgagcgtc
     2341 aggctgcctg ctgaggactg atggtggatt tctctctttg ccttaaacct ctttatttca
     2401 ctgcgccaac actttctctt tgtacatatt cgtgccaacc ttctgaaaag gaagctataa
     2461 aaacagaagt tgtaatttaa gagtgtgaat aaccatcttc tgcttgggga tcggtgaaac
     2521 acatgccttt tagcaggaag caaatctgtc cttttttaag tttataaaat gtgcatttta
     2581 cagtatcaaa tatttataat cttatttgaa atggatgaat gttccctact tacaactgtg
     2641 gttatcaaaa ttgtgaccat tccaacctgt gcatttttgt gtgtttaaat tcctgaaagt
     2701 tacactaaat aaa
//
