LOCUS       NM_001109169            2950 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus empty spiracles homeobox 2 (Emx2), mRNA.
ACCESSION   NM_001109169 XM_001065767 XM_574698
VERSION     NM_001109169.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2950)
  AUTHORS   Wang L, Jin J, Zhou Y, Tian Z, He B, Huang Y and Ding F.
  TITLE     EMX2 is epigenetically silenced and suppresses
            epithelial-mesenchymal transition in human esophageal
            adenocarcinoma
  JOURNAL   Oncol Rep 42 (5), 2169-2178 (2019)
   PUBMED   31432154
REFERENCE   2  (bases 1 to 2950)
  AUTHORS   Aykut B, Ochs M, Radhakrishnan P, Brill A, Hocker H, Schwarz S,
            Weissinger D, Kehm R, Kulu Y, Ulrich A and Schneider M.
  TITLE     EMX2 gene expression predicts liver metastasis and survival in
            colorectal cancer
  JOURNAL   BMC Cancer 17 (1), 555 (2017)
   PUBMED   28830374
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2950)
  AUTHORS   Zhang Y, Cao G, Yuan QG, Li JH and Yang WB.
  TITLE     Empty Spiracles Homeobox 2 (EMX2) Inhibits the Invasion and
            Tumorigenesis in Colorectal Cancer Cells
  JOURNAL   Oncol Res 25 (4), 537-544 (2017)
   PUBMED   27712600
REFERENCE   4  (bases 1 to 2950)
  AUTHORS   Yue D, Li H, Che J, Zhang Y, Tolani B, Mo M, Zhang H, Zheng Q, Yang
            Y, Cheng R, Jin JQ, Luh TW, Yang C, Tseng HH, Giroux-Leprieur E,
            Woodard GA, Hao X, Wang C, Jablons DM and He B.
  TITLE     EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung
            Squamous Cell Carcinomas
  JOURNAL   PLoS One 10 (7), e0132134 (2015)
   PUBMED   26132438
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2950)
  AUTHORS   Giroux Leprieur E, Hirata T, Mo M, Chen Z, Okamoto J, Clement G, Li
            H, Wislez M, Jablons DM and He B.
  TITLE     The homeobox gene EMX2 is a prognostic and predictive marker in
            malignant pleural mesothelioma
  JOURNAL   Lung Cancer 85 (3), 465-471 (2014)
   PUBMED   25023662
REFERENCE   6  (bases 1 to 2950)
  AUTHORS   Lopez-Bendito G, Chan CH, Mallamaci A, Parnavelas J and Molnar Z.
  TITLE     Role of Emx2 in the development of the reciprocal connectivity
            between cortex and thalamus
  JOURNAL   J Comp Neurol 451 (2), 153-169 (2002)
   PUBMED   12209834
  REMARK    Erratum:[J Comp Neurol 2002 Dec 23;454(4):495]
REFERENCE   7  (bases 1 to 2950)
  AUTHORS   Bishop KM, Rubenstein JL and O'Leary DD.
  TITLE     Distinct actions of Emx1, Emx2, and Pax6 in regulating the
            specification of areas in the developing neocortex
  JOURNAL   J Neurosci 22 (17), 7627-7638 (2002)
   PUBMED   12196586
REFERENCE   8  (bases 1 to 2950)
  AUTHORS   Shinozaki K, Miyagi T, Yoshida M, Miyata T, Ogawa M, Aizawa S and
            Suda Y.
  TITLE     Absence of Cajal-Retzius cells and subplate neurons associated with
            defects of tangential cell migration from ganglionic eminence in
            Emx1/2 double mutant cerebral cortex
  JOURNAL   Development 129 (14), 3479-3492 (2002)
   PUBMED   12091317
REFERENCE   9  (bases 1 to 2950)
  AUTHORS   Tole S, Goudreau G, Assimacopoulos S and Grove EA.
  TITLE     Emx2 is required for growth of the hippocampus but not for
            hippocampal field specification
  JOURNAL   J Neurosci 20 (7), 2618-2625 (2000)
   PUBMED   10729342
REFERENCE   10 (bases 1 to 2950)
  AUTHORS   Wlodarczyk BC, Craig JC, Bennett GD, Calvin JA and Finnell RH.
  TITLE     Valproic acid-induced changes in gene expression during neurulation
            in a mouse model
  JOURNAL   Teratology 54 (6), 284-297 (1996)
   PUBMED   9098922
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000055.1.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_001109169.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001109169.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR471054.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1255              JACYVU010000055.1  1047568-1048822
            1256-1440           JACYVU010000055.1  1050953-1051137
            1441-2950           JACYVU010000055.1  1053069-1054578
FEATURES             Location/Qualifiers
     source          1..2950
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..2950
                     /gene="Emx2"
                     /gene_synonym="RGD1564797"
                     /note="empty spiracles homeobox 2"
                     /db_xref="GeneID:499380"
                     /db_xref="RGD:1564797"
     exon            1..1255
                     /gene="Emx2"
                     /gene_synonym="RGD1564797"
                     /inference="alignment:Splign:2.1.0"
     CDS             847..1608
                     /gene="Emx2"
                     /gene_synonym="RGD1564797"
                     /note="empty spiracles homolog 2"
                     /codon_start=1
                     /product="homeobox protein EMX2"
                     /protein_id="NP_001102639.1"
                     /db_xref="GeneID:499380"
                     /db_xref="RGD:1564797"
                     /translation="MFQPAPKRCFTIESLVAKDSPLPASRSEDPIRPAALSYANSSPI
                     NPFLNGFHSAAAAAAAGRGVYSNPDLVFAEAVSHPPNPAVPVHPVPPPHALAAHPLPS
                     SHSPHPLFASQQRDPSTFYPWLIHRYRYLGHRFQGNDTSPESFLLHNALARKPKRIRT
                     AFSPSQLLRLEHAFEKNHYVVGAERKQLAHSLSLTETQVKVWFQNRRTKFKRQKLEEE
                     GSDSQQKKKGTHHINRWRIATKQASPEEIDVTSDD"
     exon            1256..1440
                     /gene="Emx2"
                     /gene_synonym="RGD1564797"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..2950
                     /gene="Emx2"
                     /gene_synonym="RGD1564797"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcaggagg aggagaggaa cgaggaagag gaggagaaga gggaagcgga ggagccgaag
       61 gaggaggaga gaaactgcag cgggtgccgc gagagcgagg gagctagccc ggagcgcagg
      121 gcgaagacac caagaggtct gcggccgggc gggcggctgg aggcacggcc ggggcagtgg
      181 cgccgactcc gttccattct gggaccggat ccaggcctcc gggttcccag gcgttcgcct
      241 ccctctgacg cactttaaag agtctccccc ccttccacct cagggcgagt aatagcgacc
      301 aatcatcaag ccatttacca ggcttcggag gaagctgttt atgtgatccc cgcactaatt
      361 aggctcatga actaacaaat cgtttgcact actagtgaag aagcgaacac ttccatggat
      421 tgtccttgga cttagggcgc cctgcccgcc ttttgcaaag gaaagaaaac ttttttttgc
      481 ctccccgaga acccccctcc ctgcctctaa ctccaacccc cccccaacgc cacctcgctc
      541 aaaaaaatat taccccaatc cacgcctgca aattcttctg gaaggatttt cccccctctc
      601 tccaggttgg gcgcgtttgg tgcaagattc tcgggatctt cggctttgcc tctcctcccc
      661 ctccccctcc tttccttttt cctttccttt ctttcttcct tcctttcttt tccttacccc
      721 cacccccacc ccaaacaaac gagtccccca ttctcctcgg tcttcgccgc gggcagcggg
      781 cggcggaggc agcgcgccgc ggtcgccggg agcagggagc ccagggcgcc cgctcctcgg
      841 cgcagcatgt ttcagccggc gcctaagcgc tgcttcacca tcgagtcgct ggtggccaag
      901 gacagtcccc tgcctgcctc acgctccgag gatcccatcc gtcccgcggc gctcagctac
      961 gccaattcca gccccataaa tccgttcctc aacggcttcc actcggccgc cgccgccgcc
     1021 gccgcgggca ggggcgtcta ctccaacccg gacttggtgt tcgccgaggc ggtctcgcac
     1081 ccgcccaacc ccgccgtgcc ggtgcacccg gtgccgccgc cgcacgccct ggccgcccac
     1141 cccctgccct cctcgcattc gccacacccc ctcttcgcct cgcagcagcg ggacccgtcc
     1201 accttctacc cctggctcat ccaccgctac cgatatctgg gtcatcgctt ccaagggaac
     1261 gacacaagtc ccgagagttt ccttttgcac aacgctctgg ctcgaaagcc gaagcggatt
     1321 cgaaccgcct tctctccgtc ccagctttta aggctagaac acgcgttcga gaagaatcat
     1381 tacgtggtgg gagcggaaag gaagcagctg gcgcacagtc tcagccttac ggaaactcag
     1441 gtaaaagtat ggtttcagaa ccggagaacg aaattcaaaa ggcaaaagct agaggaagaa
     1501 ggctcagatt cccaacaaaa gaaaaaaggg acacaccaca ttaaccggtg gagaattgct
     1561 accaagcagg cgagtccgga ggaaatagac gtgacctcag acgattaaaa gtacaaacct
     1621 attcccacag aaatggacag cacggagcaa gagagacagg gagaggaggg gaagaaaaac
     1681 cctacagaac aaaaaacaaa ctgcacacac attcaccgag aaagggggag agggaatcac
     1741 agcagacttt ggacatcgag ggcactggac cgggacccgg cgctggggca ccactcacgg
     1801 gacaggaacg gcagaggacc gaggcccctt catcaacatg caaccctcgt ctaaagaggc
     1861 agctgagtga gtgagagaga cagagactgg gagggagaga gaaaggagag agagagagag
     1921 agagagagag agagagagag agagagagag agagagagaa tgagaatgaa tgatctggtc
     1981 cttctgaggc aaaggcacat tctgacaagg ggagctgtca gtcaaatgcc aaaccaggga
     2041 aacaagatga ttggcggcgt attccgctta tcgaagtcca tttagaaatg ataatgattt
     2101 tttttttgga aaaaaaaggc acaggacttt taattttgca cttcgcagtg tttctccctc
     2161 atctttaatt agaaataaca tgcaaaattc catgtctagc cccaccctac acctgtttca
     2221 aaaacttgaa ttgcatgtaa cagttgttgg gcgaatggtg tctaaaaact gaattgtaat
     2281 tttactcttc ctttaaaggc aggttctgtg tatttttatt ttttattttt tctgagaaat
     2341 gtgcagtctg taaaaacact ttttttttga taccttctat tgtcaaagtg attgtgaaag
     2401 ctaaatgaag taggctcgga aatagtggtc ctctgacaga gaaatgaggg agcaggatgg
     2461 ggatggaggg cgggggaggg tgcccctgag aagagtcagg acttacacta ggggttaaaa
     2521 acaacacatg ataaagaccc aaattaattc tatttcttgg atatttcctt ttctaacatt
     2581 ctgattcttt aaatcaccaa atcaaccttt ccttttagtg gttggagaca ttgaccgcat
     2641 tcaaccactc aacacaatgg ccattcagaa cttttaagtc tgtttattgc aaaagtggaa
     2701 ggaaggactg tagttaatgg ggtgatagtg gcgtggccaa ggacatggga gttttcaagc
     2761 actgagtttc tcttccaaga ccatagactt actaaagagg gttacaaatg cttccttagt
     2821 gtcttctata ccagaatgta aatatttttg tgttttgtgt taatttgtta gaattctaac
     2881 acactatata cttccaagaa gtatgtcaat gtcaatattt tgtcaataaa gatttatcaa
     2941 tatgccctca
//
