LOCUS       NM_001007721            3154 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus epithelial membrane protein 2 (Emp2), mRNA.
ACCESSION   NM_001007721 XM_340744
VERSION     NM_001007721.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3154)
  AUTHORS   Pan,J., Luo,X., Zhao,S., Li,J. and Jiang,Z.
  TITLE     miR-340-5p mediates the therapeutic effect of mesenchymal stem
            cells on corneal neovascularization
  JOURNAL   Graefes Arch Clin Exp Ophthalmol 260 (2), 497-507 (2022)
   PUBMED   34495369
  REMARK    GeneRIF: miR-340-5p mediates the therapeutic effect of mesenchymal
            stem cells on corneal neovascularization.
REFERENCE   2  (bases 1 to 3154)
  AUTHORS   Gee,H.Y., Ashraf,S., Wan,X., Vega-Warner,V., Esteve-Rudd,J.,
            Lovric,S., Fang,H., Hurd,T.W., Sadowski,C.E., Allen,S.J.,
            Otto,E.A., Korkmaz,E., Washburn,J., Levy,S., Williams,D.S.,
            Bakkaloglu,S.A., Zolotnitskaya,A., Ozaltin,F., Zhou,W. and
            Hildebrandt,F.
  TITLE     Mutations in EMP2 cause childhood-onset nephrotic syndrome
  JOURNAL   Am J Hum Genet 94 (6), 884-890 (2014)
   PUBMED   24814193
REFERENCE   3  (bases 1 to 3154)
  AUTHORS   Gordon,L.K., Kiyohara,M., Fu,M., Braun,J., Dhawan,P., Chan,A.,
            Goodglick,L. and Wadehra,M.
  TITLE     EMP2 regulates angiogenesis in endometrial cancer cells through
            induction of VEGF
  JOURNAL   Oncogene 32 (46), 5369-5376 (2013)
   PUBMED   23334331
REFERENCE   4  (bases 1 to 3154)
  AUTHORS   Morales,S.A., Telander,D.G., Leon,D., Forward,K., Braun,J.,
            Wadehra,M. and Gordon,L.K.
  TITLE     Epithelial membrane protein 2 controls VEGF expression in ARPE-19
            cells
  JOURNAL   Invest Ophthalmol Vis Sci 54 (3), 2367-2372 (2013)
   PUBMED   23439602
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3154)
  AUTHORS   Morales,S.A., Telander,D.G., Mareninov,S., Nagy,A., Wadehra,M.,
            Braun,J. and Gordon,L.K.
  TITLE     Anti-EMP2 diabody blocks epithelial membrane protein 2 (EMP2) and
            FAK mediated collagen gel contraction in ARPE-19 cells
  JOURNAL   Exp Eye Res 102, 10-16 (2012)
   PUBMED   22728127
REFERENCE   6  (bases 1 to 3154)
  AUTHORS   Wadehra,M., Forbes,A., Pushkarna,N., Goodglick,L., Gordon,L.K.,
            Williams,C.J. and Braun,J.
  TITLE     Epithelial membrane protein-2 regulates surface expression of
            alphavbeta3 integrin in the endometrium
  JOURNAL   Dev Biol 287 (2), 336-345 (2005)
   PUBMED   16216233
REFERENCE   7  (bases 1 to 3154)
  AUTHORS   Wadehra,M., Goodglick,L. and Braun,J.
  TITLE     The tetraspan protein EMP2 modulates the surface expression of
            caveolins and glycosylphosphatidyl inositol-linked proteins
  JOURNAL   Mol Biol Cell 15 (5), 2073-2083 (2004)
   PUBMED   14978215
REFERENCE   8  (bases 1 to 3154)
  AUTHORS   Wadehra,M., Su,H., Gordon,L.K., Goodglick,L. and Braun,J.
  TITLE     The tetraspan protein EMP2 increases surface expression of class I
            major histocompatibility complex proteins and susceptibility to
            CTL-mediated cell death
  JOURNAL   Clin Immunol 107 (2), 129-136 (2003)
   PUBMED   12763482
REFERENCE   9  (bases 1 to 3154)
  AUTHORS   Wadehra,M., Iyer,R., Goodglick,L. and Braun,J.
  TITLE     The tetraspan protein epithelial membrane protein-2 interacts with
            beta1 integrins and regulates adhesion
  JOURNAL   J Biol Chem 277 (43), 41094-41100 (2002)
   PUBMED   12189152
REFERENCE   10 (bases 1 to 3154)
  AUTHORS   Wilson,H.L., Wilson,S.A., Surprenant,A. and North,R.A.
  TITLE     Epithelial membrane proteins induce membrane blebbing and interact
            with the P2X7 receptor C terminus
  JOURNAL   J Biol Chem 277 (37), 34017-34023 (2002)
   PUBMED   12107182
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081865.1.
            
            On Nov 29, 2004 this sequence version replaced XM_340744.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081865.1, CK478294.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3154
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..3154
                     /gene="Emp2"
                     /gene_synonym="EMP-2"
                     /note="epithelial membrane protein 2"
                     /db_xref="GeneID:360468"
                     /db_xref="RGD:1359629"
     exon            1..87
                     /gene="Emp2"
                     /gene_synonym="EMP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            88..239
                     /gene="Emp2"
                     /gene_synonym="EMP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..680
                     /gene="Emp2"
                     /gene_synonym="EMP-2"
                     /codon_start=1
                     /product="epithelial membrane protein 2"
                     /protein_id="NP_001007722.1"
                     /db_xref="GeneID:360468"
                     /db_xref="RGD:1359629"
                     /translation="MLVILAFIIVFHIVSTALLFISTIDNAWWVGDGFSADIWRVCTN
                     STNCTEINDLSSTEEFSGYSVMQAVQATMILSTILSCISFLIFLLQLFRLKQGERFVL
                     TAIIQLMSCLCVMIGASVYTDRRQDLHHQNSQLYYLLQEGSYGYSFILAWVAFAFTFI
                     SGLMYMILRKRK"
     exon            240..345
                     /gene="Emp2"
                     /gene_synonym="EMP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            346..492
                     /gene="Emp2"
                     /gene_synonym="EMP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            493..3130
                     /gene="Emp2"
                     /gene_synonym="EMP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgcgcag tgccagcccg gagcttcaaa acagccggcg cctcgcctca cgcgcagccc
       61 gccactgtgt ccagacgccc gcgctcgatt tggaattgtc tcgccatctt tgtctcctca
      121 ttcctctctg aacttcctgc tgccttcgct gccctgtgaa catgttggtg attcttgcct
      181 tcatcatcgt cttccacatc gtgtctacgg cactcttgtt catttcaacc attgacaatg
      241 cctggtgggt aggagatggc ttctcagctg acatctggag agtgtgcacc aacagcacaa
      301 actgtacaga gatcaatgac ctgagcagta ccgaggagtt ttcaggttac tctgtgatgc
      361 aggcggtgca ggccaccatg atcctctcca ccatcctctc ctgcatctcc ttcctcatct
      421 ttctgctcca gctcttccgc ctcaagcagg gagagaggtt cgtcctgacg gccatcatcc
      481 agctcatgtc ctgtctgtgt gtcatgatcg gggcttccgt ctatacagac cggcggcaag
      541 accttcacca tcagaacagc cagctctatt acctactgca agaaggcagc tacggttact
      601 ccttcatcct ggcctgggtg gctttcgcct tcactttcat cagcggcctc atgtacatga
      661 tcctgaggaa gcgcaaatag gtgtcggaag cccggccact cccacactat ggcgtccagt
      721 cacataacca ttttgtatat aatcattttt tttgtggttt ttctagcaaa cattgtttcc
      781 tttaaaagct tttatagaag aagaagagaa gacagaggca gagaagagga gtttctgcat
      841 acttgggatc acagagcaga ccatggaggc tggcattcag aatgcttgcc taccgaaagt
      901 ctcagcaaga tcagcaatgt agaaatctac aggatgcctc tcacgggtgg ctctgcgctg
      961 tgggtgtggc caacggtggg gaaagccagt ctttgggagc agactctttg taggtgtctg
     1021 ccctgccctc ttcccctgcc cactccattc cgacagccac agtgggatga taaggtccaa
     1081 atttgggata tctatgctca gatattaaac ctaagttcat gtaagaagtg ggcaaagact
     1141 agccctggtt tgtctgtaag gaacccagag tttcccaacc ccgctgccgt gaattaggtc
     1201 atcacacaaa tttgttgagg tttgctcatg tttgccttaa ggatagtgac cccttaaccc
     1261 agttgtcatg tttaggcact gaaggtccat aggtagttcc tcagggcatc tatcacatgt
     1321 aggctcacaa gtctacttcc aagaccctca gaatccttta tcaagggggt ggtgggcctg
     1381 ggtgtccgaa tttctgatga gctccctgca atatgctaaa tgcactaaag ccaggggtca
     1441 gccctagagc tgggggagca aagccaccct gagaacgtca ccactctcat cacaacgagg
     1501 gggccccact gccagccaca tcttggcttc cacagctgct tatatctggg acacttggaa
     1561 ggcgggctgg tcagtctcct ccccgactac actagagggt ctctcttttt ctccctgccc
     1621 tttctaatgt ggatgcttcc atttggcccc tatttctgta gcctcagaag agccatcttc
     1681 cattcattca tccacccatc attcaacatg aatgagtcta agtgcaaggg ataccctttc
     1741 aaaacaatcc ctcacgagac tcagtctagt gaaaacacac accagaagac aaatggagaa
     1801 actgccaacc ataatgaaac agcagggatt tgaaccctcc agggtgaggg gggccacttt
     1861 ctgtgtctgc ttttaagtac cttgagagat cttgattgct ctgaacagag gttcccttgt
     1921 tccagtgcca ttcattgggt agtgcccact gggttccacc agagaatact tctacagagc
     1981 atcctttact ccccacaggg agacaggaaa ggattccccc aagctgtggc tcttaagatg
     2041 gtcctcaaag aaaaatccag tcatttccga gtgtgctctg aaaccggagg ccacggggag
     2101 gttttcagta gagctggagg agggatgtgc cacacccgag actcaggaaa tctatgatgg
     2161 cagccttctc cctccgatac cctttccatt tttgagcatg agttggagag gtgactctgg
     2221 gacaggtgtg tatctgtgtt tagacacatt tgcatgtgag ttgctcaagg gaggggatat
     2281 ttgccaatag ctcagtccca gtggagctgg gggatgttgg gatctgagtg gcttttaggg
     2341 tcatcattgg ccacttcttc agtacaagac tgacttccct cccttcctcc ctttcttcta
     2401 tcttcctttc cttccttcct tagagggact gccaaggtga catggggcag tgacaggaca
     2461 aatgatcacc tgttgtctta atgtactttc taccgcttac tgttgacttg attgtagagt
     2521 tggcttcatg tcttgtgagt cccaaggaag gagtcctctc tactttcccc ttgtggcctt
     2581 ttctgtaata gctgattaac aattgttctg atgatcatga tggaaacaga ccacctcaga
     2641 aacagaggca cgaaagtctg agcccgcaca aattcccacc tcagaaaccc ccagggtttc
     2701 tacagaagtg cccttgtcta atgcaatggg gatggccctg tgggttgtct ctgcttgctg
     2761 ctgtgaccag ctcagtgcct acagccaccg gtggcatgag aagtgcttct ctcctgctct
     2821 atgccctgca tttgggatgc taagaagagg taaggatgtg aggaagaaga gatccaccct
     2881 tctcctaggt aggatcagct ctcaatggtg cttatcacta gtcatcaaag aacatggcag
     2941 tcagctgcga tatccaagaa gcaagtatta ggaccaaacc tgtcaccgta tttaaaggaa
     3001 ctttagtttg catatcttac atttttataa agtactgtaa ttcagggggg tggggcatgt
     3061 gacagagaca gactaacccg tgtttgtcat ttgaataaaa attattttgg gtctctgttt
     3121 aaagaattca aaaaaaaaaa aaaaaaaaaa aaaa
//
