LOCUS       NM_012843               2685 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus epithelial membrane protein 1 (Emp1), mRNA.
ACCESSION   NM_012843
VERSION     NM_012843.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2685)
  AUTHORS   Lee,H.S., Sherley,J.L., Chen,J.J., Chiu,C.C., Chiou,L.L.,
            Liang,J.D., Yang,P.C., Huang,G.T. and Sheu,J.C.
  TITLE     EMP-1 is a junctional protein in a liver stem cell line and in the
            liver
  JOURNAL   Biochem Biophys Res Commun 334 (4), 996-1003 (2005)
   PUBMED   16036215
  REMARK    GeneRIF: This report is the first to indicate EMP-1 to be a
            junctional protein in the liver.
REFERENCE   2  (bases 1 to 2685)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   3  (bases 1 to 2685)
  AUTHORS   Wilson,H.L., Wilson,S.A., Surprenant,A. and North,R.A.
  TITLE     Epithelial membrane proteins induce membrane blebbing and interact
            with the P2X7 receptor C terminus
  JOURNAL   J Biol Chem 277 (37), 34017-34023 (2002)
   PUBMED   12107182
REFERENCE   4  (bases 1 to 2685)
  AUTHORS   Chen,Y., Medvedev,A., Ruzanov,P., Marvin,K.W. and Jetten,A.M.
  TITLE     cDNA cloning, genomic structure, and chromosome mapping of the
            human epithelial membrane protein CL-20 gene (EMP1), a member of
            the PMP22 family
  JOURNAL   Genomics 41 (1), 40-48 (1997)
   PUBMED   9126480
REFERENCE   5  (bases 1 to 2685)
  AUTHORS   Taylor,V., Welcher,A.A., Program,A.E. and Suter,U.
  TITLE     Epithelial membrane protein-1, peripheral myelin protein 22, and
            lens membrane protein 20 define a novel gene family
  JOURNAL   J Biol Chem 270 (48), 28824-28833 (1995)
   PUBMED   7499407
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087031.1.
            
            On Dec 26, 2004 this sequence version replaced NM_012843.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087031.1, DY320853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2685
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q43"
     gene            1..2685
                     /gene="Emp1"
                     /gene_synonym="CL-20; EMP-1; ENP1MR; TMP"
                     /note="epithelial membrane protein 1"
                     /db_xref="GeneID:25314"
                     /db_xref="RGD:2552"
     exon            1..109
                     /gene="Emp1"
                     /gene_synonym="CL-20; EMP-1; ENP1MR; TMP"
                     /inference="alignment:Splign:2.1.0"
     exon            110..223
                     /gene="Emp1"
                     /gene_synonym="CL-20; EMP-1; ENP1MR; TMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..628
                     /gene="Emp1"
                     /gene_synonym="CL-20; EMP-1; ENP1MR; TMP"
                     /note="tumor-associated membrane protein"
                     /codon_start=1
                     /product="epithelial membrane protein 1"
                     /protein_id="NP_036975.1"
                     /db_xref="GeneID:25314"
                     /db_xref="RGD:2552"
                     /translation="MLVLLAGLFVVHIATAIMLFVSTIANVWMVADGIDSSIGLWKNC
                     TSGSCDGSLSYGNDDAIKAVQAFMILSIIFSIISLVVFVFQLFTMEKGNRFFLSGSTM
                     LVCWLCILIGVSIYTHHYAHSEGNFFPSSHQGYCFILTWICFCFSFIIGILYMVLRKK
                     "
     exon            224..320
                     /gene="Emp1"
                     /gene_synonym="CL-20; EMP-1; ENP1MR; TMP"
                     /inference="alignment:Splign:2.1.0"
     exon            321..461
                     /gene="Emp1"
                     /gene_synonym="CL-20; EMP-1; ENP1MR; TMP"
                     /inference="alignment:Splign:2.1.0"
     exon            462..2654
                     /gene="Emp1"
                     /gene_synonym="CL-20; EMP-1; ENP1MR; TMP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtcaggt ccctcccctc actgtggtca caaacctcct gaagagagga ccagaccagc
       61 agccagcgcc accactcagg gcatctgcct ctgtcactgg atactccaga attctctact
      121 caggagttac aaaaaagaag ccaagatgtt ggtgctactg gccggtctct tcgtggtcca
      181 catcgccact gccattatgc tgtttgtctc caccattgcc aacgtctgga tggtggcgga
      241 cggtatagac tcgtccatag ggctttggaa gaactgcacc agtggcagct gtgacggctc
      301 tctgagctac ggcaatgatg atgctatcaa ggcagtgcaa gctttcatga tcctctccat
      361 catcttctct ataatctccc tcgtggtctt cgtgttccag ctcttcacca tggagaaggg
      421 aaaccggttc ttcctctcgg gatccaccat gctggtgtgc tggctgtgca ttctgattgg
      481 agtgtctatc tacactcacc actacgccca cagcgaaggg aactttttcc ccagcagcca
      541 tcaaggctac tgtttcatcc tgacctggat ttgcttctgc ttcagcttca tcatcggcat
      601 actctatatg gtcctgagga agaaataagc tcgtgggcat ctggggtggg ggtggggaag
      661 tagggaggag gaagcaactg aatccgggag ggaagcagaa gtcactgtgt agggataacc
      721 aagggagggg aggggggaag ggagggggaa aggaagagta ggagaggccc aaacccaaac
      781 catatctggg ggggcgtggt tctctactgc caaacgccca tccttggaag aaagttgttg
      841 gctactatgc tgatgcttcc ttgaggccac cagagagtcc tcctctagcc accaaatatg
      901 gccccatcta tcctcaatta ccgacacttg gggcctcacc agctgccatt ccactggcgc
      961 cactcttgag ggtgactgct gggtcataca ctgaggtctt gcaaacccat atcaatgagt
     1021 tctgacagtg gtacaagtcc tagcaagagc agatcactgc ctctatgctg aggctaagcc
     1081 tcgaagccac cttatccttg tgacctgaaa ccaaacctca aatccagatc ccaagtgcct
     1141 ctagtgggag ctttggccag gaagctgatg cccgtatttg gtggcctttc taacaaaagt
     1201 gaagaaagag agatggttta taaggtcaag ctgatagaat tggttgaacc aagaagtaga
     1261 aatatttacc gcagaggatc tgggagacag gtggggatag gcagagcccc tcagtcatgc
     1321 ttcactgagc tgtccctcat ggagacctcc tgctctggac tctgctagac cctcacttaa
     1381 agccaaggca gcttttctgg aatttttcta gattctctag agccaaagat gaaaacaccc
     1441 cacaaaccgt agggtcaaag tgcatgccca ccacagtgca atagtaaagt ttttaggatt
     1501 ccccaatgca cccaccgtgt cctggaaatg taacccggga gagatgcaca tgttccatcg
     1561 ccatacgatt ctgttaagct tcctcctaat taagaacatt tgaggaagtc taatgatgac
     1621 caaaataaca ctggggacca gaacatgaca tctaaacaca gtggtcactg tagctttgac
     1681 ctgggctgga gtggtctcct ctcaacagct ttcaacacac tattttccag ccaaagatgg
     1741 caattctgta agccaattaa aatacacacc aatctaaact aaagaacaag tcccgggggt
     1801 gcaggggaag gtgctatctg gttatggagc actaagcata ctatatttca cttatgttaa
     1861 gaacagagtg cctgctctta ggaaaaaacg cagtttggtg agatgaataa agtcctggtg
     1921 gtgggcagac agtttctttt ttaaaactgg agaaactctt agggtgtcca gtcagatggt
     1981 agctgaattg ttggggctgc aagggtattc ctacataaga cttagaggta gcatgacatc
     2041 tcagatttct gccttaaagg gctttccttt tagaaatagt ttctcctatt gcccttagaa
     2101 gaccaccccg ggaagagtct gagatatctt ttctacattt cttttcctag gaatattctt
     2161 acccatttct catatccatt tcttttggga gggagttgtt atgctatact tgctggtatt
     2221 tatgtaaagg gaccattact aagtatattt ctctagtgta ttatgtttaa gggaatgttc
     2281 aagtaggtta cttaactgct gagctgatgg tagagatact ggtcaggaaa gctataataa
     2341 ttcttaaatt ataatttgac caccatacat ttgttctagg ctgtcttatg ttcataagaa
     2401 aatcaacaga aaaagatagt cacattttgt taaaaagttg atttatgact ggagagaaag
     2461 aaccatgcat tcccttgtct tttacttctt ttctgtgaca tttacgtctc atgtaatttg
     2521 cattgcattg gtgggttatt ctagtactgt atttggcttc ttcattaata ggatatttca
     2581 tatactataa ttgtaaatat tttgatacaa atgtttataa ctctagggat ataaaaacaa
     2641 attctgattc cctaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
