LOCUS       NM_138921               2988 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus EMAP like 2 (Eml2), transcript variant 2, mRNA.
ACCESSION   NM_138921 XM_001075500
VERSION     NM_138921.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2988)
  AUTHORS   Li,C., Ma,W., Zhao,Y. and Wang,H.
  TITLE     Changes in the expression of endothelial monocyte-activating
            polypeptide II in the rat hippocampus following status epilepticus
  JOURNAL   Int J Mol Med 47 (2), 699-707 (2021)
   PUBMED   33416103
  REMARK    GeneRIF: Changes in the expression of endothelial
            monocyteactivating polypeptide II in the rat hippocampus following
            status epilepticus.
REFERENCE   2  (bases 1 to 2988)
  AUTHORS   Richards,M.W., Law,E.W., Rennalls,L.P., Busacca,S., O'Regan,L.,
            Fry,A.M., Fennell,D.A. and Bayliss,R.
  TITLE     Crystal structure of EML1 reveals the basis for Hsp90 dependence of
            oncogenic EML4-ALK by disruption of an atypical beta-propeller
            domain
  JOURNAL   Proc Natl Acad Sci U S A 111 (14), 5195-5200 (2014)
   PUBMED   24706829
REFERENCE   3  (bases 1 to 2988)
  AUTHORS   Xie,H., Xue,Y.X., Liu,L.B., Liu,Y.H. and Wang,P.
  TITLE     Role of RhoA/ROCK signaling in endothelial-monocyte-activating
            polypeptide II opening of the blood-tumor barrier: role of
            RhoA/ROCK signaling in EMAP II opening of the BTB
  JOURNAL   J Mol Neurosci 46 (3), 666-676 (2012)
   PUBMED   21647708
  REMARK    GeneRIF: RhoA/ROCK signaling plays a role in
            endothelial-monocyte-activating polypeptide (EMAP) II-induced
            increase in blood-tumor barrier (BTB) permeability in rat brain
            microvascular endothelial cells.
REFERENCE   4  (bases 1 to 2988)
  AUTHORS   Ly,C.D., Roche,K.W., Lee,H.K. and Wenthold,R.J.
  TITLE     Identification of rat EMAP, a delta-glutamate receptor binding
            protein
  JOURNAL   Biochem Biophys Res Commun 291 (1), 85-90 (2002)
   PUBMED   11829466
REFERENCE   5  (bases 1 to 2988)
  AUTHORS   Eichenmuller,B., Everley,P., Palange,J., Lepley,D. and
            Suprenant,K.A.
  TITLE     The human EMAP-like protein-70 (ELP70) is a microtubule
            destabilizer that localizes to the mitotic apparatus
  JOURNAL   J Biol Chem 277 (2), 1301-1309 (2002)
   PUBMED   11694528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 21, 2023 this sequence version replaced NM_138921.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF335571.1, SRR26360194.1374748.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               JAXUCZ010000001.1  87955924-87956258
            336-554             JAXUCZ010000001.1  87958646-87958864
            555-678             JAXUCZ010000001.1  87958969-87959092
            679-783             JAXUCZ010000001.1  87959194-87959298
            784-812             JAXUCZ010000001.1  87961443-87961471
            813-942             JAXUCZ010000001.1  87961994-87962123
            943-1092            JAXUCZ010000001.1  87964673-87964822
            1093-1162           JAXUCZ010000001.1  87966283-87966352
            1163-1273           JAXUCZ010000001.1  87966441-87966551
            1274-1369           JAXUCZ010000001.1  87971228-87971323
            1370-1504           JAXUCZ010000001.1  87972088-87972222
            1505-1604           JAXUCZ010000001.1  87974577-87974676
            1605-1759           JAXUCZ010000001.1  87976586-87976740
            1760-1885           JAXUCZ010000001.1  87976884-87977009
            1886-2017           JAXUCZ010000001.1  87981263-87981394
            2018-2085           JAXUCZ010000001.1  87981969-87982036
            2086-2174           JAXUCZ010000001.1  87982459-87982547
            2175-2272           JAXUCZ010000001.1  87982722-87982819
            2273-2360           JAXUCZ010000001.1  87983436-87983523
            2361-2456           JAXUCZ010000001.1  87983912-87984007
            2457-2587           JAXUCZ010000001.1  87984811-87984941
            2588-2988           JAXUCZ010000001.1  87986966-87987366
FEATURES             Location/Qualifiers
     source          1..2988
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2988
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /note="EMAP like 2"
                     /db_xref="GeneID:192360"
                     /db_xref="RGD:621066"
     exon            1..335
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2713
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     echinoderm microtubule associated protein like 2"
                     /codon_start=1
                     /product="echinoderm microtubule-associated protein-like 2
                     isoform 2"
                     /protein_id="NP_620276.3"
                     /db_xref="GeneID:192360"
                     /db_xref="RGD:621066"
                     /translation="MATGGRAWGGDRARAGAAGAGGGCGGAMAERGPAFCGLYDTSSL
                     LQYCNDDNLSGTSGMEVDDRVSALEQRLQLQEDELAVLKAALADALRRLRACEEQGAA
                     LRARSIPKGRAPPRLGTTASVCQLLKGLPTRTPLNGSGPPRRVGGYATSPSSPKKEAS
                     SGRSSRRYLSPERLASVRREDPRSRTTSSSSNCSAKKEGKTKEVIFSMEEGSVKMFLR
                     GRPVPMLIPDELAPTYSLDTRSELPSSRLKLDWVYGYRGRDCRANLYLLPTGEVVYFV
                     ASVAVLYSVEEQRQRHYLGHNDDIKCLAVHPDMVTIATGQVAGTTKEGKPLPPHVRVW
                     DSVSLSTLHVLGLGVFDRAVCCVAFSKSNGGNLLCAVDESNDHVLSVWDWAKESKVVD
                     SKCSNEAVLVATFHPTDPNLLITCGKSHIYFWSLEGGNLSKRQGLFEKHEKPKYVLCV
                     TFLEGGDVVTGDSGGNLYVWGKGGNRITQEVLGAHDGGVFALCALRDGTLVSGGGRDR
                     RVVLWGSDYSKVQEVEVPEDFGPVRTVAEGRGDTLYVGTTRNSILLGSVHTGFSLLVQ
                     GHVEELWGLATHPSRAQFVSCGQDKLVHLWSSETHQPVWSRSIEDPARSAGFHPSGSV
                     LAVGTVTGRWLLLDTDTRDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVD
                     QGGRKVSRLGKCSGHSSFITHLDWAQDSTCFVTNSGDYEILYWDAATCKQITSADTVR
                     NVQWATATCVLGFGVFGIWPEGADGTDINAVARSHDGNLLVSADDFGKVHLFSYPCCQ
                     PRALSHKYGGHSSHVTNVAFLWDDSMVLTTGGKDTSVLQWRVA"
     exon            336..554
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..678
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..783
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..812
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..942
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1092
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1162
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1273
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1369
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1504
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1604
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1759
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1885
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2017
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2085
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2174
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2272
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2360
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2456
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2587
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2988
                     /gene="Eml2"
                     /gene_synonym="Emap; Emap-2; Eml1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtacctagg gggaccccga cgtagccaat cctgacctga agactgttgg gggtgggggc
       61 gactgacaga gcagtctctg gacatccttt ccgggcatcc taggggatga cccctgtgcc
      121 aggctcagag ccggccgcct gatgctgggt gggccgagct ggggatgctg gaacgaaggg
      181 cgttgctatg gcaacgggag gcagggcctg ggggggggac cgggcccgag ctggggctgc
      241 gggggccggc ggtggctgtg gtggggcaat ggcggagcgc ggcccggcct tctgtggcct
      301 ctacgacacg tcctctctgc tgcaatactg caacgatgac aatctgtccg gcaccagcgg
      361 catggaggtg gacgaccgcg tgtcggcgct ggagcagcgg ctgcagctgc aagaagatga
      421 gctggcggtc ctaaaggcgg cgctggcgga cgcgctgcgt cgcctgcggg catgcgaaga
      481 acaaggcgca gcgctgcgcg cgaggagcat ccctaagggt cgggcgcccc cgcgtctggg
      541 caccactgcc tcggtgtgtc agctcctgaa aggccttccc accaggacgc ccctcaatgg
      601 ctccggaccc ccgcgacgcg tgggcggcta tgccacctcc ccatcttccc ccaagaaaga
      661 ggcgagctcc ggacgcagca gccgtcgcta cttgtcacct gagcgcctgg cctctgtgcg
      721 tcgagaggac ccccgtagtc gtaccacatc ttccagcagt aattgtagcg ccaaaaagga
      781 agggaaaacc aaagaagtta tcttcagcat ggaggaggga tccgtgaaga tgtttctgcg
      841 gggacgccct gtgcccatgc tgatcccaga cgagctggcg cccacctata gcctggacac
      901 tcgttctgag ctgccttcca gccggctaaa gctagattgg gtctatggct atcgaggccg
      961 ggactgcagg gccaaccttt acctcctgcc caccggggag gtggtgtact tcgtggcctc
     1021 tgtggctgta ctgtacagcg tagaggagca gagacaacga cactacctgg gacacaatga
     1081 tgacatcaaa tgtctggctg tccatccgga tatggtcacc atcgccacgg gacaggtggc
     1141 aggaaccaca aaggaaggca agcctctgcc accccatgtg cgtgtgtggg actcagtttc
     1201 cctttccacc ttacacgtcc tgggcctggg ggtgtttgac agagctgtgt gctgtgtggc
     1261 cttctccaaa tccaatgggg gcaacctgct atgtgcagtg gacgaatcca acgatcatgt
     1321 gctctctgtg tgggactggg ccaaggagag caaagtggtg gatagcaagt gttctaatga
     1381 ggctgtgctg gtggctacct tccaccccac tgatcccaac ctgctgataa cctgtggcaa
     1441 atcccacatc tacttctgga gcctggaagg aggcaacctg agcaagcggc agggcctgtt
     1501 tgagaaacac gagaagccaa agtatgtgct gtgtgtgacc ttcttggaag gtggcgacgt
     1561 ggtcactgga gactctgggg ggaacctcta tgtctggggc aaaggtggaa accgcatcac
     1621 ccaggaagtt ctaggagccc atgatggtgg cgtgtttgcg ctctgcgccc tgcgggacgg
     1681 gacgctggtg tctggagggg gccgtgatcg tcgggtggtc ctctggggtt cagactacag
     1741 caaggtgcaa gaggtggagg tcccagagga cttcggccct gtacgcaccg tggcagaggg
     1801 caggggagac acactgtacg tggggaccac ccgtaactcc atcttgcttg gctcggtgca
     1861 cacaggtttc tctctgcttg tccagggaca tgtggaagaa ctgtggggcc tggccacaca
     1921 tcctagcagg gcacagtttg tgagctgtgg gcaggataag ctggtgcatc tgtggagctc
     1981 ggagacccac cagccagtgt ggagcaggag cattgaggac cctgcccgtt cggctggctt
     2041 ccaccccagt ggctctgtcc tagcggtggg cacagtgacc ggcaggtggc tgctactgga
     2101 cacagacacc cgtgacctgg tggctatcca cacagatggc aatgagcaga tctctgtggt
     2161 cagcttttca ccagacgggg cgtacctggc tgtgggctcc cacgacaact tggtgtacgt
     2221 gtacacggtg gaccagggtg gccgcaaggt cagccgcctg ggcaagtgct cgggccattc
     2281 cagttttatc actcacctgg attgggccca ggacagcacc tgctttgtca ccaactctgg
     2341 agactacgaa attctgtact gggacgctgc cacctgtaag cagatcacca gtgcagacac
     2401 cgtgagaaat gtgcaatggg ctactgctac ttgtgtgttg ggttttggag tttttgggat
     2461 ctggcctgag ggggcagacg gcacagacat caatgctgtg gcccgctctc acgatgggaa
     2521 cttgctggtt tctgctgacg acttcggcaa agtgcacctg ttcagctacc cctgctgtca
     2581 gccgagagct ctcagccaca aatatggtgg acacagcagc catgtgacta atgtggcctt
     2641 cttgtgggat gacagcatgg tcctaaccac tgggggcaaa gacacgagcg tgctgcagtg
     2701 gcgggtagcc tgaagcaggg gtgtggggcc agggtagagt cctgtggcag ggctgagatc
     2761 tatttttggg agatgtctat tgtgaagtac agtaatatat acccagagta tgtctatagc
     2821 agagggggtt atggggcggg cgggtgagca gacagacaga ggtctctatt tatcggggtg
     2881 ggacgaatgg gccaccatgc cttgtgggag ccattggtgt ttggtttggg gtattttttt
     2941 ttaagtttat tcttttatat cattcagaaa tacagactta tgcactga
//
