LOCUS       NM_001399709            3957 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus EMAP like 1 (Eml1), transcript variant 1, mRNA.
ACCESSION   NM_001399709
VERSION     NM_001399709.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3957)
  AUTHORS   Zhang,Y., Guan,T., Li,Z., Guo,B., Luo,X., Guo,L., Li,M., Xu,M.,
            Liu,M. and Liu,Y.
  TITLE     Eml1 promotes axonal growth by enhancing alphaTAT1-mediated
            microtubule acetylation
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (7), 119770 (2024)
   PUBMED   38897390
  REMARK    GeneRIF: Eml1 promotes axonal growth by enhancing
            alphaTAT1-mediated microtubule acetylation.
REFERENCE   2  (bases 1 to 3957)
  AUTHORS   He,Y., Liu,H., Luo,S., Amos,C.I., Lee,J.E., Yang,K., Qureshi,A.A.,
            Han,J. and Wei,Q.
  TITLE     Genetic variants of EML1 and HIST1H4E in myeloid cell-related
            pathway genes independently predict cutaneous melanoma-specific
            survival
  JOURNAL   Am J Cancer Res 11 (6), 3252-3262 (2021)
   PUBMED   34249459
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3957)
  AUTHORS   Grosenbaugh,D.K., Joshi,S., Fitzgerald,M.P., Lee,K.S., Wagley,P.K.,
            Koeppel,A.F., Turner,S.D., McConnell,M.J. and Goodkin,H.P.
  TITLE     A deletion in Eml1 leads to bilateral subcortical heterotopia in
            the tish rat
  JOURNAL   Neurobiol Dis 140, 104836 (2020)
   PUBMED   32179177
  REMARK    GeneRIF: A deletion in Eml1 leads to bilateral subcortical
            heterotopia in the tish rat.
REFERENCE   4  (bases 1 to 3957)
  AUTHORS   Collins,S.C., Uzquiano,A., Selloum,M., Wendling,O., Gaborit,M.,
            Osipenko,M., Birling,M.C., Yalcin,B. and Francis,F.
  TITLE     The neuroanatomy of Eml1 knockout mice, a model of subcortical
            heterotopia
  JOURNAL   J Anat 235 (3), 637-650 (2019)
   PUBMED   31173351
REFERENCE   5  (bases 1 to 3957)
  AUTHORS   Kielar,M., Tuy,F.P., Bizzotto,S., Lebrand,C., de Juan Romero,C.,
            Poirier,K., Oegema,R., Mancini,G.M., Bahi-Buisson,N., Olaso,R., Le
            Moing,A.G., Boutourlinsky,K., Boucher,D., Carpentier,W.,
            Berquin,P., Deleuze,J.F., Belvindrah,R., Borrell,V., Welker,E.,
            Chelly,J., Croquelois,A. and Francis,F.
  TITLE     Mutations in Eml1 lead to ectopic progenitors and neuronal
            heterotopia in mouse and human
  JOURNAL   Nat Neurosci 17 (7), 923-933 (2014)
   PUBMED   24859200
REFERENCE   6  (bases 1 to 3957)
  AUTHORS   Richards,M.W., Law,E.W., Rennalls,L.P., Busacca,S., O'Regan,L.,
            Fry,A.M., Fennell,D.A. and Bayliss,R.
  TITLE     Crystal structure of EML1 reveals the basis for Hsp90 dependence of
            oncogenic EML4-ALK by disruption of an atypical beta-propeller
            domain
  JOURNAL   Proc Natl Acad Sci U S A 111 (14), 5195-5200 (2014)
   PUBMED   24706829
REFERENCE   7  (bases 1 to 3957)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   8  (bases 1 to 3957)
  AUTHORS   Lee,K.S., Schottler,F., Collins,J.L., Lanzino,G., Couture,D.,
            Rao,A., Hiramatsu,K., Goto,Y., Hong,S.C., Caner,H., Yamamoto,H.,
            Chen,Z.F., Bertram,E., Berr,S., Omary,R., Scrable,H., Jackson,T.,
            Goble,J. and Eisenman,L.
  TITLE     A genetic animal model of human neocortical heterotopia associated
            with seizures
  JOURNAL   J Neurosci 17 (16), 6236-6242 (1997)
   PUBMED   9236234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16093048,
                              SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               JAXUCZ010000006.1  133048430-133048599
            171-353             JAXUCZ010000006.1  133150019-133150201
            354-486             JAXUCZ010000006.1  133157589-133157721
            487-684             JAXUCZ010000006.1  133174031-133174228
            685-713             JAXUCZ010000006.1  133188059-133188087
            714-843             JAXUCZ010000006.1  133192017-133192146
            844-993             JAXUCZ010000006.1  133194573-133194722
            994-1063            JAXUCZ010000006.1  133195407-133195476
            1064-1174           JAXUCZ010000006.1  133197224-133197334
            1175-1270           JAXUCZ010000006.1  133198320-133198415
            1271-1405           JAXUCZ010000006.1  133199719-133199853
            1406-1505           JAXUCZ010000006.1  133200429-133200528
            1506-1660           JAXUCZ010000006.1  133201624-133201778
            1661-1786           JAXUCZ010000006.1  133205899-133206024
            1787-1918           JAXUCZ010000006.1  133206473-133206604
            1919-1986           JAXUCZ010000006.1  133208491-133208558
            1987-2075           JAXUCZ010000006.1  133210060-133210148
            2076-2173           JAXUCZ010000006.1  133215242-133215339
            2174-2261           JAXUCZ010000006.1  133215454-133215541
            2262-2357           JAXUCZ010000006.1  133216902-133216997
            2358-2488           JAXUCZ010000006.1  133218035-133218165
            2489-3957           JAXUCZ010000006.1  133220174-133221642
FEATURES             Location/Qualifiers
     source          1..3957
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..3957
                     /gene="Eml1"
                     /note="EMAP like 1"
                     /db_xref="GeneID:362783"
                     /db_xref="RGD:1306374"
     exon            1..170
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2614
                     /gene="Eml1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     EMAP-1; echinoderm microtubule associated protein like 1"
                     /codon_start=1
                     /product="echinoderm microtubule-associated protein-like 1
                     isoform 1"
                     /protein_id="NP_001386638.1"
                     /db_xref="GeneID:362783"
                     /db_xref="RGD:1306374"
                     /translation="MSDGEGPSADDSASAASSMEISDRIASLEQRVQMQEDDIQLLKS
                     ALADVVRRLNITEEQQAVLNRKGPTKARPLGQTLPLRTTVNNGTVLPKKPSASLPSPS
                     GSRKEMVVPVTKSTHSTEGLSAMEAPLSHACPSCSINRTSSSERVSPGGRRESSGDSK
                     GSRNRTGSTSSSSSGKKNSESKPKEPTFSPEEGYVKMFLRGRPVTMYMPKDQVDSYSL
                     EAKAELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYA
                     GHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDR
                     AVTCIAFSKSNGGSHLCAVDDSNDHVLSVWDWQREERLADVKCSNEAVFAADFHPTDT
                     NIIVTCGKSHLYFWTLEGNSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNIL
                     VWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRRLISWNGNYQKLHKAEIP
                     EQFGPIRTVAEGKGNVILIGTTRNFVLQGTLTGDFTPITQGHTDELWGLAIHASKPQF
                     LTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETK
                     DLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSF
                     ITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGV
                     WPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYSGHSSHVTNV
                     DFLCEDSHLISTGGKDTSIMQWRVI"
     exon            171..353
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..486
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..684
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..713
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            714..843
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..993
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1063
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1174
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1270
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1405
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1505
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1660
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1786
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1918
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..1986
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2075
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2173
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2261
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2357
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2488
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..3957
                     /gene="Eml1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtggccag gctggcgagg caggacactg cctgggggct ggacacggag cagtcccaag
       61 ccaggctggg tgggtgacgg ctgttgaggg ctctgagcgt ccccgcaggc tggtggccag
      121 ctggctgccc atctccccca ccatgtcgga cggcgagggc ccctcagctg atgacagcgc
      181 gtctgctgcc agcagcatgg agatatcaga ccgcatcgcc tctctggagc agcgggtcca
      241 gatgcaggag gatgacattc agctgctcaa gtcggcgctg gccgacgtgg ttcggaggct
      301 gaacatcaca gaggagcaac aggctgtcct taacaggaaa ggacctacca aagcgagacc
      361 actggggcag accctgccac ttagaaccac cgtcaacaat ggcaccgtgt taccaaagaa
      421 acccagtgct tccctcccat cgccctcggg gtccaggaaa gaaatggttg tgccggtaac
      481 caaaagtaca cacagcactg aaggactgtc cgctatggaa gctccgctct cacatgcctg
      541 cccttcctgc agcatcaaca ggaccagctc ttccgaacga gtgtctccag gcggccggag
      601 ggagagctcc ggggactcca aaggaagccg gaaccgcacc ggctctacca gcagctcgtc
      661 cagcggcaag aagaacagtg agagcaaacc caaggagcct acattcagtc cagaagaggg
      721 gtatgtaaaa atgtttcttc gaggccgccc cgtcaccatg tacatgccca aagaccaagt
      781 ggattcctac agtttggaag cgaaagctga attgccaacg aaacggctga agctggagtg
      841 ggtctacggg taccgggggc gagactgtcg taataacctg tacctgctcc cgaccgggga
      901 gacggtgtac ttcatagcgt cggttgtggt gctttacaac gtggaggaac agctgcagag
      961 gcattacgcg ggccacaacg acgacgtcaa gtgcctagcg gtccaccctg acagaatcac
     1021 catagcaaca ggacaagtgg cgggcacatc taaagatgga aagcaactgc cgccacacgt
     1081 gcgtatctgg gactctgtga ccctgaacac tctgcatgtc atcggaatag gcttttttga
     1141 ccgggctgtc acctgcatcg cattctcaaa atccaacgga ggaagccacc tctgtgctgt
     1201 ggatgactcc aatgaccatg tgttgtctgt gtgggactgg cagagagagg agaggctggc
     1261 tgacgtgaag tgttcgaacg aagcggtatt tgctgcggac ttccacccca cagacaccaa
     1321 tatcatagtc acctgcggga agtcacatct ctacttttgg accctagaag gaaattccct
     1381 taacaagaag caagggttgt ttgagaaaca agagaagcca aagtttgtcc tttgcgtgac
     1441 gttttctgaa aatggcgaca ccattactgg agattcaagt ggcaacatct tggtgtgggg
     1501 aaaaggtaca aatcgaataa gctatgcagt tcaaggggcc cacgagggcg gcatttttgc
     1561 actttgtatg ctgagagatg gcacgctggt gtccggagga gggaaggacc ggcgcctcat
     1621 ttcctggaac ggaaactatc aaaaacttca caaagcagag attcctgagc agtttggccc
     1681 aatacggaca gtggctgagg ggaagggcaa tgtcatcttg attggcacta ctagaaactt
     1741 tgtcctgcaa ggcaccttga ccggggactt cacacccatc actcagggtc acactgatga
     1801 gctctggggg ctggccatcc atgcctccaa acctcagttc ttgacctgtg gacatgacaa
     1861 gcacgccact ctctgggacg ccgttggtca ccggccagtc tgggacaaaa tcatagagga
     1921 tccagctcag tcctctggtt ttcatccttc agggtctgtg gttgcagtcg ggaccctgac
     1981 tgggaggtgg tttgtgtttg acacggaaac gaaggacctg gtcaccgtcc acacggatgg
     2041 gaatgagcag ctctccgtga tgcggtattc tccagatggg aacttcctgg caatcggctc
     2101 ccatgacaac tgcatctaca tatacggagt cagcgacaat ggaaggaagt acacgcgagt
     2161 tggcaagtgc tccggccatt ccagcttcat cacccacttg gactggtccg tgaactcaca
     2221 attcctggtg tcaaattccg gggactacga gatcctctac tgggtcccat ctgcctgtaa
     2281 gcaagtcgtg agtgtggaaa ccacacggga catcgagtgg gccacctata cctgcacctt
     2341 gggattccat gtctttggag tgtggcctga gggctcagat ggaacagaca tcaatgctgt
     2401 ctgccgggcc cacgagaaaa agctcctgtc cacaggcgat gacttcggca aagtgcacct
     2461 cttctcatac ccatgctcac agttcagggc tccgagccac atctacagtg gacacagcag
     2521 ccacgtcacc aacgtagact tcctctgtga agacagccac cttatctcca cgggtgggaa
     2581 agacacaagc atcatgcagt ggcgggtcat ttagtccccg tgagagcccg aggagacaga
     2641 ctcatgttct acttggtcac tgtgatttct gttttgtcta cagactctta acaaacctca
     2701 ggaaaactgt ccctctgcca gttaccttag ttggggagcc agcgcgcgtc acaccagata
     2761 agcggctttg agcccgcttc tgtcatatag gacaggatag agtgcatgtt gggtaaagga
     2821 agttcccaag gtttacacgg catcaacaga agggactgat gggtccttac agtcactttt
     2881 ctatgaactc ttcaaaaaaa aaaaatggcc acagaatgcc ttttaaaata ttgtagatag
     2941 tcctcactgc ttcaccgtgt taagtctgat atttatgata accaagtaca gaactgggtt
     3001 cgctgttgac taattggtcc taaaaggata aatcacataa ctgatttgcc cagctgaatc
     3061 aggaatgcaa atgccagact ttccttggtc atgtaactaa aaccccatta actcctccct
     3121 ttgggagggt ggcaagaaag gaggctgtgt cccccccgga caagcagttt gtactacaga
     3181 atcgctgagt ttcagtgggt gtacttctat gctctggtca gactgtcctg cctgaggaca
     3241 cggccagttt ctttagcacc tccacaaact gcaccccgtc tctgttcctg tgccccaatt
     3301 tgtggcgaga catttagcca ccactctcca catattaatg gcatgatacg gtattgtcct
     3361 cgtagagagt ttagcaaagt tatgataaaa tgcccaaggc cgggccttgc tgtgtgtgcc
     3421 ctggacactg tacgtttgta cagaccaagc aggtcaagtc ggagagagac tgtgtggagg
     3481 cagcctgtgg agtgcagcgc ctccgaggct ctgggcataa gaaggtttcc ttccctgact
     3541 ctggtgcacg gacagcacgc agctaacagg ctgaaactat gctctgacga gtagaacata
     3601 ggtgtctaaa ggtgtcagga aggccttacc tttgtgtgac agacggaatt gattgtttac
     3661 attggggact gtatctccga ttttcaaata gaggaatcac agacttaagg gcagacactg
     3721 agatttcttt ttgtaaactc atttaagcaa gtgaggagtt gagttatctg aactctggag
     3781 tactggccat ttacggtgat gaaggacagc gctgaagaca tttcccttgc cgtctccagc
     3841 ccgccgggaa aagacagcgc cagaaaataa cgtgactcga gatgaagctg tttttaatgt
     3901 atccttatca aatatattct ataaggaaat aaaatctgaa agtggatttc ttactga
//
