LOCUS       NP_001388876             375 aa            linear   ROD 03-APR-2024
DEFINITION  probable crossover junction endonuclease EME2 isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001388876 XP_008765827
VERSION     NP_001388876.1
DBSOURCE    REFSEQ: accession NM_001401947.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 375)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 3, 2022 this sequence version replaced XP_008765827.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.116841.1,
                                           SRR26643429.35722.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     Protein         1..375
                     /product="probable crossover junction endonuclease EME2
                     isoform 1"
                     /note="probable crossover junction endonuclease EME2;
                     essential meiotic endonuclease 1 homolog 2"
                     /calculated_mol_wt=41017
     Region          66..256
                     /region_name="XPF_nuclease-like"
                     /note="nuclease domain of XPF/MUS81 family proteins;
                     cl41760"
                     /db_xref="CDD:425391"
     Site            order(157,214,217..218,221)
                     /site_type="other"
                     /note="putative nucleic acid substrate binding site
                     [nucleotide binding]"
                     /db_xref="CDD:410849"
     CDS             1..375
                     /gene="Eme2"
                     /gene_synonym="RGD1304924"
                     /coded_by="NM_001401947.1:18..1145"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:302982"
                     /db_xref="RGD:1304924"
ORIGIN      
        1 maevgpervp gshrgrgrgp rlghrrpqtw eisdsdaega parevgtpar ssvgerraaa
       61 kalradqvle rlvvcvdpav ledagsdilm ealgtlgcec riepqhqars lqwsvvrpdp
      121 alsnvpqegk aeneqeqlll lepqeflqga vqltqmtdpp csvpwlspes ptrshlavig
      181 ldaylcsckp ssqktwppkk seeaqarvai swseveealv llqlhanldv llvaswrels
      241 qyvcaftkal aqlpskrfrd sqafsfctag hwasgqqvtr dgsglrgvww rqirqfnrvs
      301 pavadavvta fpsprllqqa lldcsteqer lslladlpvk apggkqprrv gpdlsrrici
      361 fltttnpdil ldlss
//
