LOCUS       NM_001105830            2268 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus essential meiotic structure-specific endonuclease
            1 (Eme1), mRNA.
ACCESSION   NM_001105830 XM_001081297 XM_006247179 XM_220879
VERSION     NM_001105830.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2268)
  AUTHORS   Fugger,K., Chu,W.K., Haahr,P., Kousholt,A.N., Beck,H., Payne,M.J.,
            Hanada,K., Hickson,I.D. and Sorensen,C.S.
  TITLE     FBH1 co-operates with MUS81 in inducing DNA double-strand breaks
            and cell death following replication stress
  JOURNAL   Nat Commun 4, 1423 (2013)
   PUBMED   23361013
REFERENCE   2  (bases 1 to 2268)
  AUTHORS   Mistry,H., Gibson,L., Yun,J.W., Sarras,H., Tamblyn,L. and
            McPherson,J.P.
  TITLE     Interplay between Np95 and Eme1 in the DNA damage response
  JOURNAL   Biochem Biophys Res Commun 375 (3), 321-325 (2008)
   PUBMED   18692478
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Oct 27, 2022 this sequence version replaced
            XM_006247179.4, NM_001105830.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2512976.1,
                                           SRR26360186.984070.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                JAXUCZ010000010.1  80092244-80092301   c
            59-859              JAXUCZ010000010.1  80089290-80090090   c
            860-987             JAXUCZ010000010.1  80089080-80089207   c
            988-1074            JAXUCZ010000010.1  80087031-80087117   c
            1075-1193           JAXUCZ010000010.1  80086833-80086951   c
            1194-1314           JAXUCZ010000010.1  80086394-80086514   c
            1315-1430           JAXUCZ010000010.1  80086057-80086172   c
            1431-1620           JAXUCZ010000010.1  80084468-80084657   c
            1621-2268           JAXUCZ010000010.1  80083585-80084232   c
FEATURES             Location/Qualifiers
     source          1..2268
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2268
                     /gene="Eme1"
                     /note="essential meiotic structure-specific endonuclease
                     1"
                     /db_xref="GeneID:287634"
                     /db_xref="RGD:1309067"
     exon            1..58
                     /gene="Eme1"
                     /inference="alignment:Splign:2.1.0"
     exon            59..859
                     /gene="Eme1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1797
                     /gene="Eme1"
                     /note="essential meiotic endonuclease 1 homolog 1"
                     /codon_start=1
                     /product="crossover junction endonuclease EME1"
                     /protein_id="NP_001099300.2"
                     /db_xref="GeneID:287634"
                     /db_xref="RGD:1309067"
                     /translation="MALRRLSLSLLSTESDSEELPTFAFLKKEPASTDSNPPQREKNI
                     VVVTSDIEASCPPSPGLKDPPCVPSAAEAPTQAGPVRVLSSSSEDEDGLVSLAERITW
                     KLLRNKQLSPERSRSPLKTGSDHQKNASTPCDWKRQPCPKIPDVPLHSALEKSPANDK
                     DSLLDNQCHQLPAYQATGRELAVTKTNPDLPLPKKRTKHIQTAQSRGPQGCWQPRQAS
                     RKENTPRQQERKKKAEMVNRLRAQRPEECLKHIVVVLDPVLLQMEGGGQLLGALQAME
                     CSCVIEAQVVPQSITWRRKTELEEDGDDWVEEPTILVLVLKEVFMSMVYNSKQGNPGS
                     TEKGKETLRGFVTDVTARTGKALSLVIVDQEKCLRAQNPPKRRKSGMANKKAKEKHQQ
                     RRESSTRLMVSRVDMEEALVDLQLYTEAQARIVQSWRELADFACAFTKAVAEAPFKKL
                     RDQGSFSFFLEKDWAGGVKADHAGRGLALIWRRQIQQLNRVSSEMAGAIVDAYPSPQL
                     LVQAYQQCFSEQERQNLLANIQVRRGEGVTATSRRVGPELSRRIYLQMTTVQPDLILD
                     SVD"
     exon            860..987
                     /gene="Eme1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1074
                     /gene="Eme1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1193
                     /gene="Eme1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1314
                     /gene="Eme1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1430
                     /gene="Eme1"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1620
                     /gene="Eme1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..2268
                     /gene="Eme1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatagatct acttccgggt cttgcgtaca attcaaagag tggcgggagc aataacaggc
       61 tattaagttg atagctctaa tgggttgatg gcgctaagaa ggttatccct ctctctgctg
      121 tccacggaga gtgactctga ggaactgccc acattcgcct ttctgaagaa ggaaccagct
      181 tcaacggaca gcaatccacc tcagagagag aagaacattg ttgttgtcac ctcagatatt
      241 gaggcctcct gtcctccatc accaggctta aaagacccac catgtgtccc cagtgcagcg
      301 gaagctccca cacaagcagg gccagtcaga gtgctgagca gtagcagtga ggatgaagat
      361 ggattggtct ctctggctga aaggatcaca tggaagcttt tgaggaacaa acagctgagc
      421 cctgagcgct ctcgctcccc acttaaaacg ggttcagatc accaaaaaaa tgcaagtaca
      481 ccatgtgact ggaaaaggca accgtgtcca aagattcctg atgttcctct ccacagtgcc
      541 ctagagaaga gtccagcaaa tgacaaagac tccctcttag acaatcagtg ccatcaactt
      601 cctgcctacc aggctacagg cagggagttg gcagtcacca aaacaaatcc tgacctccct
      661 ctacccaaga agagaaccaa gcacattcag acagcccaga gcagaggccc tcagggatgc
      721 tggcagccaa gacaggcaag caggaaggaa aacaccccaa ggcagcagga aaggaaaaag
      781 aaggcagaga tggtcaacag gctcagagcc cagaggccag aggaatgcct gaaacacatc
      841 gtggtggtgc tggatccagt ccttttacag atggaaggtg ggggccagct cctgggagcg
      901 ctgcaggcca tggagtgcag ctgtgtgatt gaagctcagg tcgtacctca aagtatcact
      961 tggaggagga agacagagct ggaagaggat ggagatgact gggtggaaga gccaacaatc
     1021 ctggtgttgg tcctcaaaga ggtcttcatg tccatggtct acaactcaaa gcagggaaat
     1081 cctggcagca ctgagaaagg gaaggagaca cttcggggct ttgtaactga tgtcacagca
     1141 aggacaggga aagcattgtc actggtgatt gtggaccagg agaaatgcct cagggctcag
     1201 aatcccccga aaagaaggaa atcaggaatg gcaaataaaa aggccaaaga gaagcatcag
     1261 cagagacgag agtccagcac aaggctcatg gtgtccaggg tagacatgga agaggcattg
     1321 gtggatctgc agctatatac agaagcccag gctcggatcg tgcagagctg gagagagctg
     1381 gccgacttcg cctgtgcatt tacaaaggct gtggctgaag cgcccttcaa gaaactccgg
     1441 gatcaaggca gcttctcctt cttcctggag aaagactggg ctggaggggt gaaagcggac
     1501 catgctggta gaggacttgc actgatctgg aggcggcaga ttcagcagct gaaccgagtc
     1561 agctcagaaa tggccggcgc tattgtggat gcctatcctt ctccacagct cctggtgcag
     1621 gcttatcagc agtgtttttc tgaacaagaa cgccagaatt tgctggctaa catacaggtg
     1681 cgacgtgggg aaggtgtgac agccacctcc cgccgtgttg ggccagaatt atccaggcgg
     1741 atctaccttc aaatgaccac agtgcaacca gatctcatct tagacagtgt tgactgatat
     1801 cccatagcaa caggatggaa gcttccccaa ccgtggcacc tgacagcaga ggggtcagaa
     1861 gtacctccta gtgcaattag ggagcaagtc tcccatctct gggaacagaa ggctgagaca
     1921 ctctaatcta cctccaccag caattaccgc ttctctccca gcaagcaaga tgccatggac
     1981 agccatccta ccccgtccca gtgaccttca cagcacaaaa gagaaaggca gaccactcag
     2041 acacggattt aataattgta gaaatccaaa gaataagcat caaatctcga agtcagagtg
     2101 aactcttgcc tgcgggttgg cttgactacg cccagccact gagctgcctc aaccagccag
     2161 ggatctatga ggctgacttc tgttttcatg atgtcaccat atgtagtatg tattttgtct
     2221 caataaagca tttgtaccga tggctctgga gcttggagga agactaaa
//
