LOCUS       NM_012948               1270 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus emerin (Emd), mRNA.
ACCESSION   NM_012948
VERSION     NM_012948.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1270)
  AUTHORS   Li,H.P., Liu,J.T., Chen,Y.X., Wang,W.B., Han,Y., Yao,Q.P. and
            Qi,Y.X.
  TITLE     Suppressed nuclear envelope proteins activate autophagy of vascular
            smooth muscle cells during cyclic stretch application
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (1), 118855 (2021)
   PUBMED   32926941
  REMARK    GeneRIF: Suppressed nuclear envelope proteins activate autophagy of
            vascular smooth muscle cells during cyclic stretch application.
REFERENCE   2  (bases 1 to 1270)
  AUTHORS   Piekarowicz,K., Machowska,M., Dratkiewicz,E., Lorek,D.,
            Madej-Pilarczyk,A. and Rzepecki,R.
  TITLE     The effect of the lamin A and its mutants on nuclear structure,
            cell proliferation, protein stability, and mobility in embryonic
            cells
  JOURNAL   Chromosoma 126 (4), 501-517 (2017)
   PUBMED   27534416
REFERENCE   3  (bases 1 to 1270)
  AUTHORS   Shimojima,M., Yuasa,S., Motoda,C., Yozu,G., Nagai,T., Ito,S.,
            Lachmann,M., Kashimura,S., Takei,M., Kusumoto,D., Kunitomi,A.,
            Hayashiji,N., Seki,T., Tohyama,S., Hashimoto,H., Kodaira,M.,
            Egashira,T., Hayashi,K., Nakanishi,C., Sakata,K., Yamagishi,M. and
            Fukuda,K.
  TITLE     Emerin plays a crucial role in nuclear invagination and in the
            nuclear calcium transient
  JOURNAL   Sci Rep 7, 44312 (2017)
   PUBMED   28290476
  REMARK    GeneRIF: Emerin plays a crucial role in nuclear invagination and in
            the nuclear calcium transient in Emery-Dreifuss muscular dystrophy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1270)
  AUTHORS   Qi,Y.X., Yao,Q.P., Huang,K., Shi,Q., Zhang,P., Wang,G.L., Han,Y.,
            Bao,H., Wang,L., Li,H.P., Shen,B.R., Wang,Y., Chien,S. and
            Jiang,Z.L.
  TITLE     Nuclear envelope proteins modulate proliferation of vascular smooth
            muscle cells during cyclic stretch application
  JOURNAL   Proc Natl Acad Sci U S A 113 (19), 5293-5298 (2016)
   PUBMED   27114541
  REMARK    GeneRIF: Our findings establish the pathogenetic role of emerin and
            lamin A/C repression in stretch-induced VSMC proliferation and
            suggest mechanobiological mechanism underlying this process that
            involves the sequence-specific binding of emerin and lamin A/C to
            specific transcription factor motifs.
REFERENCE   5  (bases 1 to 1270)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1270)
  AUTHORS   Tunnah,D., Sewry,C.A., Vaux,D., Schirmer,E.C. and Morris,G.E.
  TITLE     The apparent absence of lamin B1 and emerin in many tissue nuclei
            is due to epitope masking
  JOURNAL   J Mol Histol 36 (5), 337-344 (2005)
   PUBMED   16283426
  REMARK    GeneRIF: We now show that epitope masking in the nucleus is often
            responsible for failure to detect emerin and lamins in human, rat
            and pig tissues.
REFERENCE   7  (bases 1 to 1270)
  AUTHORS   Holaska,J.M., Kowalski,A.K. and Wilson,K.L.
  TITLE     Emerin caps the pointed end of actin filaments: evidence for an
            actin cortical network at the nuclear inner membrane
  JOURNAL   PLoS Biol 2 (9), E231 (2004)
   PUBMED   15328537
REFERENCE   8  (bases 1 to 1270)
  AUTHORS   Dabauvalle,M.C., Muller,E., Ewald,A., Kress,W., Krohne,G. and
            Muller,C.R.
  TITLE     Distribution of emerin during the cell cycle
  JOURNAL   Eur J Cell Biol 78 (10), 749-756 (1999)
   PUBMED   10569247
REFERENCE   9  (bases 1 to 1270)
  AUTHORS   Ellis,J.A., Craxton,M., Yates,J.R. and Kendrick-Jones,J.
  TITLE     Aberrant intracellular targeting and cell cycle-dependent
            phosphorylation of emerin contribute to the Emery-Dreifuss muscular
            dystrophy phenotype
  JOURNAL   J Cell Sci 111 (Pt 6), 781-792 (1998)
   PUBMED   9472006
REFERENCE   10 (bases 1 to 1270)
  AUTHORS   Bione,S., Maestrini,E., Rivella,S., Mancini,M., Regis,S., Romeo,G.
            and Toniolo,D.
  TITLE     Identification of a novel X-linked gene responsible for
            Emery-Dreifuss muscular dystrophy
  JOURNAL   Nat Genet 8 (4), 323-327 (1994)
   PUBMED   7894480
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012948.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X98377.1, BC059151.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000021.1  157190438-157190626
            190-297             JAXUCZ010000021.1  157190799-157190906
            298-375             JAXUCZ010000021.1  157191043-157191120
            376-512             JAXUCZ010000021.1  157191341-157191477
            513-559             JAXUCZ010000021.1  157192610-157192656
            560-1270            JAXUCZ010000021.1  157192739-157193449
FEATURES             Location/Qualifiers
     source          1..1270
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..1270
                     /gene="Emd"
                     /note="emerin"
                     /db_xref="GeneID:25437"
                     /db_xref="RGD:2551"
     exon            1..189
                     /gene="Emd"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..890
                     /gene="Emd"
                     /codon_start=1
                     /product="emerin"
                     /protein_id="NP_037080.2"
                     /db_xref="GeneID:25437"
                     /db_xref="RGD:2551"
                     /translation="MDDYAVLSDTELAAVLRQYNIPHGPIVGSTRKLYEKKIFEYETQ
                     RRRLSPPSSSSSSFSYRFSDLDSASVDSDMYDLPKKEDALLYQSKDYNDDYYEESYLT
                     TRTYGEPESVGMSKSFRRPGTSLVDADDTFHHQVRDDIFSSSEEEGKDRERPIYGRDS
                     AYQSIAHYRPISNVSRSSLGLSYYPTSSTSSVSSSSSSPSSWLTRRAIRPEKQAPTAA
                     LGQDRQVPLWGQLLLFLAFAAFLLFVYYSIQAEEGNPFWMDP"
     exon            190..297
                     /gene="Emd"
                     /inference="alignment:Splign:2.1.0"
     exon            298..375
                     /gene="Emd"
                     /inference="alignment:Splign:2.1.0"
     exon            376..512
                     /gene="Emd"
                     /inference="alignment:Splign:2.1.0"
     exon            513..559
                     /gene="Emd"
                     /inference="alignment:Splign:2.1.0"
     exon            560..1270
                     /gene="Emd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcttcct ctgctaggct ccgagctgtc tgtttcttgg gccctgtgta taggtgccgg
       61 ccgcccctgg cgttcaacac cgcttccagg tgccggccgt gtctgccatg gacgactatg
      121 cggttttgtc cgatactgag ctggccgcag tgctacgcca gtacaacatc ccgcatgggc
      181 ctattgtggg ctccactcgc aagctctacg aaaagaaaat cttcgagtac gagacccaga
      241 gaaggaggct ttcgcccccc agctcgtcat cgtcttcatt ctcctatcgg ttctcagact
      301 tggattcagc ctccgtggac tcagacatgt atgatctgcc caaaaaggag gacgccttac
      361 tttaccagag caaggactat aatgatgact actatgagga gagctatttg actaccagga
      421 catacgggga gcccgagtct gtgggcatgt ccaagagctt ccgccggcca gggacctcac
      481 ttgtagatgc tgatgatacc ttccatcacc aggtgcgtga tgacattttc tcttcttcag
      541 aagaggaagg caaggatagg gaacgcccca tctatggccg agacagtgcc taccagagca
      601 tcgcacacta ccgccccatt tccaatgtct ccaggagctc cctgggctta tcatattatc
      661 ctacatcctc cacctcttct gtgtcctcct cttcatcttc tccctcttca tggcttaccc
      721 gacgtgccat tcgaccagaa aagcaggccc ctactgctgc tctgggccag gatcgacagg
      781 tcccactctg gggccagctg ttactcttcc tggcctttgc tgcctttctg ctctttgttt
      841 actattccat acaagctgaa gaaggcaacc ccttctggat ggatccctaa gggtattggt
      901 ttcagagcag ctcttaacag gagttttggc tgactgcctt agcagtgttt gctgggggtg
      961 gggggtaggg gcttttttgt gtattctagt tagagggtac agggcctagc ctacggcagt
     1021 gcttgtctcc acctcatctt gccaaggaag cagcaaatgc tggctttcca cagcccagta
     1081 ggcccgtatg taccttcctc tggagcctcc tagccttatt gcctctgact cttagggtat
     1141 ggggatctgg tggggaggac ctcacttcat tagaggaaaa cttggtggtg gcagtggtag
     1201 ttgtcatgca tgcctgtttg ttgtcacctt ttcagggggt attaacaagg ccatcctggc
     1261 tttgctttcg
//
