LOCUS       NM_001004221            1683 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ER membrane protein complex subunit 10 (Emc10),
            mRNA.
ACCESSION   NM_001004221 XM_214946
VERSION     NM_001004221.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1683)
  AUTHORS   Reboll,M.R., Korf-Klingebiel,M., Klede,S., Polten,F., Brinkmann,E.,
            Reimann,I., Schonfeld,H.J., Bobadilla,M., Faix,J., Kensah,G.,
            Gruh,I., Klintschar,M., Gaestel,M., Niessen,H.W., Pich,A.,
            Bauersachs,J., Gogos,J.A., Wang,Y. and Wollert,K.C.
  TITLE     EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10)
            Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue
            Repair After Myocardial Infarction
  JOURNAL   Circulation 136 (19), 1809-1823 (2017)
   PUBMED   28931551
REFERENCE   2  (bases 1 to 1683)
  AUTHORS   Christianson,J.C., Olzmann,J.A., Shaler,T.A., Sowa,M.E.,
            Bennett,E.J., Richter,C.M., Tyler,R.E., Greenblatt,E.J.,
            Harper,J.W. and Kopito,R.R.
  TITLE     Defining human ERAD networks through an integrative mapping
            strategy
  JOURNAL   Nat Cell Biol 14 (1), 93-105 (2011)
   PUBMED   22119785
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1683)
  AUTHORS   Wang,X., Gong,W., Liu,Y., Yang,Z., Zhou,W., Wang,M., Yang,Z.,
            Wen,J. and Hu,R.
  TITLE     Molecular cloning of a novel secreted peptide, INM02, and
            regulation of its expression by glucose
  JOURNAL   J Endocrinol 202 (3), 355-364 (2009)
   PUBMED   19570817
  REMARK    GeneRIF: as a novel secreted protein, INM02 (MGC93975) is
            associated with functions of pancreatic islets, especially of
            beta-cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and BC079041.1.
            
            On Jun 18, 2015 this sequence version replaced NM_001004221.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079041.1, SRR26360172.652078.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                JAXUCZ010000001.1  104125359-104125368 c
            11-1683             BC079041.1         1-1673
FEATURES             Location/Qualifiers
     source          1..1683
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1683
                     /gene="Emc10"
                     /gene_synonym="Inm02"
                     /note="ER membrane protein complex subunit 10"
                     /db_xref="GeneID:292878"
                     /db_xref="RGD:1303214"
     exon            1..207
                     /gene="Emc10"
                     /gene_synonym="Inm02"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..870
                     /gene="Emc10"
                     /gene_synonym="Inm02"
                     /note="UPF0510 protein INM02"
                     /codon_start=1
                     /product="ER membrane protein complex subunit 10
                     precursor"
                     /protein_id="NP_001004221.2"
                     /db_xref="GeneID:292878"
                     /db_xref="RGD:1303214"
                     /translation="MALGSSQRFGMVAAGAGVTQLLVLLLMVAAVPSRARGSGCRVGA
                     AARGVGADGHEAEGCGTVALLLEHSFEIGDGANFQKRGSLLWNQQDGTLSATQRQLSE
                     EERGRLRDVAAVNGLYRVRVPRRPGTLDGSEAGGHVSSFVPACSLVESHLSDQLTLHV
                     DVAGNVVGLSVVVYPGGCRGSEVEDEDLELFNTSVHLRPPGTAPGPETAAFIERLEME
                     QAQKAKNPQEQKSFFAKYWMYIIPVVLFLMMSGAPDAGGQGGGGGGGSSR"
     exon            208..280
                     /gene="Emc10"
                     /gene_synonym="Inm02"
                     /inference="alignment:Splign:2.1.0"
     exon            281..390
                     /gene="Emc10"
                     /gene_synonym="Inm02"
                     /inference="alignment:Splign:2.1.0"
     exon            391..495
                     /gene="Emc10"
                     /gene_synonym="Inm02"
                     /inference="alignment:Splign:2.1.0"
     exon            496..677
                     /gene="Emc10"
                     /gene_synonym="Inm02"
                     /inference="alignment:Splign:2.1.0"
     exon            678..771
                     /gene="Emc10"
                     /gene_synonym="Inm02"
                     /inference="alignment:Splign:2.1.0"
     exon            772..1635
                     /gene="Emc10"
                     /gene_synonym="Inm02"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcggcat gcggcgcagg cgcacgagcc tcaggatgag atctgtgttt cctagggtgc
       61 tgtatggcgc tcggctcttc ccagcgcttc ggtatggtgg ccgcgggtgc cggcgtgacc
      121 cagctgctag tgctcttgtt gatggtagcc gcggttccta gcagagcccg gggcagcggc
      181 tgccgggtcg gagccgccgc gcgcggggtg ggagctgatg gccatgaagc tgagggctgt
      241 ggcactgtgg cattgctgct ggaacattca tttgagattg gtgatggcgc caacttccag
      301 aagcgtggct ctctgctctg gaaccagcag gacggcacct tgtcggcgac acagcgacag
      361 ctcagcgagg aagagcgggg ccgactccgg gatgtggctg ctgtcaatgg cctctacagg
      421 gttcgggtcc caaggcggcc tgggacactt gatggttcag aagctggtgg ccacgtgtct
      481 tcctttgtcc cagcgtgttc cctggttgag tcacatctct cggaccagct gaccttgcac
      541 gtggatgtgg ctggcaacgt ggtaggcctg tcggtggtag tgtaccccgg gggctgccgg
      601 ggctctgagg tggaagatga ggacctggag ctgttcaata catctgttca tctgcggcct
      661 ccaggcaccg ctccaggccc cgagacggcg gccttcattg agcggctgga gatggagcag
      721 gcccagaagg ccaagaatcc tcaggaacag aagtctttct ttgccaaata ctggatgtac
      781 atcattccag tcgtgctgtt cctcatgatg tcgggagcgc cggacgccgg gggccagggc
      841 ggtggtgggg gtgggggcag cagccggtga gcagctgtgc cacctagagc ccctcagagc
      901 ctcttgtcct tggccagccc tagaaggact ctatctccct gttgcatgaa tatggaaggc
      961 cgtcccttcc catgagccct ctggccttct tgtaagtccc tcattctctc cctgagcctc
     1021 tctctctgtt cctgttgact gagagttggg tgtagctccc tgtagccagc tcactggctt
     1081 ccctgggcac tgcagctgtg tcccaccatg tggtaccgtg tccctctttc tgctaaccgc
     1141 ctgtcccact ccactccacc atacactttg ggaacttgcc gagctctctc cagcctctgt
     1201 gcctttgccc tgcagccctg ttcaccctca ctgtcacact caggctcttt gccaaggata
     1261 tgtggcccag aggcctctgc tgttagtggc tgggtctgcc tccagcccac tcttcatgtg
     1321 gcatgccatg ctgtgctctg cccccccctc tggtgcccca gaataccatg gtgactttca
     1381 ccactatcct ttcggtctct ggatgtccag cctggatcca tcaccaggag aggactgtgg
     1441 gcctccatgt tagtctgtct tctgtgaatg cacactctag taacttgtgt gcaggttttg
     1501 agagccagtt ttgcactagc tgctcgacag ctgctggcat ggccgtgctc ttgcacatgc
     1561 acggccgtgg gcatggggat tgctgtgcag cctcagctat gctgtggctg ttgattaaac
     1621 catcccctaa acagcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1681 aaa
//
