LOCUS       NM_001108690            6364 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ER membrane protein complex subunit 1 (Emc1),
            mRNA.
ACCESSION   NM_001108690 XM_001071619 XM_342959
VERSION     NM_001108690.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6364)
  AUTHORS   Fu,B., Wang,L., Li,S. and Dorf,M.E.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   2  (bases 1 to 6364)
  AUTHORS   Yamamoto,S., Yamazaki,T., Komazaki,S., Yamashita,T., Osaki,M.,
            Matsubayashi,M., Kidoya,H., Takakura,N., Yamazaki,D. and
            Kakizawa,S.
  TITLE     Contribution of calumin to embryogenesis through participation in
            the endoplasmic reticulum-associated degradation activity
  JOURNAL   Dev Biol 393 (1), 33-43 (2014)
   PUBMED   25009997
REFERENCE   3  (bases 1 to 6364)
  AUTHORS   Christianson,J.C., Olzmann,J.A., Shaler,T.A., Sowa,M.E.,
            Bennett,E.J., Richter,C.M., Tyler,R.E., Greenblatt,E.J.,
            Harper,J.W. and Kopito,R.R.
  TITLE     Defining human ERAD networks through an integrative mapping
            strategy
  JOURNAL   Nat Cell Biol 14 (1), 93-105 (2011)
   PUBMED   22119785
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342959.3, XM_001071619.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132284,
                              SAMD00132298 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6364
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..6364
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /note="ER membrane protein complex subunit 1"
                     /db_xref="GeneID:362643"
                     /db_xref="RGD:1310427"
     exon            1..120
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..3007
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /codon_start=1
                     /product="ER membrane protein complex subunit 1 precursor"
                     /protein_id="NP_001102160.1"
                     /db_xref="GeneID:362643"
                     /db_xref="RGD:1310427"
                     /translation="MAAAVESWFCLCAVLLVPAAAVYEDQVGKFDWRQQYVGKLKFAS
                     LEFSPGSKKLVVATEKNVIAALNSRTGEILWRHVDKGTAEGAVDAMLVHGQDAITVSN
                     GGRIMRSWETNIGGLNWEITLDSGSFQALGLVGLQETVRYVAVLKKTTLTLHHLSSGH
                     LKWVEHLPESDSILYQMVYSYGSGVVWALGIVPFSHVNIVKFNVEDGEIVQQVRVWTP
                     WLQHLTGACGVVDEAVLVCPDPSSHSLHTLALETEWELRQIPLQSPDLEFGSGFQPQV
                     LPTQPSPVAPSRAQFFLQLSPGHYALLHYHHGAVTLLKNFPQATLVSFATTGEKTVAA
                     VMTCRTEVQKPGSAGDGSVASFPETSGAQDSLACFNQTYTINLYLVETGRRLLDTSIS
                     FSLEQKGTRPEQLYVQVFLKKDDSVGYRALVQTQDHLQLFLQQLAGKVVLWSREESLA
                     EVVCLEMVDLPLTGAQAELEGEFGKKADGLLGMFLKRLSSQLILLQAWTSHLWKMFYD
                     ARKPRSQIKNEINIDTLARDEFNLQKMMVMVTASGKLFGIESSSGTILWKQYLPNVKP
                     DSSFKLMVQRTTAHFPHPPQCTLLVKDKETGMSSLFVFNPIFGKWSQVAPPVLKRPIL
                     QSLLLPVMDQDYAKVLLLVDDEYKVTAFPATRNVLRQLHELAPSIFFYLVDAEQGRLS
                     GYRLRKDLTTELSWELIIPPEVQRVVQVKGKRSSEHVHSQGRVMGDRSVLYKSLNPNL
                     LAVVTESTDVHHERTFIGIFLIDGVTGRIIHSSVQKKARGPVHLVHSENWVVYQYWNS
                     KARRNELTALELYEGTEQYNATAFSSLDRPQLPQVLQQSYIFPSSISAMEATITERGI
                     TSRHLLIGLPSGAILSLPKALLDPRRPEIPTEQSREENLIPYSPDVQVHAERFINYNQ
                     TVSRMRGIYTAPSGLESTCLVVAYGLDIYQTRVYPSKQFDVLKDDYDYVLISSVLFGL
                     VFATMITKRLAQVKLLNRAWR"
     exon            121..245
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            246..311
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            312..405
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            406..534
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            535..661
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            662..811
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            812..979
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1051
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1114
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1237
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1334
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1457
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1657
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1807
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1969
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2089
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2227
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2401
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2612
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2697
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2827
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..6364
                     /gene="Emc1"
                     /gene_synonym="RGD1310427"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgggcggt gcttgggctt caatcatggc ggcggctgtg gagtcctggt tctgcctctg
       61 tgctgtgcta cttgtccctg cggccgcagt ctacgaagac caagtgggca agtttgactg
      121 gagacagcag tacgttggga agctcaagtt tgcctccttg gagttctccc ctggatccaa
      181 gaagttggtt gtggccacag agaagaatgt gattgcagca ttgaattctc ggactggaga
      241 gattttgtgg cgccatgttg acaagggtac agcagaaggg gctgtggatg ccatgctggt
      301 ccatgggcaa gatgcaatca ctgtatccaa tggagggcgc atcatgcgtt cttgggagac
      361 taacatcggg ggcctgaact gggagataac tctggacagt ggcagtttcc aggcactcgg
      421 gctggtgggc ctccaggaga cagtgaggta cgttgcggtt ctgaagaaga cgaccctcac
      481 tctccatcac ctctctagtg ggcacctgaa gtgggtggag catctgccag aaagtgacag
      541 catcctctac cagatggtgt attcctacgg ctccggggtg gtgtgggccc ttggcatcgt
      601 tcccttcagc catgtgaaca tcgtcaagtt taacgtggag gatggagaga ttgttcagca
      661 ggtcagggtt tggaccccct ggctgcagca cctgactgga gcctgtggtg ttgtagacga
      721 ggctgtcctg gtatgcccag accccagctc acattcgctc cacactttgg ccctggagac
      781 ggagtgggaa ctgcggcaga tccccctgca gtctcctgac ttagaatttg gaagtggatt
      841 ccagccccaa gtgctgccca cgcagcccag cccagtggct ccttctcggg cccagttctt
      901 cctgcagttg tccccgggcc actatgctct actgcactac caccacggcg ccgtgactct
      961 gctcaaaaac tttccccagg ccacacttgt cagctttgct accacagggg agaagacagt
     1021 ggctgcagtc atgacctgtc gcactgaagt gcaaaaacct ggcagtgctg gagatgggtc
     1081 tgtggcgagc ttccctgaga catctggtgc acaggactct ctggcttgct tcaatcagac
     1141 ctacaccatt aacctgtact tagtagagac aggtcggcgg ctactagaca cttcgatttc
     1201 cttcagcttg gagcagaagg gcactcgacc tgagcagctg tacgtccagg tgttcttgaa
     1261 gaaggatgac tcggtgggct accgggcctt ggtgcagaca caggaccatc tgcagctgtt
     1321 cctgcagcag cttgccggga aggtggtgtt gtggagccga gaggagtccc tggcagaagt
     1381 cgtgtgcctg gagatggtgg atctccccct gactggggca caggctgagc tggaaggaga
     1441 atttggcaag aaggcagatg gcttgctggg gatgttcctg aaacgcctgt cttcccagct
     1501 catcctgctc caggcctgga cttcccacct ctggaaaatg ttctacgacg ctcggaagcc
     1561 ccgaagccag attaagaatg agatcaacat cgacaccttg gctagagatg agttcaacct
     1621 gcagaaaatg atggtgatgg taacagcctc aggcaagctc tttggcatcg agagcagctc
     1681 tggcaccatt ctgtggaaac agtatctgcc caatgttaag ccggactcct cctttaagct
     1741 gatggtccag aggactactg cccatttccc ccacccgccc cagtgcacgc tgctggtgaa
     1801 ggacaaggaa acaggaatga gctctctgtt tgtcttcaac cccatttttg gcaagtggag
     1861 tcaggtagct cccccagtgt tgaagcgccc catcctgcag tccttgcttc tcccggtcat
     1921 ggatcaagac tatgccaagg tgttgctgtt ggtggatgat gaatacaagg tcacagcttt
     1981 cccagctact cggaatgttt tgcgacagct acatgaactt gccccctcca tcttcttcta
     2041 cttggtggat gccgagcagg ggcggctcag cgggtatcgg cttcgcaagg atctcactac
     2101 agaactgagt tgggagctga tcatcccccc agaagtgcaa cgggtcgtcc aggtgaaggg
     2161 gaagcgcagc agtgagcacg tgcactccca gggccgggtg atgggggatc gaagcgtgct
     2221 ctacaagagt ctgaacccca acttgctggc tgtggtgacg gagagcacgg atgtccatca
     2281 cgagcgcacc tttattggca tcttcctcat tgacggtgtc actggccgca ttatccactc
     2341 ctctgtgcag aagaaggcta ggggccctgt ccaccttgtg cattcagaga actgggtggt
     2401 gtaccagtac tggaactcta aggctcggcg caatgagctg acggccctgg agctctacga
     2461 gggcactgag cagtacaatg ccactgcctt cagctcccta gaccgacccc agctgcccca
     2521 ggtcctccag cagtcctaca tcttcccttc ctccatcagt gccatggagg ctaccatcac
     2581 cgagcggggc atcaccagcc ggcacttgct cattgggctg ccttctggag caatcctttc
     2641 cctccccaaa gccttgctgg atccccggcg cccagagatc ccaacagaac aaagcagaga
     2701 agagaacctg atcccgtatt ccccagatgt ccaggtccat gcagagcgat tcatcaacta
     2761 taaccagaca gtctctcgaa tgcgaggcat ctatacagcg ccctcaggcc tggagtccac
     2821 atgtttggtt gtggcctatg gtctggatat ttaccaaact cgagtttacc catccaagca
     2881 gttcgatgtc ctgaaagatg actatgacta tgtgctcatc agcagtgtcc tttttggcct
     2941 ggtttttgcc accatgatca cgaagaggct ggcacaggtg aaactcctca atcgagcctg
     3001 gcggtaaaat gggagcatcc tgccagagtg gagcctcggg gaagagagac agctaaagag
     3061 atatggccat ggactgttgg atcgttgaga ttgggttggg ttcttgtctc acttaagttt
     3121 tgaggaagaa gatgcacctt catgtagaac tgctttggga atacggtgac ccacacagtc
     3181 cttgtgggtc agatacccac ctcagcgagg acctccatgc atttgatcac tgctctgttt
     3241 cctgtatgtg cccatccatg gatgctgtgg gtgttttgtc tttgtttttt tccttctgtg
     3301 agatctcagg tttctttctt ctgaggctgt ttaaattgac tttcgttatc cttttgtgtc
     3361 tccagtctta ctagacatac tctgacatcc tattctctgc ctcttgcttt caagcctgat
     3421 gggtcagctc tgcctttaag gtgtgcatgg ctgcctgact gatggggtgg atgcaggaac
     3481 gttcttagcc aaggtctgag ggtttctccc tgaagtaaga gaagttaggg agtgagaact
     3541 aattttaacc aagttttcat tccagccacc attttttttt tcaacctatt aaagccaagc
     3601 acataacagt aatttgattt ttttcaccca caacctataa tttttctcct gagtataaca
     3661 aggctaaaac ctttaattct ctgtctgtct gcctgtctgt ctgtctgtct tccttccttc
     3721 cttcctttct tttggttttg ggagacagga tttctctgtg taaccctggc tgtcctggaa
     3781 ctctctctgt agaccaggct ggtcttgaac tcaacagata tctgcctgct tctgcttccc
     3841 gagtgctgga atcaaaggtg tgtgctacca cctgccttag ggcaaaggcc ttttaaagct
     3901 accagattgt ctgcaccatg gtgagatcgt gaggtcccag tacgtcatat ctcattgtcc
     3961 ctacaggccc ctctagacat cctatagccc agctggagga aagggtcttt gttaaaacct
     4021 tatttattct tgattggttt tttttttttt ttgagacaga gttttgctca gtaatccatg
     4081 ctcgcctcaa acttgctatt ctcctgcctt agcctcccag tgttgggatt gcaggtgttt
     4141 gccatcatgc ttggtagtgg gcaagtttta aatttcattg gtataatttt ctatgtggca
     4201 ttaggcatag aatccaaggt ctctcatgcc aggcaagttc tctgcactga gctctccata
     4261 aggcgagccg tgagggctgt tatttttctt aagtagtttt aaaatcttac taatttaagt
     4321 tttgggggga ggggctggaa ggaggatgct gggactcgaa cccagggcct catatgttag
     4381 tgcacactct acttctacta ctgtgttaga gcctcaacac atctaacctt tttacttatt
     4441 ttattgggac ggggtctcac catgtagccc tggctggact agaactagtt gtatagacca
     4501 cgggtgggct tttgtgtggg gtgtgtgcat tcctgcctgg ggcttttgtg gggcgtgtgt
     4561 gtgtgtgtgt atgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgcgcgcgc acgcactctt
     4621 ttctgtgtgt actcctatat gggcttctgt atgctgcaca gaaagaatcc taagttttat
     4681 cttgtttgtg aatttggtga ctgactgatt gtttttttga tggctcagcg gttaagagcg
     4741 ctgactgttc ttccagaggt ccagagttca attcccagca accacatggt ggctcacaac
     4801 catctgtaat gggatctgat accctctctg gtgtgtctga agacagctac agtgcactta
     4861 tatacctaaa ataaataaat aattcttaaa aaaacaaaaa aacaaaaaca gaaacaaaga
     4921 gagaagaggg acggcaatga tgaccatgct ctctgaataa agctgatgat cagtgacttt
     4981 gcctcagctc tgttttgtgt cttcagagtt cacttccaag ctacttttgc atccaaatta
     5041 aaaaaaaaga aaaaagaaaa aaagaaaagc cagatgtggt agcatacccc tataaaagca
     5101 gcagttgaga ggtagaggag ggagggtcag aagttgaagt gtgtgactga agtcgaaggg
     5161 tatcttcagc tacatgctca gcctaggcta taagaaacag tggttacaag tatctgctgc
     5221 cttttcagtt cagttcccag cactcgcact gggcgcctca caagcacctg taactccgcc
     5281 tcaaggagat tcagcatcct ctccctgctc tgcgcgtaca caaatgcatg tacagaataa
     5341 ctttcaaaaa aatcagggaa aaatggagct atttagggca acatgccaac atccttgtca
     5401 gcgataacca gtttcctctc ctgggttagt gatcatctgt cacttccagt gacaggccct
     5461 atactgctgg ctttgtaaga agcggcctgg gagaaggcat tgggacccat tctgctctag
     5521 ttttgttttg ttacaaggtc tcaccttgca actctgactg gcctgaatga acagagatgc
     5581 gcttggatta aaggcatata ccctagactc caaggatagt cttgagatag agtggctgga
     5641 attttgtgca agataagtga ttctcaccac actatcctgt tttgtttgct ttaagattta
     5701 ttttttatga gtgtttcccc tcatttgtgt gagtgcctgg tgcccatgga ggccagaaga
     5761 tgttggatcc tccaggaact ggagttaggg atgattgcga gccaccatgt gggtcctggg
     5821 aactgaactg aggtttctgg aggatttgcc tcctatagtg cctgccaggt ttctacagta
     5881 cagttagtct gcaagactat ttttcctact tatgtgccag aatcttaaag gggtaatggt
     5941 caggaagtga ccctttatga agctcctgat atttcacctt taactaatac catttcacca
     6001 aagctgctca aagcaggagg ctctgctaag gccaggggaa tggagagatg gctcagtggt
     6061 taagagcact gatgcagtac tgattgctct ttctgaggtc ctgagttcaa atcccagcaa
     6121 ctgcatggtg gctcacaacc atctgtaatg agatctgatg ccctcttctg gtgtgtctga
     6181 agacagctac agtatactta aatgtaataa ataaatctta aaaaaaaaaa aaagccaagg
     6241 cataggtgaa gtcttaactt ttctcctaag tcctgtgtag accaagcttg ccttgaattc
     6301 acaatgctct gccttctcaa ccttgagatt aaaagtctgg gccaccatgc ctggcttcat
     6361 tttt
//
