LOCUS       NM_080899               7686 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus elongator acetyltransferase complex subunit 1
            (Elp1), mRNA.
ACCESSION   NM_080899 XM_346739
VERSION     NM_080899.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7686)
  AUTHORS   Close,P., Gillard,M., Ladang,A., Jiang,Z., Papuga,J., Hawkes,N.,
            Nguyen,L., Chapelle,J.P., Bouillenne,F., Svejstrup,J., Fillet,M.
            and Chariot,A.
  TITLE     DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and
            migration of melanoma cells as subunits of Elongator
  JOURNAL   J Biol Chem 287 (39), 32535-32545 (2012)
   PUBMED   22854966
REFERENCE   2  (bases 1 to 7686)
  AUTHORS   Lei,Y., Zhang,Y., Cao,Y., Edvinsson,L. and Xu,C.B.
  TITLE     Up-regulation of bradykinin receptors in rat bronchi via I kappa B
            kinase-mediated inflammatory signaling pathway
  JOURNAL   Eur J Pharmacol 634 (1-3), 149-161 (2010)
   PUBMED   20184874
  REMARK    GeneRIF: Organ culture of bronchi induces IkappaB kinase mediated
            inflammatory changes resulting in airway hyperresponsiveness to
            bradykinin via the up-regulation of bradykinin receptors.
REFERENCE   3  (bases 1 to 7686)
  AUTHORS   Schuller,M., Izakovicova Holla,L., Buckova,D., Znojil,V.,
            Stelcl,M., Rybnicek,O. and Vacha,J.
  TITLE     The role of the IKAP gene polymorphisms in atopic diseases in the
            middle European population
  JOURNAL   J Hum Genet 48 (6), 300-304 (2003)
   PUBMED   12774215
REFERENCE   4  (bases 1 to 7686)
  AUTHORS   Gavrilyuk,V., Dello Russo,C., Heneka,M.T., Pelligrino,D.,
            Weinberg,G. and Feinstein,D.L.
  TITLE     Norepinephrine increases I kappa B alpha expression in astrocytes
  JOURNAL   J Biol Chem 277 (33), 29662-29668 (2002)
   PUBMED   12050158
REFERENCE   5  (bases 1 to 7686)
  AUTHORS   Kupfer,R. and Scheinman,R.I.
  TITLE     Measurement of IKK activity in primary rat T cells: rapid
            activation and inactivation
  JOURNAL   J Immunol Methods 266 (1-2), 155-164 (2002)
   PUBMED   12133632
REFERENCE   6  (bases 1 to 7686)
  AUTHORS   Hawkes,N.A., Otero,G., Winkler,G.S., Marshall,N., Dahmus,M.E.,
            Krappmann,D., Scheidereit,C., Thomas,C.L., Schiavo,G.,
            Erdjument-Bromage,H., Tempst,P. and Svejstrup,J.Q.
  TITLE     Purification and characterization of the human elongator complex
  JOURNAL   J Biol Chem 277 (4), 3047-3052 (2002)
   PUBMED   11714725
REFERENCE   7  (bases 1 to 7686)
  AUTHORS   Anderson,S.L., Coli,R., Daly,I.W., Kichula,E.A., Rork,M.J.,
            Volpi,S.A., Ekstein,J. and Rubin,B.Y.
  TITLE     Familial dysautonomia is caused by mutations of the IKAP gene
  JOURNAL   Am J Hum Genet 68 (3), 753-758 (2001)
   PUBMED   11179021
REFERENCE   8  (bases 1 to 7686)
  AUTHORS   Slaugenhaupt,S.A., Blumenfeld,A., Gill,S.P., Leyne,M., Mull,J.,
            Cuajungco,M.P., Liebert,C.B., Chadwick,B., Idelson,M., Reznik,L.,
            Robbins,C., Makalowska,I., Brownstein,M., Krappmann,D.,
            Scheidereit,C., Maayan,C., Axelrod,F.B. and Gusella,J.F.
  TITLE     Tissue-specific expression of a splicing mutation in the IKBKAP
            gene causes familial dysautonomia
  JOURNAL   Am J Hum Genet 68 (3), 598-605 (2001)
   PUBMED   11179008
REFERENCE   9  (bases 1 to 7686)
  AUTHORS   Takeoka,S., Unoki,M., Onouchi,Y., Doi,S., Fujiwara,H., Miyatake,A.,
            Fujita,K., Inoue,I., Nakamura,Y. and Tamari,M.
  TITLE     Amino-acid substitutions in the IKAP gene product significantly
            increase risk for bronchial asthma in children
  JOURNAL   J Hum Genet 46 (2), 57-63 (2001)
   PUBMED   11281413
REFERENCE   10 (bases 1 to 7686)
  AUTHORS   Bar-On,E., Floman,Y., Sagiv,S., Katz,K., Pollak,R.D. and Maayan,C.
  TITLE     Orthopaedic manifestations of familial dysautonomia. A review of
            one hundred and thirty-six patients
  JOURNAL   J Bone Joint Surg Am 82 (11), 1563-1570 (2000)
   PUBMED   11097445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jun 3, 2021 this sequence version replaced NM_080899.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF388201.1, SRR26360176.928879.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000005.1  76300825-76300985   c
            162-324             JAXUCZ010000005.1  76298413-76298575   c
            325-477             JAXUCZ010000005.1  76297095-76297247   c
            478-559             JAXUCZ010000005.1  76295030-76295111   c
            560-640             JAXUCZ010000005.1  76293905-76293985   c
            641-726             JAXUCZ010000005.1  76291077-76291162   c
            727-823             JAXUCZ010000005.1  76289335-76289431   c
            824-914             JAXUCZ010000005.1  76288979-76289069   c
            915-1038            JAXUCZ010000005.1  76287961-76288084   c
            1039-1132           JAXUCZ010000005.1  76287164-76287257   c
            1133-1363           JAXUCZ010000005.1  76285149-76285379   c
            1364-1528           JAXUCZ010000005.1  76283927-76284091   c
            1529-1628           JAXUCZ010000005.1  76282254-76282353   c
            1629-1814           JAXUCZ010000005.1  76279488-76279673   c
            1815-1921           JAXUCZ010000005.1  76278111-76278217   c
            1922-2025           JAXUCZ010000005.1  76277321-76277424   c
            2026-2079           JAXUCZ010000005.1  76275383-76275436   c
            2080-2185           JAXUCZ010000005.1  76275187-76275292   c
            2186-2301           JAXUCZ010000005.1  76274166-76274281   c
            2302-2375           JAXUCZ010000005.1  76273771-76273844   c
            2376-2454           JAXUCZ010000005.1  76273450-76273528   c
            2455-2534           JAXUCZ010000005.1  76273287-76273366   c
            2535-2672           JAXUCZ010000005.1  76271988-76272125   c
            2673-2758           JAXUCZ010000005.1  76271806-76271891   c
            2759-2907           JAXUCZ010000005.1  76271186-76271334   c
            2908-3031           JAXUCZ010000005.1  76270284-76270407   c
            3032-3129           JAXUCZ010000005.1  76269856-76269953   c
            3130-3331           JAXUCZ010000005.1  76266464-76266665   c
            3332-3393           JAXUCZ010000005.1  76265253-76265314   c
            3394-3456           JAXUCZ010000005.1  76262545-76262607   c
            3457-3517           JAXUCZ010000005.1  76261963-76262023   c
            3518-3631           JAXUCZ010000005.1  76259426-76259539   c
            3632-3743           JAXUCZ010000005.1  76258810-76258921   c
            3744-3871           JAXUCZ010000005.1  76257947-76258074   c
            3872-4026           JAXUCZ010000005.1  76257017-76257171   c
            4027-4102           JAXUCZ010000005.1  76255302-76255377   c
            4103-7686           JAXUCZ010000005.1  76248545-76252128   c
FEATURES             Location/Qualifiers
     source          1..7686
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..7686
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /note="elongator acetyltransferase complex subunit 1"
                     /db_xref="GeneID:140934"
                     /db_xref="RGD:620072"
     exon            1..161
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            162..324
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..4170
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /note="IKK complex-associated protein; ikappaB kinase
                     complex-associated protein; elongator complex protein
                     1-like; inhibitor of kappa light polypeptide enhancer in
                     B-cells, kinase complex-associated protein; inhibitor of
                     kappa light polypeptide gene enhancer in B-cells, kinase
                     complex-associated protein"
                     /codon_start=1
                     /product="elongator complex protein 1"
                     /protein_id="NP_543175.2"
                     /db_xref="GeneID:140934"
                     /db_xref="RGD:620072"
                     /translation="MRNLKLHQTLEFRDIQAPGKPQCFCLRAEQGTVLIGSERGLTEV
                     DPVKKEVKTEISLVAEGFLPEDGSGCIVGIQDLLDQESVCVATASGDVIVCNVSTQQL
                     ECVGNVASGISVMSWSPDQELLLLATAQQTLIMMTRDYEVITEQQIHQDDFGEGKFIT
                     VGWGSKDTQFHGSEGRPITFPVQMHESALSWDDHRPQITWRGDGQFFAVSVVCSQTGA
                     RKIRVWNREFALQSTSESVPGLGPSLAWKPSGSLIASTQDKPNQQDVVFFEKNGLLHG
                     YFTLPFLKDEVKVNDLLWNADSSVLAVWLEDLPKEGSSTLKSYVQLWTVGNYHWYLKQ
                     SLPFSTTGKNQIVSLLWDPVTPGRLHVLCQGWRYLCCDWHWTTDRSSGNSADDLANVA
                     VIDGNKVLVTVFQRTVTPPPMCTYRLLIPHPVNQVMFSAHLGNDLAVLDASNQISVYK
                     CDDKPDMDSTVKLGAVGGTGFKVPLRTPHLEKRYRIQFGNKEEEEDVSPLQFRFLTWI
                     EGDAFLAISHSHSSPQSIIHHLTMAGSEGDEEQGQLNVSSSVTVDGVVIGLCCCSKTK
                     SSAVQLADGQVLKYLWESPSSAVEPWKNSEGRPVRFARPCTQMEAAAIGGEECVLGLT
                     DRCRFFINDTEVASNITSFAVCDDFLLVTTHSHTCQCFSLSGASLKMLQAGLCGSQVP
                     SGEILRKVERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKLMFKEA
                     FECMRKLRINLNLIHDHNPKVFLENVETFIKQIDSVNHLNLFFTELKEEDVTKTMYPP
                     PVTKSVQVSTNPDGKKVDLICDAMRVAMETINPRKFCLSILTSHVKKTTPELDIVLQK
                     VHELQGKIPFEPESVSAEEALKYLLLLVDVNELFNHSLGTYDFDLVLMVAEKSQKDPK
                     EYLPFLNTLKKMETNYQRFTIDKYLKRYEKALGHLSKCGPEYFTECLNLIKDKNLYKE
                     ALKLYRPDSPQYQAVSVAYGEHLVQEHLYEPAGLVFARCGAHEKALEAFLACGSWQQA
                     LCMAAQLQMAKDKVAGLARTLAGKLVEQRKHSEAATVLEQYAQDYEEAVLLLLEGSAW
                     EEALRLVYKYDRVDIIETSVKPSILEAQKNYMDFLDSQTATFIRHKNRLKVVRELKSQ
                     APRVHVDHEVAHGRETDLFSETSSIRSGSEMSGRYSHSNSRISARSSKNRRKAERKKH
                     SLKEGSPLEGLALLEALSEVVQSIEKLKDEVHAILKVLFLFEFEEQARELQRAFESTL
                     QLMGTALPDIWTLTGQQSSATPVLGPSSTVNSIMASYQQQKTCVPVLDAWACLPPKID
                     QRSQWKLSLLE"
     exon            325..477
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            478..559
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            560..640
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            641..726
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            727..823
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            824..914
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1038
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1132
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1363
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1528
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1628
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1814
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1921
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2025
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2079
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2185
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2301
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2375
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2454
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2534
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2672
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2758
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2907
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3031
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3129
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3331
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3332..3393
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3456
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3517
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3631
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3743
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3871
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3872..4026
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            4027..4102
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
     exon            4103..7686
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgcgccgc ctttcttgtg ctacctggcg ggtttcgctc atcggtggtt cgtgtctctt
       61 gtttcccgtg tgctttggcg tttcccttcc aaacccagtg taccgtgagg gttcggagcc
      121 gcgcactgag gcgagggcgc agttccgcta gggcgttgta gaaattgttt catcatgaga
      181 aatctgaagt tgcatcagac cctggaattt agggacattc aggcaccagg gaaacctcag
      241 tgtttctgtc tgcgagctga acaggggaca gttctgattg gctcagaacg tggactgaca
      301 gaagtagatc ctgtgaaaaa agaagtgaag actgaaattt ctttggtggc agaaggtttt
      361 cttccagagg atggaagtgg ctgcattgtg ggtattcagg acttgctgga tcaagaatct
      421 gtgtgtgtgg ccactgcctc tggggacgtc atagtctgca atgtcagcac acagcagctg
      481 gaatgtgttg ggaatgtggc cagtggtatc tctgtcatga gctggagtcc tgatcaagaa
      541 ctgctgctgc ttgccacagc tcaacagacc ctgattatga tgacaagaga ctatgaagta
      601 atcacagagc agcagatcca ccaggatgat tttggagaag gcaagtttat caccgttgga
      661 tggggcagta aggacacgca gttccacggc tcagaaggca ggccaataac ctttccggtg
      721 caaatgcatg agtctgcctt gtcctgggat gaccacagac cacaaattac ctggcgtggg
      781 gatgggcaat tttttgctgt gagtgttgtt tgctcacaaa caggggctcg gaaaatccga
      841 gtatggaacc gagagtttgc cttgcagtca accagtgagt ctgtgccagg gctggggccc
      901 tccctggctt ggaaaccctc aggcagtctg attgcatcta ctcaggataa acccaaccag
      961 caagacgttg tgttttttga gaaaaatgga cttcttcatg ggtattttac acttcctttc
     1021 ttgaaagatg aagttaaggt aaatgacttg ctgtggaatg cagattcctc ggtgcttgct
     1081 gtgtggctag aagacctccc gaaggaaggc agttccactc tgaaaagcta tgtccagctc
     1141 tggaccgtgg ggaactatca ctggtatctc aagcaaagcc tgcccttcag caccacgggg
     1201 aagaaccaga tcgtgtctct gctgtgggac ccagtgacgc cgggccgact gcatgttctc
     1261 tgtcagggct ggcggtatct atgctgtgac tggcactgga ccactgatcg gagctctgga
     1321 aatagtgccg atgacttggc aaatgtggct gtcattgatg gaaacaaggt gttggtaaca
     1381 gtcttccagc ggactgtgac cccacctccc atgtgtacct accggctgct gatcccacat
     1441 ccagtgaatc aagtcatgtt ctctgctcac cttggaaatg accttgctgt ccttgacgcc
     1501 agtaaccaga tttctgtcta caagtgtgat gataaaccag acatggattc cacagtgaaa
     1561 ctaggagctg tgggtggaac tggatttaaa gttcctctta gaacacctca tctggaaaaa
     1621 agatacagga ttcagtttgg gaacaaggaa gaggaggagg atgtaagccc actgcaattt
     1681 cgatttctca cctggattga aggtgacgct ttcctggcca taagccacag tcactccagc
     1741 ccacagtcca tcattcacca tctgactatg gccggttctg agggggatga ggaacaagga
     1801 cagctgaatg tcagttcatc tgtgacagtg gatggagttg tcattggttt atgttgctgt
     1861 tctaagacca agtcatcagc agtacagctg gctgacggcc aggtgctcaa gtacctttgg
     1921 gagtcgcctt cttcggctgt ggagccctgg aagaactctg aagggcgtcc tgtccgattt
     1981 gctcgtccat gcacacagat ggaagcagcc gccattggag gggaggaatg tgtccttggt
     2041 ctgaccgaca ggtgtcgctt tttcatcaac gacactgagg ttgcatcaaa tatcacgtca
     2101 tttgcagtgt gtgatgactt tctactggtg acaacccatt cccacacctg ccagtgtttc
     2161 tctctaagtg gtgcctcact taaaatgctg caggcaggtc tgtgtggcag tcaggtgccc
     2221 agtggagaga ttctgaggaa ggtggagagg ggttcccgga tcgtcacagt cgtcccccag
     2281 gacacaaagc ttatactcca gatgccgagg gggaacttgg aggttgttca tcatcgggcc
     2341 ttggtcttgg ctcagattcg gaagtggctg gacaaactta tgtttaaaga agcgtttgaa
     2401 tgcatgagga aactgagaat taacctcaat ctgattcatg atcataaccc caaggtgttt
     2461 cttgaaaatg tggaaacctt cataaaacag attgattctg taaatcatct aaacttgttt
     2521 ttcacagaac taaaggaaga agatgtcaca aagaccatgt accctccccc ggttaccaag
     2581 agtgtccagg tgtccacaaa tcctgatgga aagaaagttg acctcatctg tgacgctatg
     2641 agagtggcca tggagaccat caatcctcgc aagttctgcc tgtccatact cacatctcat
     2701 gtgaagaaga cgactccaga actggacatt gtgctgcaga aggtacacga acttcaagga
     2761 aaaattccct ttgaacctga gagtgtgagt gcagaggagg ctttgaaata cctgctgctc
     2821 ctggtagatg ttaatgaatt atttaatcat tctcttggga cctatgactt tgatttggtc
     2881 ctcatggtag ctgagaagtc acaaaaggat cctaaggaat atcttccatt tcttaataca
     2941 cttaagaaaa tggaaactaa ttaccaacgg ttcaccatag acaagtactt gaaacgatat
     3001 gaaaaggccc ttggacacct cagcaagtgt ggacctgagt atttcacaga atgcttaaat
     3061 ttgataaaag ataaaaactt gtataaagaa gctctgaagt tatatcggcc agactcacca
     3121 cagtaccagg cggtcagtgt tgcttatggc gagcacctgg tgcaggagca cctgtacgag
     3181 ccagcagggc ttgtgtttgc ccgctgtggg gcccatgaga aggctctgga agcgtttttg
     3241 gcttgtggca gctggcagca agccctttgt atggctgccc agcttcagat ggccaaagac
     3301 aaggtggctg gccttgctag aactctggca ggaaagctgg tcgagcagag gaaacacagt
     3361 gaggcagcaa cagtcctgga acagtacgcc caggattatg aagaagccgt gctcttgctg
     3421 ctagaaggat ctgcctggga agaagctctg aggctggtat acaagtatga cagagtggat
     3481 attatagaaa ccagcgtaaa gccttccatt ttagaagccc aaaaaaatta catggacttt
     3541 ctggactctc agacagccac attcattcgc cataaaaacc gcttgaaggt ggttcgagag
     3601 ctcaagagcc aagcaccacg ggtgcatgtg gatcacgagg tggcccatgg ccgagagacg
     3661 gacctcttct cggaaaccag cagtattagg agtggcagcg agatgagtgg cagatactcc
     3721 cacagtaact ccaggatatc tgcgaggtca tctaaaaacc gccgcaaggc agaacggaag
     3781 aagcatagcc tcaaagaagg gagccccctg gagggcctgg cacttctgga ggcgctgagt
     3841 gaggtggtac agagcattga gaagctgaaa gatgaagtgc acgctatttt aaaggtgctc
     3901 tttctctttg agttcgaaga gcaagcaagg gagttacaga gggcctttga gagtactctg
     3961 cagctgatgg ggacggcact tccagacatc tggactctca ccggccaaca gagttcagcc
     4021 acacctgtcc taggtcccag ttccactgtg aatagtatca tggcttctta ccagcagcag
     4081 aagacttgtg tccctgttct cgatgcttgg gcttgtttgc caccgaagat cgaccagaga
     4141 agccagtgga agctgagcct gctggaatga ctgccctgtt aagaaggcat cgctgggaag
     4201 accatttgtg cttctggttc ttgctcctca gagacctgac tgtggagaac tgggatgtgg
     4261 gatagtccgc ctttgaactg cctgcagtgg cagtgagcag caccaggccc cagccagctc
     4321 cagtctctgg cctttctttg gtgtatacat cttaggtact atgtcagaac ttttgtctta
     4381 gccagcatat tacattcttt gtaaaagttg ctgttcagcc agtcacagtg cgacatgtct
     4441 ataaccccag caaccgagga ggctgaggca gaaacactga tggaagttca agaccagtgt
     4501 aggctacagc aaggccttgt ctcaaaacaa cccagcctga tgttcttgta ctagtactgt
     4561 ctgaaagcat ggatcttatg cagatcatga actgggttcc cagatccagg cctggtttct
     4621 gttacaacct tggacgctca tcattgattt gatcctcagt tcctgttgtt catagggaat
     4681 gatgtttcat ggcttctacc tcaaaaaatg aagacaagtg aaaccacatt tctcagttgt
     4741 cgtgtgttgt taacagcatg cagtgtgcac acaggcagtt agtgcggcca gcatccagta
     4801 aggtgtgatt gcagagctgt gtcttttcct ccaactcaga gcagaattca aggctaactg
     4861 tgtttgtaca ccgagaggtg actccgtggt aaagagcagt tgtcgctttt gcagaggacc
     4921 tgggtttgac tcccagcacc cacacgacag ctcgcaaccg tctgttttct ccagttctag
     4981 gaaatctaac gtcccctttt gatctctgag cacatgtggt acataaacac atgcaggcaa
     5041 aatactcctc tacacacaaa gtcttttaaa aaaatttttt ttaattaaat gtgttatcct
     5101 accatgttat gtgctactaa ctttaattgg gctcagcctc ctctggctgg cactgttaca
     5161 gggactgttc gattgcatga gtatattctg ctaaagtgtc gtcagcagta gggtggactt
     5221 cagtgagggg tagacagcag gcatgcatgg tagcagggtt ggaggtgacc ctctgttccc
     5281 cagacactgc cttttgacta aagcattttg tctgtgtcca ggtagactca tttagctttt
     5341 tgtatggtgt cttaagatca gatgtggaga tgcagagttt ggagtttgcc tagctggttc
     5401 ggtctggctt tagatcagta tttccttact gtgctccctc ctcagttttg gaactgtaat
     5461 atatacccta tgctgttgta tgatggacgt gtgcgatttg ctctttgctt ttgattttac
     5521 agaggattag aaataaggtt gcataaatct cagaagaaac tttgaacttt ggacttttaa
     5581 actttgttga gagtgtgtta gtctatgggg acttttgaag ttggactaaa tgcattttgc
     5641 attgttatta tggctgcaag cctagggggt gccagttgtg gaaagtggtg gtttgagtag
     5701 gtatacataa gactcatgtg tttgaaccct aggcccatgg agagtggcac tattaggtgt
     5761 ggccttgttg gtgtagatga ggccttgctg gaggaagtgt gtcactgtgg aggtgtgctt
     5821 tgaggtcttc tatactcaag ctccacccag tgtagattct tgccttgtcc agcactgtct
     5881 gcctgcaggc tgcagttttc ccgccatgac agtaatagac taaatctctg agactgtaag
     5941 ccagccccag tgaaatgtga gttgccgtgg tcatggtgtc tcttcacagc agtgaaaccc
     6001 taagacagta actaacctgt ctttcgttct gtttccaaaa atctttggaa gaatgaaagt
     6061 actttctctc ttttgtcaag tctagaaatt gaccagttta ttttaatgag atattttaaa
     6121 aattattctt cgacaatttc atattttcac ataatgtact tgatttgttc tcatttccct
     6181 ttcttctgct gaaatccttt ttcttcccaa gaatcccctc ttctattttc atgtcttttt
     6241 aactttactt gggattgaga attactcgaa catggagaat ttgttatgag tgtatcacta
     6301 gtaaagtaat atccttcccc aacaagagtt tcatggataa tccttgagta caattaaaat
     6361 ctcttgtgtg gttttaatat cagagtcagg ctttcattac tatgtgtaaa ctaaaagaaa
     6421 atgctgtttg gccctcaata tatagatgca ttcaaaattg taatttaaga aaacttatgg
     6481 ggctggggat ttagctcagt ggtagagcgc ttacctagga agcacaaggc cctgggttcg
     6541 gtccccagct ccggaaaaaa aaaaaaaaga aaacttacct aagcatgtta tataattcaa
     6601 cttttctggg tattttaaat ttttcacaaa atagaaaaag aggagacaat atattatact
     6661 tcagagagct agctctacgt tttgactcac cctatgatag gtttactccc aactagatga
     6721 cagtttcaag aggctgcgag tactttgtga tgactctttg gcaggcagct gtgaaccctc
     6781 taacttatgt gtgtgatgtt tattgtactg aaaagtcttg ccatggatgt tgaagaaccc
     6841 atgctaacag actgcaaatg gaggtaaatg tgcctgctgc caatggcatg gactttcaca
     6901 gtgctcgctt tccttaatgt tatagagccc agtgagttgg gcacaccttt aagcccagca
     6961 ctcaggaggc aggggcatgt ggatcttcga gttcaaggcc agcgtggtct acagagcgag
     7021 ttccaggaca aagagcccct ttctcaaaca aacaaaaaat gtagtggtac agcagtaaga
     7081 attaatgaga accagttgcc atccctctta actgtgcagg attaaatttt gctcattttg
     7141 agattgaatg gtagagcagg ccttccgtac tgaaggttga gaggaaggga ctggtagggt
     7201 gtggggcaag gtgagtgaga gctaaggctg aggaaagctg ctgagcttta gaaaatagag
     7261 ctgcccctag gtttaggctc tatctcagca aatccttacc acagtaagaa aaaatgtatg
     7321 tttctctggc ttatactgag taaggtttgc tcttgctctg tgttgaatca agtagctttg
     7381 ttcagtgctg cagacatcaa caggaaactt gtaaagagcc actttcttca gtctggactt
     7441 cacacttaca ccttctaaaa gctgaggcag aaactaacat ttgaaggtgt tgaggaattt
     7501 tcattgttat tttgtggtga tgggcattga accccttcag ggccctgcac atggcaaatc
     7561 aagagagcta cactctcaga cctaatgttt tcattatatc tttatgaata tatcttggta
     7621 tataacttag tacttgtaca catcttaaat aaatttgtct ctttatatac atatacactt
     7681 gaaaaa
//
