LOCUS       NP_543175               1331 aa            linear   ROD 31-MAR-2024
DEFINITION  elongator complex protein 1 [Rattus norvegicus].
ACCESSION   NP_543175 XP_346740
VERSION     NP_543175.2
DBSOURCE    REFSEQ: accession NM_080899.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1331)
  AUTHORS   Close,P., Gillard,M., Ladang,A., Jiang,Z., Papuga,J., Hawkes,N.,
            Nguyen,L., Chapelle,J.P., Bouillenne,F., Svejstrup,J., Fillet,M.
            and Chariot,A.
  TITLE     DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and
            migration of melanoma cells as subunits of Elongator
  JOURNAL   J Biol Chem 287 (39), 32535-32545 (2012)
   PUBMED   22854966
REFERENCE   2  (residues 1 to 1331)
  AUTHORS   Lei,Y., Zhang,Y., Cao,Y., Edvinsson,L. and Xu,C.B.
  TITLE     Up-regulation of bradykinin receptors in rat bronchi via I kappa B
            kinase-mediated inflammatory signaling pathway
  JOURNAL   Eur J Pharmacol 634 (1-3), 149-161 (2010)
   PUBMED   20184874
  REMARK    GeneRIF: Organ culture of bronchi induces IkappaB kinase mediated
            inflammatory changes resulting in airway hyperresponsiveness to
            bradykinin via the up-regulation of bradykinin receptors.
REFERENCE   3  (residues 1 to 1331)
  AUTHORS   Schuller,M., Izakovicova Holla,L., Buckova,D., Znojil,V.,
            Stelcl,M., Rybnicek,O. and Vacha,J.
  TITLE     The role of the IKAP gene polymorphisms in atopic diseases in the
            middle European population
  JOURNAL   J Hum Genet 48 (6), 300-304 (2003)
   PUBMED   12774215
REFERENCE   4  (residues 1 to 1331)
  AUTHORS   Gavrilyuk,V., Dello Russo,C., Heneka,M.T., Pelligrino,D.,
            Weinberg,G. and Feinstein,D.L.
  TITLE     Norepinephrine increases I kappa B alpha expression in astrocytes
  JOURNAL   J Biol Chem 277 (33), 29662-29668 (2002)
   PUBMED   12050158
REFERENCE   5  (residues 1 to 1331)
  AUTHORS   Kupfer,R. and Scheinman,R.I.
  TITLE     Measurement of IKK activity in primary rat T cells: rapid
            activation and inactivation
  JOURNAL   J Immunol Methods 266 (1-2), 155-164 (2002)
   PUBMED   12133632
REFERENCE   6  (residues 1 to 1331)
  AUTHORS   Hawkes,N.A., Otero,G., Winkler,G.S., Marshall,N., Dahmus,M.E.,
            Krappmann,D., Scheidereit,C., Thomas,C.L., Schiavo,G.,
            Erdjument-Bromage,H., Tempst,P. and Svejstrup,J.Q.
  TITLE     Purification and characterization of the human elongator complex
  JOURNAL   J Biol Chem 277 (4), 3047-3052 (2002)
   PUBMED   11714725
REFERENCE   7  (residues 1 to 1331)
  AUTHORS   Anderson,S.L., Coli,R., Daly,I.W., Kichula,E.A., Rork,M.J.,
            Volpi,S.A., Ekstein,J. and Rubin,B.Y.
  TITLE     Familial dysautonomia is caused by mutations of the IKAP gene
  JOURNAL   Am J Hum Genet 68 (3), 753-758 (2001)
   PUBMED   11179021
REFERENCE   8  (residues 1 to 1331)
  AUTHORS   Slaugenhaupt,S.A., Blumenfeld,A., Gill,S.P., Leyne,M., Mull,J.,
            Cuajungco,M.P., Liebert,C.B., Chadwick,B., Idelson,M., Reznik,L.,
            Robbins,C., Makalowska,I., Brownstein,M., Krappmann,D.,
            Scheidereit,C., Maayan,C., Axelrod,F.B. and Gusella,J.F.
  TITLE     Tissue-specific expression of a splicing mutation in the IKBKAP
            gene causes familial dysautonomia
  JOURNAL   Am J Hum Genet 68 (3), 598-605 (2001)
   PUBMED   11179008
REFERENCE   9  (residues 1 to 1331)
  AUTHORS   Takeoka,S., Unoki,M., Onouchi,Y., Doi,S., Fujiwara,H., Miyatake,A.,
            Fujita,K., Inoue,I., Nakamura,Y. and Tamari,M.
  TITLE     Amino-acid substitutions in the IKAP gene product significantly
            increase risk for bronchial asthma in children
  JOURNAL   J Hum Genet 46 (2), 57-63 (2001)
   PUBMED   11281413
REFERENCE   10 (residues 1 to 1331)
  AUTHORS   Bar-On,E., Floman,Y., Sagiv,S., Katz,K., Pollak,R.D. and Maayan,C.
  TITLE     Orthopaedic manifestations of familial dysautonomia. A review of
            one hundred and thirty-six patients
  JOURNAL   J Bone Joint Surg Am 82 (11), 1563-1570 (2000)
   PUBMED   11097445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jun 3, 2021 this sequence version replaced NP_543175.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF388201.1, SRR26360176.928879.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1331
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     Protein         1..1331
                     /product="elongator complex protein 1"
                     /note="IKK complex-associated protein; ikappaB kinase
                     complex-associated protein; elongator complex protein
                     1-like; inhibitor of kappa light polypeptide enhancer in
                     B-cells, kinase complex-associated protein; inhibitor of
                     kappa light polypeptide gene enhancer in B-cells, kinase
                     complex-associated protein"
                     /calculated_mol_wt=149068
     Region          1..953
                     /region_name="IKI3"
                     /note="IKI3 family; pfam04762"
                     /db_xref="CDD:428111"
     Region          112..147
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          198..231
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Site            803
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95163; propagated from
                     UniProtKB/Swiss-Prot (Q8VHU4.1)"
     Region          884..1331
                     /region_name="Mediates dimerization.
                     /evidence=ECO:0000250|UniProtKB:O95163"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHU4.1)"
     Region          <939..1100
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          1167..1207
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHU4.1)"
     Site            1170
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95163; propagated from
                     UniProtKB/Swiss-Prot (Q8VHU4.1)"
     Site            1173
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95163; propagated from
                     UniProtKB/Swiss-Prot (Q8VHU4.1)"
     Region          1190..1208
                     /region_name="Required for binding to tRNA.
                     /evidence=ECO:0000250|UniProtKB:Q06706"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHU4.1)"
     CDS             1..1331
                     /gene="Elp1"
                     /gene_synonym="Ikbkap"
                     /coded_by="NM_080899.2:175..4170"
                     /db_xref="GeneID:140934"
                     /db_xref="RGD:620072"
ORIGIN      
        1 mrnlklhqtl efrdiqapgk pqcfclraeq gtvligserg ltevdpvkke vkteislvae
       61 gflpedgsgc ivgiqdlldq esvcvatasg dvivcnvstq qlecvgnvas gisvmswspd
      121 qellllataq qtlimmtrdy eviteqqihq ddfgegkfit vgwgskdtqf hgsegrpitf
      181 pvqmhesals wddhrpqitw rgdgqffavs vvcsqtgark irvwnrefal qstsesvpgl
      241 gpslawkpsg sliastqdkp nqqdvvffek ngllhgyftl pflkdevkvn dllwnadssv
      301 lavwledlpk egsstlksyv qlwtvgnyhw ylkqslpfst tgknqivsll wdpvtpgrlh
      361 vlcqgwrylc cdwhwttdrs sgnsaddlan vavidgnkvl vtvfqrtvtp ppmctyrlli
      421 phpvnqvmfs ahlgndlavl dasnqisvyk cddkpdmdst vklgavggtg fkvplrtphl
      481 ekryriqfgn keeeedvspl qfrfltwieg daflaishsh sspqsiihhl tmagsegdee
      541 qgqlnvsssv tvdgvviglc ccsktkssav qladgqvlky lwespssave pwknsegrpv
      601 rfarpctqme aaaiggeecv lgltdrcrff indtevasni tsfavcddfl lvtthshtcq
      661 cfslsgaslk mlqaglcgsq vpsgeilrkv ergsrivtvv pqdtklilqm prgnlevvhh
      721 ralvlaqirk wldklmfkea fecmrklrin lnlihdhnpk vflenvetfi kqidsvnhln
      781 lfftelkeed vtktmypppv tksvqvstnp dgkkvdlicd amrvametin prkfclsilt
      841 shvkkttpel divlqkvhel qgkipfepes vsaeealkyl lllvdvnelf nhslgtydfd
      901 lvlmvaeksq kdpkeylpfl ntlkkmetny qrftidkylk ryekalghls kcgpeyftec
      961 lnlikdknly kealklyrpd spqyqavsva ygehlvqehl yepaglvfar cgahekalea
     1021 flacgswqqa lcmaaqlqma kdkvaglart lagklveqrk hseaatvleq yaqdyeeavl
     1081 lllegsawee alrlvykydr vdiietsvkp sileaqknym dfldsqtatf irhknrlkvv
     1141 relksqaprv hvdhevahgr etdlfsetss irsgsemsgr yshsnsrisa rssknrrkae
     1201 rkkhslkegs pleglallea lsevvqsiek lkdevhailk vlflfefeeq arelqrafes
     1261 tlqlmgtalp diwtltgqqs satpvlgpss tvnsimasyq qqktcvpvld awaclppkid
     1321 qrsqwklsll e
//
