LOCUS       NM_134383               2497 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ELOVL fatty acid elongase 6 (Elovl6), mRNA.
ACCESSION   NM_134383 XM_001075165
VERSION     NM_134383.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2497)
  AUTHORS   Liu,R., Wang,M., Li,E., Yang,Y., Li,J., Chen,S., Shen,W.J.,
            Azhar,S., Guo,Z. and Hu,Z.
  TITLE     Dysregulation of microRNA-125a contributes to obesity-associated
            insulin resistance and dysregulates lipid metabolism in mice
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1865 (5), 158640 (2020)
   PUBMED   31988048
REFERENCE   2  (bases 1 to 2497)
  AUTHORS   Sunaga,H., Matsui,H., Anjo,S., Syamsunarno,M.R., Koitabashi,N.,
            Iso,T., Matsuzaka,T., Shimano,H., Yokoyama,T. and Kurabayashi,M.
  TITLE     Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven
            Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell
            Phenotype Through AMP-Activated Protein Kinase/Kruppel-Like Factor
            4 (AMPK/KLF4) Signaling
  JOURNAL   J Am Heart Assoc 5 (12), e004014 (2016)
   PUBMED   27881420
  REMARK    GeneRIF: dysregulation of Elovl6-driven long-chain fatty acid
            metabolism induces phenotypic switching of VSMC via ROS production
            and AMPK/KLF4 signaling that leads to growth arrest and
            downregulation of VSMC marker expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2497)
  AUTHORS   Tan,C.Y., Virtue,S., Bidault,G., Dale,M., Hagen,R., Griffin,J.L.
            and Vidal-Puig,A.
  TITLE     Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6
  JOURNAL   Cell Rep 13 (10), 2039-2047 (2015)
   PUBMED   26628376
REFERENCE   4  (bases 1 to 2497)
  AUTHORS   Senyilmaz,D., Virtue,S., Xu,X., Tan,C.Y., Griffin,J.L.,
            Miller,A.K., Vidal-Puig,A. and Teleman,A.A.
  TITLE     Regulation of mitochondrial morphology and function by
            stearoylation of TFR1
  JOURNAL   Nature 525 (7567), 124-128 (2015)
   PUBMED   26214738
REFERENCE   5  (bases 1 to 2497)
  AUTHORS   Green,C.D. and Olson,L.K.
  TITLE     Modulation of palmitate-induced endoplasmic reticulum stress and
            apoptosis in pancreatic beta-cells by stearoyl-CoA desaturase and
            Elovl6
  JOURNAL   Am J Physiol Endocrinol Metab 300 (4), E640-E649 (2011)
   PUBMED   21266672
  REMARK    GeneRIF: Overt type 2 diabetes is associated with diminished islet
            expression of SCD and Elovl6, and this can disrupt desaturation of
            saturated FAs to MUFAs, rendering beta-cells more susceptible to
            saturated FA-induced ER stress and apoptosis.
REFERENCE   6  (bases 1 to 2497)
  AUTHORS   Turyn,J., Stojek,M. and Swierczynski,J.
  TITLE     Up-regulation of stearoyl-CoA desaturase 1 and elongase 6 genes
            expression in rat lipogenic tissues by chronic food restriction and
            chronic food restriction/refeeding
  JOURNAL   Mol Cell Biochem 345 (1-2), 181-188 (2010)
   PUBMED   20721682
  REMARK    GeneRIF: increased expression genes encoding Scd1, Elovl6, and
            other key lipogenic enzymes may favor fat storage after chronic
            food restriction/refeeding and may be part of the molecular
            mechanism by which food restriction/refeeding increases body weight
REFERENCE   7  (bases 1 to 2497)
  AUTHORS   Green,C.D., Ozguden-Akkoc,C.G., Wang,Y., Jump,D.B. and Olson,L.K.
  TITLE     Role of fatty acid elongases in determination of de novo
            synthesized monounsaturated fatty acid species
  JOURNAL   J Lipid Res 51 (7), 1871-1877 (2010)
   PUBMED   20228221
  REMARK    GeneRIF: These findings demonstrate that coordinated induction of
            fatty acid elongases Elovl5 and 6 and desaturase activity is
            required for balanced synthesis of specific n-7 versus n-9 MUFA
            species.
REFERENCE   8  (bases 1 to 2497)
  AUTHORS   Kiba,T., Kintaka,Y., Suzuki,Y., Nakata,E., Ishigaki,Y. and Inoue,S.
  TITLE     Gene expression profiling in rat liver after VMH lesioning
  JOURNAL   Exp Biol Med (Maywood) 234 (7), 758-763 (2009)
   PUBMED   19429849
  REMARK    GeneRIF: Gene expressions of ELOVL6 and SPC24 were upregulated, and
            SERPINA7 was downregulated in the livers of rats with ventromedial
            hypothalamic lesions.
REFERENCE   9  (bases 1 to 2497)
  AUTHORS   Inagaki,K., Aki,T., Fukuda,Y., Kawamoto,S., Shigeta,S., Ono,K. and
            Suzuki,O.
  TITLE     Identification and expression of a rat fatty acid elongase involved
            in the biosynthesis of C18 fatty acids
  JOURNAL   Biosci Biotechnol Biochem 66 (3), 613-621 (2002)
   PUBMED   12005057
REFERENCE   10 (bases 1 to 2497)
  AUTHORS   Moon,Y.A., Shah,N.A., Mohapatra,S., Warrington,J.A. and Horton,J.D.
  TITLE     Identification of a mammalian long chain fatty acyl elongase
            regulated by sterol regulatory element-binding proteins
  JOURNAL   J Biol Chem 276 (48), 45358-45366 (2001)
   PUBMED   11567032
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_134383.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB071986.1, SRR26643294.11410.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000002.1  220738095-220738151
            58-178              JAXUCZ010000002.1  220738302-220738422
            179-310             JAXUCZ010000002.1  220814681-220814812
            311-462             JAXUCZ010000002.1  220838628-220838779
            463-2497            JAXUCZ010000002.1  220843494-220845528
FEATURES             Location/Qualifiers
     source          1..2497
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..2497
                     /gene="Elovl6"
                     /gene_synonym="Lce2; rELO2"
                     /note="ELOVL fatty acid elongase 6"
                     /db_xref="GeneID:171402"
                     /db_xref="RGD:620585"
     exon            1..57
                     /gene="Elovl6"
                     /gene_synonym="Lce2; rELO2"
                     /inference="alignment:Splign:2.1.0"
     exon            58..178
                     /gene="Elovl6"
                     /gene_synonym="Lce2; rELO2"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..893
                     /gene="Elovl6"
                     /gene_synonym="Lce2; rELO2"
                     /EC_number="2.3.1.199"
                     /note="elongation of very long chain fatty acids protein
                     6; fatty acyl-CoA elongase; long-chain fatty-acyl
                     elongase; 3-keto acyl-CoA synthase Elovl6; fatty acid
                     elongase 2; ELOVL family member 6, elongation of long
                     chain fatty acids; ELOVL FA elongase 6; very long chain
                     3-oxoacyl-CoA synthase 6; very long chain 3-ketoacyl-CoA
                     synthase 6; elongation of very long chain fatty acids
                     protein 6-like"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 6"
                     /protein_id="NP_599210.1"
                     /db_xref="GeneID:171402"
                     /db_xref="RGD:620585"
                     /translation="MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFI
                     FGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMLYILMTKGLKQSVCDQS
                     FYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMV
                     AGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVINYLVFN
                     WMQHDNDQCYSHFQNIFWSSLMYLSYLLLFCHFFFEAYIGKVKKATKAE"
     exon            179..310
                     /gene="Elovl6"
                     /gene_synonym="Lce2; rELO2"
                     /inference="alignment:Splign:2.1.0"
     exon            311..462
                     /gene="Elovl6"
                     /gene_synonym="Lce2; rELO2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..2497
                     /gene="Elovl6"
                     /gene_synonym="Lce2; rELO2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggatgcgga cgctgggagg agagcccctg agctaggagc tgggagccga ggcgcagaga
       61 acacgtagcg actccgaaga tcagccccaa tgaacatgtc agtgttgact ttacaagaat
      121 atgaattcga gaagcagttc aacgagaatg aagccatcca atggatgcag gaaaactgga
      181 agaaatcttt cctgttttct gcgctgtacg ctgcctttat atttggtggt cggcatctga
      241 tgaacaagcg ggccaagttt gaactgcgga agccgctcgt gctctggtca ctgactcttg
      301 cggtcttcag tatattcggt gctcttcgaa ctggtgctta catgctgtac attttgatga
      361 ccaaaggcct gaagcagtca gtttgtgacc agagttttta caacggacct gtcagcaaat
      421 tctgggctta cgcgtttgtg ctcagcaaag cacccgaact aggtgatacg atattcatca
      481 ttctgaggaa gcagaagctg atcttcctgc actggtacca ccacatcact gtgctcctgt
      541 actcttggta ctcctacaaa gacatggtag ctgggggtgg ttggttcatg actatgaact
      601 atggcgtaca cgccgtcatg tactcttact acgccttgcg ggctgcgggt ttccgggtct
      661 cccggaagtt tgccatgttc atcacgttgt cccagatcac tcagatgctg atgggctgtg
      721 tcattaacta cctggtcttc aactggatgc agcatgacaa tgaccagtgc tactcccact
      781 ttcagaacat cttctggtcc tcactcatgt acctcagcta ccttctgctc ttctgccatt
      841 tcttctttga ggcctacatc ggcaaagtga agaaagcgac gaaggccgag tagtgtcaga
      901 gctgaggagg aagacatagc tcagggtcat cacgaaaaat aatagacaaa aagaaaatgg
      961 cacaaggaat cacatatggt gcagctaaaa caaaacaaaa cattatgagc aaacgctaag
     1021 cccaaggcag cttgggagtg aagattaggt tgtaagttta tgatcctttt tgggtgagga
     1081 ctcactgaga gcactgctgc tgagggaccc ccttccctct tacctgtcaa ctctagaaca
     1141 cactagaagc caaggcagcc atgggcaagg agattagtgg acagcaagca aaacactgca
     1201 ggaagagggg ggagatctat tcagagtttt ttgttttgtt ttgttttgtt tttctctaag
     1261 gataaaggag tttccccttt tcaaactgtg tgagcacacc cacgcgcatg cggacacaca
     1321 cacacacaca catacacaca cacacacaca catacacaca cacacacaca cacacacaca
     1381 cacacacaca cacaatcttt tccacaggaa accagagctg gtagaaaaga taaacggtaa
     1441 gcgacagggt ttctatctag gacagcaatg cttttgcaaa aacctaagcc ttttaaagaa
     1501 gttagcttgt aactccttga caaaagatgt cttaattctt tttactgtaa ctgaaagtca
     1561 aaaaggtaga taccttcccc ttcactgcac agcctcgggc ttgttcgttt gctacaacgg
     1621 agcagaggac agttcttccg tgatacttta tttctgggag aaagaaaacc atgcagccca
     1681 aatcccgaga aggcggccca tagctaaccc tgcagttgaa gcatcacact gacagctgtt
     1741 atttctgctc ttcggtgaga attgaagcag ccgttgttca attaccccaa actttaggat
     1801 gggggagtaa atacggaatt gaaaagaaag aagctcgact ggttggcttg aaaatggaat
     1861 cttgtactat ctataacaaa actcagccca tcgtccctgg agctggaagg actatcagaa
     1921 gagaccagaa ctgaagattc atccaataca cagatggcat gttcgcctcc ttccccgttt
     1981 gacctcacac atagtcctgg ctttctaaat gaggtcctat gacccagtct gtgttttcta
     2041 tatttttgtg actttcaaaa acagatccgc agggctctgc atttggggta aacactgtgt
     2101 ttctgcagcc tctgcattcg ctcccttcag caatgcagag gcgtgagaag tgccctctgc
     2161 tggcttagtg agaagcttca acaaacactt cataataggt tgaaatagct gaccacaaag
     2221 ggcctgcgta gattaaaccc taagttaagt tctaagtgct gtcaaacacc tgacatatat
     2281 ttgaccaaat cagaagagag agaacctcta tgcttcaagt aagcttcata aaaaattttt
     2341 aaagtgactt tcacttggga actcagaaag tcaatgtatt aagagccata ttcttaaaaa
     2401 aaaaaaaaaa gaaagaaaga aaagaagaag aaagctagac aatgttatct gtaatatttc
     2461 agtcctttac aagccaaata aatgtgtcga tgttcct
//
