LOCUS       NM_134382               2682 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus ELOVL fatty acid elongase 5 (Elovl5), mRNA.
ACCESSION   NM_134382 XM_001075440 XM_006243417
VERSION     NM_134382.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2682)
  AUTHORS   Wang,W., Zhang,Z.Z., Wu,Y., Wang,R.Q., Chen,J.W., Chen,J.,
            Zhang,Y., Chen,Y.J., Geng,M., Xu,Z.D., Dai,M., Li,J.H. and Pan,L.L.
  TITLE     (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and
            Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein
            E Knockout Mice: Involvement of TTC39B
  JOURNAL   Front Pharmacol 9, 195 (2018)
   PUBMED   29593532
  REMARK    Erratum:[Front Pharmacol. 2018 May 01;9:459. doi:
            10.3389/fphar.2018.00459.. PMID: 29745376]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2682)
  AUTHORS   Gonzalez,R.S., Rodriguez-Cruz,M., Maldonado,J. and Saavedra,F.J.
  TITLE     Role of maternal tissue in the synthesis of polyunsaturated fatty
            acids in response to a lipid-deficient diet during pregnancy and
            lactation in rats
  JOURNAL   Gene 549 (1), 7-23 (2014)
   PUBMED   25046614
  REMARK    GeneRIF: Results show that genes with the highest expression in the
            mammary gland, liver and adipose tissue were Elovl5, Fads2, and
            Fasn, respectively, in a low-lipid diet than in adequate-lipid
            diet.
REFERENCE   3  (bases 1 to 2682)
  AUTHORS   Di Gregorio,E., Borroni,B., Giorgio,E., Lacerenza,D., Ferrero,M.,
            Lo Buono,N., Ragusa,N., Mancini,C., Gaussen,M., Calcia,A.,
            Mitro,N., Hoxha,E., Mura,I., Coviello,D.A., Moon,Y.A., Tesson,C.,
            Vaula,G., Couarch,P., Orsi,L., Duregon,E., Papotti,M.G.,
            Deleuze,J.F., Imbert,J., Costanzi,C., Padovani,A., Giunti,P.,
            Maillet-Vioud,M., Durr,A., Brice,A., Tempia,F., Funaro,A.,
            Boccone,L., Caruso,D., Stevanin,G. and Brusco,A.
  TITLE     ELOVL5 mutations cause spinocerebellar ataxia 38
  JOURNAL   Am J Hum Genet 95 (2), 209-217 (2014)
   PUBMED   25065913
REFERENCE   4  (bases 1 to 2682)
  AUTHORS   Gregory,M.K., Cleland,L.G. and James,M.J.
  TITLE     Molecular basis for differential elongation of omega-3
            docosapentaenoic acid by the rat Elovl5 and Elovl2
  JOURNAL   J Lipid Res 54 (10), 2851-2857 (2013)
   PUBMED   23873268
  REMARK    GeneRIF: Critical residues in Elovl2 and Elovl5 define their
            substrate specificities and their ability to elongate
            docosapentaenoic acid.
REFERENCE   5  (bases 1 to 2682)
  AUTHORS   Soh,J., Iqbal,J., Queiroz,J., Fernandez-Hernando,C. and
            Hussain,M.M.
  TITLE     MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by
            decreasing lipid synthesis and lipoprotein secretion
  JOURNAL   Nat Med 19 (7), 892-900 (2013)
   PUBMED   23749231
REFERENCE   6  (bases 1 to 2682)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 2682)
  AUTHORS   Leonard,A.E., Pereira,S.L., Sprecher,H. and Huang,Y.S.
  TITLE     Elongation of long-chain fatty acids
  JOURNAL   Prog Lipid Res 43 (1), 36-54 (2004)
   PUBMED   14636670
  REMARK    Review article
REFERENCE   8  (bases 1 to 2682)
  AUTHORS   Leonard,A.E., Kelder,B., Bobik,E.G., Chuang,L.T., Lewis,C.J.,
            Kopchick,J.J., Mukerji,P. and Huang,Y.S.
  TITLE     Identification and expression of mammalian long-chain PUFA
            elongation enzymes
  JOURNAL   Lipids 37 (8), 733-740 (2002)
   PUBMED   12371743
REFERENCE   9  (bases 1 to 2682)
  AUTHORS   Inagaki,K., Aki,T., Fukuda,Y., Kawamoto,S., Shigeta,S., Ono,K. and
            Suzuki,O.
  TITLE     Identification and expression of a rat fatty acid elongase involved
            in the biosynthesis of C18 fatty acids
  JOURNAL   Biosci Biotechnol Biochem 66 (3), 613-621 (2002)
   PUBMED   12005057
REFERENCE   10 (bases 1 to 2682)
  AUTHORS   Leonard,A.E., Bobik,E.G., Dorado,J., Kroeger,P.E., Chuang,L.T.,
            Thurmond,J.M., Parker-Barnes,J.M., Das,T., Huang,Y.S. and
            Mukerji,P.
  TITLE     Cloning of a human cDNA encoding a novel enzyme involved in the
            elongation of long-chain polyunsaturated fatty acids
  JOURNAL   Biochem J 350 Pt 3 (Pt 3), 765-770 (2000)
   PUBMED   10970790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Sep 23, 2022 this sequence version replaced
            XM_006243417.3, NM_134382.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.32023.1,
                                           SRR26643287.20709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               JAXUCZ010000008.1  87671164-87671274
            112-176             JAXUCZ010000008.1  87710150-87710214
            177-364             JAXUCZ010000008.1  87713840-87714027
            365-442             JAXUCZ010000008.1  87729023-87729100
            443-614             JAXUCZ010000008.1  87730002-87730173
            615-739             JAXUCZ010000008.1  87732988-87733112
            740-874             JAXUCZ010000008.1  87734710-87734844
            875-2682            JAXUCZ010000008.1  87735811-87737618
FEATURES             Location/Qualifiers
     source          1..2682
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..2682
                     /gene="Elovl5"
                     /gene_synonym="rELO1"
                     /note="ELOVL fatty acid elongase 5"
                     /db_xref="GeneID:171400"
                     /db_xref="RGD:620583"
     exon            1..111
                     /gene="Elovl5"
                     /gene_synonym="rELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            112..176
                     /gene="Elovl5"
                     /gene_synonym="rELO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1018
                     /gene="Elovl5"
                     /gene_synonym="rELO1"
                     /EC_number="2.3.1.199"
                     /note="elongation of very long chain fatty acids-like 5;
                     elongation of very long chain fatty acids protein 5;
                     3-keto acyl-CoA synthase Elovl5; fatty acid elongase 1;
                     elongation of long chain fatty acids family member 5;
                     ELOVL family member 5, elongation of long chain fatty
                     acids; ELOVL FA elongase 5; very long chain 3-oxoacyl-CoA
                     synthase 5; very long chain 3-ketoacyl-CoA synthase 5"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 5"
                     /protein_id="NP_599209.1"
                     /db_xref="GeneID:171400"
                     /db_xref="RGD:620583"
                     /translation="MEHFDASLSTYFRALLGPRDTRVKGWFLLDNYIPTFVCSAIYLL
                     IVWLGPKYMKNRQPFSCRGILVVYNLGLTLLSLYMFYELVTGVWEGKYNFFCQGTRSA
                     GESDMKVIRVLWWYYFSKLIEFMDTFFFILRKNNHQITVLHVYHHATMLNIWWFVMNW
                     VPCGHSYFGATLNSFIHVLMYSYYGLSSVPSMRPYLWWKKYITQGQLVQFVLTIIQTS
                     CGVIWPCSFPLGWLYFQIGYMISLIALFTNFYIQTYNKKGASRRKEHLKGHQNGSMTA
                     VNGHTNNFASLENSVTSRKQRKD"
     exon            177..364
                     /gene="Elovl5"
                     /gene_synonym="rELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..442
                     /gene="Elovl5"
                     /gene_synonym="rELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..614
                     /gene="Elovl5"
                     /gene_synonym="rELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..739
                     /gene="Elovl5"
                     /gene_synonym="rELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            740..874
                     /gene="Elovl5"
                     /gene_synonym="rELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..2682
                     /gene="Elovl5"
                     /gene_synonym="rELO1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttgcacc gcggctgctg cttgctcgtg ttcccgcgtc cgcttgcaca tcctcctgct
       61 tgcgcggtcc tgctgccgtc cggtgctcct cgtcgccgct cacgccgaga ggtttaaaat
      121 ggaacatttc gatgcgtcac tcagtaccta tttcagggca ttactgggcc cccgagacac
      181 acgagtcaaa ggatggtttc ttctggacaa ttacatccct acgtttgtct gctctgccat
      241 ttatttactc atcgtgtggc tgggaccaaa atacatgaaa aacaggcagc cgttctcttg
      301 ccgaggcatc ctggtggtgt ataatcttgg gctcaccctg ctgtctctct acatgttcta
      361 tgagttggtg acaggtgtgt gggaaggcaa atacaacttc ttctgtcagg gaacacgcag
      421 cgcaggagaa tcagatatga aggttattcg tgtcctctgg tggtactact tttccaaact
      481 catagaattc atggacacct ttttcttcat tcttcgtaag aacaaccacc agatcacagt
      541 cctgcacgtc taccaccatg ccactatgct caacatctgg tggtttgtca tgaactgggt
      601 tccctgcggc cattcgtact tcggtgcgac gctcaacagc ttcatccacg tcctcatgta
      661 ctcgtactat ggcctgtcct ctgtcccttc catgcgtccc tacctctggt ggaaaaagta
      721 catcactcag gggcagctgg tccagtttgt gctgacaatc atccagacca gctgcggggt
      781 catctggccg tgctccttcc ctctcgggtg gctgtacttc cagatcggat acatgatttc
      841 cctgattgct ctcttcacaa acttctacat tcagacttac aacaagaaag gggcctctcg
      901 gaggaaagag cacctgaagg gccaccagaa cgggtctatg actgccgtca atggacacac
      961 caacaacttt gcttccctgg agaacagtgt gacgtcaagg aagcagcgga aggattgaca
     1021 agccgagccg aagcctccag accaaggcgt gtgattgtaa gcacagtatg agttgtgccc
     1081 tgacgctcac aacagctgct gtcatagtct ggccctacta tctgcagtgt gacttatgta
     1141 ggaccgtttt catcagttca aaacccctag aatatgtata cagattatac aagtaggcat
     1201 acgattctct cacatttctg ggctctcatc gccccccgcg ctagactgtg gaaagggaat
     1261 gttgttgtag tatacgacac tgctgttgcc ttattagttg taacacgata ggtgctgaat
     1321 tgtggttcac aatttaaaac actgtaatcc aaactttttt ttttttaagt gtagaccatg
     1381 catgtgactg taaatttgta cagtgttgtt aacagtagaa gaacacacat gccttaagac
     1441 ttaaaaagca gggcccaaag cttattagtt taattagggt atgtttcgac tttgtattca
     1501 tttgtaatag ctctgtttag aaaaatcaaa tgcgtgattt atgaaattag tgtgtgatgt
     1561 gtaactacaa gtgactggga gatgcgaaac ctgacggtac cttccgtttt acataagcag
     1621 gctcaagtct agtgggacag tcagtttaac tttttaacaa atcttatttt tttattttga
     1681 gtgccactat caatgtgttt aaagaggtgg ggaaagggtc ccaagcatct ggaggcactt
     1741 atgtacctgt ccctggtccc ccagagtcta gggccactgt agggtgagta ggccactttt
     1801 tatttctgaa gtgcttagtg tttttataca ggagagaaaa agggccattc tgtttcccac
     1861 cacttggaga gaggaaacta cctttcagga aaggtgatta gacatttatt atgtgacagt
     1921 cacacacacg cccagtgatg ggaaactggt tgcctgggtc caaatttttt ttgttctttt
     1981 ctgtagtgct actttgacat acccttcctt ttaaaatgtg cctaatttac caagagacca
     2041 ggaagcaccg taatcatttt gaggcaaaat taaagagctg gagcacgcag gaactgggtg
     2101 tttggggagc aatcgcttta ttcagtgtaa atctcggtgg catctgtaat ttttttctgc
     2161 ttagcatcta aagattgatt taaagcgctt gtttaaaagt aacagatagt gcgctggaga
     2221 cgttggtcat acaagtgggg actattgtta catgtgtcat ctttaaagtg ttgaaagttt
     2281 agcctttgaa caccttctgc attgaagaaa attgattgaa ccactcgtga cacatcctag
     2341 aagacaattg acaatgtaca aactaattgt gggtttgata tttatgtaaa taccagttta
     2401 ccatgcttta attttgcaca ttcatattct aaggagccag ttggtcctca ttagcctctg
     2461 tttggacgga gttgcagcgt ctgtttacat tgatcttctc taatctagag cgtccatgtg
     2521 tgtctccatc cgagggtacc gctcgcaggt tctttacata tcttagtaca aaactataac
     2581 attcagtagt gtgctgtcaa agtgtgctta gctcatctgg atatacccac actgtcaaat
     2641 aatgtctaaa cattaatcat taaaaccttt ttgattaccc gg
//
