LOCUS       NM_001191796            1413 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ELOVL fatty acid elongase 4 (Elovl4), mRNA.
ACCESSION   NM_001191796 XM_236476
VERSION     NM_001191796.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1413)
  AUTHORS   Nagaraja,R.Y., Stiles,M.A., Sherry,D.M., Agbaga,M.P. and Ahmad,M.
  TITLE     Synapse-Specific Defects in Synaptic Transmission in the Cerebellum
            of W246G Mutant ELOVL4 Rats-a Model of Human SCA34
  JOURNAL   J Neurosci 43 (33), 5963-5974 (2023)
   PUBMED   37491316
  REMARK    GeneRIF: Synapse-Specific Defects in Synaptic Transmission in the
            Cerebellum of W246G Mutant ELOVL4 Rats-a Model of Human SCA34.
REFERENCE   2  (bases 1 to 1413)
  AUTHORS   Nagaraja,R.Y., Sherry,D.M., Fessler,J.L., Stiles,M.A., Li,F.,
            Multani,K., Orock,A., Ahmad,M., Brush,R.S., Anderson,R.E.,
            Agbaga,M.P. and Deak,F.
  TITLE     W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and
            Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34
  JOURNAL   Mol Neurobiol 58 (10), 4921-4943 (2021)
   PUBMED   34227061
  REMARK    GeneRIF: W246G Mutant ELOVL4 Impairs Synaptic Plasticity in
            Parallel and Climbing Fibers and Causes Motor Defects in a Rat
            Model of SCA34.
REFERENCE   3  (bases 1 to 1413)
  AUTHORS   Barabas,P., Liu,A., Xing,W., Chen,C.K., Tong,Z., Watt,C.B.,
            Jones,B.W., Bernstein,P.S. and Krizaj,D.
  TITLE     Role of ELOVL4 and very long-chain polyunsaturated fatty acids in
            mouse models of Stargardt type 3 retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (13), 5181-5186 (2013)
   PUBMED   23479632
REFERENCE   4  (bases 1 to 1413)
  AUTHORS   Ohno,Y., Suto,S., Yamanaka,M., Mizutani,Y., Mitsutake,S.,
            Igarashi,Y., Sassa,T. and Kihara,A.
  TITLE     ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid
            synthesis
  JOURNAL   Proc Natl Acad Sci U S A 107 (43), 18439-18444 (2010)
   PUBMED   20937905
REFERENCE   5  (bases 1 to 1413)
  AUTHORS   Agbaga,M.P., Brush,R.S., Mandal,M.N., Henry,K., Elliott,M.H. and
            Anderson,R.E.
  TITLE     Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the
            biosynthesis of very long chain fatty acids
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12843-12848 (2008)
   PUBMED   18728184
REFERENCE   6  (bases 1 to 1413)
  AUTHORS   Grayson,C. and Molday,R.S.
  TITLE     Dominant negative mechanism underlies autosomal dominant
            Stargardt-like macular dystrophy linked to mutations in ELOVL4
  JOURNAL   J Biol Chem 280 (37), 32521-32530 (2005)
   PUBMED   16036915
REFERENCE   7  (bases 1 to 1413)
  AUTHORS   Bernstein,P.S., Tammur,J., Singh,N., Hutchinson,A., Dixon,M.,
            Pappas,C.M., Zabriskie,N.A., Zhang,K., Petrukhin,K., Leppert,M. and
            Allikmets,R.
  TITLE     Diverse macular dystrophy phenotype caused by a novel complex
            mutation in the ELOVL4 gene
  JOURNAL   Invest Ophthalmol Vis Sci 42 (13), 3331-3336 (2001)
   PUBMED   11726641
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 17, 2010 this sequence version replaced XM_236476.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.45646.1,
                                           SRR26643288.34891.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840110,
                                           SAMN12840111 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000008.1  93609380-93609479   c
            101-288             JAXUCZ010000008.1  93592431-93592618   c
            289-369             JAXUCZ010000008.1  93590626-93590706   c
            370-541             JAXUCZ010000008.1  93587329-93587500   c
            542-669             JAXUCZ010000008.1  93585952-93586079   c
            670-1413            JAXUCZ010000008.1  93582930-93583673   c
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1413
                     /gene="Elovl4"
                     /note="ELOVL fatty acid elongase 4"
                     /db_xref="GeneID:315851"
                     /db_xref="RGD:1305630"
     CDS             1..945
                     /gene="Elovl4"
                     /EC_number="2.3.1.199"
                     /note="elongation of very long chain fatty acids-like 4;
                     elongation of very long chain fatty acids protein 4;
                     elongation of very long chain fatty acids (FEN1/Elo2,
                     SUR4/Elo3, yeast)-like 4"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 4"
                     /protein_id="NP_001178725.1"
                     /db_xref="GeneID:315851"
                     /db_xref="RGD:1305630"
                     /translation="MGLLDSEPGSVLNAVSTAFNDTVEFYRWTWSIADKRVEDWPLMQ
                     SPWPTLSISTLYLLFVWLGPKWMKDREPFQMRLVLIIYNFGMVLLNLFIFRELFMGSY
                     NAGYSYICQSVDYSNDVNEVRIAAALWWYFVSKGVEYLDTVFFILRKKNNQVSFLHVY
                     HHCTMFTLWWIGIKWVAGGQAFFGAQMNSFIHVIMYSYYGLTAFGPWIQKYLWWKRYL
                     TMLQLVQFHVTIGHTALSLYTDCPFPKWMHWALIAYAISFIFLFLNFYTRTYNEPKKS
                     KTGKTATNGISANGVNKSEKQLVLENGKPQKNGKPKGE"
     exon            1..100
                     /gene="Elovl4"
                     /inference="alignment:Splign:2.1.0"
     exon            101..288
                     /gene="Elovl4"
                     /inference="alignment:Splign:2.1.0"
     exon            289..369
                     /gene="Elovl4"
                     /inference="alignment:Splign:2.1.0"
     exon            370..541
                     /gene="Elovl4"
                     /inference="alignment:Splign:2.1.0"
     exon            542..669
                     /gene="Elovl4"
                     /inference="alignment:Splign:2.1.0"
     exon            670..1413
                     /gene="Elovl4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggggctgc tggactcaga gcccggcagc gtcctgaacg cagtgtccac ggcgttcaac
       61 gacaccgtgg agttctaccg ctggacctgg tccattgcag ataaacgtgt agaagactgg
      121 ccgctgatgc agtctccatg gccaacacta agcataagca cactctatct cctgttcgtg
      181 tggctggggc cgaagtggat gaaagaccga gagccgtttc aaatgcgctt agtgctcata
      241 atctataatt ttggcatggt tttgcttaac cttttcatct tcagagagct attcatggga
      301 tcatacaacg caggatacag ctatatttgc cagtcagtgg attattctaa tgacgttaat
      361 gaagtcagga tagctgctgc cttgtggtgg tactttgtat cgaaaggagt cgagtatttg
      421 gacacagtgt tttttatcct gaggaagaaa aacaaccagg tgtctttcct tcacgtgtac
      481 catcactgca ccatgttcac actgtggtgg attggaatca agtgggtggc aggaggccaa
      541 gcatttttcg gggcccagat gaattctttc atccatgtga tcatgtactc ctactatggg
      601 ctgactgcat tcggcccctg gatccagaaa tacctttggt ggaagcggta cctgaccatg
      661 ctgcagctgg ttcagttcca tgtgaccatt gggcacacag cactgtctct ctacaccgac
      721 tgccccttcc ccaagtggat gcactgggct ctgatcgcct atgccatcag cttcatcttc
      781 ctcttcctca acttctacac tcggacatac aatgagccca agaagtcaaa aaccggaaag
      841 acggccacga atggcatctc agcgaacggt gtgaacaagt cagagaagca gcttgtgtta
      901 gaaaacggga aaccccagaa gaacgggaag ccaaaaggag agtaaatcga actgggcctt
      961 aaccggtgac agtgaggaaa ctcctgtgtc atttaaaagt tcaggggcaa cagaagcaga
     1021 ggatctgggg tggggagaaa ggcagatagg gtctgtgcac cttcagactg agtaaacctt
     1081 tcaatatacg gttcctagat gttttattta tgaagttttt attttaaaca tttttttatt
     1141 agccttcatg ttgtccagac caaagcaatc ccaacgtgac cttggagcct ctcctcctgt
     1201 tcgctcacct gtgcagtggg tggaaatttc acctatcttc catttactct ttcctcagtc
     1261 tgaattttag atgatcacag aacacagttt tatgaaaaaa attttttttc cctaaatcac
     1321 tagtttccta ctggttgcaa atcagttacc tgacattttc ttgttcagag acagaacaag
     1381 aaaatacatt cgaatttgga tccatttact aac
//
