LOCUS       NM_001107602            1870 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ELOVL fatty acid elongase 3 (Elovl3), mRNA.
ACCESSION   NM_001107602 XM_001065915 XM_219951
VERSION     NM_001107602.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1870)
  AUTHORS   Ohno,Y., Suto,S., Yamanaka,M., Mizutani,Y., Mitsutake,S.,
            Igarashi,Y., Sassa,T. and Kihara,A.
  TITLE     ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid
            synthesis
  JOURNAL   Proc Natl Acad Sci U S A 107 (43), 18439-18444 (2010)
   PUBMED   20937905
REFERENCE   2  (bases 1 to 1870)
  AUTHORS   Westerberg,R., Mansson,J.E., Golozoubova,V., Shabalina,I.G.,
            Backlund,E.C., Tvrdik,P., Retterstol,K., Capecchi,M.R. and
            Jacobsson,A.
  TITLE     ELOVL3 is an important component for early onset of lipid
            recruitment in brown adipose tissue
  JOURNAL   J Biol Chem 281 (8), 4958-4968 (2006)
   PUBMED   16326704
REFERENCE   3  (bases 1 to 1870)
  AUTHORS   Westerberg,R., Tvrdik,P., Unden,A.B., Mansson,J.E., Norlen,L.,
            Jakobsson,A., Holleran,W.H., Elias,P.M., Asadi,A., Flodby,P.,
            Toftgard,R., Capecchi,M.R. and Jacobsson,A.
  TITLE     Role for ELOVL3 and fatty acid chain length in development of hair
            and skin function
  JOURNAL   J Biol Chem 279 (7), 5621-5629 (2004)
   PUBMED   14581464
REFERENCE   4  (bases 1 to 1870)
  AUTHORS   Leonard,A.E., Bobik,E.G., Dorado,J., Kroeger,P.E., Chuang,L.T.,
            Thurmond,J.M., Parker-Barnes,J.M., Das,T., Huang,Y.S. and
            Mukerji,P.
  TITLE     Cloning of a human cDNA encoding a novel enzyme involved in the
            elongation of long-chain polyunsaturated fatty acids
  JOURNAL   Biochem J 350 Pt 3 (Pt 3), 765-770 (2000)
   PUBMED   10970790
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_219951.4, XM_001065915.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK226520.1, CK226519.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132278,
                                           SAMD00132288 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1870
                     /gene="Elovl3"
                     /note="ELOVL fatty acid elongase 3"
                     /db_xref="GeneID:309449"
                     /db_xref="RGD:1307263"
     exon            1..274
                     /gene="Elovl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..986
                     /gene="Elovl3"
                     /EC_number="2.3.1.199"
                     /note="elongation of very long chain fatty acids-like 3;
                     elongation of very long chain fatty acids protein 3;
                     elongation of very long chain fatty acids (FEN1/Elo2,
                     SUR4/Elo3, yeast)-like 3"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 3"
                     /protein_id="NP_001101072.1"
                     /db_xref="GeneID:309449"
                     /db_xref="RGD:1307263"
                     /translation="MDTSMNFSRGLKTELIQPYDFEMSQDLRPFLEEYWVSSFFIVLV
                     YLLLIIFGQNYMKTRKGFSLQRPLILWSFCLAIFSILGTLRMWKFMGTVLFTMGLKQT
                     VCFTDYTNDAIVKFWSWVFLLSKVVELGDTAFIILRKRPLIFVHWYHHSTVLLFTSFG
                     YKNKVPSGGWFMTMNLGVHSVMYTYYTMKAAKVKHPNILPMVITSLQILQMVLGTIFG
                     ILNYIWRQERGCYTTSEHFFWSFVLYGTYFILFAQFFHRAYLRPKRKAESKSQ"
     exon            275..406
                     /gene="Elovl3"
                     /inference="alignment:Splign:2.1.0"
     exon            407..558
                     /gene="Elovl3"
                     /inference="alignment:Splign:2.1.0"
     exon            559..1870
                     /gene="Elovl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgggctg gttagcagcg cacgtgccag gctccggggc ccttctgctt acacacacgt
       61 tctttttgcc cagggtttct tcatccctga gacccactcc atcttctact cccttggctc
      121 tcgcccagcc cttaccccaa gctctgaacc tcgtcgtctg caaaatcgaa atggacacat
      181 ccatgaattt ctcacgtggg ttaaaaacgg agctgatcca accctatgac ttcgagatgt
      241 cgcaggactt aaggcccttt ttggaggagt actgggtaag ctcgtttttc atagttcttg
      301 tctatctgtt gctcatcatt ttcggtcaaa actacatgaa aacgcggaag ggcttcagct
      361 tgcagaggcc tctcatcctc tggtccttct gcctggcaat attcagtatc ctgggtacac
      421 tgaggatgtg gaagtttatg ggaaccgtgc tgtttacaat gggcctcaag caaactgtgt
      481 gctttaccga ctacactaat gatgccatag tgaaattctg gtcctgggtc tttcttctca
      541 gcaaggtggt tgaactcgga gacacggcct tcatcatcct acgtaagcgt ccactcatct
      601 ttgttcactg gtaccaccac agcacagtgc tactgtttac gagctttgga tacaagaaca
      661 aagtgccttc cggtggctgg ttcatgacca tgaacttggg cgtacattcc gtcatgtaca
      721 cctactacac tatgaaggcg gccaaagtga agcatcccaa catccttccc atggtcatca
      781 ctagcctgca gatcctgcag atggttttgg gcaccatctt tggcatactg aattacatct
      841 ggaggcagga gagaggatgc tacacgacat cggaacactt cttctggtcc ttcgtgcttt
      901 atgggaccta tttcatccta ttcgctcaat tcttccaccg agcctacctc aggcccaagc
      961 gcaaagctga gtccaagagc caatgagagt tggaaggaaa gatggggcct cagcctttcc
     1021 ttcatggcac taagggttag gggtgggaga atgattaggt taccttccct atatggtttc
     1081 ccccatggga tatgtatcct caaagttgca ggaagctatg acaaccaaga atatgtcacc
     1141 cttgggatag gggtgtggtc tggtactttg atgtttctgt ttatcacgtg aagaaaaacc
     1201 aaaccctagg aaggcgatag gactgaggtc tttaaaatcg agttatttat atttatgttt
     1261 agaaatcttt ctcttcttgc tctatttttt aaattaaaga gtcaacgtga ttctgaggat
     1321 tcgtggactt caaggggaaa gtgaactctg tggtaagagg aggctgctca cagggagtga
     1381 tctgtcggtg gggagcctga aggtgtgtgg agggatagag gcacacacaa acaataagaa
     1441 tcctaagcct tgtaggcgct taataaatgt ctgtcacaga ctagaagttt attgctgtta
     1501 gagacccatg cctctgagaa gaacagtgag aaacaagtcc taaagtcata ggctaaactg
     1561 caaaaacaga tccctgcaag gaagcgctgg agaccaggcc taccagctgt cctccctgag
     1621 accaccaggt ggcgtcgcag caccagcaga ggacgatcgc tgtcaactag ctggtcacgc
     1681 caagcttcgt aaattcttta ctccaaggag accctgcttc cccatcctgg agaaaaggag
     1741 tgagacggaa gccttagaag cctggacgct cactccgttc ccgtacatcc agctgtcctt
     1801 ttggacaatg ggaaggatgg ggggaaggag ggctcaaccg caagtctgaa tcatcaggcc
     1861 tttgacagtc
//
