LOCUS       NM_001044275            1507 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ELOVL fatty acid elongase 1 (Elovl1), mRNA.
ACCESSION   NM_001044275 XM_001053380
VERSION     NM_001044275.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1507)
  AUTHORS   Sassa,T., Ohno,Y., Suzuki,S., Nomura,T., Nishioka,C., Kashiwagi,T.,
            Hirayama,T., Akiyama,M., Taguchi,R., Shimizu,H., Itohara,S. and
            Kihara,A.
  TITLE     Impaired epidermal permeability barrier in mice lacking elovl1, the
            gene responsible for very-long-chain fatty acid production
  JOURNAL   Mol Cell Biol 33 (14), 2787-2796 (2013)
   PUBMED   23689133
REFERENCE   2  (bases 1 to 1507)
  AUTHORS   Ohno,Y., Suto,S., Yamanaka,M., Mizutani,Y., Mitsutake,S.,
            Igarashi,Y., Sassa,T. and Kihara,A.
  TITLE     ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid
            synthesis
  JOURNAL   Proc Natl Acad Sci U S A 107 (43), 18439-18444 (2010)
   PUBMED   20937905
REFERENCE   3  (bases 1 to 1507)
  AUTHORS   Ofman,R., Dijkstra,I.M., van Roermund,C.W., Burger,N.,
            Turkenburg,M., van Cruchten,A., van Engen,C.E., Wanders,R.J. and
            Kemp,S.
  TITLE     The role of ELOVL1 in very long-chain fatty acid homeostasis and
            X-linked adrenoleukodystrophy
  JOURNAL   EMBO Mol Med 2 (3), 90-97 (2010)
   PUBMED   20166112
REFERENCE   4  (bases 1 to 1507)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1507)
  AUTHORS   Leonard,A.E., Bobik,E.G., Dorado,J., Kroeger,P.E., Chuang,L.T.,
            Thurmond,J.M., Parker-Barnes,J.M., Das,T., Huang,Y.S. and
            Mukerji,P.
  TITLE     Cloning of a human cDNA encoding a novel enzyme involved in the
            elongation of long-chain polyunsaturated fatty acids
  JOURNAL   Biochem J 350 Pt 3 (Pt 3), 765-770 (2000)
   PUBMED   10970790
REFERENCE   6  (bases 1 to 1507)
  AUTHORS   LORCH,J.
  TITLE     Note on the cytological localization of alkaline phosphatase
  JOURNAL   Q J Microsc Sci 88 (Pt 2), 159-161 (1947)
   PUBMED   20253178
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085795.1.
            
            On Aug 24, 2006 this sequence version replaced XM_001053380.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00155329, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1507
                     /gene="Elovl1"
                     /note="ELOVL fatty acid elongase 1"
                     /db_xref="GeneID:679532"
                     /db_xref="RGD:1587151"
     exon            1..138
                     /gene="Elovl1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..198
                     /gene="Elovl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..992
                     /gene="Elovl1"
                     /EC_number="2.3.1.199"
                     /note="elongation of very long chain fatty acids protein
                     1; elongation of very long chain fatty acids (FEN1/Elo2,
                     SUR4/Elo3, yeast)-like 1"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 1"
                     /protein_id="NP_001037740.1"
                     /db_xref="GeneID:679532"
                     /db_xref="RGD:1587151"
                     /translation="MEAVVNLYQELMKCADPRIQNYPLMGSPLLITSILLTYVYFVLS
                     LGPRIMANRKPFQLRGFMIVYNFSLVTLSLYIVYEFLMSGWLSTYTWRCDPVDFSNNP
                     EALRMVRVAWLFMLSKVIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGIKIAP
                     GGMGSFHAMINSSVHVVMYLYYGLSALGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQ
                     YYFMPSCNYQYPIIIHLIWMYGTIFFILFSNFWYHSYTKGKRLPRAVQQNGAAASMKV
                     KAN"
     exon            199..389
                     /gene="Elovl1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..470
                     /gene="Elovl1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..527
                     /gene="Elovl1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..633
                     /gene="Elovl1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..770
                     /gene="Elovl1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..1482
                     /gene="Elovl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaactgaga attcatggct ggtttgggag agaatgctgg gtgtggattt ttggcaattc
       61 ttctggcttt ggccagaggt tctggccaga agtttctgga gaacctacaa acgtagctta
      121 tctggctggt caaaggtgag tccttagcca ggatggaggc tgttgtgaac ttgtaccagg
      181 aattgatgaa gtgtgcagat ccccggatcc aaaactatcc tctgatggga tcccccttgc
      241 taataacatc catccttctg acctatgtgt acttcgtcct atcacttggg cctcgaatca
      301 tggctaatcg gaagcctttc caacttcgag gcttcatgat tgtctacaat ttctcactgg
      361 tgacactctc cctctacatt gtctatgagt tcctcatgtc tggctggctg agtacgtata
      421 cctggcgctg tgaccctgta gacttttcca ataaccctga agcacttcgg atggttcgag
      481 tggcctggct cttcatgctt tccaaggtca ttgaactcat ggacacagtg atatttattc
      541 tccggaagaa ggatgggcaa gtgaccttcc tccatgtctt ccaccactcg gtgcttccct
      601 ggagctggtg gtgggggata aagattgctc caggaggaat gggctctttc catgccatga
      661 taaactcctc tgtacacgtc gtcatgtacc tctactacgg attgtctgcc ctgggccctg
      721 tggctcagcc ctacctttgg tggaagaaac acatgacagc cattcagctg atccagttcg
      781 tcctggtctc actgcacatc agccaatact acttcatgcc cagctgcaac taccaatatc
      841 ctatcatcat ccacctcatc tggatgtacg gcaccatctt cttcatactg ttctccaact
      901 tctggtatca ctcttacacc aaggggaagc ggctgccccg tgcagttcag caaaatggag
      961 ctgcagcgtc catgaaggtc aaggccaact agcaccaggg cctagatggt gcccacctaa
     1021 gtgccttggg actgcagctg ggcagcaccc acaagtgtcc tctccaccta cacccatgac
     1081 caggactctt gtggtcagga ctgaataggc ggattggctc tcttccccac agctggtcta
     1141 cagggaccac tgtccccatt ccttctccca gccagttcca gggatgtggc ctcatgctgt
     1201 ctgccaccag aactggaggc tggaaagggc tggacactta cttcccactc cctgccttaa
     1261 aaactcggga gaacactcag ggctggcccg cgcccgggcc ttgtggcctt tctcctcaca
     1321 ctgaagaggt cagcaataat ctgtcactgt ggactcaggc gcccttttca ctcctcatgg
     1381 aagcatgagc ttctgggcca aaggtcagga tgggcaggcc acaggcctgg caatgcaggc
     1441 tgtgcactca actgtgtctt aattaaagtg acaggaaacc acaaaaaaaa aaaaaaaaaa
     1501 aaaaaaa
//
