LOCUS       NM_001270562            2054 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus elongin C (Eloc), transcript variant 3, mRNA.
ACCESSION   NM_001270562
VERSION     NM_001270562.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Semenza,G.L.
  TITLE     Regulation of oxygen homeostasis by hypoxia-inducible factor 1
  JOURNAL   Physiology (Bethesda) 24, 97-106 (2009)
   PUBMED   19364912
  REMARK    Review article
REFERENCE   2  (bases 1 to 2054)
  AUTHORS   Woo,J.S., Imm,J.H., Min,C.K., Kim,K.J., Cha,S.S. and Oh,B.H.
  TITLE     Structural and functional insights into the B30.2/SPRY domain
  JOURNAL   EMBO J 25 (6), 1353-1363 (2006)
   PUBMED   16498413
REFERENCE   3  (bases 1 to 2054)
  AUTHORS   Kamura,T., Burian,D., Yan,Q., Schmidt,S.L., Lane,W.S., Querido,E.,
            Branton,P.E., Shilatifard,A., Conaway,R.C. and Conaway,J.W.
  TITLE     Muf1, a novel Elongin BC-interacting leucine-rich repeat protein
            that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin
            ligase
  JOURNAL   J Biol Chem 276 (32), 29748-29753 (2001)
   PUBMED   11384984
REFERENCE   4  (bases 1 to 2054)
  AUTHORS   Kamura,T., Koepp,D.M., Conrad,M.N., Skowyra,D., Moreland,R.J.,
            Iliopoulos,O., Lane,W.S., Kaelin,W.G. Jr., Elledge,S.J.,
            Conaway,R.C., Harper,J.W. and Conaway,J.W.
  TITLE     Rbx1, a component of the VHL tumor suppressor complex and SCF
            ubiquitin ligase
  JOURNAL   Science 284 (5414), 657-661 (1999)
   PUBMED   10213691
REFERENCE   5  (bases 1 to 2054)
  AUTHORS   Garrett,K.P., Tan,S., Bradsher,J.N., Lane,W.S., Conaway,J.W. and
            Conaway,R.C.
  TITLE     Molecular cloning of an essential subunit of RNA polymerase II
            elongation factor SIII
  JOURNAL   Proc Natl Acad Sci U S A 91 (12), 5237-5241 (1994)
   PUBMED   8202474
REFERENCE   6  (bases 1 to 2054)
  AUTHORS   Bradsher,J.N., Jackson,K.W., Conaway,R.C. and Conaway,J.W.
  TITLE     RNA polymerase II transcription factor SIII. I. Identification,
            purification, and properties
  JOURNAL   J Biol Chem 268 (34), 25587-25593 (1993)
   PUBMED   8244996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1, FM110992.1 and AI555412.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by
            NM_001270562.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All four variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.21217.1, BQ780612.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                JAXUCZ010000005.1  7444985-7445018
            35-734              FM110992.1         1-700
            735-1915            JAXUCZ010000005.1  7459885-7461065
            1916-2054           AI555412.1         1-139               c
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..2054
                     /gene="Eloc"
                     /gene_synonym="Tceb1"
                     /note="elongin C"
                     /db_xref="GeneID:64525"
                     /db_xref="RGD:620658"
     exon            1..84
                     /gene="Eloc"
                     /gene_synonym="Tceb1"
                     /inference="alignment:Splign:2.1.0"
     exon            85..136
                     /gene="Eloc"
                     /gene_synonym="Tceb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..471
                     /gene="Eloc"
                     /gene_synonym="Tceb1"
                     /note="transcription elongation factor B polypeptide 1;
                     SIII p15; elongin 15 kDa subunit; stromal
                     membrane-associated protein SMAP1B homolog; RNA polymerase
                     II transcription factor SIII subunit C; elongation factor
                     SIII p15 subunit; transcription elongation factor B
                     (SIII), polypeptide 1; transcription elongation factor B
                     subunit 1"
                     /codon_start=1
                     /product="elongin-C"
                     /protein_id="NP_001257491.1"
                     /db_xref="GeneID:64525"
                     /db_xref="RGD:620658"
                     /translation="MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKA
                     MLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALE
                     LLMAANFLDC"
     exon            137..280
                     /gene="Eloc"
                     /gene_synonym="Tceb1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..2037
                     /gene="Eloc"
                     /gene_synonym="Tceb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagctgggg gtgggggggg cggccctgaa taggggctgt ggcggtacgt ggggttacgg
       61 ctgtggtggc tgcgggactg gctagaaact agtaacttcc tctgggatca aatagaattt
      121 tataagaaca caatggatgg agaggagaaa acctatggtg gctgtgaagg ccctgatgcc
      181 atgtatgtga aattaatatc ttctgatggt catgaattta ttgtaaaaag agaacatgca
      241 ttaacatcag gaacaataaa ggccatgttg agtggtccag gtcagtttgc ggagaatgaa
      301 accaatgagg tcaactttag agagatccct tcacatgtgc tatcgaaagt gtgcatgtat
      361 tttacctaca aggtccgcta tactaacagc tccactgaaa ttcctgaatt cccaattgca
      421 cctgaaattg cactggaact gctgatggcc gcgaacttcc tagattgtta aataaaataa
      481 attataataa actgttaatt tttttcagta tttaatacct gtagttcagt tagtaatttt
      541 tcacatgtag catgttgcct gtatgaagct gaactctaaa gtgaatcgct gagcagattt
      601 cttctgtcat ttgcatagca gagttgaaat ttgtttgcta catcaacaaa ttaaggaagt
      661 ttcacaagcc aaaaaataaa taaataatgc cagtttatag gtggtttgct ttctcctttg
      721 gatgtgacct ttaaagttat acctgatata gcaaatcctg gaatgtaagc gtaaatgaat
      781 atattctaca ggtaaataca ggggctaagg atttttatgt ttttagtgtt tttttaagaa
      841 ccagttctga tcttaagcca ctgagcatta ttagaattat gcaaataatt acatgaaaaa
      901 catgtttata acttagccga accttgattt ttgtaactca aagaataaga gttgaaattt
      961 cttatgtgtt ttttgataaa ctgcagtatt gtttaagtgc atcttgtgtt ttgtttattg
     1021 ccacaattca agtactttat ttaaaagcaa ttttggaagc taaccaggta tattttttag
     1081 aatagtaact gaactgtagc tgtctagtca agtaaatgat gacttaagag ttctgtgcac
     1141 tgtgtttgaa cattctgaag catgacttct atcatcaggg tgtctcaagt ttccattctt
     1201 catggtttct tggagtaaca cttcatggtg ttgagatgtg tcctaaacac ttcatgagct
     1261 tgatccaaac ttagagtcta ggtgtgccaa gctcttctag tcttcctgca tcactggaat
     1321 gctatgaaaa tagtaatgga gggctgtggc acgagccctg tgctcttaga tgtaccacca
     1381 gataggtacc ctcctagcgt atcttccagc caaccataca tactaaaagc catgggtctg
     1441 ctgaagtcac attcatgagt cacattcagc ctttaaatga gcagacaaaa tctctgaatg
     1501 tgttggctag atctctgcct tggcatggtg gagcgctgaa gtgaatagga tggtgggatg
     1561 tggttgcctc cagtggctgt cacaggtctg tctgcaagcc ttctacattc ttcccaggac
     1621 cggaagctgc agaaaccgta acttctcagc atggaagtgg ttccatgtaa gttggtttat
     1681 ttttagtaat gtttcaaggc atgctggcac acagcttagt acagtgttct ggaagtacag
     1741 gaattgtgtt tcgggctaca agtattggag actcagtggt agtgccactg tgacaaagcc
     1801 ctctgcttgc tcagtctcta gctaacgtac ttgccctttc tgtcagcgct aattcaaagc
     1861 ccaaaagaca gtagctagaa agaagagtta gcttgagcca gtttttgcag gctactctgt
     1921 gttcggtcca gaggtagcct taacttcaga acattaaaat tacaacactc taggcaaatt
     1981 gtatatggta cagcaaatgg tacattgtgt taataaacgc tgtattggct gaaaaggaaa
     2041 aaaaaaaaaa aaaa
//
