LOCUS       NM_031129                484 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus elongin B (Elob), mRNA.
ACCESSION   NM_031129 XM_001056409
VERSION     NM_031129.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Semenza,G.L.
  TITLE     Regulation of oxygen homeostasis by hypoxia-inducible factor 1
  JOURNAL   Physiology (Bethesda) 24, 97-106 (2009)
   PUBMED   19364912
  REMARK    Review article
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Ferguson,J.E. 3rd, Wu,Y., Smith,K., Charles,P., Powers,K., Wang,H.
            and Patterson,C.
  TITLE     ASB4 is a hydroxylation substrate of FIH and promotes vascular
            differentiation via an oxygen-dependent mechanism
  JOURNAL   Mol Cell Biol 27 (18), 6407-6419 (2007)
   PUBMED   17636018
REFERENCE   3  (bases 1 to 484)
  AUTHORS   Woo,J.S., Imm,J.H., Min,C.K., Kim,K.J., Cha,S.S. and Oh,B.H.
  TITLE     Structural and functional insights into the B30.2/SPRY domain
  JOURNAL   EMBO J 25 (6), 1353-1363 (2006)
   PUBMED   16498413
REFERENCE   4  (bases 1 to 484)
  AUTHORS   Brower,C.S., Sato,S., Tomomori-Sato,C., Kamura,T., Pause,A.,
            Stearman,R., Klausner,R.D., Malik,S., Lane,W.S., Sorokina,I.,
            Roeder,R.G., Conaway,J.W. and Conaway,R.C.
  TITLE     Mammalian mediator subunit mMED8 is an Elongin BC-interacting
            protein that can assemble with Cul2 and Rbx1 to reconstitute a
            ubiquitin ligase
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10353-10358 (2002)
   PUBMED   12149480
REFERENCE   5  (bases 1 to 484)
  AUTHORS   Kamura,T., Burian,D., Yan,Q., Schmidt,S.L., Lane,W.S., Querido,E.,
            Branton,P.E., Shilatifard,A., Conaway,R.C. and Conaway,J.W.
  TITLE     Muf1, a novel Elongin BC-interacting leucine-rich repeat protein
            that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin
            ligase
  JOURNAL   J Biol Chem 276 (32), 29748-29753 (2001)
   PUBMED   11384984
REFERENCE   6  (bases 1 to 484)
  AUTHORS   Kamura,T., Koepp,D.M., Conrad,M.N., Skowyra,D., Moreland,R.J.,
            Iliopoulos,O., Lane,W.S., Kaelin,W.G. Jr., Elledge,S.J.,
            Conaway,R.C., Harper,J.W. and Conaway,J.W.
  TITLE     Rbx1, a component of the VHL tumor suppressor complex and SCF
            ubiquitin ligase
  JOURNAL   Science 284 (5414), 657-661 (1999)
   PUBMED   10213691
REFERENCE   7  (bases 1 to 484)
  AUTHORS   Garrett,K.P., Aso,T., Bradsher,J.N., Foundling,S.I., Lane,W.S.,
            Conaway,R.C. and Conaway,J.W.
  TITLE     Positive regulation of general transcription factor SIII by a
            tailed ubiquitin homolog
  JOURNAL   Proc Natl Acad Sci U S A 92 (16), 7172-7176 (1995)
   PUBMED   7638163
REFERENCE   8  (bases 1 to 484)
  AUTHORS   Bradsher,J.N., Jackson,K.W., Conaway,R.C. and Conaway,J.W.
  TITLE     RNA polymerase II transcription factor SIII. I. Identification,
            purification, and properties
  JOURNAL   J Biol Chem 268 (34), 25587-25593 (1993)
   PUBMED   8244996
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC058463.1.
            
            On Aug 31, 2012 this sequence version replaced NM_031129.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058463.1, CB567054.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132295, SAMD00132303
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-484               BC058463.1         5-488
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..484
                     /gene="Elob"
                     /gene_synonym="Tceb2"
                     /note="elongin B"
                     /db_xref="GeneID:81807"
                     /db_xref="RGD:621200"
     exon            1..43
                     /gene="Elob"
                     /gene_synonym="Tceb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..397
                     /gene="Elob"
                     /gene_synonym="Tceb2"
                     /note="transcription elongation factor B polypeptide 2;
                     SIII p18; elongin 18 kDa subunit; RNA polymerase II
                     transcription factor SIII subunit B; transcription
                     elongation factor B (SIII) polypeptide 2 (18kD, elongin
                     B); transcription elongation factor B (SIII), polypeptide
                     2; transcription elongation factor B subunit 2"
                     /codon_start=1
                     /product="elongin-B"
                     /protein_id="NP_112391.1"
                     /db_xref="GeneID:81807"
                     /db_xref="RGD:621200"
                     /translation="MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPEEQRL
                     YKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALRIEPFSSPPELPDV
                     MKPQDSGGSANEQAVQ"
     exon            44..178
                     /gene="Elob"
                     /gene_synonym="Tceb2"
                     /inference="alignment:Splign:2.1.0"
     exon            179..284
                     /gene="Elob"
                     /gene_synonym="Tceb2"
                     /inference="alignment:Splign:2.1.0"
     exon            285..454
                     /gene="Elob"
                     /gene_synonym="Tceb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgcgc cggcgcgtcg agccagaagc agccgccggg atggacgtgt ttctcatgat
       61 ccggcgccac aagaccacca tctttacgga cgccaaggag tcgagcacgg tgttcgaact
      121 gaagcgcatc gtcgagggca tcctcaagcg gccgccagag gagcagcggc tgtacaagga
      181 cgaccagctc cttgatgatg gaaaaactct gggcgaatgt ggcttcacca gtcagacagc
      241 aaggccacag gccccagcca cagtgggcct ggcctttcga gcagatgaca cctttgaagc
      301 gctgcgtatt gaacccttct ccagccctcc ggagcttcca gatgtgatga agccacagga
      361 ttctggaggc agtgccaatg aacaagctgt gcagtgaggg ccccaggcct accccctaga
      421 aacccattcc cccaataaaa aaaagatttg gctgaaaaaa aaaaaaaaaa aaaaaaaaaa
      481 aaaa
//
