LOCUS       NM_017103               2745 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus elongin A (Eloa), mRNA.
ACCESSION   NM_017103
VERSION     NM_017103.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2745)
  AUTHORS   Weems,J.C., Slaughter,B.D., Unruh,J.R., Boeing,S., Hall,S.M.,
            McLaird,M.B., Yasukawa,T., Aso,T., Svejstrup,J.Q., Conaway,J.W. and
            Conaway,R.C.
  TITLE     Cockayne syndrome B protein regulates recruitment of the Elongin A
            ubiquitin ligase to sites of DNA damage
  JOURNAL   J Biol Chem 292 (16), 6431-6437 (2017)
   PUBMED   28292928
REFERENCE   2  (bases 1 to 2745)
  AUTHORS   Kawauchi,J., Inoue,M., Fukuda,M., Uchida,Y., Yasukawa,T.,
            Conaway,R.C., Conaway,J.W., Aso,T. and Kitajima,S.
  TITLE     Transcriptional properties of mammalian elongin A and its role in
            stress response
  JOURNAL   J Biol Chem 288 (34), 24302-24315 (2013)
   PUBMED   23828199
  REMARK    GeneRIF: Elongin A transcription elongation activity, but not its
            ubiquitination activity, is most important for its function in
            induction of transcription of ATF3 and p21.
REFERENCE   3  (bases 1 to 2745)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   4  (bases 1 to 2745)
  AUTHORS   Kamura,T., Burian,D., Yan,Q., Schmidt,S.L., Lane,W.S., Querido,E.,
            Branton,P.E., Shilatifard,A., Conaway,R.C. and Conaway,J.W.
  TITLE     Muf1, a novel Elongin BC-interacting leucine-rich repeat protein
            that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin
            ligase
  JOURNAL   J Biol Chem 276 (32), 29748-29753 (2001)
   PUBMED   11384984
REFERENCE   5  (bases 1 to 2745)
  AUTHORS   Aso,T., Haque,D., Barstead,R.J., Conaway,R.C. and Conaway,J.W.
  TITLE     The inducible elongin A elongation activation domain: structure,
            function and interaction with the elongin BC complex
  JOURNAL   EMBO J 15 (20), 5557-5566 (1996)
   PUBMED   8896449
REFERENCE   6  (bases 1 to 2745)
  AUTHORS   Aso,T., Lane,W.S., Conaway,J.W. and Conaway,R.C.
  TITLE     Elongin (SIII): a multisubunit regulator of elongation by RNA
            polymerase II
  JOURNAL   Science 269 (5229), 1439-1443 (1995)
   PUBMED   7660129
REFERENCE   7  (bases 1 to 2745)
  AUTHORS   Bradsher,J.N., Jackson,K.W., Conaway,R.C. and Conaway,J.W.
  TITLE     RNA polymerase II transcription factor SIII. I. Identification,
            purification, and properties
  JOURNAL   J Biol Chem 268 (34), 25587-25593 (1993)
   PUBMED   8244996
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081815.1.
            
            On Jun 10, 2007 this sequence version replaced NM_017103.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081815.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2745
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2745
                     /gene="Eloa"
                     /gene_synonym="El; Tceb3"
                     /note="elongin A"
                     /db_xref="GeneID:25562"
                     /db_xref="RGD:3827"
     exon            1..141
                     /gene="Eloa"
                     /gene_synonym="El; Tceb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2388
                     /gene="Eloa"
                     /gene_synonym="El; Tceb3"
                     /note="transcription elongation factor B polypeptide 3;
                     SIII p110; elongin 110 kDa subunit; RNA polymerase II
                     transcription factor SIII subunit A; RNA polymerase II
                     transcription factor SIII subunit A1; transcription
                     elongation factor B subunit 3; transcription elongation
                     factor B (SIII), polypeptide 3; RNA polymerase II
                     transcription factor elongin subunit A (110 kDa)"
                     /codon_start=1
                     /product="elongin-A"
                     /protein_id="NP_058799.2"
                     /db_xref="GeneID:25562"
                     /db_xref="RGD:3827"
                     /translation="MAAESALQVVEKLQARLAANPDPKKLLKYLKKLSVLPITVDILV
                     ETGVGKTVNSFRKHEQVGNFARDLVAQWKKLVPVERNNEAEDQDFEKSNSRKRPRDVP
                     QQEEEAEGNYQESWQASGSQPYSPEHRQKKHRKLPELERPHKVAHGHERRDERKRCHK
                     VSPPYSSDPESSDYGHVQSPPPSSPHQMYTDLSRSPEMDQEPIVSHPKPGKVHSNTFQ
                     DRLGVSHLGEHQGKGAVSQNKPHKSSHKEKRPVDARGDEKSSVMGREKSHKASSKEES
                     RRLLSEDSAKEKLPSSVVKKEKDREGNSLKKKLSPALDVASDNHFKKPKHKDSEKIKS
                     DKNKQSVDSVDSGRGTGDPLPRAKDKVPNNLKAQEGKVRTNSDRKSPGSLPKVEEMDM
                     DDEFEQPTMSFESYLSYDQPRKKKKKVVKTSGTALGEKGLKKKDSKSTSKNLNSAQKL
                     PKVNENKSDKLQPAGAEPTRPRKVPTDVLPALPDIPLPAIQTNYRPLPSLELISSFQP
                     KRKAFSSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSIF
                     EVGGVPYSVLEPVLERCTPDQLYRIEECNHVLIEETDQLWKVHCHRDFKEERPEEYES
                     WREMYLRLQDAREQRLRLLTNNIRSAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKF
                     GTGGAAVPEKVRIKPAPYTTGSSHVPASNSSSSFHSSPEELAYEGPSTSSAHLAPVAS
                     SSVSYDPRKPAVKKIAPMMAKTIKAFKNRFSRR"
     exon            142..198
                     /gene="Eloa"
                     /gene_synonym="El; Tceb3"
                     /inference="alignment:Splign:2.1.0"
     exon            199..305
                     /gene="Eloa"
                     /gene_synonym="El; Tceb3"
                     /inference="alignment:Splign:2.1.0"
     exon            306..1485
                     /gene="Eloa"
                     /gene_synonym="El; Tceb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1600
                     /gene="Eloa"
                     /gene_synonym="El; Tceb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1756
                     /gene="Eloa"
                     /gene_synonym="El; Tceb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1854
                     /gene="Eloa"
                     /gene_synonym="El; Tceb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2035
                     /gene="Eloa"
                     /gene_synonym="El; Tceb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2147
                     /gene="Eloa"
                     /gene_synonym="El; Tceb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2326
                     /gene="Eloa"
                     /gene_synonym="El; Tceb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2710
                     /gene="Eloa"
                     /gene_synonym="El; Tceb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagttgcg gcccgaggac gctacgcgag cccagttccg gcgaggaggc cgcgccagtg
       61 acagcgatgg cggcggagtc ggcgctccaa gttgtggaga agctgcaggc gcgcctggct
      121 gcgaacccgg accccaagaa gctattgaaa tatttgaaga aactttccgt cttacctatt
      181 acagtagaca ttcttgtgga gactggggtg gggaaaacag tgaacagctt tcggaaacat
      241 gagcaagtgg gaaactttgc cagagacctg gttgcccagt ggaagaagct ggttccagta
      301 gaacgaaaca atgaggctga ggatcaggat tttgagaaga gcaattcccg caagcgtccc
      361 cgagatgttc cccagcagga ggaggaagcg gaggggaact accaggaaag ctggcaagcc
      421 tcaggcagcc agccctacag ccctgagcac agacagaaaa agcacagaaa acttcctgag
      481 cttgaaaggc ctcacaaagt ggctcatggt cacgagagga gagatgaaag gaagaggtgt
      541 cacaaagtgt caccaccata ttcttcagac cccgagtcgt ctgactatgg tcatgttcaa
      601 tctcctccac cttcaagtcc ccatcaaatg tatacagacc tctctaggtc cccagagatg
      661 gaccaggaac ccatcgtctc acacccgaag cctgggaaag tccacagtaa tacctttcag
      721 gacagactag gggttagtca cctgggtgag caccaaggga aaggggctgt tagccaaaac
      781 aagccacaca aatcttccca caaggagaaa cgccctgtgg atgccagggg ggatgagaag
      841 agctctgtca tgggcagaga gaagtcacac aaagcctctt ccaaagagga gagccgaagg
      901 ctactctcag aggacagtgc caaggagaag ctgccctcca gtgttgtcaa gaaagagaag
      961 gacagagaag gcaacagcct caagaagaag ttgtcacctg ccttagatgt tgcttcagac
     1021 aaccacttta aaaagcccaa acacaaggac tccgagaaaa tcaagtctga caaaaacaag
     1081 cagagtgtag atagcgtgga ctcaggacga gggacaggag acccattacc cagagccaag
     1141 gataaagttc ccaacaacct gaaggctcag gaggggaaag taagaactaa ctcggatcga
     1201 aagtcaccag gctcactccc taaagtagaa gagatggaca tggatgatga gtttgagcag
     1261 cccaccatgt cctttgagtc atacctcagc tatgaccagc cccgcaagaa aaagaagaag
     1321 gttgtgaaaa cttccggtac agcacttgga gaaaaaggac ttaaaaagaa ggactctaaa
     1381 agcactagta aaaacttgaa ctcggctcag aaattaccca aggtgaatga aaacaagtca
     1441 gacaagttgc agccagctgg agccgaaccc acgaggccta gaaaggtccc tactgatgtg
     1501 ctgccagcat tgccagacat ccccttgccc gccatacaaa ccaactatcg tccccttccc
     1561 tccctcgagt tgatctcctc ctttcagcca aagcgaaaag ctttctcttc accccaggaa
     1621 gaagaagaag ctgggttcac aggacgcaga atgaattcta agatgcaggt gtattcaggt
     1681 tccaagtgtg cctatctccc caaaatgatg accttgcacc agcagtgtat ccgggtgctt
     1741 aagaataata ttgactccat ctttgaagtg ggaggagtcc cctattctgt tcttgaacct
     1801 gtcttggaga ggtgcacacc cgatcagctc taccgaatag aggaatgcaa tcatgtatta
     1861 attgaggaaa cagatcagtt gtggaaagtt cactgtcacc gggactttaa ggaagaaaga
     1921 ccagaagagt atgagtcttg gagggagatg tacctgaggc ttcaggacgc ccgagagcag
     1981 cggctgcgcc tgctcacaaa caacatccgg tctgcacatg ccaataagcc aaaaggacga
     2041 caagcaaaga tggcctttgt gaactctgtg gccaagccac cgagagatgt tcgacggagg
     2101 caggagaagt ttggaaccgg gggagcagct gtccctgaga aagtcaggat taagccagca
     2161 ccatatacaa caggaagcag ccatgttcct gccagcaaca gcagcagcag cttccactca
     2221 agtcctgagg agctggccta cgaagggccc agtaccagca gtgcccactt agctcctgtg
     2281 gccagcagct ctgtttccta tgatcccagg aaaccagctg tgaagaaaat tgccccgatg
     2341 atggccaaga ccattaaagc attcaagaac agattttccc gacgataaac aggacttgcc
     2401 ttggaggttg agtctggaag caggactaca gggactatgg ggacgggaga agaggatgtc
     2461 cacagaagac ccgtatcttt tgctctgtgg aacttttggc ctctgactcc tgcacagttc
     2521 caggtgtccc cctctgtgcc tcagccctgc accctgcttg tagcacactt cagatttctg
     2581 aagacagtat gagcctcagt cttactgagg actttaagat cagttatact tttgttgcta
     2641 attagcatct ttgtaaacta taagacatag ttttaattaa taaatattgc ccccagatgt
     2701 atttataata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
