LOCUS       NM_012722               3615 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus elastin (Eln), mRNA.
ACCESSION   NM_012722 XM_341061 XM_347155
VERSION     NM_012722.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3615)
  AUTHORS   Li,J., Cao,J., Yan,C. and Gong,X.
  TITLE     TGF-alpha/EGFR signaling promotes lipopolysaccharide-induced
            abnormal elastin deposition and alveolar simplification
  JOURNAL   Exp Cell Res 437 (1), 113997 (2024)
   PUBMED   38508328
  REMARK    GeneRIF: TGF-alpha/EGFR signaling promotes
            lipopolysaccharide-induced abnormal elastin deposition and alveolar
            simplification.
REFERENCE   2  (bases 1 to 3615)
  AUTHORS   Liang,K., Cui,M., Fu,X., Ma,J., Zhang,K., Zhang,D. and Zhai,S.
  TITLE     LncRNA Xist induces arterial smooth muscle cell apoptosis in
            thoracic aortic aneurysm through miR-29b-3p/Eln pathway
  JOURNAL   Biomed Pharmacother 137, 111163 (2021)
   PUBMED   33761588
  REMARK    GeneRIF: LncRNA Xist induces arterial smooth muscle cell apoptosis
            in thoracic aortic aneurysm through miR-29b-3p/Eln pathway.
REFERENCE   3  (bases 1 to 3615)
  AUTHORS   Minami,A., Fujita,Y., Goto,J., Iuchi,A., Fujita,K., Mikami,Y.,
            Shiratori,M., Ishii,A., Mitragotri,S., Iwao,Y., Kanazawa,H.,
            Kurebayashi,Y., Takahashi,T., Otsubo,T., Ikeda,K. and Suzuki,T.
  TITLE     Enhancement of elastin expression by transdermal administration of
            sialidase isozyme Neu2
  JOURNAL   Sci Rep 11 (1), 3302 (2021)
   PUBMED   33558588
  REMARK    GeneRIF: Enhancement of elastin expression by transdermal
            administration of sialidase isozyme Neu2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3615)
  AUTHORS   Svard,A., Hammerman,M. and Eliasson,P.
  TITLE     Elastin levels are higher in healing tendons than in intact tendons
            and influence tissue compliance
  JOURNAL   FASEB J 34 (10), 13409-13418 (2020)
   PUBMED   32794252
  REMARK    GeneRIF: Elastin levels are higher in healing tendons than in
            intact tendons and influence tissue compliance.
REFERENCE   5  (bases 1 to 3615)
  AUTHORS   Chang,C.J., Huang,C.C., Chen,P.R. and Lai,Y.J.
  TITLE     Remodeling Matrix Synthesis in a Rat Model of Aortocaval Fistula
            and the Cyclic Stretch: Impaction in Pulmonary Arterial
            Hypertension-Congenital Heart Disease
  JOURNAL   Int J Mol Sci 21 (13), 4676 (2020)
   PUBMED   32630068
  REMARK    GeneRIF: Remodeling Matrix Synthesis in a Rat Model of Aortocaval
            Fistula and the Cyclic Stretch: Impaction in Pulmonary Arterial
            Hypertension-Congenital Heart Disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3615)
  AUTHORS   Hernandez,M.R.
  TITLE     Ultrastructural immunocytochemical analysis of elastin in the human
            lamina cribrosa. Changes in elastic fibers in primary open-angle
            glaucoma
  JOURNAL   Invest Ophthalmol Vis Sci 33 (10), 2891-2903 (1992)
   PUBMED   1526740
REFERENCE   7  (bases 1 to 3615)
  AUTHORS   Giro,M.G., Duvic,M., Smith,L.T., Kennedy,R., Rapini,R., Arnett,F.C.
            and Davidson,J.M.
  TITLE     Buschke-Ollendorff syndrome associated with elevated elastin
            production by affected skin fibroblasts in culture
  JOURNAL   J Invest Dermatol 99 (2), 129-137 (1992)
   PUBMED   1629625
REFERENCE   8  (bases 1 to 3615)
  AUTHORS   Pierce,R.A., Alatawi,A., Deak,S.B. and Boyd,C.D.
  TITLE     Elements of the rat tropoelastin gene associated with alternative
            splicing
  JOURNAL   Genomics 12 (4), 651-658 (1992)
   PUBMED   1572637
REFERENCE   9  (bases 1 to 3615)
  AUTHORS   Schwartz,E., Thieberg,M., Cruickshank,F.A. and Lebwohl,M.
  TITLE     Elastase digestion of normal and pseudoxanthoma elasticum lesional
            skin elastins
  JOURNAL   Exp Mol Pathol 55 (2), 190-195 (1991)
   PUBMED   1936214
REFERENCE   10 (bases 1 to 3615)
  AUTHORS   Pierce,R.A., Deak,S.B., Stolle,C.A. and Boyd,C.D.
  TITLE     Heterogeneity of rat tropoelastin mRNA revealed by cDNA cloning
  JOURNAL   Biochemistry 29 (41), 9677-9683 (1990)
   PUBMED   1702999
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085910.1.
            
            On or before Nov 22, 2004 this sequence version replaced
            XM_341061.1, XM_347155.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3615
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3615
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /note="elastin"
                     /db_xref="GeneID:25043"
                     /db_xref="RGD:67394"
     exon            1..90
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..2633
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /note="Tropoelastin"
                     /codon_start=1
                     /product="elastin precursor"
                     /protein_id="NP_036854.1"
                     /db_xref="GeneID:25043"
                     /db_xref="RGD:67394"
                     /translation="MAGLTAAVPQPGVLLILLLNLLHPAQPGGVPGAVPGGVPGGLPG
                     GVPGGVYYPGAGIGGGLGGGALGPGGKPPKPGAGLLGAFGAGPGGLGGAGPGAGLSYA
                     SRPGGVLVPGGGAGAAAAYKAAAKAGAGLGGIGGVPGGVGVGGVPGAVGVGGVPGAVG
                     GIGGIGGLGVSTGAVVPQLGAGVGAGGKPGKVPGVGLPGVYPGGVLPGTGARFPGVGV
                     LPGVPTGTGVKAKVPGGGGGAFSGIPGVGPFGGQQPGVPLGYPIKAPKLPGGYGLPYT
                     NGKLPYGVAGAGGKAGYPTGTGVGSQAAVAAAKAAKYGAGGGGVLPGVGGGGIPGGAG
                     AIPGIGGITGAGTPAAAAAAKAAAKAAKYGAAGGLVPGGPGVRVPGAGIPGVGIPGVG
                     GIPGVGGIPGVGGIPGVGGPGIGGPGIVGGPGAVSPAAAAKAAAKAAKYGARGGVGIP
                     TYGVGAGGFPGYGVGAGAGLGGASQAAAAAAAAKAAKYGAGGAGTLGGLVPGAVPGAL
                     PGAVPGALPGAVPGALPGAVPGVPGTGGVPGAGTPAAAAAAAAAKAAAKAGQYGLGPG
                     VGGVPGGVGVGGLPGGVGPGGVTGIGTGPGTGLVPGDLGGAGTPAAAKSAAKAAAKAQ
                     YRAAAGLGAGVPGLGVGAGVPGFGAGAGGFGAGAGVPGFGAGAVPGSLAASKAAKYGA
                     AGGLGGPGGLGGPGGLGGPGGLGGPGGLGGPGGLGGVPGGVAGGAPAAAAAAKAAAKA
                     AQYGLGGAGGLGAGGLGAGGLGAGGLGAGGLGAGGLGAGGVIPGAVGLGGVSPAAAAK
                     AAKYGAAGLGGVLGARPFPGGGVAARPGFGLSPIYPGGGAGGLGVGGKPPKPYGGALG
                     ALGYQGGGCFGKSCGRKRK"
     exon            91..165
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            166..198
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            199..231
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            232..261
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            262..297
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            298..387
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            388..522
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            523..585
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            586..633
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            634..705
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            706..738
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            739..810
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            811..852
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            853..897
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            898..945
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1035
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1095
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1275
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1329
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1419
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1470
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1620
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1689
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1821
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1881
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2007
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2046
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2178
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2235
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2373
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2412
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2463
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2508
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2538
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2589
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..3590
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgagatggc gggtctgaca gcggcagtcc cgcagcctgg cgtcttgctg atcctcttgc
       61 tcaacctcct ccatcccgcg cagcctggag gggttccagg agctgtgcct ggtggagttc
      121 ctggcggact tcctggtgga gttcccggtg gagtctatta tccaggagct ggtatcggag
      181 gaggcctggg aggaggagct ctgggacctg gaggaaaacc gcctaagcca ggtgccggac
      241 ttctgggagc gtttggagca ggtcctggag gacttggagg tgctggcccc ggggcaggtc
      301 tctcctatgc ttcaaggcca ggtggtgttc tggtgcctgg gggaggagca ggggctgcag
      361 cagcttataa agccgcggcc aaagctgggg ctgggcttgg aggcattggc ggagttccag
      421 ggggtgttgg agttggtgga gttcctgggg ctgttggagt tggcggagtt cctggggctg
      481 tcggtggtat tggtggcatc ggtggcttag gagtctcaac aggtgctgtg gtgcctcaac
      541 ttggagctgg agtcggagcc ggaggaaagc ctgggaaagt tcctggtgtc ggtcttccag
      601 gtgtataccc aggtggagtg ctcccaggaa caggagctcg gttccctggt gtgggagtgc
      661 tccctggagt tcccactggc acaggagtca aggccaaggt tccgggtgga ggaggtggtg
      721 ctttttctgg aatcccaggg gtcgggccct ttgggggtca gcagcctggt gtcccactgg
      781 gttatcccat caaagcgcca aagctgccag gtggctatgg actgccctat accaatggga
      841 aactgcccta tggagtggct ggtgcagggg gcaaagctgg ctacccaaca gggacagggg
      901 tcgggtccca ggcagcagtg gcagcagcta aagcagcgaa gtatggtgct ggaggaggtg
      961 gagtcctccc tggtgttgga gggggtggca ttcctggtgg tgctggcgca attcctggga
     1021 ttggaggcat tacaggcgct ggaactcccg cagcagctgc tgctgcaaag gctgccgcta
     1081 aggctgctaa gtatggagct gctggaggct tagtgcctgg tggaccagga gttagggtcc
     1141 caggtgctgg aatcccaggt gttgggatcc caggtgtcgg tggcattcca ggtgttggtg
     1201 gcattccagg tgttggtggc atcccaggtg ttgggggccc tggtatcgga ggtccaggca
     1261 ttgtgggtgg accaggggct gtgtcaccag ctgcagctgc caaagctgct gccaaagctg
     1321 ccaagtatgg agccagaggt ggagttggca tcccgacata cggggttggt gctggtggct
     1381 ttcctggcta tggtgttgga gctggagctg gacttggagg tgcaagccaa gctgctgctg
     1441 ccgctgccgc tgccaaagct gccaagtacg gtgccggagg agctggaacc ctgggaggcc
     1501 tggtgccagg tgcagtacca ggtgcactgc caggtgcagt accaggtgca ctgccaggtg
     1561 cagtaccagg tgcactgcca ggtgcagtgc caggtgtgcc gggcactggt ggagtgccag
     1621 gagcaggtac ccctgcggct gcagctgctg ccgccgctgc caaggcagcc gccaaggcag
     1681 gccagtatgg tttgggccct ggtgttggtg gcgttcccgg tggagttggt gttggtgggc
     1741 ttcccggtgg agttggccct ggtggtgtta ctggtattgg aactggtcct ggcaccggcc
     1801 ttgtacctgg tgatcttgga ggagcaggga caccagctgc tgccaaatct gctgctaagg
     1861 cggctgccaa agcccagtac agggctgctg ctgggcttgg ggccggtgtc cctggacttg
     1921 gggttggtgc tggtgtcccc ggatttgggg ctggtgctgg tggatttggg gctggtgctg
     1981 gtgtccctgg atttggagct ggagcagttc ctggatccct ggctgcatcc aaagctgcta
     2041 aatacggagc agcaggtggc cttggagggc ctggaggact tggtgggcct ggaggacttg
     2101 gtgggcccgg aggacttggt gggcctggag gactcggtgg gcctggagga ctcggtggtg
     2161 ttcctggtgg agtagcagga ggtgcacctg ctgctgctgc tgctgccaaa gctgccgcta
     2221 aggctgccca gtacggtctt ggtggagctg gaggactcgg ggccggtgga ctgggagccg
     2281 gaggactggg ggccggtgga ctgggagccg gaggactggg agctggtgga ctgggggctg
     2341 ggggagtgat ccctggtgct gtaggccttg gaggtgtgtc ccctgctgca gctgctaagg
     2401 ctgccaaata tggtgctgct ggccttggag gtgtcctagg agccaggcca ttcccaggcg
     2461 gaggagtggc agcaagacct gggtttggac tttctcctat ctacccaggt ggtggtgctg
     2521 ggggcctggg agttggtgga aaacccccga agccctatgg aggagccctt ggagccctgg
     2581 gatatcaagg tgggggctgc tttgggaaat cttgtggccg gaagagaaag tgatcttctg
     2641 gggacccctg actcgcgacc tcatcaacgt tggtgctact gcttggtgga gaatgtaaac
     2701 cttctatgac caccccccct actccatccc cccgaccccc acctgggagg ggacaacagg
     2761 ccagtggcct tggaaaaccc acaggacaag gaaatcagac agcagcagcc acgtacccct
     2821 aactagaaac ccccccacat atcagaggcc agggcgggtg tcccatctct tcccacccag
     2881 gagctccccc acacagtatc catctccaag agaaattggt gctacatgtt ggtgcttctt
     2941 ctttgtgggg ggagggagga gggaagggta tcccaggagg gactccccct tccctgaagc
     3001 ccctctatta agatggtgca caccttcgct gggcagtcct gcctccccct gcccaccagg
     3061 agccattcct ggctgcatcc cattggtacc caagtaccag aagcctcgac attagatttg
     3121 gtaacacgat ccctctctct ctttgggtcc cctgtccctg actcccatta acaatagcta
     3181 cttcccacac ctgggacacc ttgaagtccg acgacttctc acactgggaa tagctccctt
     3241 gttcttgtgg aatccacctg ccaaccaccc atccacggac tcatccatcc ttccatccgt
     3301 catccatcca tccgtccgtc cgtccgtcct gactgcctag tgccactgtc tggctaggca
     3361 cacccactat caacctggtt cacctgtcat ggcagcctgt acccaccccc gccacacacc
     3421 ccgacgctgg cctagggtgc aaagggttgt gcgggctggt ccttcccaca tgcagtactg
     3481 taatccccgt ccctcctgga gccactctat tacagagcat gtctcaccaa ccccacctct
     3541 ttgtgtttcg ctgtgataga tcaataaaat attttatttt ttgtcctgga aaaaaaaaaa
     3601 aaaaaaaaaa aaaaa
//
