LOCUS       NP_036854                875 aa            linear   ROD 23-APR-2024
DEFINITION  elastin precursor [Rattus norvegicus].
ACCESSION   NP_036854 XP_341062 XP_347156
VERSION     NP_036854.1
DBSOURCE    REFSEQ: accession NM_012722.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 875)
  AUTHORS   Li,J., Cao,J., Yan,C. and Gong,X.
  TITLE     TGF-alpha/EGFR signaling promotes lipopolysaccharide-induced
            abnormal elastin deposition and alveolar simplification
  JOURNAL   Exp Cell Res 437 (1), 113997 (2024)
   PUBMED   38508328
  REMARK    GeneRIF: TGF-alpha/EGFR signaling promotes
            lipopolysaccharide-induced abnormal elastin deposition and alveolar
            simplification.
REFERENCE   2  (residues 1 to 875)
  AUTHORS   Liang,K., Cui,M., Fu,X., Ma,J., Zhang,K., Zhang,D. and Zhai,S.
  TITLE     LncRNA Xist induces arterial smooth muscle cell apoptosis in
            thoracic aortic aneurysm through miR-29b-3p/Eln pathway
  JOURNAL   Biomed Pharmacother 137, 111163 (2021)
   PUBMED   33761588
  REMARK    GeneRIF: LncRNA Xist induces arterial smooth muscle cell apoptosis
            in thoracic aortic aneurysm through miR-29b-3p/Eln pathway.
REFERENCE   3  (residues 1 to 875)
  AUTHORS   Minami,A., Fujita,Y., Goto,J., Iuchi,A., Fujita,K., Mikami,Y.,
            Shiratori,M., Ishii,A., Mitragotri,S., Iwao,Y., Kanazawa,H.,
            Kurebayashi,Y., Takahashi,T., Otsubo,T., Ikeda,K. and Suzuki,T.
  TITLE     Enhancement of elastin expression by transdermal administration of
            sialidase isozyme Neu2
  JOURNAL   Sci Rep 11 (1), 3302 (2021)
   PUBMED   33558588
  REMARK    GeneRIF: Enhancement of elastin expression by transdermal
            administration of sialidase isozyme Neu2.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 875)
  AUTHORS   Svard,A., Hammerman,M. and Eliasson,P.
  TITLE     Elastin levels are higher in healing tendons than in intact tendons
            and influence tissue compliance
  JOURNAL   FASEB J 34 (10), 13409-13418 (2020)
   PUBMED   32794252
  REMARK    GeneRIF: Elastin levels are higher in healing tendons than in
            intact tendons and influence tissue compliance.
REFERENCE   5  (residues 1 to 875)
  AUTHORS   Chang,C.J., Huang,C.C., Chen,P.R. and Lai,Y.J.
  TITLE     Remodeling Matrix Synthesis in a Rat Model of Aortocaval Fistula
            and the Cyclic Stretch: Impaction in Pulmonary Arterial
            Hypertension-Congenital Heart Disease
  JOURNAL   Int J Mol Sci 21 (13), 4676 (2020)
   PUBMED   32630068
  REMARK    GeneRIF: Remodeling Matrix Synthesis in a Rat Model of Aortocaval
            Fistula and the Cyclic Stretch: Impaction in Pulmonary Arterial
            Hypertension-Congenital Heart Disease.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 875)
  AUTHORS   Hernandez,M.R.
  TITLE     Ultrastructural immunocytochemical analysis of elastin in the human
            lamina cribrosa. Changes in elastic fibers in primary open-angle
            glaucoma
  JOURNAL   Invest Ophthalmol Vis Sci 33 (10), 2891-2903 (1992)
   PUBMED   1526740
REFERENCE   7  (residues 1 to 875)
  AUTHORS   Giro,M.G., Duvic,M., Smith,L.T., Kennedy,R., Rapini,R., Arnett,F.C.
            and Davidson,J.M.
  TITLE     Buschke-Ollendorff syndrome associated with elevated elastin
            production by affected skin fibroblasts in culture
  JOURNAL   J Invest Dermatol 99 (2), 129-137 (1992)
   PUBMED   1629625
REFERENCE   8  (residues 1 to 875)
  AUTHORS   Pierce,R.A., Alatawi,A., Deak,S.B. and Boyd,C.D.
  TITLE     Elements of the rat tropoelastin gene associated with alternative
            splicing
  JOURNAL   Genomics 12 (4), 651-658 (1992)
   PUBMED   1572637
REFERENCE   9  (residues 1 to 875)
  AUTHORS   Schwartz,E., Thieberg,M., Cruickshank,F.A. and Lebwohl,M.
  TITLE     Elastase digestion of normal and pseudoxanthoma elasticum lesional
            skin elastins
  JOURNAL   Exp Mol Pathol 55 (2), 190-195 (1991)
   PUBMED   1936214
REFERENCE   10 (residues 1 to 875)
  AUTHORS   Pierce,R.A., Deak,S.B., Stolle,C.A. and Boyd,C.D.
  TITLE     Heterogeneity of rat tropoelastin mRNA revealed by cDNA cloning
  JOURNAL   Biochemistry 29 (41), 9677-9683 (1990)
   PUBMED   1702999
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085910.1.
            
            On or before Nov 22, 2004 this sequence version replaced
            XP_341062.1, XP_347156.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     Protein         1..875
                     /product="elastin precursor"
                     /note="Tropoelastin"
                     /calculated_mol_wt=70920
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2761
     Site            39
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            75
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            87
                     /site_type="hydroxylation"
                     /note="Hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            105
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            207
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            220
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            223
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            244
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            337
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            374
                     /site_type="hydroxylation"
                     /note="Hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            401
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            407
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            412
                     /site_type="hydroxylation"
                     /note="Hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            417
                     /site_type="hydroxylation"
                     /note="Hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            517
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            538
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            636
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            645
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            661
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            669
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            720
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     Site            847
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99372.2)"
     CDS             1..875
                     /gene="Eln"
                     /gene_synonym="RATTREL11; TREL11; Trela; Trela26"
                     /coded_by="NM_012722.1:6..2633"
                     /db_xref="GeneID:25043"
                     /db_xref="RGD:67394"
ORIGIN      
        1 magltaavpq pgvllillln llhpaqpggv pgavpggvpg glpggvpggv yypgagiggg
       61 lgggalgpgg kppkpgagll gafgagpggl ggagpgagls yasrpggvlv pgggagaaaa
      121 ykaaakagag lggiggvpgg vgvggvpgav gvggvpgavg giggigglgv stgavvpqlg
      181 agvgaggkpg kvpgvglpgv ypggvlpgtg arfpgvgvlp gvptgtgvka kvpgggggaf
      241 sgipgvgpfg gqqpgvplgy pikapklpgg yglpytngkl pygvagaggk agyptgtgvg
      301 sqaavaaaka akygaggggv lpgvggggip ggagaipgig gitgagtpaa aaaakaaaka
      361 akygaagglv pggpgvrvpg agipgvgipg vggipgvggi pgvggipgvg gpgiggpgiv
      421 ggpgavspaa aakaaakaak ygarggvgip tygvgaggfp gygvgagagl ggasqaaaaa
      481 aaakaakyga ggagtlgglv pgavpgalpg avpgalpgav pgalpgavpg vpgtggvpga
      541 gtpaaaaaaa aakaaakagq yglgpgvggv pggvgvgglp ggvgpggvtg igtgpgtglv
      601 pgdlggagtp aaaksaakaa akaqyraaag lgagvpglgv gagvpgfgag aggfgagagv
      661 pgfgagavpg slaaskaaky gaagglggpg glggpgglgg pgglggpggl ggpgglggvp
      721 ggvaggapaa aaaakaaaka aqyglggagg lgagglgagg lgagglgagg lgagglgagg
      781 vipgavglgg vspaaaakaa kygaaglggv lgarpfpggg vaarpgfgls piypgggagg
      841 lgvggkppkp yggalgalgy qgggcfgksc grkrk
//
