LOCUS       NM_001395578            3672 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus engulfment and cell motility 1 (Elmo1), mRNA.
ACCESSION   NM_001395578 XM_039095896
VERSION     NM_001395578.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3672)
  AUTHORS   Blazejczyk,M., Macias,M., Korostynski,M., Firkowska,M.,
            Piechota,M., Skalecka,A., Tempes,A., Koscielny,A., Urbanska,M.,
            Przewlocki,R. and Jaworski,J.
  TITLE     Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in
            Hippocampal Neurons
  JOURNAL   Mol Neurobiol 54 (4), 2562-2578 (2017)
   PUBMED   26993296
  REMARK    GeneRIF: prolonged overexpression of Elmo1 in cultured hippocampal
            neurons increased axonal growth, decreased dendritic spine density,
            and affected their shape.
REFERENCE   2  (bases 1 to 3672)
  AUTHORS   Kim,J.Y., Oh,M.H., Bernard,L.P., Macara,I.G. and Zhang,H.
  TITLE     The RhoG/ELMO1/Dock180 signaling module is required for spine
            morphogenesis in hippocampal neurons
  JOURNAL   J Biol Chem 286 (43), 37615-37624 (2011)
   PUBMED   21900250
  REMARK    GeneRIF: The RhoG/ELMO1/Dock180 signaling module is required for
            spine morphogenesis in hippocampal neurons.
REFERENCE   3  (bases 1 to 3672)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 3672)
  AUTHORS   Shimazaki,A., Tanaka,Y., Shinosaki,T., Ikeda,M., Watada,H.,
            Hirose,T., Kawamori,R. and Maeda,S.
  TITLE     ELMO1 increases expression of extracellular matrix proteins and
            inhibits cell adhesion to ECMs
  JOURNAL   Kidney Int 70 (10), 1769-1776 (2006)
   PUBMED   17021600
  REMARK    GeneRIF: Cell adhesion to extracellular matrix proteins was
            considerably inhibited in cells overexpressing ELMO1. This suggest
            that ELMO1 contributes to the development and progression of
            chronic glomerular injury.
REFERENCE   5  (bases 1 to 3672)
  AUTHORS   Katoh,H. and Negishi,M.
  TITLE     RhoG activates Rac1 by direct interaction with the Dock180-binding
            protein Elmo
  JOURNAL   Nature 424 (6947), 461-464 (2003)
   PUBMED   12879077
  REMARK    GeneRIF: RhoG activates Rac1 through Elmo and Dock180 to control
            cell morphology.
REFERENCE   6  (bases 1 to 3672)
  AUTHORS   Scott,M.P., Zappacosta,F., Kim,E.Y., Annan,R.S. and Miller,W.T.
  TITLE     Identification of novel SH3 domain ligands for the Src family
            kinase Hck. Wiskott-Aldrich syndrome protein (WASP),
            WASP-interacting protein (WIP), and ELMO1
  JOURNAL   J Biol Chem 277 (31), 28238-28246 (2002)
   PUBMED   12029088
REFERENCE   7  (bases 1 to 3672)
  AUTHORS   Brugnera,E., Haney,L., Grimsley,C., Lu,M., Walk,S.F.,
            Tosello-Trampont,A.C., Macara,I.G., Madhani,H., Fink,G.R. and
            Ravichandran,K.S.
  TITLE     Unconventional Rac-GEF activity is mediated through the
            Dock180-ELMO complex
  JOURNAL   Nat Cell Biol 4 (8), 574-582 (2002)
   PUBMED   12134158
REFERENCE   8  (bases 1 to 3672)
  AUTHORS   Gumienny,T.L., Brugnera,E., Tosello-Trampont,A.C., Kinchen,J.M.,
            Haney,L.B., Nishiwaki,K., Walk,S.F., Nemergut,M.E., Macara,I.G.,
            Francis,R., Schedl,T., Qin,Y., Van Aelst,L., Hengartner,M.O. and
            Ravichandran,K.S.
  TITLE     CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is
            required for phagocytosis and cell migration
  JOURNAL   Cell 107 (1), 27-41 (2001)
   PUBMED   11595183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jul 20, 2021 this sequence version replaced XM_039095896.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.766232.1,
                                           SRR26643295.54673.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000017.1  49517978-49518159   c
            183-333             JAXUCZ010000017.1  49424566-49424716   c
            334-374             JAXUCZ010000017.1  49402319-49402359   c
            375-447             JAXUCZ010000017.1  49401263-49401335   c
            448-498             JAXUCZ010000017.1  49366621-49366671   c
            499-668             JAXUCZ010000017.1  49356210-49356379   c
            669-704             JAXUCZ010000017.1  49339615-49339650   c
            705-804             JAXUCZ010000017.1  49324120-49324219   c
            805-956             JAXUCZ010000017.1  49315348-49315499   c
            957-1034            JAXUCZ010000017.1  49313163-49313240   c
            1035-1085           JAXUCZ010000017.1  49309787-49309837   c
            1086-1208           JAXUCZ010000017.1  49308498-49308620   c
            1209-1340           JAXUCZ010000017.1  49306227-49306358   c
            1341-1445           JAXUCZ010000017.1  49245609-49245713   c
            1446-1554           JAXUCZ010000017.1  49205396-49205504   c
            1555-1691           JAXUCZ010000017.1  49132016-49132152   c
            1692-1855           JAXUCZ010000017.1  49025478-49025641   c
            1856-1968           JAXUCZ010000017.1  49017805-49017917   c
            1969-2076           JAXUCZ010000017.1  49008364-49008471   c
            2077-2159           JAXUCZ010000017.1  48998291-48998373   c
            2160-2237           JAXUCZ010000017.1  48988507-48988584   c
            2238-3671           JAXUCZ010000017.1  48982188-48983621   c
FEATURES             Location/Qualifiers
     source          1..3672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q11"
     gene            1..3672
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /note="engulfment and cell motility 1"
                     /db_xref="GeneID:361251"
                     /db_xref="RGD:1308182"
     exon            1..182
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            183..333
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2439
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /note="engulfment and cell motility 1, ced-12 homolog;
                     engulfment and cell motility 1 splice 1"
                     /codon_start=1
                     /product="engulfment and cell motility protein 1"
                     /protein_id="NP_001382507.1"
                     /db_xref="GeneID:361251"
                     /db_xref="RGD:1308182"
                     /translation="MPPPSDIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLA
                     NHEYFALQHADSSNFYITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLE
                     ALKDLASLSRDVTFAQEFINLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLT
                     AFVELMDHGIVSWDTFSVAFIKKIASFVNKSAIDISILQRSLAILESMVLNSHDLYQK
                     VAQEITIGQLIPHLQGTDQEIQTYTIAVINALFLKAPDERRQEMANILAQKQLRYIIL
                     THVIRAQRAINNEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDA
                     ESEPNNSSGSMEKRKSMYTRDYKKLGFINHVNPAMDFTQTPPGMLALDNMLYFAKHHQ
                     DAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFFTHDR
                     SFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQN
                     LSYTEILKIRQSERMNQEDFQSRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLN
                     ARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPH
                     MKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLT
                     RNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNYDFVYDCN"
     exon            334..374
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            375..447
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            448..498
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            499..668
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            669..704
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            705..804
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            805..956
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1035
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1086
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1209
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1341
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1446
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1555
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1692
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1856
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1969
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2077
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2160
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2238
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..3672
                     /gene="Elmo1"
                     /gene_synonym="ELMO1s"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgtaagt gcgtgcgttc gggcagtggc agcgggagag gatgggcacg agatagaggc
       61 agagccaccg cagtccgcgg ctccgagagg ggcgtcagag cctcgggccc cggtctacgg
      121 ctccgtccct agtgctccgg cctctgggag ccctagtcgc tgcgtcctga gaccccaggc
      181 aggtgtagac acgtgtgaca gtccacgcag taggacccct atttctaccg gctttggact
      241 tcctcctgtc gcacaatgcc gccgccttcg gacatcgtga aggtggccat agaatggcct
      301 ggcgcctacc ctaaactcat ggagattgac cagaaaaaac cactgtctgc cataataaag
      361 gaagtctgcg atgggtggtc tcttgccaac catgaatatt ttgctctgca gcatgctgat
      421 agttcaaact tctacatcac agaaaagaat cgcaacgaaa taaaaaatgg cactattctt
      481 cgattaacca cgtccccagc tcaaaatgcc cagcagctcc atgaacgaat acagtcatca
      541 agtatggacg ccaagttgga agccctgaag gacttggcca gcctctcccg ggatgttacc
      601 tttgctcagg agttcataaa cctggatggc atttcactcc tcactcagat ggtggaaagt
      661 ggcactgaac gataccagaa gttgcagaag attatgaagc cctgctttgg agacatgctg
      721 tccttcactc tcacagcctt tgtggagctg atggaccatg gcatcgtgtc atgggataca
      781 ttctcagtgg cgttcattaa gaagatagca agctttgtga acaagtctgc catagacatc
      841 tcaatcctgc agcggtcctt ggccattttg gagtcaatgg ttctcaatag ccatgacctc
      901 taccaaaagg tagctcagga gatcaccatt ggccaactca ttcctcatct tcaggggaca
      961 gaccaagaaa tccagactta caccattgct gtaatcaatg cacttttcct gaaagcgcct
     1021 gatgagagga gacaggagat ggctaatatt ttggctcaga agcagctgcg ctacatcatt
     1081 ttaacccatg tcatccgagc acagcgggcc atcaacaacg agatggcaca ccagttatat
     1141 gttctccaag tgctgacctt taaccttctg gaagatagga tgatgaccaa gatggacccc
     1201 caggaccagg cccaaaggga catcatattt gaacttcgaa ggattgcttt tgatgcagag
     1261 tcagaaccga ataatagcag cggcagcatg gagaaacgca agtccatgta cactcgggat
     1321 tataaaaaac ttggcttcat taatcatgtc aatcctgcca tggactttac acagacccct
     1381 cccgggatgc tggctctgga caacatgctg tatttcgcta agcaccacca ggatgcatac
     1441 atccggattg tgcttgagaa cagcagccga gaagataagc atgaatgtcc ttttggacgc
     1501 agcagtatag aactgaccaa gatgctgtgt gagatcctga aagtgggcga gctgcctagt
     1561 gagacctgca acgactttca cccgatgttc ttcacccatg acagatcttt tgaagagttt
     1621 ttctgcattt gtatccagct cctgaacaaa acatggaagg aaatgagggc aacatctgaa
     1681 gacttcaaca aggtaatgca ggtggtgaag gagcaggtta tgagagcgct tacaaccaag
     1741 cctagctccc tggaccagtt caagagcaag ctgcaaaacc tgagctacac tgagatcctg
     1801 aaaatccgcc agtctgagag gatgaaccag gaagatttcc agtctcgccc gattttggaa
     1861 ctaaaggaga agatccagcc agaaatctta gagctgatta aacagcagcg tctgaatcgc
     1921 cttgtggaag ggacctgctt taggaaactc aatgctcgtc ggagacaaga taagttttgg
     1981 tattgtcggc tttcaccaaa tcacaaggtc ttacattatg gtgacttgga agagagcccc
     2041 caaggagaag tgccccatga ttccctgcag gacaaattgc cggtggcaga tatcaaagca
     2101 gtggtgacgg gaaaggactg cccgcatatg aaagagaaag gtgcccttaa acaaaacaag
     2161 gaggtgcttg aacttgcttt ctccatctta tatgactcaa attgccaact gaattttatt
     2221 gctcctgaca agcatgagta ctgcatctgg acagatgggc tgaatgcact gcttgggaag
     2281 gacatgatga gtgacctgac acgaaatgac ctggacaccc tgctgagcat ggagatcaag
     2341 cttcgcctac tggacctgga aaacatccag attccggatg cacctccccc catccccaag
     2401 gagcctagca actatgactt tgtttatgac tgtaactgaa ctggctgggc cctggacaca
     2461 ttcctcccaa actggaagat ctagctatca gcagagaaga gagcaaacac atccacatgt
     2521 tgcaaccacc ctttggtgga gtagaagctg caggtcactt cttcctttgg cctcattttt
     2581 agccctcccc cccacccttc ctggcatatc accatctcct taaatctatt tcctaactca
     2641 gtgttttaga tcctttccca ttgctacagc tcactgatgg gtcatgagca aaagtcaccc
     2701 ctagtaagaa agtcaaaaag tcttctcatt gtaaccagct atgagcatat ccatccttcc
     2761 ttccttcctt ccttcctccc tacctccttc cttccttcct tcaatctttc cttcttgcct
     2821 ggagtaggaa agccatttag tcccaagctg ccccatattt gctcaccaaa ccaagagaaa
     2881 tgcctaaggc cagggctgga tgagatggct ctgctagtga ataagaagac caaaggcctc
     2941 ctaccccttc tctccagggt cacctctcat catcagctct atgtgagttg agaccgcttt
     3001 ctcgttgcct ctctccccct tccctgcctt ggtcttgctt tggtccactt tggtctcaca
     3061 tgtagcagca gcagcctcat tgtagttctc tacagcatca ggtctcctaa acagtccaga
     3121 gtccatgcct gttccttgtc tgcactgtga ccatgaccac cctctctatc acactgtcta
     3181 gtcgtgggcc tcctgtcctt gctccagccc ggacctgcct tctttatttc ttcaagctcc
     3241 cagcccttag cagaaagcac aaatgaagtc agtagtcctg ctccatctct gatagactaa
     3301 acctaaccgc ctctaaggca gctgttgcta tccaacagtt ccgtgtcacc ttctccctgt
     3361 ggctcctgcc acaacccagg ttccccaggg tggtcaagct gtcagacatc caagtttaca
     3421 tcgttgtaat tattataggt ctttaaaatt tacaagggtt tggggttatt ttgttttgtt
     3481 ttgttggctt tgtttttgta taaaagagtc taacattttt tgccaaacag atatatattt
     3541 aatgaaaaga agagatacat aaatgtgtgt actttccagc cttttttttt aattatttta
     3601 accccaaaca tcttcctgag aataacattc ccttaaacat gctgtggaat aaaattaaat
     3661 gtgatgagtt gg
//
