LOCUS       NM_001108059            2779 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus ETS transcription factor ELK1 (Elk1), mRNA.
ACCESSION   NM_001108059 XM_001055949 XM_001078496
VERSION     NM_001108059.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2779)
  AUTHORS   Wei,S., Ling,D., Zhong,J., Chang,R., Ling,X., Chen,Z. and Duan,R.
  TITLE     Elk1 enhances inflammatory cell infiltration and exacerbates acute
            lung injury/acute respiratory distress syndrome by suppressing
            Fcgr2b transcription
  JOURNAL   Mol Med 30 (1), 53 (2024)
   PUBMED   38649840
  REMARK    GeneRIF: Elk1 enhances inflammatory cell infiltration and
            exacerbates acute lung injury/acute respiratory distress syndrome
            by suppressing Fcgr2b transcription.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2779)
  AUTHORS   Lu,Z., Miao,Z., Zhu,J. and Zhu,G.
  TITLE     ETS-domain containing protein (Elk1) suppression protects cortical
            neurons against oxygen-glucose deprivation injury
  JOURNAL   Exp Cell Res 371 (1), 42-49 (2018)
   PUBMED   30053446
  REMARK    GeneRIF: Elk1 suppression protects cortical neurons against
            oxygen-glucose deprivation injury.
            Erratum:[Exp Cell Res. 2018 Nov 1;372(1):83. doi:
            10.1016/j.yexcr.2018.09.007.. PMID: 30266209]
REFERENCE   3  (bases 1 to 2779)
  AUTHORS   Sobrier,M.L., Tsai,Y.C., Perez,C., Leheup,B., Bouceba,T.,
            Duquesnoy,P., Copin,B., Sizova,D., Penzo,A., Stanger,B.Z.,
            Cooke,N.E., Liebhaber,S.A. and Amselem,S.
  TITLE     Functional characterization of a human POU1F1 mutation associated
            with isolated growth hormone deficiency: a novel etiology for IGHD
  JOURNAL   Hum Mol Genet 25 (3), 472-483 (2016)
   PUBMED   26612202
REFERENCE   4  (bases 1 to 2779)
  AUTHORS   Mahajan,M.A. and Stanley,F.M.
  TITLE     Insulin-activated Elk-1 recruits the TIP60/NuA4 complex to increase
            prolactin gene transcription
  JOURNAL   Mol Cell Endocrinol 382 (1), 159-169 (2014)
   PUBMED   24075908
  REMARK    GeneRIF: insulin activates prolactin gene transcription by
            activating Elk-1 that recruits the NuA4 complex to the promoter.
REFERENCE   5  (bases 1 to 2779)
  AUTHORS   Rahim,G., Araud,T., Jaquier-Gubler,P. and Curran,J.
  TITLE     Alternative splicing within the elk-1 5' untranslated region serves
            to modulate initiation events downstream of the highly conserved
            upstream open reading frame 2
  JOURNAL   Mol Cell Biol 32 (9), 1745-1756 (2012)
   PUBMED   22354998
REFERENCE   6  (bases 1 to 2779)
  AUTHORS   Sharrocks,A.D.
  TITLE     Complexities in ETS-domain transcription factor function and
            regulation: lessons from the TCF (ternary complex factor)
            subfamily. The Colworth Medal Lecture
  JOURNAL   Biochem Soc Trans 30 (2), 1-9 (2002)
   PUBMED   12023815
REFERENCE   7  (bases 1 to 2779)
  AUTHORS   Vanhoutte,P., Nissen,J.L., Brugg,B., Gaspera,B.D., Besson,M.J.,
            Hipskind,R.A. and Caboche,J.
  TITLE     Opposing roles of Elk-1 and its brain-specific isoform, short
            Elk-1, in nerve growth factor-induced PC12 differentiation
  JOURNAL   J Biol Chem 276 (7), 5189-5196 (2001)
   PUBMED   11050086
REFERENCE   8  (bases 1 to 2779)
  AUTHORS   Kyosseva,S.V., Elbein,A.D., Hutton,T.L., Griffin,S.T., Mrak,R.E.,
            Sturner,W.Q. and Karson,C.N.
  TITLE     Increased levels of transcription factors Elk-1, cyclic adenosine
            monophosphate response element-binding protein, and activating
            transcription factor 2 in the cerebellar vermis of schizophrenic
            patients
  JOURNAL   Arch Gen Psychiatry 57 (7), 685-691 (2000)
   PUBMED   10891039
REFERENCE   9  (bases 1 to 2779)
  AUTHORS   Kaminska,B., Kaczmarek,L., Zangenehpour,S. and Chaudhuri,A.
  TITLE     Rapid phosphorylation of Elk-1 transcription factor and activation
            of MAP kinase signal transduction pathways in response to visual
            stimulation
  JOURNAL   Mol Cell Neurosci 13 (6), 405-414 (1999)
   PUBMED   10383826
REFERENCE   10 (bases 1 to 2779)
  AUTHORS   Sgambato,V., Vanhoutte,P., Pages,C., Rogard,M., Hipskind,R.,
            Besson,M.J. and Caboche,J.
  TITLE     In vivo expression and regulation of Elk-1, a target of the
            extracellular-regulated kinase signaling pathway, in the adult rat
            brain
  JOURNAL   J Neurosci 18 (1), 214-226 (1998)
   PUBMED   9412502
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FM043339.1 and
            JAXUCZ010000021.1.
            
            On Mar 16, 2012 this sequence version replaced NM_001108059.2.
            
            Summary: This gene is a member of the Ets family of transcription
            factors and of the ternary complex factor (TCF) subfamily. Proteins
            of the TCF subfamily form a ternary complex by binding to the the
            serum response factor and the serum response element in the
            promoter of the c-fos proto-oncogene. The protein encoded by this
            gene is a nuclear target for the ras-raf-MAPK signaling cascade.
            Multiple isoforms are produced from this gene by the use of
            alternative translational start codons. [provided by RefSeq, Mar
            2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1163361.1,
                                           SRR21887622.2108921.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 22354998
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               FM043339.1         7-566
            561-853             JAXUCZ010000021.1  3705913-3706205
            854-1285            JAXUCZ010000021.1  3706734-3707165
            1286-1387           JAXUCZ010000021.1  3707673-3707774
            1388-2779           JAXUCZ010000021.1  3707861-3709252
FEATURES             Location/Qualifiers
     source          1..2779
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq11"
     gene            1..2779
                     /gene="Elk1"
                     /note="ETS transcription factor ELK1"
                     /db_xref="GeneID:314436"
                     /db_xref="RGD:1598663"
     exon            1..90
                     /gene="Elk1"
                     /inference="alignment:Splign:2.1.0"
     exon            91..168
                     /gene="Elk1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..412
                     /gene="Elk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      180..188
                     /regulatory_class="uORF"
                     /gene="Elk1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:22354998]"
                     /note="this uORF is known as uORF2 and is predicted to
                     encode a 2 aa peptide (PMID:22354998)"
     CDS             203..1486
                     /gene="Elk1"
                     /note="ELK1, member of ETS oncogene family; ELK1, ETS
                     transcription factor"
                     /codon_start=1
                     /product="ETS domain-containing protein Elk-1"
                     /protein_id="NP_001101529.1"
                     /db_xref="GeneID:314436"
                     /db_xref="RGD:1598663"
                     /translation="MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVAR
                     LWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQ
                     PEVSVTSAVAMAPATVHSGPGDNATGKPGTPKGAGMTGQGGLARSSRNEYMRSGLYST
                     FTIQSLQPQPPLHPRPASVLPNTTPAGVPAPPSGSRSTSPNPLEACLEAEEAGLPLQV
                     ILTPPEAPNQKSEELSLNPGFGRPQPPEVKVEGPKEELEVTEVGGFSPEAVKAEQEVS
                     PSEGLLARLPAILTENTAQVCGLSTSTTEITQPQKGRKPRDLELPLSPSLLGGQGPER
                     TPGSGTSSGLQAQGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKL
                     SFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP"
     exon            413..853
                     /gene="Elk1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1285
                     /gene="Elk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1387
                     /gene="Elk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..2779
                     /gene="Elk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttggaac ccgggcctgg ggggcggtgg ggcctcgtat ggagcccccg ccccccggag
       61 ctgccgctgc caccgccgcg ccacacgcag gtacattggt gcacacctac ctttattccc
      121 agtactcagg aagctgaggc aagagttcaa gaccagcctg gctacatagt acccctggga
      181 tggcgtgagt gcttccctag tgatggaccc atctgtgaca ctgtggcagt ttctgctgca
      241 gcttctaaga gaacaaggta atggccacat catctcctgg acctcacggg atggtggtga
      301 gttcaagttg gtggatgcag aagaggtggc ccggctatgg ggactgcgca agaacaagac
      361 caacatgaat tatgacaagc ttagccgggc cttgcgctac tactatgata agaatatcat
      421 ccgcaaggtg agcggccaga agtttgtcta caagtttgtg tcctacccag aggttgcagg
      481 gtgctccact gaagactgcc caccccagcc tgaggtgtct gtaacctcgg ccgtagcaat
      541 ggcccctgct actgtccatt caggcccagg ggacaatgcc actggaaagc caggaacacc
      601 aaagggtgca ggaatgacag gccaaggtgg cttagcacga agcagccgga atgaatacat
      661 gcgctcgggc ctctattcta ccttcacaat acagtccctg cagccacagc caccccttca
      721 tcctcggcct gcctcagtgc ttcccaacac tacccctgca ggagtaccag cacccccctc
      781 agggagcagg agcaccagtc caaacccctt agaagcctgc ttggaggcag aagaggctgg
      841 tctgcccctg caggttatct taaccccacc agaggcccca aaccagaaat ctgaagagtt
      901 gagtctgaac ccaggttttg gccgtccaca acccccagaa gtcaaagtgg aggggcctaa
      961 ggaagaattg gaagttacag aggttggagg cttcagtcca gaagctgtca aagctgaaca
     1021 agaagtctca ccctcagaag gcctgctggc tcggctccca gccatcctaa cagagaatac
     1081 agcacaggtg tgtggcctct ccacctccac cactgagatc acccaacccc agaagggccg
     1141 gaagccccga gacctggaac ttccacttag cccaagcctg ctaggtggcc aaggacccga
     1201 acggactcca ggatcaggaa caagctctgg tcttcaggca caggggccag cactaacacc
     1261 atccttgctc cccacacata ccttgacccc ggtgctgctg acacccagct cgctgccccc
     1321 cagcatccat ttctggagca ctctgagtcc aattgcaccg cgtagtccag ccaagctctc
     1381 cttccagttt ccgtccagtg gcagcgcaca ggtgcacatc ccttccatca gcgtggatgg
     1441 cctctcgact cccgtggtgc tctccccagg gccccaaaag ccatgactac catcaccacc
     1501 cctttttgga gtccatccat ccatgctcct gaactctcca gttagccatc tcaaggagaa
     1561 acaattcaac tgacagactt aagctctggt tgtggtgggg tggatattcc tgggaaagag
     1621 gatatttcac ttaactcctc cacccaaaac agacaacttc ttcttcgcca gccttccagt
     1681 ggccgccctt acacgtctcc tacttcagtg gtggggcggt ttatttattt attttttgaa
     1741 ggccactagg aagaatctgg cccaaccttt ttaggggagt gggtaagata tctcccccat
     1801 ttcctcccca ttttttccta aaacgagaca atcagggtat ggcttgagaa gaacctttct
     1861 ttctttattt ctcagcctgc cttggggagt tgagggtgcc ccatcttcat tttgagacat
     1921 gagttgaaga gctcatttgt ttgattttat tattcctggc tgtttctgag tccagggagc
     1981 acttgtacga tttaatggtt tgggagtggt agcgagggaa tcaacactgt taaaatagga
     2041 attgctacct ccccaacctt cttctcagtc agcttgttct tttctcaagt taccttttgg
     2101 ccagagagga atattccttt tgttgttctt ccccctaaga agccattcct ttgtctgcca
     2161 aatttcatag gggcctgtct attacctccc aatggagggt ttttttgggg ggggatggtc
     2221 cccgtctggg gggcccctcc agccagtact ccaggtctct gtctcccacc cccttccatt
     2281 ttgatagtat aatctatttt taaatggggc ttttcaatag gggagaggga aacatctctt
     2341 cctatatcgg atgggtgggt aggtaggtgg gtgggaagta agggttttgg aggcggtctt
     2401 cctgccaccc ccaagtgttt atttttgata ccaaacatgt attttcagct cccttcctcc
     2461 catcccccca atttcctgta ggcaggtaca aaggaccctt ttaagtatcc ctggagttgg
     2521 gagggaggaa tgggggacat ggagcctgtc ttatatcaat ctaggctgga gagcagtgaa
     2581 ttaaaagact cccaggctca cctcctgtca gcactggccc agaccaggcc tgaagatctg
     2641 gggttggtga tttgggggac ggtgctatac tcgtctccac tgtttgtttt gcttccccaa
     2701 aatggacctt tttttctaag agtcccagag aatggggaat tgttcctgta aatatatatt
     2761 tttaaaggtg ttgctgaaa
//
