LOCUS       NM_001077651            3873 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus ELAV like RNA binding protein 4 (Elavl4), mRNA.
ACCESSION   NM_001077651 XM_001062986 XM_001063055 XM_001063104 XM_001063163
            XM_001063217 XM_001063277 XM_001063323 XM_001063372 XM_001063429
            XM_006238592
VERSION     NM_001077651.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3873)
  AUTHORS   Zheng,Z., Chen,B., Jin,Z., Gao,M., Tang,C., Mao,Y., Qu,Y. and
            Liu,Y.
  TITLE     Downregulation of P2Y2 and HuD during the development of the
            enteric nervous system in fetal rats with anorectal malformations
  JOURNAL   Mol Med Rep 20 (2), 1297-1305 (2019)
   PUBMED   31173231
  REMARK    GeneRIF: downregulation of P2Y2 and HuD may partly be related to
            the development of the enteric nervous system in anorectal
            malformations embryos.
REFERENCE   2  (bases 1 to 3873)
  AUTHORS   Gomes,C., Lee,S.J., Gardiner,A.S., Smith,T., Sahoo,P.K., Patel,P.,
            Thames,E., Rodriguez,R., Taylor,R., Yoo,S., Heise,T., Kar,A.N.,
            Perrone-Bizzozero,N. and Twiss,J.L.
  TITLE     Axonal localization of neuritin/CPG15 mRNA is limited by
            competition for HuD binding
  JOURNAL   J Cell Sci 130 (21), 3650-3662 (2017)
   PUBMED   28871047
  REMARK    GeneRIF: The data indicate that endogenous Nrn1 and Gap43 mRNAs
            compete for binding to HuD for their axonal localization and
            activity of the Nrn1 3'UTR.
REFERENCE   3  (bases 1 to 3873)
  AUTHORS   Kong,M., Wu,Y. and Liu,Y.
  TITLE     The impact of HuD protein on the intestinal nervous system in the
            terminal rectum of animal models of congenital anorectal
            malformation
  JOURNAL   Mol Med Rep 16 (4), 4797-4802 (2017)
   PUBMED   28849006
  REMARK    GeneRIF: the HuD protein is abnormally expressed in the nerve
            plexuses of the intestinal wall of the terminal rectum of ARM
            embryonic rats, which suggests that HuD may participate in the
            development and maturation of the ENS in ARM embryonic rats.
REFERENCE   4  (bases 1 to 3873)
  AUTHORS   Kim,H.H., Lee,S.J., Gardiner,A.S., Perrone-Bizzozero,N.I. and
            Yoo,S.
  TITLE     Different motif requirements for the localization zipcode element
            of beta-actin mRNA binding by HuD and ZBP1
  JOURNAL   Nucleic Acids Res 43 (15), 7432-7446 (2015)
   PUBMED   26152301
  REMARK    GeneRIF: Both ZBP1 and HuD bind the zipcode element in rat
            beta-actin mRNA's 3' UTR. Differences between HuD and ZBP1 were
            observed in their binding preference to the element.
REFERENCE   5  (bases 1 to 3873)
  AUTHORS   Sosanya,N.M., Cacheaux,L.P., Workman,E.R., Niere,F.,
            Perrone-Bizzozero,N.I. and Raab-Graham,K.F.
  TITLE     Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic
            Branch Variability through the Capture of Ca2+/Calmodulin-dependent
            Protein Kinase II alpha (CaMKIIalpha) mRNAs by the RNA-binding
            Protein HuD
  JOURNAL   J Biol Chem 290 (26), 16357-16371 (2015)
   PUBMED   25944900
  REMARK    GeneRIF: mTOR inhibition reduces HuD binding and promotes
            deadenylation of CaMKIIalpha mRNA.
REFERENCE   6  (bases 1 to 3873)
  AUTHORS   King,P.H.
  TITLE     RNA-binding analyses of HuC and HuD with the VEGF and c-myc
            3'-untranslated regions using a novel ELISA-based assay
  JOURNAL   Nucleic Acids Res 28 (7), E20 (2000)
   PUBMED   10710437
REFERENCE   7  (bases 1 to 3873)
  AUTHORS   Aranda-Abreu,G.E., Behar,L., Chung,S., Furneaux,H. and Ginzburg,I.
  TITLE     Embryonic lethal abnormal vision-like RNA-binding proteins regulate
            neurite outgrowth and tau expression in PC12 cells
  JOURNAL   J Neurosci 19 (16), 6907-6917 (1999)
   PUBMED   10436048
REFERENCE   8  (bases 1 to 3873)
  AUTHORS   Clayton,G.H., Perez,G.M., Smith,R.L. and Owens,G.C.
  TITLE     Expression of mRNA for the elav-like neural-specific RNA binding
            protein, HuD, during nervous system development
  JOURNAL   Brain Res Dev Brain Res 109 (2), 271-280 (1998)
   PUBMED   9729424
REFERENCE   9  (bases 1 to 3873)
  AUTHORS   Dobashi,Y., Shoji,M., Wakata,Y. and Kameya,T.
  TITLE     Expression of HuD protein is essential for initial phase of
            neuronal differentiation in rat pheochromocytoma PC12 cells
  JOURNAL   Biochem Biophys Res Commun 244 (1), 226-229 (1998)
   PUBMED   9514914
REFERENCE   10 (bases 1 to 3873)
  AUTHORS   Steller,U., Kohls,S., Muller,B., Soller,R., Muller,R., Schlender,J.
            and Blohm,D.H.
  TITLE     The RNA binding protein HuD: rat cDNA and analysis of the
            alternative spliced mRNA in neuronal differentiating cell lines P19
            and PC12
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 285-296 (1996)
   PUBMED   8717365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1 and BC158558.1.
            
            On or before Jun 25, 2015 this sequence version replaced
            XM_006238592.2, NM_001077651.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.925747.1, BC158558.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                JAXUCZ010000005.1  130367633-130367663 c
            32-1493             BC158558.1         1-1462
            1494-3873           JAXUCZ010000005.1  130285418-130287797 c
FEATURES             Location/Qualifiers
     source          1..3873
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..3873
                     /gene="Elavl4"
                     /gene_synonym="HuD"
                     /note="ELAV like RNA binding protein 4"
                     /db_xref="GeneID:432358"
                     /db_xref="RGD:1560027"
     exon            1..156
                     /gene="Elavl4"
                     /gene_synonym="HuD"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1290
                     /gene="Elavl4"
                     /gene_synonym="HuD"
                     /note="hu-antigen D; paraneoplastic encephalomyelitis
                     antigen HuD; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D); ELAV like
                     neuron-specific RNA binding protein 4"
                     /codon_start=1
                     /product="ELAV-like protein 4"
                     /protein_id="NP_001071119.2"
                     /db_xref="GeneID:432358"
                     /db_xref="RGD:1560027"
                     /translation="MEWNGLKMIISTMEPQVSNGPTSNTSNGPSSNNRNCPSPMQTGA
                     ATDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDP
                     KDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQY
                     GRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNP
                     SQKSSQALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRLMSGPVPPSACPP
                     RFSPITIDGMTSLVGMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVI
                     RDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHKS"
     exon            157..397
                     /gene="Elavl4"
                     /gene_synonym="HuD"
                     /inference="alignment:Splign:2.1.0"
     exon            398..501
                     /gene="Elavl4"
                     /gene_synonym="HuD"
                     /inference="alignment:Splign:2.1.0"
     exon            502..655
                     /gene="Elavl4"
                     /gene_synonym="HuD"
                     /inference="alignment:Splign:2.1.0"
     exon            656..881
                     /gene="Elavl4"
                     /gene_synonym="HuD"
                     /inference="alignment:Splign:2.1.0"
     exon            882..920
                     /gene="Elavl4"
                     /gene_synonym="HuD"
                     /inference="alignment:Splign:2.1.0"
     exon            921..3873
                     /gene="Elavl4"
                     /gene_synonym="HuD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttgtatg tgtagcttga gttgttgctt ccttctctgg gcagcagctc tgtaagaagg
       61 gaatgtcggc ttttacataa cgttcctctc tgcttttgac acactgtgtg agggtccatc
      121 ttctgatcac agatggagtg gaatggcttg aagatgataa ttagcaccat ggagcctcag
      181 gtgtcaaatg gaccgacatc caatacaagc aatggaccct ccagcaacaa cagaaactgt
      241 ccttctccca tgcagacagg cgctgccaca gacgacagca aaaccaacct catcgtcaac
      301 tatttacccc agaatatgac ccaagaggaa ttcaggagtc tctttgggag cattggtgaa
      361 atcgaatcct gcaaactcgt gagagacaaa attacaggac agagtttagg gtatggattt
      421 gttaactata ttgatccaaa ggatgcagag aaagccatca acactttaaa tggactcaga
      481 ctccagacca aaaccataaa ggtgtcgtac gcccgtccga gctcggcctc aatcagggat
      541 gctaacctgt acgttagtgg ccttcccaag accatgaccc agaaggagct ggagcagctt
      601 ttctctcagt acggtcgcat catcacctca cgcatcctgg ttgatcaagt cacaggagtc
      661 tctagagggg tgggattcat ccgctttgat aagaggattg aggcagaaga agccatcaaa
      721 gggctgaatg gccagaagcc cagcggtgct acagaaccga ttactgtgaa gtttgccaac
      781 aaccccagcc agaagtccag ccaggccctg ctctcccagc tgtaccagtc ccccaacagg
      841 cgataccctg gccctctcca ccaccaggct caaagattca ggctggacaa tttgcttaat
      901 atggcctatg gcgtaaagag actgatgtct ggaccagtcc ccccttctgc ttgtcccccc
      961 aggttctccc caatcaccat tgacgggatg acaagtcttg tgggaatgaa catccctggt
     1021 cacacaggga caggctggtg catcttcgtc tataacctgt cccctgattc tgatgagagt
     1081 gtcctctggc agctctttgg cccctttggc gcagtgaaca acgtcaaggt catccgtgac
     1141 ttcaacacca acaaatgcaa gggattcggc tttgtcacca tgaccaacta cgatgaggca
     1201 gccatggcca tcgccagcct caatggttac cgcctgggag acagagtgtt gcaagtttcc
     1261 tttaaaacca acaaagccca caagtcctga atttctcacc cttacttatt aaaaaatata
     1321 tataaatata tacgaacaaa acatgcgcgc acacacatac acaaaagaga gagacaaact
     1381 ttccaaggct tatattcaac catggacttt ataagcccgc gttgcctaag tattaaaaca
     1441 ttggattatc ctgaggtgta ccaggaaagg attttataat gcttagaaaa aaagaaaaaa
     1501 aaaacaaaaa aaataccttt gatgcattga atgttctttc atagctgtcg ttgttgaata
     1561 taatatacat agatagcaat gtgcagggat ttttacccag ccagctaact ttactacctt
     1621 ccttgaaggt gggtcttttt aagatgacca ttcgctcatt tgaagaagaa aaacaaaaaa
     1681 cacaaaaaaa taacaatttt tacaaagtaa tggaattcaa aggaagaaaa aaaagatttt
     1741 tcttttttgc caaaatgttg atccaatcag attggttaaa aacaccccca cacaaattaa
     1801 agaggaataa taaaaattgc aaaaattaaa aaaaaacttt tgcaaatttt tttatttttc
     1861 cttttttctt ttatatcatg tgaactaaaa cagtcttctg ttaggggacg gggaaagggg
     1921 gtacctgatg acattaacaa tttaataaca ttaacattgt tgccaaagag gtggtctctt
     1981 tgctgaaaat gggtttcaag aaaaatctat ttttataaaa tataaagaat ttttacaaga
     2041 gaatctggat ttgagaaaaa atattttgac tggctaattt aggggaaatt gacaactttg
     2101 tcgcgttcat actgcactgg taacttttta gagatcaaga tgtgtgtttt aaactggatt
     2161 cgtagactgt tttttgaagg atgggctata aacagatgat cttcatatct tttcatagca
     2221 tgtaataata ataaaaaata ttaattgcta ggggaaagga gtgttcgttc tacccagggt
     2281 accacagttc cccacagtca aaacccaaaa gcaaggagat gagttgaaag acagtttttc
     2341 tttaagtcat cagtatggga tgtcagcaga acaaaaatta aaaagattca ttttcctttt
     2401 aatctaaaac ttccttagtt tgagcagtag gtgctacaaa attatttaca tatcttagta
     2461 tcatagttaa atgtaaacgt gtttaggaga ggaaaaaaaa agatacattt gctttacatt
     2521 cattaagcaa ttttctaatt cactttgtag cccatgctga taaaattggg ctgtgtgggt
     2581 acatttgaaa cactgtttat gttgcttgaa acacttattt atttaattgc agatgtgatg
     2641 atgcctatgg ccaagatcaa atatagctag attggctaga ctacttgttt gtttacttaa
     2701 actttgggaa gaagcatatt attgtgtcct tctgttgtgt gtgtatgtgt atatataata
     2761 taaatatata tataaagtta ttttttcttt ggttaattta ttataagttg taacacttgg
     2821 ctagttttgt ttgtatatgt cttaaaatgt tttcttatga tatttaagtg acagttaaag
     2881 aggtatcaag gtaacttgtg tagaactatt gtttgatata ttgtcatgtt tgttgtgaat
     2941 attttttctt actgcacagt agaaaatttt aaaaaaaata ctgggtcttt attttaatgt
     3001 aattcagatt ggggaaaact aaacagagct aagggaacaa aaggactgtg ggagcaaact
     3061 cccacatcca gtgcactgat cattttagta cgtttgtgct ttgtacggtt atatatttaa
     3121 aacaaaaata aaacaaaaaa aaatccaaga gttcatgctc ttccctgggt aatagaaaca
     3181 gttactcgct atgcataatc tagttgatag taaaatttgc tattgctttt cttgtcttgt
     3241 tatataaaat cttttcaata caagtttagt cttaatggta ataaaacgtt atggttattt
     3301 ataacttgtg cttattttgt gcattttttc ccatgctgaa cccactaagt gcatgtagac
     3361 aggactgttg tttgcacact gaagaggcaa actttgtagt agtcgttgta gtggtagaca
     3421 gataacggaa accgaggctg catcatagac tactccttta aatttttttt ctattttttt
     3481 tcctcttttc ggtttttgga gaaaaataaa aacaccagat ttcagttcag agaacactcg
     3541 ttcaacattc agggaaacct ttatatgtca cctgctatga atgaatgcag tttgctggca
     3601 aagttctgat gcatttgctt agcattcatg ggaaaggcat gccaaaatct cttctctatg
     3661 atgtgttcaa tctgggggaa aaaaaaggaa aaaaaatctt aggaccaggc agttgtatac
     3721 tttagttaca aatgaatgac ttcatgttaa tcttgctagt ttagatgatt tctgagggaa
     3781 agtattgtaa atgttttttt ttcataatct tgttgtgttt gaattatttg tactttatct
     3841 gtccagacaa taaatgaaag tgtgtagaat gaa
//
