LOCUS       NM_001302217            4145 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus ELAV like RNA binding protein 2 (Elavl2), mRNA.
ACCESSION   NM_001302217 XM_006238391
VERSION     NM_001302217.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4145)
  AUTHORS   Cheng,N., Zhang,Z., Guo,Y., Qiu,Z.L., Du,J.Y., Hei,Z.Q. and Li,X.
  TITLE     Weighted gene co-expression network analysis reveals specific
            modules and hub genes related to neuropathic pain in dorsal root
            ganglions
  JOURNAL   Biosci Rep 39 (11) (2019)
   PUBMED   31696225
  REMARK    GeneRIF: Weighted gene co-expression network analysis reveals
            specific modules and hub genes related to neuropathic pain in
            dorsal root ganglions.
REFERENCE   2  (bases 1 to 4145)
  AUTHORS   Bayes,A., Collins,M.O., Reig-Viader,R., Gou,G., Goulding,D.,
            Izquierdo,A., Choudhary,J.S., Emes,R.D. and Grant,S.G.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4145)
  AUTHORS   Yamada,T., Yang,Y., Hemberg,M., Yoshida,T., Cho,H.Y., Murphy,J.P.,
            Fioravante,D., Regehr,W.G., Gygi,S.P., Georgopoulos,K. and Bonni,A.
  TITLE     Promoter decommissioning by the NuRD chromatin remodeling complex
            triggers synaptic connectivity in the mammalian brain
  JOURNAL   Neuron 83 (1), 122-134 (2014)
   PUBMED   24991957
REFERENCE   4  (bases 1 to 4145)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4145)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 4145)
  AUTHORS   Bitel,C.L., Perrone-Bizzozero,N.I. and Frederikse,P.H.
  TITLE     HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell
            identity are also utilized in the lens
  JOURNAL   Mol Vis 16, 2301-2316 (2010)
   PUBMED   21139978
  REMARK    GeneRIF: The predominant expression of REST4, HuB/C/D and nPTB in
            post-mitotic fiber cells, together with miR-124 expression in
            vertebrate lenses, was shown.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4145)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   8  (bases 1 to 4145)
  AUTHORS   Hambardzumyan,D., Sergent-Tanguy,S., Thinard,R., Bonnamain,V.,
            Masip,M., Fabre,A., Boudin,H., Neveu,I. and Naveilhan,P.
  TITLE     AUF1 and Hu proteins in the developing rat brain: implication in
            the proliferation and differentiation of neural progenitors
  JOURNAL   J Neurosci Res 87 (6), 1296-1309 (2009)
   PUBMED   19115409
  REMARK    GeneRIF: findings indicated a specific developmental pattern of
            expression of HuB in the postnatal cerebellum; data suggest
            critical roles for HuB at the very earliest stages of neuronal
            differentiation, such as cell cycle exit
REFERENCE   9  (bases 1 to 4145)
  AUTHORS   Fornaro,M., Raimondo,S., Lee,J.M. and Giacobini-Robecchi,M.G.
  TITLE     Neuron-specific Hu proteins sub-cellular localization in primary
            sensory neurons
  JOURNAL   Ann Anat 189 (3), 223-228 (2007)
   PUBMED   17534028
  REMARK    GeneRIF: Part of a family of RNa-binding proteins found in sensory
            neurons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jun 3, 2021 this sequence version replaced NM_001302217.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB098713.1, SRR26643298.27828.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-486               JAXUCZ010000005.1  111201802-111202287 c
            487-577             JAXUCZ010000005.1  111140327-111140417 c
            578-821             JAXUCZ010000005.1  111137305-111137548 c
            822-925             JAXUCZ010000005.1  111107519-111107622 c
            926-1079            JAXUCZ010000005.1  111089536-111089689 c
            1080-1305           JAXUCZ010000005.1  111086351-111086576 c
            1306-1344           JAXUCZ010000005.1  111080075-111080113 c
            1345-4145           JAXUCZ010000005.1  111076705-111079505 c
FEATURES             Location/Qualifiers
     source          1..4145
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q32"
     gene            1..4145
                     /gene="Elavl2"
                     /gene_synonym="Elav2; Hub"
                     /note="ELAV like RNA binding protein 2"
                     /db_xref="GeneID:286973"
                     /db_xref="RGD:628611"
     exon            1..486
                     /gene="Elavl2"
                     /gene_synonym="Elav2; Hub"
                     /inference="alignment:Splign:2.1.0"
     exon            487..577
                     /gene="Elavl2"
                     /gene_synonym="Elav2; Hub"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..1672
                     /gene="Elavl2"
                     /gene_synonym="Elav2; Hub"
                     /note="embryonic lethal, abnormal vision-like 2;
                     hu-antigen B; RNA binding protein HuB; ELAV (embryonic
                     lethal, abnormal vision, Drosophila)-like 2 (Hu antigen
                     B); ELAV like neuron-specific RNA binding protein 2"
                     /codon_start=1
                     /product="ELAV-like protein 2"
                     /protein_id="NP_001289146.1"
                     /db_xref="GeneID:286973"
                     /db_xref="RGD:628611"
                     /translation="MAVRLCDVASLLRSGSWAAEPWTGQVIAAMETQLSNGPTCNNTA
                     NGPTTVNNNCSSPVDSGNTEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRD
                     KITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSG
                     LPKTMTQKELEQLFSQYGRIITSRILVDQVTGISRGVGFIRFDKRIEAEEAIKGLNGQ
                     KPPGATEPITVKFANNPSQKTNQAILSQLYQSPNRRYPGPLAQQAQRFRLDNLLNMAY
                     GVKRFSPMTIDGMTSLAGINIPGHPGTGWCIFVYNLAPDADESILWQMFGPFGAVTNV
                     KVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTHKA"
     exon            578..821
                     /gene="Elavl2"
                     /gene_synonym="Elav2; Hub"
                     /inference="alignment:Splign:2.1.0"
     exon            822..925
                     /gene="Elavl2"
                     /gene_synonym="Elav2; Hub"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1079
                     /gene="Elavl2"
                     /gene_synonym="Elav2; Hub"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1305
                     /gene="Elavl2"
                     /gene_synonym="Elav2; Hub"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1344
                     /gene="Elavl2"
                     /gene_synonym="Elav2; Hub"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..4145
                     /gene="Elavl2"
                     /gene_synonym="Elav2; Hub"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggttggtg atacggtgct ataaatctgt ggtccagtcc acctcccttt taagacgtcc
       61 tcccccctta tttctgttct cacttagaga tgcagcagct tacttctgta gcgacctact
      121 aaaaagcaac acggagaaag acatcgtctt tttgaaaaaa cgttctttcg tctcttttct
      181 ttgttccttg gtttgttttt cttgcacctt tttgtttagt tgaacggcaa taggagtagt
      241 ctctccgtct ttttaaactc tcttttttaa gtttcccctc ccctttcata tttttttcat
      301 catttctttt agcattggac tttggggtcg aaagcatttc tttttatttg cttcttttaa
      361 gccgagcaca gtttaggttt cgtgctgtct taagagaact atccagcagc ttcttgctca
      421 tccttattgg gagaactgca ccgttacttt aaaaatacac acacacaaaa accttaaggg
      481 agaaagacgg caactccaaa ctaacatggc agtcagactg tgtgatgtgg cttctctgct
      541 tagaagcggt tcgtgggcag cagagccttg gaccgggcag gtaattgctg ccatggaaac
      601 acaactgtct aatgggccaa cttgcaataa cacagccaat ggtccaacca ctgtaaacaa
      661 caactgctcc tcaccagttg actccgggaa cacagaggac agcaagacca acctaatagt
      721 caactacctt cctcagaaca tgacacagga agaactaaag agtctttttg ggagcattgg
      781 cgagattgag tcctgtaagc ttgtaagaga caaaataaca gggcagagct tgggttacgg
      841 ctttgtgaac tacattgatc ccaaggatgc agagaaagcg atcaacactc tgaatggatt
      901 gagacttcaa accaaaacaa taaaagtttc ctatgctcgt ccaagttcag cttctatcag
      961 agatgcaaac ttatatgtca gtggtcttcc aaaaaccatg acccagaagg agctggagca
     1021 gctgttttca cagtatgggc gcatcattac ttctcggatt cttgtcgacc aggtcactgg
     1081 catatcaagg ggtgtagggt ttattcgatt tgacaagcgg attgaggcag aagaagctat
     1141 caaaggccta aatggccaga aacctcctgg tgccacagag ccaatcactg taaagtttgc
     1201 taataatcca agccaaaaaa ccaatcaggc catcctgtcc cagctgtacc agtctccaaa
     1261 cagaaggtac ccaggaccgc tagctcagca agcgcagcgc tttaggttgg acaatctgct
     1321 caatatggct tatggagtga agaggttttc accaatgacg attgatggaa tgaccagtct
     1381 ggctggaatt aatattcctg ggcaccctgg aacaggctgg tgcatatttg tgtacaacct
     1441 ggcgcctgat gcagacgaaa gtatcctgtg gcaaatgttt gggccttttg gagctgtcac
     1501 caacgtgaag gtcatccgtg actttaacac caataaatgc aaaggttttg gatttgtgac
     1561 tatgacaaac tatgatgagg ctgccatggc gatagctagc ctcaatggat accgtctggg
     1621 agacagagta ctgcaggtct cctttaagac aaacaaaacg cacaaagcct aatgagctcc
     1681 tgtcctcagt ccatttatat atgaaaacta tacaacacaa gcaagttaag agaaacttta
     1741 tacattagta aatgtctttg taagtcagtg ttgagatggg gataaatgac tacttagcat
     1801 cctaagaaat atgtgagatt ttttattgct agtatttgaa ttaaaacttc ttaaatatct
     1861 tttatgtttg aatatggaca agaggtacag ggtttttacc tgtcacattg cattctattg
     1921 ccttctttga agaaggtgga ccttttaaag tgtttcagct aagggaagac atttcttttc
     1981 tttttacata accgccttga gcctgtgagt aagtactgag gctttgtgtt gtagctcttc
     2041 agttggctgt ctttcccacc tccttagctt tccttctctt tctccttatt gtttttgttt
     2101 tttgtttttt ttttcctttc cattctctaa ttagctttgt gtttggttta catttaaagc
     2161 attgctgtta tgtctcagaa aagtattttg aagtttacat ttttatttat gaagttacaa
     2221 acagtattta ttttgtaatt ctgatttggg ctggggcagg gggggcgaca ttataaacgc
     2281 ttattgtaag aatactggag aacttttcgt aaagcagtac cttgccaaag agataagagc
     2341 ctctttgatg tgggtttaaa aaaagcatct atttttataa aaaagaaaat ttggagaaac
     2401 tttttactgg tcctggaaca aatattttga cttgaatact ttgagaaatc tcttcatatg
     2461 acacctagtg agcttttaaa atttaccagg aaatttgcaa cggttggaaa atttagaaag
     2521 atttatgatg tagaaaaata cttttgagat ctttgtatga gaggaattga gtcagtgagg
     2581 gaacactgct ggtttcattt tcgtaatcac cagtggggcg tctgatcatc ctggttgtta
     2641 tgtgatagat ggctcacatt gatttgtgat tttgaaacaa ataaaaaaat ttacaaaaga
     2701 atatataaga gcaggcaaga aatttaaatt accaagagat gggggaaaat ctgttcttcc
     2761 taaagaaatc ccttcagata gagctcatgg tgtttagtga tgtacttgca gtatcgtttg
     2821 aagaattgtt ttgtcttaag aaagatgaga tgttgcacac gtttggattg cagcaagtca
     2881 gcaaaggcga cctgagttgg atatatttga aggcattttg agagttatgt ttaaggctaa
     2941 cacctgagct ttgtgtgatg taaataagac cttgtgttta tgaacctttc agctaatttt
     3001 atttttttcc cttacatatc aagtgatgtt caggttttga atgttttgta tcagtttttt
     3061 tctttgtaaa tggcattaac attgttacct gaggtcttgc ttattcactt ctgttgtcct
     3121 gaggacttga atttacagtg catcagattc gttggctaat tctgtctgta gatagtctag
     3181 cttcagctgt ttatggtgat gctacatttt cgtttataaa tatgtttgtg gtaaaaaaaa
     3241 agaaaaatga gtataaccat aggttttgaa caaatttcct tacatttttc atacaaaatc
     3301 ataaatatct gtatgctatt gaaatttaac tttgtatgat gcttaaacca ctatttgggg
     3361 aaataataaa ataagtcttt accatgtatg aaagaaattt taaaaaatac aaaatatttt
     3421 ctgattagca tctagcttat aataaatttt caaaaaagct gaaggcaact gttgccttca
     3481 tcaggatgca ctgagaacta tatagttacg tcctgcgttt tgtataaact gagatgctca
     3541 tatgcttccc cttagaacag gcaatgtgct atgcataaca tagttgtaca ttatctttgc
     3601 agttgctttg agttttattt tttattattt aaaactgtag ttataaaaac ttttcagtat
     3661 agtgcagtac atatactgtg aggcgcgtgc tgaagtgaac aagcgagttt tcatgctgac
     3721 ccactcaatg ctactcagaa ctcaattggc ttagcacttt ctcatatcct taggtgcatt
     3781 tagattgtca gagttaacct gcgttaaaaa aaataaaata aaatacatgt atatattaaa
     3841 aaaaataagg tttcccttgt gggaaaacag cagctacacg cttctttcct gtactactgt
     3901 agcaaaccaa ggcattgatg agagggcatg caaattgtgc ttcactttac agtgtttatc
     3961 agagcactta ataaaatgta aggctggtat ttatttgaag ttgtacagta tgacttaatt
     4021 cccatctgtt ggaatagaaa atatattctg ttgagtattt aagaggctgt acatgttttc
     4081 ttttgtgttt gggttctttg tgctttttca tgttcggtac atcaataaac aaagttgaag
     4141 ggaaa
//
