LOCUS       NM_001106767             905 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus elastase, neutrophil expressed (Elane), mRNA.
ACCESSION   NM_001106767 XM_001077083 XM_234883
VERSION     NM_001106767.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 905)
  AUTHORS   Chen,L., Li,M., Lin,Y., Li,Y., Liang,M. and Zeng,K.
  TITLE     Neutrophil elastase in dexmedetomidine alleviating sepsis-related
            renal injury in rats
  JOURNAL   Int Immunopharmacol 122, 110441 (2023)
   PUBMED   37393835
  REMARK    GeneRIF: Neutrophil elastase in dexmedetomidine alleviating
            sepsis-related renal injury in rats.
            Erratum:[Int Immunopharmacol. 2024 Feb 15;128:111577. PMID:
            38281885]
REFERENCE   2  (bases 1 to 905)
  AUTHORS   Fraser,D.D., Cepinskas,G., Slessarev,M., Martin,C., Daley,M.,
            Miller,M.R., O'Gorman,D.B., Gill,S.E., Patterson,E.K. and Dos
            Santos,C.C.
  TITLE     Inflammation Profiling of Critically Ill Coronavirus Disease 2019
            Patients
  JOURNAL   Crit Care Explor 2 (6), e0144 (2020)
   PUBMED   32696007
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 905)
  AUTHORS   Horinokita,I., Hayashi,H., Oteki,R., Mizumura,R., Yamaguchi,T.,
            Usui,A., Yuan,B. and Takagi,N.
  TITLE     Involvement of Progranulin and Granulin Expression in Inflammatory
            Responses after Cerebral Ischemia
  JOURNAL   Int J Mol Sci 20 (20), 5210 (2019)
   PUBMED   31640144
  REMARK    GeneRIF: Study provides evidence that an increase in the activity
            of elastase to cleave PGRN, and to produce GRN, was involved in an
            inflammatory response at the early stages after cerebral ischemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 905)
  AUTHORS   Li,G., Jia,J., Ji,K., Gong,X., Wang,R., Zhang,X., Wang,H. and
            Zang,B.
  TITLE     The neutrophil elastase inhibitor, sivelestat, attenuates
            sepsis-related kidney injury in rats
  JOURNAL   Int J Mol Med 38 (3), 767-775 (2016)
   PUBMED   27430552
  REMARK    GeneRIF: Data show that sivelestat decreases neutrophil elastase
            (NE) expression in sepsis.
REFERENCE   5  (bases 1 to 905)
  AUTHORS   Vicuna,L., Strochlic,D.E., Latremoliere,A., Bali,K.K.,
            Simonetti,M., Husainie,D., Prokosch,S., Riva,P., Griffin,R.S.,
            Njoo,C., Gehrig,S., Mall,M.A., Arnold,B., Devor,M., Woolf,C.J.,
            Liberles,S.D., Costigan,M. and Kuner,R.
  TITLE     The serine protease inhibitor SerpinA3N attenuates neuropathic pain
            by inhibiting T cell-derived leukocyte elastase
  JOURNAL   Nat Med 21 (5), 518-523 (2015)
   PUBMED   25915831
  REMARK    GeneRIF: SerpinA3N attenuates neuropathic pain by inhibiting T
            cell-derived leukocyte elastase
REFERENCE   6  (bases 1 to 905)
  AUTHORS   Taoka,Y., Okajima,K., Murakami,K., Johno,M. and Naruo,M.
  TITLE     Role of neutrophil elastase in compression-induced spinal cord
            injury in rats
  JOURNAL   Brain Res 799 (2), 264-269 (1998)
   PUBMED   9675307
  REMARK    Erratum:[Brain Res. 2011 Aug 23;1408:98]
REFERENCE   7  (bases 1 to 905)
  AUTHORS   Belaaouaj,A., McCarthy,R., Baumann,M., Gao,Z., Ley,T.J.,
            Abraham,S.N. and Shapiro,S.D.
  TITLE     Mice lacking neutrophil elastase reveal impaired host defense
            against gram negative bacterial sepsis
  JOURNAL   Nat Med 4 (5), 615-618 (1998)
   PUBMED   9585238
REFERENCE   8  (bases 1 to 905)
  AUTHORS   Guo,L., Yamaguchi,Y., Ikei,S., Sugita,H. and Ogawa,M.
  TITLE     Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage
            induced by lipopolysaccharide in rat model of cerulein pancreatitis
  JOURNAL   Dig Dis Sci 40 (10), 2177-2183 (1995)
   PUBMED   7587785
REFERENCE   9  (bases 1 to 905)
  AUTHORS   Crinnion,J.N., Homer-Vanniasinkam,S., Hatton,R., Parkin,S.M. and
            Gough,M.J.
  TITLE     Role of neutrophil depletion and elastase inhibition in modifying
            skeletal muscle reperfusion injury
  JOURNAL   Cardiovasc Surg 2 (6), 749-753 (1994)
   PUBMED   7858993
REFERENCE   10 (bases 1 to 905)
  AUTHORS   Brower,M.S. and Harpel,P.C.
  TITLE     Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor
            and C1 inactivator by human polymorphonuclear leukocyte elastase
  JOURNAL   J Biol Chem 257 (16), 9849-9854 (1982)
   PUBMED   6980881
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474029.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_234883.2, XM_001077083.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680421,
                              SAMN06680426 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..905
                     /gene="Elane"
                     /gene_synonym="Ela2"
                     /note="elastase, neutrophil expressed"
                     /db_xref="GeneID:299606"
                     /db_xref="RGD:1307968"
     exon            1..87
                     /gene="Elane"
                     /gene_synonym="Ela2"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..827
                     /gene="Elane"
                     /gene_synonym="Ela2"
                     /EC_number="3.4.21.37"
                     /note="neutrophil elastase; elastase 2, neutrophil"
                     /codon_start=1
                     /product="neutrophil elastase precursor"
                     /protein_id="NP_001100237.1"
                     /db_xref="GeneID:299606"
                     /db_xref="RGD:1307968"
                     /translation="MQPTMALHRPSNQTLASMLLALLLVCPALASEIVGGRPAQPHAW
                     PFMVSLQRRGGHFCGATLIARNFVMSAAHCVNGRNFQSVQVVLGAHDLRRREPTRQIF
                     SVQRIFENGFDPSRLLNDIVIIQLNGSATINANVQVAELPAQGQGVGNRTPCVAMGWG
                     RLGTNRPLPSVLQELNVTVVTNLCRRRVNVCTLVPRRQAGICFGDSGGPLVCNNLVQG
                     IDSFIRGGCGSGFYPDAFAPVAEFADWINSIIRSHDDRPLTNPKDREREGRTN"
     exon            88..244
                     /gene="Elane"
                     /gene_synonym="Ela2"
                     /inference="alignment:Splign:2.1.0"
     exon            245..386
                     /gene="Elane"
                     /gene_synonym="Ela2"
                     /inference="alignment:Splign:2.1.0"
     exon            387..620
                     /gene="Elane"
                     /gene_synonym="Ela2"
                     /inference="alignment:Splign:2.1.0"
     exon            621..905
                     /gene="Elane"
                     /gene_synonym="Ela2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccacgag aatgcagccc accatggctc tccaccgacc atccaaccag actctggctt
       61 ccatgctgct ggccttgctc ctggtctgtc cagcactggc ctcagagatt gttggtggcc
      121 ggccagccca gccccatgct tggcccttca tggtgtccct gcagcggcgt ggaggtcact
      181 tctgtggtgc cacactcatt gccaggaact tcgtcatgtc agcagcccac tgtgtgaatg
      241 gccgaaattt ccagtcagtg caagtggtgc tgggagccca tgacctgcgg cgacgggagc
      301 ccactcgaca aatcttctct gtgcagcgca tctttgagaa cggctttgac ccgtcacgtc
      361 tcctgaatga cattgtgatt atccagctca atggctcagc taccattaac gccaatgtgc
      421 aggtggctga gctgcctgcc cagggccagg gcgtgggtaa cagaactccg tgtgtggcca
      481 tgggctgggg caggttgggc acaaacagac cgttgcccag tgtgctccaa gagctcaatg
      541 tgacagtggt gactaacctg tgccgccgac gtgtgaatgt atgcactctg gtgccacgcc
      601 ggcaggcagg catctgcttt ggggactctg gtggaccctt ggtctgtaac aaccttgtcc
      661 aaggcattga ctccttcatc cgaggaggct gtggatctgg attctaccca gatgccttcg
      721 cccctgtggc tgagtttgca gactggatca attccattat ccgcagccat gatgaccggc
      781 cacttaccaa tcccaaagac cgagagagag agggcaggac caactaaggc ccgtcccccc
      841 gtcccccacc atagacctca ggcaccctcc ccattttatc acaataaaag caacctttgt
      901 tttgt
//
