LOCUS       NM_001037352            1254 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 6
            (Eif6), mRNA.
ACCESSION   NM_001037352 XM_223613
VERSION     NM_001037352.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1254)
  AUTHORS   Shen,C., Peng,C., Zhang,S., Li,R., Liu,S., Kuang,Y., Su,F., Liu,Y.,
            Liang,L., Xiao,Y. and Xu,H.
  TITLE     Eukaryotic translation initiation factor 6-mediated ribosome
            biogenesis promotes synovial aggression and inflammation by
            increasing the translation of SP1 in rheumatoid arthritis
  JOURNAL   Int Immunopharmacol 142 (Pt B), 113164 (2024)
   PUBMED   39288622
  REMARK    GeneRIF: Eukaryotic translation initiation factor 6-mediated
            ribosome biogenesis promotes synovial aggression and inflammation
            by increasing the translation of SP1 in rheumatoid arthritis.
REFERENCE   2  (bases 1 to 1254)
  AUTHORS   Romano,N., Ricciardi,S., Gallo,P. and Ceci,M.
  TITLE     Upregulation of eIF6 inhibits cardiac hypertrophy induced by
            phenylephrine
  JOURNAL   Biochem Biophys Res Commun 495 (1), 601-606 (2018)
   PUBMED   29128355
  REMARK    GeneRIF: Thus, this work uncovers a new translational cardiac
            regulator independent by other well-known factors such as mTOR
            signalling or eIF2beta.
REFERENCE   3  (bases 1 to 1254)
  AUTHORS   Ricciardi,S., Miluzio,A., Brina,D., Clarke,K., Bonomo,M.,
            Aiolfi,R., Guidotti,L.G., Falciani,F. and Biffo,S.
  TITLE     Eukaryotic translation initiation factor 6 is a novel regulator of
            reactive oxygen species-dependent megakaryocyte maturation
  JOURNAL   J Thromb Haemost 13 (11), 2108-2118 (2015)
   PUBMED   26391622
REFERENCE   4  (bases 1 to 1254)
  AUTHORS   Brina,D., Miluzio,A., Ricciardi,S., Clarke,K., Davidsen,P.K.,
            Viero,G., Tebaldi,T., Offenhauser,N., Rozman,J., Rathkolb,B.,
            Neschen,S., Klingenspor,M., Wolf,E., Gailus-Durner,V., Fuchs,H.,
            Hrabe de Angelis,M., Quattrone,A., Falciani,F. and Biffo,S.
  TITLE     eIF6 coordinates insulin sensitivity and lipid metabolism by
            coupling translation to transcription
  JOURNAL   Nat Commun 6, 8261 (2015)
   PUBMED   26383020
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1254)
  AUTHORS   Finch,A.J., Hilcenko,C., Basse,N., Drynan,L.F., Goyenechea,B.,
            Menne,T.F., Gonzalez Fernandez,A., Simpson,P., D'Santos,C.S.,
            Arends,M.J., Donadieu,J., Bellanne-Chantelot,C., Costanzo,M.,
            Boone,C., McKenzie,A.N., Freund,S.M. and Warren,A.J.
  TITLE     Uncoupling of GTP hydrolysis from eIF6 release on the ribosome
            causes Shwachman-Diamond syndrome
  JOURNAL   Genes Dev 25 (9), 917-929 (2011)
   PUBMED   21536732
REFERENCE   6  (bases 1 to 1254)
  AUTHORS   Miluzio,A., Beugnet,A., Volta,V. and Biffo,S.
  TITLE     Eukaryotic initiation factor 6 mediates a continuum between 60S
            ribosome biogenesis and translation
  JOURNAL   EMBO Rep 10 (5), 459-465 (2009)
   PUBMED   19373251
  REMARK    Review article
REFERENCE   7  (bases 1 to 1254)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 1254)
  AUTHORS   Chendrimada,T.P., Finn,K.J., Ji,X., Baillat,D., Gregory,R.I.,
            Liebhaber,S.A., Pasquinelli,A.E. and Shiekhattar,R.
  TITLE     MicroRNA silencing through RISC recruitment of eIF6
  JOURNAL   Nature 447 (7146), 823-828 (2007)
   PUBMED   17507929
REFERENCE   9  (bases 1 to 1254)
  AUTHORS   Bohnsack,M.T., Regener,K., Schwappach,B., Saffrich,R.,
            Paraskeva,E., Hartmann,E. and Gorlich,D.
  TITLE     Exp5 exports eEF1A via tRNA from nuclei and synergizes with other
            transport pathways to confine translation to the cytoplasm
  JOURNAL   EMBO J 21 (22), 6205-6215 (2002)
   PUBMED   12426392
REFERENCE   10 (bases 1 to 1254)
  AUTHORS   Biffo,S., Sanvito,F., Costa,S., Preve,L., Pignatelli,R.,
            Spinardi,L. and Marchisio,P.C.
  TITLE     Isolation of a novel beta4 integrin-binding protein (p27(BBP))
            highly expressed in epithelial cells
  JOURNAL   J Biol Chem 272 (48), 30314-30321 (1997)
   PUBMED   9374518
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105764.1.
            
            On Nov 25, 2005 this sequence version replaced XM_223613.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105764.1, FQ225904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1254
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1254
                     /gene="Eif6"
                     /gene_synonym="eIF-6; Itgb4bp"
                     /note="eukaryotic translation initiation factor 6"
                     /db_xref="GeneID:305506"
                     /db_xref="RGD:1305373"
     exon            1..332
                     /gene="Eif6"
                     /gene_synonym="eIF-6; Itgb4bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..963
                     /gene="Eif6"
                     /gene_synonym="eIF-6; Itgb4bp"
                     /EC_number="3.6.5.3"
                     /note="integrin beta 4 binding protein"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 6"
                     /protein_id="NP_001032429.1"
                     /db_xref="GeneID:305506"
                     /db_xref="RGD:1305373"
                     /translation="MAVRASFENNCEVGCFAKLTNTYCLVAIGGSENFYSVFEGELSD
                     TIPVVHASIAGCRIIGRMCVGNRHGLLVPNNTTDQELQHIRNSLPDSVQIRRVEERLS
                     ALGNVTTCNDYVALVHPDLDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGL
                     VHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVV
                     ESVFKLNEAKPSTIATSMRDSLIDSLT"
     exon            333..418
                     /gene="Eif6"
                     /gene_synonym="eIF-6; Itgb4bp"
                     /inference="alignment:Splign:2.1.0"
     exon            419..594
                     /gene="Eif6"
                     /gene_synonym="eIF-6; Itgb4bp"
                     /inference="alignment:Splign:2.1.0"
     exon            595..771
                     /gene="Eif6"
                     /gene_synonym="eIF-6; Itgb4bp"
                     /inference="alignment:Splign:2.1.0"
     exon            772..953
                     /gene="Eif6"
                     /gene_synonym="eIF-6; Itgb4bp"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1225
                     /gene="Eif6"
                     /gene_synonym="eIF-6; Itgb4bp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggagtcgtt tggtgaactg gtggggctct gggaggcaaa ggtcagttcc gggccgtagg
       61 gcgggaggct ttggggcaag agagtcagga aggatcccgc ggacgagacc cgggatctga
      121 ggggtttgag agggcggggc ttgaggaagc gaagctggtt gacccggctc ctgagtggat
      181 ctgtcggccc agaacccgca gtcgtgcagc ccccaggttt ctttcatggc ggtcagagcg
      241 tcgttcgaga acaactgtga ggtcggttgt tttgccaaac tcactaacac ctactgcctg
      301 gtggccatcg gagggtcaga gaacttctac agtgtgttcg agggcgagct ctccgatacc
      361 attcctgtag tgcacgcatc catcgccggc tgccgaatca tcgggcgcat gtgtgtgggg
      421 aacaggcatg ggctgctggt acccaacaac accaccgacc aggagctgca gcatatccgc
      481 aacagccttc cggattcagt gcagatacgg cgggtagagg agcggctctc agcccttggc
      541 aatgtcacca cctgcaatga ctatgtggcc ttggtccacc cagacttgga tagggagaca
      601 gaagaaatcc tggctgatgt gctcaaggtg gaagtcttca ggcagacggt tgctgaccag
      661 gtgttagttg gaagctactg tgtcttcagt aatcaaggag gtctggtgca ccctaaaact
      721 tcgatcgagg atcaggatga gctgtcctcc cttcttcagg ttccccttgt ggcaggcact
      781 gtgaaccgag ggagcgaggt gattgctgcc gggatggtag tgaatgattg gtgtgctttc
      841 tgtggcctgg acacgaccag cacagagctg tcagtggtgg agagtgtctt caagctgaat
      901 gaagccaaac ctagcaccat tgccaccagc atgcgggact ccctcattga cagcctcaca
      961 tgagtcacct tccgtgctgt cgtgtgggct cctgcctctg gactttggct cgttttccac
     1021 gcctgagtta gtctgtacca gatgctgtca gtggggcgtg gcagagctca ccagagctga
     1081 attgtttgcc caacccttca cctgtgccat ctcaactatt gttaccgaaa agcctgccgc
     1141 gtcacgctgg cttcagttcc tgtggctctt ggatggaagt tctgctatct tgtgccccac
     1201 cccattaaag gactgcctcc caccaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
