LOCUS       NM_001033681            1199 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 5A
            (Eif5a), mRNA.
ACCESSION   NM_001033681 XM_213368
VERSION     NM_001033681.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1199)
  AUTHORS   Lemay,S.E., Grobs,Y., Romanet,C., Martineau,S., Salem,M.,
            Shimauchi,T., Breuils-Bonnet,S., Bourgeois,A., Theberge,C.,
            Pelletier,A., Potus,F., Provencher,S., Bonnet,S. and Boucherat,O.
  TITLE     Hypusine Signaling Promotes Pulmonary Vascular Remodeling in
            Pulmonary Arterial Hypertension
  JOURNAL   Am J Respir Crit Care Med 209 (11), 1376-1391 (2024)
   PUBMED   38261723
REFERENCE   2  (bases 1 to 1199)
  AUTHORS   Lyu,Q., Zou,H., Luo,L., Liu,W., He,X. and Shang,F.F.
  TITLE     The Role of eIF5A1 in LPS-Induced Neuronal Remodeling of the
            Nucleus Accumbens in the Depression
  JOURNAL   J Integr Neurosci 22 (1), 14 (2023)
   PUBMED   36722231
  REMARK    GeneRIF: The Role of eIF5A1 in LPS-Induced Neuronal Remodeling of
            the Nucleus Accumbens in the Depression.
REFERENCE   3  (bases 1 to 1199)
  AUTHORS   Gulappa,T., Menon,B. and Menon,K.M.J.
  TITLE     LHCGR Expression During Follicle Stimulating Hormone-Induced
            Follicle Growth Is Negatively Regulated by Eukaryotic Initiation
            Factor 5A
  JOURNAL   Endocrinology 158 (8), 2672-2679 (2017)
   PUBMED   28605466
  REMARK    GeneRIF: The results of this study support the notion that by
            inhibiting eIF5A hypusination, FSH reduces the expression of an
            LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR
            mRNA expression by abrogating the inhibitory action of LRBP.
REFERENCE   4  (bases 1 to 1199)
  AUTHORS   Yao,T., Fujimura,T., Murayama,K. and Seko,Y.
  TITLE     Plasma levels of oxidative stress-responsive apoptosis inducing
            protein (ORAIP) in rats subjected to physicochemical oxidative
            stresses
  JOURNAL   Biosci Rep 36 (2), e00317 (2016)
   PUBMED   26934977
  REMARK    GeneRIF: secretion of ORAIP in response to oxidative stress is
            universal mechanism and plays an essential role. ORAIP will be an
            important novel biomarker as well as a specific therapeutic target
            of these oxidative stress-induced cell injuries.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1199)
  AUTHORS   Shang,F.F., Xia,Q.J., Liu,W., Xia,L., Qian,B.J., You,L., He,M.,
            Yang,J.L. and Wang,T.H.
  TITLE     miR-434-3p and DNA hypomethylation co-regulate eIF5A1 to increase
            AChRs and to improve plasticity in SCT rat skeletal muscle
  JOURNAL   Sci Rep 6, 22884 (2016)
   PUBMED   26964899
  REMARK    GeneRIF: Overexpression or knockdown of miR-434-3p in vivo
            demonstrated it was a negative post-transcriptional regulator of
            eIF5A1 expression and influenced AChRs expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1199)
  AUTHORS   Rosorius,O., Reichart,B., Kratzer,F., Heger,P., Dabauvalle,M.C. and
            Hauber,J.
  TITLE     Nuclear pore localization and nucleocytoplasmic transport of
            eIF-5A: evidence for direct interaction with the export receptor
            CRM1
  JOURNAL   J Cell Sci 112 (Pt 14), 2369-2380 (1999)
   PUBMED   10381392
REFERENCE   7  (bases 1 to 1199)
  AUTHORS   Schatz,O., Oft,M., Dascher,C., Schebesta,M., Rosorius,O.,
            Jaksche,H., Dobrovnik,M., Bevec,D. and Hauber,J.
  TITLE     Interaction of the HIV-1 rev cofactor eukaryotic initiation factor
            5A with ribosomal protein L5
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1607-1612 (1998)
   PUBMED   9465063
REFERENCE   8  (bases 1 to 1199)
  AUTHORS   Tome,M.E., Fiser,S.M., Payne,C.M. and Gerner,E.W.
  TITLE     Excess putrescine accumulation inhibits the formation of modified
            eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis
  JOURNAL   Biochem J 328 (Pt 3) (Pt 3), 847-854 (1997)
   PUBMED   9396730
REFERENCE   9  (bases 1 to 1199)
  AUTHORS   Liu,Y.P., Nemeroff,M., Yan,Y.P. and Chen,K.Y.
  TITLE     Interaction of eukaryotic initiation factor 5A with the human
            immunodeficiency virus type 1 Rev response element RNA and U6 snRNA
            requires deoxyhypusine or hypusine modification
  JOURNAL   Biol Signals 6 (3), 166-174 (1997)
   PUBMED   9285100
REFERENCE   10 (bases 1 to 1199)
  AUTHORS   Bevec,D., Jaksche,H., Oft,M., Wohl,T., Himmelspach,M., Pacher,A.,
            Schebesta,M., Koettnitz,K., Dobrovnik,M., Csonga,R., Lottspeich,F.
            and Hauber,J.
  TITLE     Inhibition of HIV-1 replication in lymphocytes by mutants of the
            Rev cofactor eIF-5A
  JOURNAL   Science 271 (5257), 1858-1860 (1996)
   PUBMED   8596953
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001033681.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101891.1, FQ220539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840117
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                JAXUCZ010000010.1  55143131-55143221   c
            92-277              JAXUCZ010000010.1  55141226-55141411   c
            278-382             JAXUCZ010000010.1  55139996-55140100   c
            383-514             JAXUCZ010000010.1  55139694-55139825   c
            515-588             JAXUCZ010000010.1  55139530-55139603   c
            589-1199            JAXUCZ010000010.1  55138821-55139431   c
FEATURES             Location/Qualifiers
     source          1..1199
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1199
                     /gene="Eif5a"
                     /note="eukaryotic translation initiation factor 5A"
                     /db_xref="GeneID:287444"
                     /db_xref="RGD:1308029"
     exon            1..91
                     /gene="Eif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            92..277
                     /gene="Eif5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..577
                     /gene="Eif5a"
                     /note="eIF-4D; eIF-5A; eIF-5A1; eIF-5A-1; eukaryotic
                     initiation factor 5A"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 5A-1"
                     /protein_id="NP_001028853.1"
                     /db_xref="GeneID:287444"
                     /db_xref="RGD:1308029"
                     /translation="MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMS
                     TSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLL
                     QDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK"
     exon            278..382
                     /gene="Eif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            383..514
                     /gene="Eif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            515..588
                     /gene="Eif5a"
                     /inference="alignment:Splign:2.1.0"
     exon            589..1199
                     /gene="Eif5a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcggcg gcagcagcac agtagcgggt tcggaggcag cagttgggct cgcggcgagc
       61 ggaccaggtc gagtcagtgc gttcgcgcga gttggaatcg aagcctctta aaatggcaga
      121 tgatttggac ttcgagacag gagatgcagg ggcctcagcc accttcccaa tgcagtgctc
      181 agcattacgt aagaatggtt ttgtggtgct caagggccgg ccatgtaaga tcgtcgagat
      241 gtctacttcg aagactggca agcatggcca tgccaaggtc catctggttg gtattgatat
      301 ttttactggg aagaaatatg aagatatctg cccgtcgact cataacatgg atgtccccaa
      361 catcaaaagg aatgatttcc agctgattgg catccaggat gggtacctat ccctgctcca
      421 ggacagtggg gaggtacgag aggaccttcg tctgcctgag ggagaccttg gcaaggagat
      481 tgagcagaag tatgactgtg gagaagagat cctgatcaca gtgctgtccg ccatgacaga
      541 ggaggcagct gttgcaatca aggccatggc aaaataactg gcttccaggg tggcggtggt
      601 ggcagcagtg atccatgagc ctacagaggc ccctccccca gctctggctg ggcccttggc
      661 tggactccta tccaatttat ttgacgtttt attttggttt tcctcacccc ttcaaactgt
      721 cggggagacc ctgcccttca cctagctccc ttggccaggc atgagggagc catggccttg
      781 gtgaagctac ctgcctcttc tctcgcagcc ctgatggggg aaagggagtg ggtactgcct
      841 gtggtttagg ttcccctctc cctttttctt tttaattcaa tttggaatca gaaagctgtg
      901 gattctggca aatggtcttg tgtcctttat cccactcaaa cccatctggt cccctgttct
      961 ccatagtcct tcacccccaa gcaccactgt acagactggg gaccagcccc cttccctgcc
     1021 tgtgtctctt cccaaacccc tctatagggg tgacaagaag agggggggga ggggacacga
     1081 tccctcctca ggcatctggg aaggccttgc ccccatgggc tttacccttt cctgtgggct
     1141 ttctccctga cacatttgtt aaaaatcaaa cctgaataaa actacaagtt taatatgaa
//
