LOCUS       NM_001329879            3734 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 5
            (Eif5), mRNA.
ACCESSION   NM_001329879 XM_006240608
VERSION     NM_001329879.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3734)
  AUTHORS   Andreev,D.E., O'Connor,P.B., Zhdanov,A.V., Dmitriev,R.I.,
            Shatsky,I.N., Papkovsky,D.B. and Baranov,P.V.
  TITLE     Oxygen and glucose deprivation induces widespread alterations in
            mRNA translation within 20 minutes
  JOURNAL   Genome Biol 16 (1), 90 (2015)
   PUBMED   25943107
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3734)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3734)
  AUTHORS   Hinnebusch,A.G.
  TITLE     The scanning mechanism of eukaryotic translation initiation
  JOURNAL   Annu Rev Biochem 83, 779-812 (2014)
   PUBMED   24499181
  REMARK    Review article
REFERENCE   4  (bases 1 to 3734)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3734)
  AUTHORS   Loughran,G., Sachs,M.S., Atkins,J.F. and Ivanov,I.P.
  TITLE     Stringency of start codon selection modulates autoregulation of
            translation initiation factor eIF5
  JOURNAL   Nucleic Acids Res 40 (7), 2898-2906 (2012)
   PUBMED   22156057
REFERENCE   6  (bases 1 to 3734)
  AUTHORS   Bohnsack,M.T., Regener,K., Schwappach,B., Saffrich,R.,
            Paraskeva,E., Hartmann,E. and Gorlich,D.
  TITLE     Exp5 exports eEF1A via tRNA from nuclei and synergizes with other
            transport pathways to confine translation to the cytoplasm
  JOURNAL   EMBO J 21 (22), 6205-6215 (2002)
   PUBMED   12426392
REFERENCE   7  (bases 1 to 3734)
  AUTHORS   Majumdar,R., Bandyopadhyay,A., Deng,H. and Maitra,U.
  TITLE     Phosphorylation of mammalian translation initiation factor 5 (eIF5)
            in vitro and in vivo
  JOURNAL   Nucleic Acids Res 30 (5), 1154-1162 (2002)
   PUBMED   11861906
REFERENCE   8  (bases 1 to 3734)
  AUTHORS   Das,S. and Maitra,U.
  TITLE     Mutational analysis of mammalian translation initiation factor 5
            (eIF5): role of interaction between the beta subunit of eIF2 and
            eIF5 in eIF5 function in vitro and in vivo
  JOURNAL   Mol Cell Biol 20 (11), 3942-3950 (2000)
   PUBMED   10805737
REFERENCE   9  (bases 1 to 3734)
  AUTHORS   Das,S., Maiti,T., Das,K. and Maitra,U.
  TITLE     Specific interaction of eukaryotic translation initiation factor 5
            (eIF5) with the beta-subunit of eIF2
  JOURNAL   J Biol Chem 272 (50), 31712-31718 (1997)
   PUBMED   9395514
REFERENCE   10 (bases 1 to 3734)
  AUTHORS   Das,K., Chevesich,J. and Maitra,U.
  TITLE     Molecular cloning and expression of cDNA for mammalian translation
            initiation factor 5
  JOURNAL   Proc Natl Acad Sci U S A 90 (7), 3058-3062 (1993)
   PUBMED   8464924
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Mar 9, 2022 this sequence version replaced NM_001329879.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062398.1, SRR26643298.37217.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000006.1  136410333-136410383
            52-245              JAXUCZ010000006.1  136410499-136410692
            246-525             JAXUCZ010000006.1  136411546-136411825
            526-607             JAXUCZ010000006.1  136411959-136412040
            608-780             JAXUCZ010000006.1  136412296-136412468
            781-892             JAXUCZ010000006.1  136412630-136412741
            893-1032            JAXUCZ010000006.1  136414007-136414146
            1033-1191           JAXUCZ010000006.1  136414417-136414575
            1192-1353           JAXUCZ010000006.1  136415028-136415189
            1354-1518           JAXUCZ010000006.1  136415437-136415601
            1519-1653           JAXUCZ010000006.1  136415861-136415995
            1654-3734           JAXUCZ010000006.1  136416747-136418827
FEATURES             Location/Qualifiers
     source          1..3734
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..3734
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /note="eukaryotic translation initiation factor 5"
                     /db_xref="GeneID:108348073"
                     /db_xref="RGD:619861"
     exon            1..51
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            52..245
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            246..525
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..1743
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /note="eukaryotic initiation factor 5; eukaryotic
                     initiation factor 5 (eIF-5)"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 5"
                     /protein_id="NP_001316808.1"
                     /db_xref="GeneID:108348073"
                     /db_xref="RGD:619861"
                     /translation="MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAK
                     ALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPEC
                     ENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDIGTGKKEKEK
                     KNRKGKDKENGSVSTSETPPPPPPNEISPPHAVEEEEDDDWGEDTTEEAQRRRMDEIS
                     DHAKGLTLSDDLERTVEERVNILFDFVKKKKEEGIIDSSDKDIVAEAERLDVKAMGPL
                     VLTEVLFDEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHI
                     LKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEE
                     EDEDENIEVVYSKTASVPKVETVKSDNKDDDIDIDAI"
     exon            526..607
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            608..780
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            781..892
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1032
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1191
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1353
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1518
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1653
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..3734
                     /gene="Eif5"
                     /gene_synonym="eIF-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcttgagcg cggcggcggc gttgttcagt cagagcgaga acattccaga ggtcgccagg
       61 ttcggcgctg ctggtgtgga cgcggacgtc gctgggacag tccctcccgc tgctaggcgg
      121 cggcacctgc ccagccgccc ctccgctcgc cgccggcccc gtcgctccgg acccggtttc
      181 cagcgcctct tcctcccagt cccgggcgag ccgcgttggg tttatgtctt tatttgacga
      241 aaacgagctg ttgcgcagcc attggtacct gtattgggga aacatagcat acaagcaaga
      301 agcttacagc ctcagtggcg aaaaattttt catgtcagag accgagaact cttgcagtcg
      361 tttatgtcat cccttcttct ccagacagaa gataccaaaa agttgcaatc aaagatctgt
      421 tcatcttatt gataaagtca ctaataagcc aaaatgtctg tcaacgtcaa ccgcagcgtg
      481 tcagaccagt tctatcgcta caagatgccc cgtttgattg ctaaggttga gggcaaagga
      541 aatggaatca agacagttat agtcaacatg gttgacgttg caaaggcgct taatcggcct
      601 ccaacgtatc ccaccaaata ttttggttgt gagctgggag cacagaccca gtttgatgtt
      661 aagaatgacc gttacattgt caatggatct catgaggcga ataagctgca agacatgttg
      721 gatggattca ttaaaaaatt tgttctctgt cctgagtgtg agaatcctga aacagatctg
      781 catgtcaatc caaagaagca aacaataggt aattcttgta aagcctgtgg gtaccgaggc
      841 atgcttgaca cacatcataa actctgtaca ttcattctca aaaacccacc tgagaatagt
      901 gacattggta caggaaagaa agagaaagaa aagaaaaata gaaagggcaa ggacaaggaa
      961 aatggctctg tatccaccag tgagacacca ccacctccac caccaaatga aattagtcct
     1021 ccacatgctg tggaagaaga ggaagatgat gattgggggg aggatacaac tgaggaagct
     1081 caaaggcgca gaatggatga aatcagtgac catgcaaaag gtctgacact tagcgatgat
     1141 ttggaaagaa ctgtagaaga gcgtgttaac atcctgtttg attttgttaa gaaaaagaaa
     1201 gaagagggca ttattgattc atctgataaa gacattgtgg ctgaggcaga aagactggat
     1261 gtaaaagcca tgggccctct cgttttgaca gaagttctct ttgatgagaa gataagagag
     1321 caaatcaaga aatacaggcg ccatttttta agattttgtc ataacaacaa aaaggcccag
     1381 cggtaccttc ttcatggttt ggaatgtgtg gtagcaatgc atcaagctca gttgatctcc
     1441 aagattccac atatcttgaa ggagatgtat gatgcagacc ttttagagga agaggtcatt
     1501 atcagctggt cagaaaaggc ctctaagaaa tatgtctcaa aagaacttgc caaagagatt
     1561 cgtgtcaaag cagagccatt tattaaatgg ttgaaggaag cggaggagga atcttctggt
     1621 ggtgaggaag aagacgaaga tgaaaatatt gaggtggtat attcgaagac tgccagtgta
     1681 ccaaaagttg aaactgtgaa gtctgacaac aaggatgacg acattgatat tgatgccatt
     1741 taaaaggatg gatgcaactt agcttaacag tgtaatgctg caaatttttc tccattatca
     1801 gccagaagtg caacatgtat gtgcaagagc taaagtggtt taacatcatg ctacacttga
     1861 tactaaaaag ctattactgt gagtggtcta taattaagcc caatgagaca tctagggagt
     1921 ccatacatat cagtgagcag ttgtagtttg cttatttata gcatgtttct ttcggaaaaa
     1981 ctagtggtgg acacatttgg atcacattta tacagttata aaaaataaag atttgatttt
     2041 ggtcattctt cagactttgg gctatgaatg gcttatgctg aagtaattgg ctacttttag
     2101 gatgttacac catttaataa cttagacttc ttaagtttgg tagattgtta ggtactgaag
     2161 acttgaagaa tgcaaacaat tataatgacc ttactcagcc attaagaaat gaagtatttt
     2221 gaaagttgtg tctccagtcc attgagattg gcaactgaca attcttgtca ttctaaggaa
     2281 atttgatgat ttaatgacag tgtgacatcc tcatgagaag taaaaatgac ctgtgtgtcc
     2341 tatggtttaa gagcaaattt tgaaacttgg agttgtggtt tttcagtttg tgtacactca
     2401 ccccaaattg tagtctattg agtcatgtgc attgcacgtt ggataagcca gggaaatgac
     2461 aaataagtat tttgtgtgta tttagtggtt gctttgtact gagagaaaag ctttgaggtg
     2521 tgattaaatc gtaaactctg attctatttg ggagaaacag gaaaaaggtg cacttaatct
     2581 aaaacagcat aagttttcaa cttttaccct taaattataa tttcaagatg tttagacata
     2641 ctgtatcttg tgtttgatgt gttccccctc cctaatatta tggtttattc tttaatgcct
     2701 tttaatttgg atataatagc ttgtacttta gattttggtt gctatcttgc caaaataagt
     2761 gttactgttt ttcaagcttg atccccttcc ctgattgtct tatttaaaga gaaagttaaa
     2821 ctcatacttc tgagtcagag cctgtatttt ggttaagact tgggatattt tttacttcac
     2881 attgaatata gctggatacc tgagaagtct ggtgatggcc actgggtggg tgcagctagc
     2941 taaggcctga ccagcccatt cagagccttg gacttcagac acaaaagtga gtttcttacc
     3001 cacttgctgg tgtaaactct atctggggtc ctgactatat ttgaatactt gtcttcaata
     3061 ttaaaaaaca tagcacattt ttctttctac aaaagtacat tctggagtta agaacccatg
     3121 tggttgattt gtgtgtggcg tgctagctca tacattattt ggatcttatt ctttgtgtca
     3181 tccatctcac agattataag actttgatta atgtaaaaag tatgcgttaa aatcatacca
     3241 aacatttggt aaaattaaaa ccttgatagg aggctgggcg tggaacagga gccatatacc
     3301 tggaatggta acaggggaat gtgctgtgtc acaccaaaga agtgggactt ggaaagtcac
     3361 ttgtctcctg ggtttcagac tctttgttgc atgggcagcc catccatatg tcattacttt
     3421 ttgagattct caagtagatc agcacatttc ggcctcaggt tggcaagatt ttgtcttaga
     3481 gctgttgctt taaagggaaa tggtcaggtc ttagacactt aggaaggtct tgggcttctg
     3541 ttcattctgg tgccaaacca gtgggattca aatttcacac aatctgggtt tttattcatg
     3601 gaggttaacc tggtaagagt aatccttcat ggctctattg aggtgtctta aaaagtttcc
     3661 tgtttcaaac agctacatta cttgattaaa acaatgttat aaaattaaat ttctgtctgc
     3721 tttaatatta aaaa
//
