LOCUS       NM_001006957            2444 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 4H
            (Eif4h), mRNA.
ACCESSION   NM_001006957 XM_213755 XM_347154
VERSION     NM_001006957.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2444)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2444)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2444)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2444)
  AUTHORS   Capossela,S., Muzio,L., Bertolo,A., Bianchi,V., Dati,G.,
            Chaabane,L., Godi,C., Politi,L.S., Biffo,S., D'Adamo,P.,
            Mallamaci,A. and Pannese,M.
  TITLE     Growth defects and impaired cognitive-behavioral abilities in mice
            with knockout for Eif4h, a gene located in the mouse homolog of the
            Williams-Beuren syndrome critical region
  JOURNAL   Am J Pathol 180 (3), 1121-1135 (2012)
   PUBMED   22234171
REFERENCE   5  (bases 1 to 2444)
  AUTHORS   Parsyan,A., Svitkin,Y., Shahbazian,D., Gkogkas,C., Lasko,P.,
            Merrick,W.C. and Sonenberg,N.
  TITLE     mRNA helicases: the tacticians of translational control
  JOURNAL   Nat Rev Mol Cell Biol 12 (4), 235-245 (2011)
   PUBMED   21427765
  REMARK    Review article
REFERENCE   6  (bases 1 to 2444)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 2444)
  AUTHORS   Martindale,D.W., Wilson,M.D., Wang,D., Burke,R.D., Chen,X.,
            Duronio,V. and Koop,B.F.
  TITLE     Comparative genomic sequence analysis of the Williams syndrome
            region (LIMK1-RFC2) of human chromosome 7q11.23
  JOURNAL   Mamm Genome 11 (10), 890-898 (2000)
   PUBMED   11003705
REFERENCE   8  (bases 1 to 2444)
  AUTHORS   Richter-Cook,N.J., Dever,T.E., Hensold,J.O. and Merrick,W.C.
  TITLE     Purification and characterization of a new eukaryotic protein
            translation factor. Eukaryotic initiation factor 4H
  JOURNAL   J Biol Chem 273 (13), 7579-7587 (1998)
   PUBMED   9516461
REFERENCE   9  (bases 1 to 2444)
  AUTHORS   Osborne,L.R., Martindale,D., Scherer,S.W., Shi,X.M., Huizenga,J.,
            Heng,H.H., Costa,T., Pober,B., Lew,L., Brinkman,J., Rommens,J.,
            Koop,B. and Tsui,L.C.
  TITLE     Identification of genes from a 500-kb region at 7q11.23 that is
            commonly deleted in Williams syndrome patients
  JOURNAL   Genomics 36 (2), 328-336 (1996)
   PUBMED   8812460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB718613.1 and BC083818.1.
            
            On Aug 4, 2012 this sequence version replaced NM_001006957.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083818.1, FQ099171.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CB718613.1         1-8
            9-2444              BC083818.1         1-2436
FEATURES             Location/Qualifiers
     source          1..2444
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2444
                     /gene="Eif4h"
                     /gene_synonym="Wbscr1"
                     /note="eukaryotic translation initiation factor 4H"
                     /db_xref="GeneID:288599"
                     /db_xref="RGD:1359222"
     exon            1..97
                     /gene="Eif4h"
                     /gene_synonym="Wbscr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..785
                     /gene="Eif4h"
                     /gene_synonym="Wbscr1"
                     /note="eIF-4H; williams-Beuren syndrome chromosomal region
                     1 protein homolog; Williams-Beuren syndrome chromosome
                     region 1 homolog"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4H"
                     /protein_id="NP_001006958.1"
                     /db_xref="GeneID:288599"
                     /db_xref="RGD:1359222"
                     /translation="MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTA
                     YVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYD
                     GALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGGSREPRGGWDSRDDFSSGYRD
                     DFLGGRGGSRPGDRRAGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTV
                     ATPLNQVANPNSAIFGGARPREEVVQKEQE"
     exon            98..285
                     /gene="Eif4h"
                     /gene_synonym="Wbscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..350
                     /gene="Eif4h"
                     /gene_synonym="Wbscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..447
                     /gene="Eif4h"
                     /gene_synonym="Wbscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..507
                     /gene="Eif4h"
                     /gene_synonym="Wbscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..645
                     /gene="Eif4h"
                     /gene_synonym="Wbscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..2420
                     /gene="Eif4h"
                     /gene_synonym="Wbscr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2397..2402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4h"
                     /gene_synonym="Wbscr1"
     polyA_site      2420
                     /gene="Eif4h"
                     /gene_synonym="Wbscr1"
ORIGIN      
        1 cgctggcccg ctggttcctc aaggagcgga gacggcaaat ggcggacttc gatacctacg
       61 acgatcgggc ctacagcagc ttcggcggcg gtagagggtc ccgcggcagt gctggtggcc
      121 atgggtcccg aagccagaag gagctaccca cagagccccc ctacacagct tacgtaggaa
      181 atctcccttt taacacagtt cagggtgaca tagatgctat ctttaaggat ctcagcatac
      241 ggagtgtgcg gctagtcaga gacaaagaca cagacaaatt taaagggttc tgctatgtag
      301 aatttgatga ggtggattcc ctgaaggagg ctctgaccta cgacggtgca ctcttgggtg
      361 accggtcact tcgtgtggac attgcagaag gcagaaaaca agacaaaggt ggctttgggt
      421 tcaggaaagg cggacctgat gacagaggaa tgggtggctc tcgagaaccg agaggtggat
      481 gggattcccg ggatgacttc agctctggct acagggatga cttcttaggg ggtagggggg
      541 gcagtcgccc tggggaccgg cgagcaggcc ctccaatggg gagtcgcttt cgagatggcc
      601 ctcctctgcg tggctccaac atggacttca gagaacccac agaagaggaa cgagcacaga
      661 gaccgcggct gcagcttaaa cctcggacag tggcaacacc cctcaatcaa gtagccaacc
      721 ccaactcagc catcttcggg ggagccaggc ccagagagga agtggttcag aaggagcaag
      781 aatgagctta ggttgggagg gaatggggtg tgggggagct ggagcaagag cacagcctgg
      841 tggcaggcag tcgccctgca ggccccattc ccgcctggca ctgtcctcct tacagcggga
      901 acacagagct tgcgagtgca tgtcagctgt taacaagtgg tttctagtac attcttggct
      961 ttgctgtatc tatctagtgc ctgttttgtg ctttctttct gttttctttc tctcccctct
     1021 cactcctggc ctctccctgc tccttcccac gccgtgtgga tgtcggtcac gtgtggaagg
     1081 tgggctgagg tgcctcatcc tttgctttct ttctttcctt tccgcgccct ggccacgctc
     1141 cgggtgtgct gtcctctgct ttttctcaga gcttctctcc aatctgcatg tcgagttctg
     1201 tgttgctgtg gcttctggga aagagctggg gccactagct aggcggctgt ggtggcctgt
     1261 tggtaggtat ccagctggga tgagcacaca gaattggagg catcttgctt taaaacaagg
     1321 aaactgcctt ctggtcccga gaggctgctg tgtttggggt cagtcacctg ccccaagcag
     1381 cctgttcagg tatagcaggc tcctgtcaaa cagtgaggcc agaagggtgc agggaattgg
     1441 gacattctgc tctggtggct ctgggtgcca gtggccatgt ggctttgctc ctgctcgctc
     1501 taagaccaag tggaagctca ttccctgctc ttcctgggcc gtggaggccc cttgggggtg
     1561 caacccgctg cagctcaatc cgcttcctgc agccgaggcc tgtaggaagc aggggtggtg
     1621 ctggagctgc accgggcagc tgtgcctgca ctgagtctgc gctctttccc ttgtgtctgt
     1681 ctgctccagg gcgcttagcc caaaaggctg ctccccacca cagctcaagg cctagagtct
     1741 ggcactttct ctgatcggtt gcacagctgt tgagaacctc agtacctggg tgtctagaaa
     1801 cctctaggct tgctgcttgc tctgtggggc agaccctgct cccacagaca gtgctgagca
     1861 ctcacttgag agcaagggga tcaatcaggc tttgctttag ctcggacagc tgtgtgtgaa
     1921 caaatggaaa gtgatttggc accgagtctc catctgttcc agtcggagca ggtaggggtc
     1981 agccagccac tagagccttg ggaaagaagg gctgaggtgc gcagcttgct cgttagccag
     2041 cagcttcctg ccagccaccc cttggctcat gattgtcttt gtcgcaaggt ctcggcaatt
     2101 tacagaactc tcactccttc cctcgcctgc catcttctct gcttctgaga taagaaccat
     2161 ttgtgtaaca ccaataccta acttaagaca gacatgcatt gcgtggttgt aatcaaagct
     2221 gatgctttca gatgatctaa tccatctcca atgcggaaaa gacagaacag gcacgtccat
     2281 ccacactgct gggcgcccag ctgactctgt aagaatggaa ttccaaacac ttaacacatt
     2341 cagttctatg acagaaagtg agtctatgga tatggtattt tgtgaatgat cttttaaata
     2401 aaagagaacc ttacataaca aaaaaaaaaa aaaaaaaaaa aaaa
//
