LOCUS       NM_001106693            5307 bp    mRNA    linear   ROD 06-MAR-2022
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 4 gamma,
            3 (Eif4g3), transcript variant 1, mRNA.
ACCESSION   NM_001106693 XM_001070313 XM_216563
VERSION     NM_001106693.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5307)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 5307)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 5307)
  AUTHORS   Sun F, Palmer K and Handel MA.
  TITLE     Mutation of Eif4g3, encoding a eukaryotic translation initiation
            factor, causes male infertility and meiotic arrest of mouse
            spermatocytes
  JOURNAL   Development 137 (10), 1699-1707 (2010)
   PUBMED   20430745
REFERENCE   4  (bases 1 to 5307)
  AUTHORS   Ramirez-Valle F, Braunstein S, Zavadil J, Formenti SC and Schneider
            RJ.
  TITLE     eIF4GI links nutrient sensing by mTOR to cell proliferation and
            inhibition of autophagy
  JOURNAL   J Cell Biol 181 (2), 293-307 (2008)
   PUBMED   18426977
REFERENCE   5  (bases 1 to 5307)
  AUTHORS   Otulakowski G, Duan W, Gandhi S and O'brodovich H.
  TITLE     Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC
            translation in fetal lung epithelia
  JOURNAL   Am J Respir Cell Mol Biol 37 (4), 457-466 (2007)
   PUBMED   17556672
  REMARK    GeneRIF: At birth increased Po(2) acts with glucocorticosteroid
            through an mTOR-related pathway to increase alpha-ENaC protein
            synthesis, thereby promoting lung fluid absorption.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216563.4, XM_001070313.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351
                              [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5307
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5307
                     /gene="Eif4g3"
                     /note="eukaryotic translation initiation factor 4 gamma,
                     3"
                     /db_xref="GeneID:298573"
                     /db_xref="RGD:1311370"
     exon            1..81
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            82..177
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..4899
                     /gene="Eif4g3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4 gamma
                     3 isoform 1"
                     /protein_id="NP_001100163.1"
                     /db_xref="GeneID:298573"
                     /db_xref="RGD:1311370"
                     /translation="MNSQPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGRGWI
                     KYCIFFQRPQIQPPRAAIPNSSPSLRPGAQTPTAVYQANQHIMMVNHLPMPYPVPQGP
                     QYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFANAYGTPFYPSQPVYQSA
                     PIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTP
                     PQQLPSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLV
                     LSGEKKEQAGQIPETAAGEPSPEPPRTSSPTTLPPLARSSLPSPMSAALSSQQLLTAE
                     DKCELSSSKDDAPPVRSPTSCTAAPGPSLTDDIGLCKKPCGVAPPDGQLVSSPVLINE
                     MNGVGEKLPAKENTVDMVRQEVLPLTLELEILEHPQEERKVECTPTPITPSTMPSFSP
                     APPTPPASPPCTPVVLSATIARSPAVATVIQRVVDEGESLRTCLSKDAKETQDKAEAE
                     SDGQTEETADPQNAHAGRSPAPVQTATTAPKTWKKTKERTRTPDEVLEAEAEPKAEEE
                     LSVDSVLEPEQEKMSQGFQFERDPSTLKRAKAEEENGEEAEPVRNGAESASEGEGGDA
                     NSGSTDSSGDGVTFPFKAESWKPADTEGKKQYDREFLLDIQFMPACIQKPEGLPPISD
                     VVLDKINQPRLPMRTLDPRILPRGPDFTPAFADFGRQTPGGRGVPLLSVGPRRSQPGQ
                     RREPRKIITVSVKEDVHLRKAENAWKPSQKRDSHADDPESIKTQELFRKVRSILNKLT
                     PQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLKVPMA
                     DKPGNTVNFRKLLLNRCQKEFEKDKADDDVFEKKQKELEAASAPEERTRLHDELEEAK
                     DKARRRSIGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDL
                     DFEKAKPRMDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLCNWVSRRADQGPKTIEQ
                     IHKEAKIEEQEEQRKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSRVLDPSKFLKIT
                     KPTIDEKIQLVPKAQLGSWGKGSSGGAKASETDALRSSASSLNRFSPLQPPAPSGSPS
                     ATPLDFDSRRALTSRGSMGREKSDKPLPAGTARPNTFLRGSSKDLLDNQSQEEQRREM
                     LETVKQLTGGVDAERASTEADRSKARELVKSEVCTVPAPDKPALSEEEVERKSKSIID
                     EFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEK
                     LSKQDFFKGFSETLELADDMAIDIPHIWLYLAELVTPMLKEGGISMRELIVEFSKPLL
                     PVGRAGVLLSEILHLLCRQMKLDFTESEGPCSSEALSKKELSAEELSQRLEKLIMEDK
                     ADDERIFDWVEANLDESQMSSPTFLRALMTAVCKAAIVADCSTFRVDTAVIKQRVPIL
                     LKYLDSDTEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKD
                     PAEQNGKGVALKSVTAFFTWLREAEEESEDN"
     exon            178..291
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            292..471
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            472..586
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            587..684
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            685..807
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            808..916
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1738
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1827
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2074
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2208
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2328
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2499
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2697
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2844
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..3081
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3186
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3319
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3414
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3508
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            3509..3626
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            3627..3844
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            3845..3960
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            3961..4133
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            4134..4259
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            4260..4341
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            4342..4488
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            4489..4570
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            4571..4717
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
     exon            4718..5307
                     /gene="Eif4g3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccagaattc ctcgaggacc ggtgcaacag cctctggagg atcggatctt ccctcccacg
       61 gtctctgcag tctatagcac gaccccttat ccctctggac agaatgcagg tccagccaca
      121 ttggtctatc ctcaagcccc tcagacaatg aattcacaac ctcaggcccg gtctccgccc
      181 agcagagcag tgccagtaca ctgcccagac aactggaaga ggaggaaggt tttggaacag
      241 actcccgttt acaggtccct ggctggaaga ggctggataa aatactgcat ttttttccag
      301 aggcctcaaa tccagcctcc cagagcggcc atcccaaaca gcagtccttc cctccgtcct
      361 ggtgcgcaga cccccaccgc cgtgtatcag gccaatcagc acatcatgat ggttaaccat
      421 ctgcctatgc catacccagt gccccagggg cctcagtact gcataccaca gtaccgccac
      481 agtggccctc cgtatgtggg gcccccacag cagtacccag ttcagccacc cggccccggg
      541 cctttttatc ctggaccagg acctggggac tttgctaatg cttatggaac gcctttttac
      601 ccaagtcagc cagtgtatca gtcagcacct atcatagtgc ctacgcagca gcagccccct
      661 ccagccaaga gagagaaaaa aactatacga attcgagatc caaatcaggg aggtaaagac
      721 ataaccgagg agattatgtc tggaggtggc agcagaaatc ccactccacc tataggaaga
      781 cccacatcca cacccactcc tcctcagcag ctgcccagcc aggcccctga gcacagccct
      841 gtggtatatg ggactgtgga gagcgctcat cttgctgcca gcacccctgt cactgcagct
      901 agcgaccaga agcaagaaga aaagccaaaa ccagacccag tgttccagtc tccttcaaca
      961 gtccttaggc tcgtgcttag tggggagaag aaagagcaag caggccagat acccgagact
     1021 gctgcaggag agcccagccc agagcctcct cggacctcat cacccaccac ccttcctcca
     1081 cttgcccgga gttcactccc ttcccccatg tccgctgccc ttagcagcca gcagctgctc
     1141 actgctgagg acaagtgtga actctcttcc tcaaaagatg atgccccccc tgtgcgcagc
     1201 cccacgtctt gcacagcagc accaggccct tcactaacag atgacattgg tctatgcaag
     1261 aaaccctgtg gtgtagcacc tcctgacggc cagctcgttt ctagtcctgt cctaattaat
     1321 gaaatgaacg gagttggtga gaaattacca gccaaggaga acactgtgga catggtgaga
     1381 caggaagtgt tgccactgac tcttgaactg gagattctgg agcatcccca ggaagaaagg
     1441 aaagtggagt gtaccccgac tcccatcacc ccgtccacga tgccttcctt ctccccagcc
     1501 cctccaactc cgccagcttc tcctccttgt actcctgttg tcctgtctgc caccattgct
     1561 cgatctcctg ctgttgccac tgtgatccag agagttgtcg acgagggaga gagcctgaga
     1621 acttgtctta gcaaggatgc caaggagaca caggacaaag cggaggcaga gtcagatggg
     1681 caaacagagg agactgcgga tccccagaac gcacatgcag gaaggagccc tgccccagtg
     1741 caaacagcta ccactgcgcc aaagacgtgg aagaaaacaa aagagcggac ccgaacccca
     1801 gatgaagtgt tagaagcaga ggcagagcct aaagcagaag aagagctttc agttgacagt
     1861 gtccttgaac ctgagcaaga gaagatgagc caagggtttc agtttgagag agacccctct
     1921 accctgaaaa gagcgaaagc tgaggaagaa aacggagaag aagcagagcc tgtgcgcaat
     1981 ggtgctgaga gtgcttccga gggggaagga ggagacgcta attcaggctc taccgatagc
     2041 tctggagatg gggtcacatt cccatttaaa gcagagtcct ggaaacctgc agatacagaa
     2101 ggcaagaagc aatatgaccg ggagttccta ttggacatcc agtttatgcc tgcctgtatc
     2161 caaaaaccag aaggcctacc tcccatcagc gatgtggttc ttgacaagat caaccagccc
     2221 agattgccaa tgcggaccct ggatcctcga attttgcctc gaggacctga tttcacccca
     2281 gcctttgcag attttggaag acagacgcct ggtggaagag gcgtgccttt gttgagtgtt
     2341 ggacctcgga ggtctcaacc tggccagaga agggagccca ggaagataat tactgtctcc
     2401 gtaaaagaag acgtgcactt gagaaaggca gagaatgcct ggaagcccag ccagaagcgg
     2461 gacagccatg ccgatgaccc cgaaagcatt aaaacgcagg aacttttcag aaaagttcga
     2521 agtatcctaa ataaactgac accacagatg ttcaaccagc tgatgaagca agtgtcggca
     2581 cttaccgtgg acacagagga gcggctaaag ggggtcatcg acctggtctt tgagaaggct
     2641 atcgatgagc ccagcttctc tgtggcgtac gcaaacatgt gtcggtgcct agtaacgctg
     2701 aaggtaccta tggcagacaa gcccggtaac acagtaaatt tccggaagct gctgcttaat
     2761 cgttgccaga aggagtttga aaaggataaa gcagatgatg acgtctttga gaagaagcag
     2821 aaagaactgg aagctgccag tgctccagag gaaagaacga ggcttcacga tgaactggaa
     2881 gaagccaagg acaaagcccg gcggagatcc atcggcaaca tcaagttcat tggagagctc
     2941 tttaaactca aaatgctgac ggaggccatc atgcatgatt gtgtggtgaa gctgctaaag
     3001 aaccatgatg aggaatccct ggagtgcctg tgtcgcctgc tcaccaccat cggcaaagac
     3061 ctggactttg agaaagcaaa gccgcgcatg gaccagtact ttaaccagat ggagaaaatt
     3121 gtcaaagaaa ggaaaacttc ctcccggatt cggttcatgc ttcaggatgt aattgacctc
     3181 aggctgtgta attgggtgtc ccgaagagca gatcaggggc caaagactat cgagcagatt
     3241 cacaaagagg ccaaaataga agaacaagag gagcaaagga aagtccagca gctgatgacc
     3301 aaggagaaga gaagaccagg cgtccaaaga gtggatgaag gtggatggaa tactgtacaa
     3361 ggggccaaga acagtcgtgt actggacccc tccaaatttt tgaaaatcac taagcccacc
     3421 attgacgaga agattcagct ggttcctaag gcacagctgg gcagctgggg caaaggcagc
     3481 agtggtggag caaaggcaag cgagactgac gccttacggt caagtgcttc cagtttaaat
     3541 agattctctc ctctgcaacc tccagcgcct tcagggtccc cgtcagccac gcctttagac
     3601 ttcgattccc ggagggcgtt aaccagtcgt gggagcatgg gcagggagaa gagcgacaag
     3661 ccgcttccag ctggaacagc ccgtcccaac acgttcctga ggggcagcag caaagacctg
     3721 ctggacaacc agtctcagga agagcagcgc agagagatgc tggagacggt gaagcagctg
     3781 acaggaggcg tggacgccga gcgggccagc actgaggccg accgaagcaa agcgagggag
     3841 ctagtcaagt cagaagtgtg cacagtgcca gcccccgaca agcctgcact gtcagaagag
     3901 gaagtagaga ggaagtccaa gtctatcatt gacgagttcc tgcacatcaa tgactttaag
     3961 gaggccacac agtgcataga ggagctgagt gcccagggcc cactgcatgt gttcgtgaag
     4021 gtgggtgtgg agttcaccct ggagcggagc cagatcacca gagatcacat gggccactta
     4081 ctgtatcagc tggtgcagtc ggaaaagctc agcaagcagg actttttcaa aggcttttct
     4141 gaaaccttgg agttggcaga tgacatggcc attgacatcc cccatatttg gttgtacctg
     4201 gctgaactag tcacccccat gttaaaagaa gggggaatct ccatgagaga acttattgtg
     4261 gaattcagca agccattact tcctgttggt agagctgggg tcctgctttc cgaaatcctg
     4321 caccttctat gcagacaaat gaagttggac ttcacggagt cagagggacc ctgctcctct
     4381 gaagcacttt caaagaaaga attgtctgct gaggagctgt ctcagcgcct ggagaaactg
     4441 atcatggagg acaaagcaga tgacgagcgg atctttgact gggtggaggc caatctagac
     4501 gaaagccaga tgagttcgcc cacattcctt agagctttaa tgacggccgt ttgcaaagca
     4561 gccattgtcg ccgactgttc taccttcaga gtggacactg ctgtgatcaa gcagagagtg
     4621 ccgatcttac tcaagtacct ggactcagac acagagaagg agctgcaagc actttatgca
     4681 ctacaagcat caatagtgaa acttgaccaa cctgccaatt tgctccggat gttttttgat
     4741 tgcctgtatg atgaggaggt gatatcagag gatgccttct acaaatggga gagcagcaag
     4801 gaccctgctg aacaaaacgg gaagggcgta gccctcaaat ctgtcacagc gtttttcacg
     4861 tggcttcggg aagcagaaga ggagtcggag gataactaat acttcaaata cacaaacgaa
     4921 acaaaagaaa caatttaagt atttttttaa aaagtttcac gtcttcgcca atcacagtgc
     4981 agcaaggcca actctcgcag aaaccccacg tgtgcgcgag tgggagaggg gacaggaatc
     5041 aggtgatcat ggaggacaaa ggtcctggat caaggagaca gcaaacctga gggcgggagc
     5101 tccaaaacca aaatacatgt actatttata gaaaatattt tctgttttaa tcttttcttt
     5161 ttaaacgagg actcatactt taaaaaaaaa aaaaacacat ttagcaaaaa aaaaaaaaat
     5221 aagaaaaaga aaaaaaaaac agttgaactt taatttattt taaggactgc aaatgccagt
     5281 gtaatttttt taatttgcag tttctgt
//
