LOCUS       NM_053857                862 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 4E
            binding protein 1 (Eif4ebp1), mRNA.
ACCESSION   NM_053857
VERSION     NM_053857.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 862)
  AUTHORS   Chen,J., Yu,J., Yuan,R., Li,N., Li,C. and Zhang,X.
  TITLE     mTOR inhibitor improves testosterone-induced myocardial hypertrophy
            in hypertensive rats
  JOURNAL   J Endocrinol 252 (3), 179-193 (2022)
   PUBMED   34874016
  REMARK    GeneRIF: mTOR inhibitor improves testosterone-induced myocardial
            hypertrophy in hypertensive rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 862)
  AUTHORS   Toyoshima,Y., Yoshizawa,F., Tokita,R., Taguchi,Y., Takahashi,S.I.,
            Kato,H. and Minami,S.
  TITLE     A translation repressor, 4E-BP1, regulates the triglyceride level
            in rat liver during protein deprivation
  JOURNAL   Am J Physiol Endocrinol Metab 318 (5), E636-E645 (2020)
   PUBMED   32208000
  REMARK    GeneRIF: These results indicate that a low-protein diet increases
            the amount of 4E-BP1, leading to TG accumulation in rat liver. We
            thus conclude that 4E-BP1 plays an important role in inducing
            hepatic steatosis under protein deprivation.
REFERENCE   3  (bases 1 to 862)
  AUTHORS   Katsara,O. and Kolupaeva,V.
  TITLE     mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation,
            precedes cartilage degeneration in rat osteoarthritic knees
  JOURNAL   J Orthop Res 36 (10), 2728-2735 (2018)
   PUBMED   29761560
  REMARK    GeneRIF: In an anterior cruciate ligament transection model of
            osteoarthritis, 4E-BP1 inactivation precedes cartilage degeneration
            and increased expression of pathogenic proteases in cartilage.
REFERENCE   4  (bases 1 to 862)
  AUTHORS   Duan,P., Hu,C., Quan,C., Yu,T., Huang,W., Chen,W., Tang,S., Shi,Y.,
            Martin,F.L. and Yang,K.
  TITLE     4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1
            signaling by modulating AMPK activation in Sertoli cells
  JOURNAL   Toxicol Lett 267, 21-31 (2017)
   PUBMED   28041982
  REMARK    GeneRIF: Suggest that 4-nonylphenol stimulates Sertoli cell
            autophagy and inhibits mTOR-p70S6K/4EBP1 activity through AMPK
            activation.
REFERENCE   5  (bases 1 to 862)
  AUTHORS   Ruoff,R., Katsara,O. and Kolupaeva,V.
  TITLE     Cell type-specific control of protein synthesis and proliferation
            by FGF-dependent signaling to the translation repressor 4E-BP
  JOURNAL   Proc Natl Acad Sci U S A 113 (27), 7545-7550 (2016)
   PUBMED   27313212
  REMARK    GeneRIF: FGF signaling differentially impacts protein synthesis
            through either stimulation or repression, in a cell-type-dependent
            manner, with 4E-BP1 being a key player.
REFERENCE   6  (bases 1 to 862)
  AUTHORS   Tinton,S.A. and Buc-Calderon,P.M.
  TITLE     Hypoxia increases the association of 4E-binding protein 1 with the
            initiation factor 4E in isolated rat hepatocytes
  JOURNAL   FEBS Lett 446 (1), 55-59 (1999)
   PUBMED   10100614
REFERENCE   7  (bases 1 to 862)
  AUTHORS   Brunn,G.J., Hudson,C.C., Sekulic,A., Williams,J.M., Hosoi,H.,
            Houghton,P.J., Lawrence,J.C. Jr. and Abraham,R.T.
  TITLE     Phosphorylation of the translational repressor PHAS-I by the
            mammalian target of rapamycin
  JOURNAL   Science 277 (5322), 99-101 (1997)
   PUBMED   9204908
REFERENCE   8  (bases 1 to 862)
  AUTHORS   Lin,T.A., Kong,X., Saltiel,A.R., Blackshear,P.J. and Lawrence,J.C.
            Jr.
  TITLE     Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis,
            degradation, and phosphorylation by a rapamycin-sensitive and
            mitogen-activated protein kinase-independent pathway
  JOURNAL   J Biol Chem 270 (31), 18531-18538 (1995)
   PUBMED   7629182
REFERENCE   9  (bases 1 to 862)
  AUTHORS   Lin,T.A., Kong,X., Haystead,T.A., Pause,A., Belsham,G.,
            Sonenberg,N. and Lawrence,J.C. Jr.
  TITLE     PHAS-I as a link between mitogen-activated protein kinase and
            translation initiation
  JOURNAL   Science 266 (5185), 653-656 (1994)
   PUBMED   7939721
REFERENCE   10 (bases 1 to 862)
  AUTHORS   Hu,C., Pang,S., Kong,X., Velleca,M. and Lawrence,J.C. Jr.
  TITLE     Molecular cloning and tissue distribution of PHAS-I, an
            intracellular target for insulin and growth factors
  JOURNAL   Proc Natl Acad Sci U S A 91 (9), 3730-3734 (1994)
   PUBMED   8170978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U05014.1 and AI603218.1.
            
            On Aug 2, 2012 this sequence version replaced NM_053857.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U05014.1, AW919144.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-831               U05014.1           1-831
            832-862             AI603218.1         1-31                c
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.3"
     gene            1..862
                     /gene="Eif4ebp1"
                     /gene_synonym="PHAS-I"
                     /note="eukaryotic translation initiation factor 4E binding
                     protein 1"
                     /db_xref="GeneID:116636"
                     /db_xref="RGD:620259"
     exon            1..194
                     /gene="Eif4ebp1"
                     /gene_synonym="PHAS-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..406
                     /gene="Eif4ebp1"
                     /gene_synonym="PHAS-I"
                     /note="4E-BP1; eIF4E-binding protein 1; phosphorylated
                     heat- and acid-stable protein regulated by insulin 1"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor
                     4E-binding protein 1"
                     /protein_id="NP_446309.1"
                     /db_xref="GeneID:116636"
                     /db_xref="RGD:620259"
                     /translation="MSAGSSCSQTPSRAIPTRRVALGDGVQLPPGDYSTTPGGTLFST
                     TPGGTRIIYDRKFLMECRNSPVAKTPPKDLPTIPGVTSPTSDEPPMQASQSHLHSSPE
                     DKRAGGEESQFEMDI"
     exon            195..374
                     /gene="Eif4ebp1"
                     /gene_synonym="PHAS-I"
                     /inference="alignment:Splign:2.1.0"
     exon            375..846
                     /gene="Eif4ebp1"
                     /gene_synonym="PHAS-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      785..790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4ebp1"
                     /gene_synonym="PHAS-I"
     polyA_site      831
                     /gene="Eif4ebp1"
                     /gene_synonym="PHAS-I"
     polyA_site      846
                     /gene="Eif4ebp1"
                     /gene_synonym="PHAS-I"
ORIGIN      
        1 gggccgaggt gccgcggggt tgctggaggg tcgtgggcgg cgtgcaggag acatgtcggc
       61 gggcagcagt tgcagccaga ctcccagccg ggctatcccc actcgccgcg tagccctcgg
      121 cgacggcgtg cagctcccgc ccggggacta cagcaccacc cccggcggca cgctcttcag
      181 caccaccccg ggaggaacca gaatcatcta tgaccggaaa ttcctgatgg agtgtcggaa
      241 ctcgcctgtg gccaaaacac ccccaaagga cctgccaacc attccagggg tcactagccc
      301 taccagcgat gagcctccca tgcaggccag ccagagccat ctgcacagca gcccggaaga
      361 taagcgggca ggtggtgaag agtcacagtt tgagatggac atttaaggga ccagccatag
      421 gacgcagtga tgcttctggg cccctggggc ccttgggagg agagccacag cagtcaggcc
      481 ttgtacccgg cagacactgg gtgtggatcg gccacccagt cctgctcctc actcagggca
      541 cctgctctgc cttccatttt gtgaatacca gcacatacct ccttgtgcct ctgttgatac
      601 tgagctgcta ctccagggta atgactctca cctacaccct ccctgcatca agcgccagcg
      661 agtggacaca gaggagtctg tcggaatgat ctggcaattc tagccccaac ctctggagca
      721 cacccacctt accttaggtt ggggtacctg ggaaagccac cctttacttc tttccctgag
      781 aggaaataaa agccacattt accctaggcc cacagccggg ccctgtctga actgtttcca
      841 agttgaaaaa aaaaaaaaaa aa
//
