LOCUS       NM_053974               2395 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 4E
            (Eif4e), mRNA.
ACCESSION   NM_053974
VERSION     NM_053974.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2395)
  AUTHORS   Dong,R., Li,X., Flores,A.D. and Lai,K.O.
  TITLE     The translation initiating factor eIF4E and arginine methylation
            underlie G3BP1 function in dendritic spine development of neurons
  JOURNAL   J Biol Chem 299 (8), 105029 (2023)
   PUBMED   37442236
  REMARK    GeneRIF: The translation initiating factor eIF4E and arginine
            methylation underlie G3BP1 function in dendritic spine development
            of neurons.
REFERENCE   2  (bases 1 to 2395)
  AUTHORS   Martinez-Alonso,E., Escobar-Peso,A., Guerra-Perez,N., Roca,M.,
            Masjuan,J. and Alcazar,A.
  TITLE     Dihydropyrimidinase-Related Protein 2 Is a New Partner in the
            Binding between 4E-BP2 and eIF4E Related to Neuronal Death after
            Cerebral Ischemia
  JOURNAL   Int J Mol Sci 24 (9), 8246 (2023)
   PUBMED   37175950
  REMARK    GeneRIF: Dihydropyrimidinase-Related Protein 2 Is a New Partner in
            the Binding between 4E-BP2 and eIF4E Related to Neuronal Death
            after Cerebral Ischemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2395)
  AUTHORS   Martinez-Alonso,E., Guerra-Perez,N., Escobar-Peso,A., Regidor,I.,
            Masjuan,J. and Alcazar,A.
  TITLE     Differential Association of 4E-BP2-Interacting Proteins Is Related
            to Selective Delayed Neuronal Death after Ischemia
  JOURNAL   Int J Mol Sci 22 (19), 10327 (2021)
   PUBMED   34638676
  REMARK    GeneRIF: Differential Association of 4E-BP2-Interacting Proteins Is
            Related to Selective Delayed Neuronal Death after Ischemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2395)
  AUTHORS   Gindina,S., Botsford,B., Cowansage,K., LeDoux,J., Klann,E.,
            Hoeffer,C. and Ostroff,L.
  TITLE     Upregulation of eIF4E, but not other translation initiation
            factors, in dendritic spines during memory formation
  JOURNAL   J Comp Neurol 529 (11), 3112-3126 (2021)
   PUBMED   33864263
  REMARK    GeneRIF: Upregulation of eIF4E, but not other translation
            initiation factors, in dendritic spines during memory formation.
REFERENCE   5  (bases 1 to 2395)
  AUTHORS   Li,B., Huang,Z., Meng,J., Yu,W. and Yang,H.
  TITLE     MiR-202-5p attenuates neurological deficits and neuronal injury in
            MCAO model rats and OGD-induced injury in Neuro-2a cells by
            targeting eIF4E-mediated induction of autophagy and inhibition of
            Akt/GSK-3beta pathway
  JOURNAL   Mol Cell Probes 51, 101497 (2020)
   PUBMED   31877332
  REMARK    GeneRIF: MiR-202-5p attenuates neurological deficits and neuronal
            injury in MCAO model rats and OGD-induced injury in Neuro-2a cells
            by targeting eIF4E-mediated induction of autophagy and inhibition
            of Akt/GSK-3beta pathway.
REFERENCE   6  (bases 1 to 2395)
  AUTHORS   Potter,M.W., Shah,S.A., Elbirt,K.K. and Callery,M.P.
  TITLE     Endotoxin (LPS) stimulates 4E-BP1/PHAS-I phosphorylation in
            macrophages
  JOURNAL   J Surg Res 97 (1), 54-59 (2001)
   PUBMED   11319880
REFERENCE   7  (bases 1 to 2395)
  AUTHORS   Makhlouf,A.A., Namboodiri,A.M. and McDermott,P.J.
  TITLE     Transcriptional regulation of the rat eIF4E gene in cardiac muscle
            cells: the role of specific elements in the promoter region
  JOURNAL   Gene 267 (1), 1-12 (2001)
   PUBMED   11311550
REFERENCE   8  (bases 1 to 2395)
  AUTHORS   Tinton,S.A. and Buc-Calderon,P.M.
  TITLE     Hypoxia increases the association of 4E-binding protein 1 with the
            initiation factor 4E in isolated rat hepatocytes
  JOURNAL   FEBS Lett 446 (1), 55-59 (1999)
   PUBMED   10100614
REFERENCE   9  (bases 1 to 2395)
  AUTHORS   Miyagi,Y., Kerr,S., Sugiyama,A., Asai,A., Shibuya,M., Fujimoto,H.
            and Kuchino,Y.
  TITLE     Abundant expression of translation initiation factor EIF-4E in
            post-meiotic germ cells of the rat testis
  JOURNAL   Lab Invest 73 (6), 890-898 (1995)
   PUBMED   8558852
REFERENCE   10 (bases 1 to 2395)
  AUTHORS   Lin,T.A., Kong,X., Haystead,T.A., Pause,A., Belsham,G.,
            Sonenberg,N. and Lawrence,J.C. Jr.
  TITLE     PHAS-I as a link between mitogen-activated protein kinase and
            translation initiation
  JOURNAL   Science 266 (5185), 653-656 (1994)
   PUBMED   7939721
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087001.1.
            
            On Dec 26, 2004 this sequence version replaced NM_053974.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087001.1, X83399.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2395
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..2395
                     /gene="Eif4e"
                     /note="eukaryotic translation initiation factor 4E"
                     /db_xref="GeneID:117045"
                     /db_xref="RGD:69647"
     exon            1..31
                     /gene="Eif4e"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..667
                     /gene="Eif4e"
                     /note="eIF-4E; eIF-4F 25 kDa subunit; mRNA cap-binding
                     protein; eukaryotic initiation factor 4E"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4E"
                     /protein_id="NP_446426.1"
                     /db_xref="GeneID:117045"
                     /db_xref="RGD:69647"
                     /translation="MATVEPETTPTTNPPPAEEEKTESNQEVANPEHYIKHPLQNRWA
                     LWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMW
                     EDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKG
                     DKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV"
     exon            32..138
                     /gene="Eif4e"
                     /inference="alignment:Splign:2.1.0"
     exon            139..234
                     /gene="Eif4e"
                     /inference="alignment:Splign:2.1.0"
     exon            235..298
                     /gene="Eif4e"
                     /inference="alignment:Splign:2.1.0"
     exon            299..412
                     /gene="Eif4e"
                     /inference="alignment:Splign:2.1.0"
     exon            413..552
                     /gene="Eif4e"
                     /inference="alignment:Splign:2.1.0"
     exon            553..2370
                     /gene="Eif4e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatcgatct aagatggcga ctgtggaacc ggaaaccacc cctaccacta atcccccacc
       61 tgcggaagag gaaaaaacag agtctaatca ggaggttgct aatccagagc actatattaa
      121 acaccctcta cagaacaggt gggcactctg gttttttaaa aatgataaaa gcaaaacttg
      181 gcaagcaaac cttcggttga tctctaagtt tgatactgtt gaagactttt gggctctata
      241 caaccatatc cagttgtcta gtaatttaat gcctggctgt gactactcac tttttaagga
      301 tggtattgag cctatgtggg aagatgagaa aaacaaacgg ggaggacgat ggctaattac
      361 attgaacaag cagcagagac gaagtgacct cgatcgcttt tggctagaga cactgctgtg
      421 ccttattgga gaatcttttg atgactacag tgatgacgtg tgtggagctg ttgtcaatgt
      481 tagagctaaa ggtgataaga tagcaatatg gacgactgaa tgtgaaaaca gagatgcagt
      541 cacacacata gggagggtat acaaggaaag gttaggactt cctccgaaga tagtgattgg
      601 ttatcagtcc cacgcagaca cagctacaaa gagcggctcc accactaaaa ataggtttgt
      661 tgtttaagaa gacaccttct gagtatcctc acaggagact gcgtcacgca atcgagattg
      721 ggagctgaac caaagcctca tcaaagcaga gtggactgca ctgaagctga ctccatccaa
      781 gtgttgctaa gatataagag aagtctcatt cgcctttgtc ttgtacttct gtgttcattc
      841 tcctccccca ccccaatttt tgctagtgtg tccaccatcc caatcaaaga attacagtat
      901 acgtcacccc agaacccaca gatgtgttcc tggcccgctc tgtaacagcc gggtagagtt
      961 accacgacac acacttgcct ttccacagta ttcgaaaaag aacgtgcatt tctgtcacct
     1021 tagcaggaaa agatctggtt ttgttccact ccatgcagga gcggatttgc tggtgtgaga
     1081 gtctaagtac agctttctag caaccttctg ttttctgtca cagcattgtc cttgctgtcc
     1141 tcttgctgat ggctgctaga tgttaattta tttgcttccc tccttgataa cattagtgat
     1201 tctgatttca gtttttcatt tgttttgctt ttgttttttt cctcatgtaa cattggtgaa
     1261 ggatccagga ctatgacaga aaggtggaat aaacattaca tttgtgcatt ctttggtaat
     1321 ttttttgttt tttgtaacta caaagctttg ctacaaattt atgcatttca ttcaaatcag
     1381 tgatctatgt ctgtgtgatc cctaaacata attgtggact ataaaaatgt aacaccataa
     1441 ttacattcct aactagaatt agttgtctgc ttttgtatct ttatgctgta ctttaacact
     1501 ttgtattact taggttattt tgctttggtt acaatggctc aagtagaaaa gcggtcccat
     1561 ccatattaag acagtgtaca aaactgtaaa taaaatgtgt acagtgaatt gtcttttaga
     1621 caactagatt tgtcctttta tttctccatc tctagaagga atctgtactc catattgcaa
     1681 ggcagtctct tgtgtcttct tagtgtcttc cccatgcaca gcctaagttt ggagcactag
     1741 tttattatta tgtttattac aatttttaat aaattgaata ggtagtatca catgtaatta
     1801 aactgatgtg gctatctttt ttgataaagt taagacacag tttttcagtc ttaggttaat
     1861 aatgtactta gaatatgtta aaattcatga gaattgggat tttggtgtat caccatttga
     1921 taggaacagt ggctataaac tgagtgttga gtttaagatg tttttactta atggccagaa
     1981 aattagaata aggaaggtta ggggaatgtg cattaggaac attagtgtta ctatctgaat
     2041 aaaacataat aaacaagtat taagaactat ttatattggt cagttgttgc agtatggttc
     2101 tctgtaaact tgaaaccttg atctattcct tgtatcattt aaagcaaaca tgaagacatt
     2161 ttgtctgcac tacataactg tgtattgttt ggatctagtg aaatgaggtg tggctgtcac
     2221 agaccaaagg gtaagctgaa ctgtgggtgg cagagtggag accgctggtg agagaagaat
     2281 gctctgtaag tggttattat tatgagttca tccttttcac actggtaact tgataaagat
     2341 ccttataaaa taaatatgga attaatagca aaaaaaaaaa aaaaaaaaaa aaaaa
//
