LOCUS       NM_001008324            3659 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 4B
            (Eif4b), mRNA.
ACCESSION   NM_001008324 XM_217058
VERSION     NM_001008324.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3659)
  AUTHORS   Nicolini,C., Ahn,Y., Michalski,B., Rho,J.M. and Fahnestock,M.
  TITLE     Decreased mTOR signaling pathway in human idiopathic autism and in
            rats exposed to valproic acid
  JOURNAL   Acta Neuropathol Commun 3, 3 (2015)
   PUBMED   25627160
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3659)
  AUTHORS   Eom,T., Muslimov,I.A., Tsokas,P., Berardi,V., Zhong,J.,
            Sacktor,T.C. and Tiedge,H.
  TITLE     Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent
            translational control
  JOURNAL   J Cell Biol 207 (2), 237-252 (2014)
   PUBMED   25332164
REFERENCE   3  (bases 1 to 3659)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3659)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 3659)
  AUTHORS   Jernigan,C.S., Goswami,D.B., Austin,M.C., Iyo,A.H., Chandran,A.,
            Stockmeier,C.A. and Karolewicz,B.
  TITLE     The mTOR signaling pathway in the prefrontal cortex is compromised
            in major depressive disorder
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 35 (7), 1774-1779 (2011)
   PUBMED   21635931
REFERENCE   6  (bases 1 to 3659)
  AUTHORS   Parsyan,A., Svitkin,Y., Shahbazian,D., Gkogkas,C., Lasko,P.,
            Merrick,W.C. and Sonenberg,N.
  TITLE     mRNA helicases: the tacticians of translational control
  JOURNAL   Nat Rev Mol Cell Biol 12 (4), 235-245 (2011)
   PUBMED   21427765
  REMARK    Review article
REFERENCE   7  (bases 1 to 3659)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001008324.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085933.1, SRR26360181.2832962.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                JAXUCZ010000007.1  135085259-135085284
            27-164              JAXUCZ010000007.1  135091679-135091816
            165-373             JAXUCZ010000007.1  135094087-135094295
            374-490             JAXUCZ010000007.1  135094560-135094676
            491-545             JAXUCZ010000007.1  135095644-135095698
            546-680             JAXUCZ010000007.1  135096148-135096282
            681-818             JAXUCZ010000007.1  135098331-135098468
            819-992             JAXUCZ010000007.1  135098563-135098736
            993-1221            JAXUCZ010000007.1  135099535-135099763
            1222-1319           JAXUCZ010000007.1  135101132-135101229
            1320-1533           JAXUCZ010000007.1  135102497-135102710
            1534-1589           JAXUCZ010000007.1  135103157-135103212
            1590-1695           JAXUCZ010000007.1  135104476-135104581
            1696-1768           JAXUCZ010000007.1  135104772-135104844
            1769-3659           JAXUCZ010000007.1  135105164-135107054
FEATURES             Location/Qualifiers
     source          1..3659
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..3659
                     /gene="Eif4b"
                     /note="eukaryotic translation initiation factor 4B"
                     /db_xref="GeneID:300253"
                     /db_xref="RGD:1306479"
     exon            1..26
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1849
                     /gene="Eif4b"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4B"
                     /protein_id="NP_001008325.1"
                     /db_xref="GeneID:300253"
                     /db_xref="RGD:1306479"
                     /translation="MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVPKPVSWADET
                     DDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGN
                     LPYDVTEDSIKDFFRGLNISAVRLPREPSNPDRLKGFGYAEFEDLDSLLSALSLNEES
                     LGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDD
                     SFGDKYRDRYESDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGS
                     GRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKL
                     NLKPRSTPKEDDSSASTSQSSRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLD
                     EPKLDRRPRERHPSWRSEETQERERSRTGSESSQTGTSATSGRNTRRRESEKSLENET
                     LNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQPSPTSG
                     GGKVAPAQPSEEGPSRKDETKVDGVSTTKGQTGHSSRGPGDGGSRDHWKELDRKDGKK
                     DQDSRSAPEPKKSEENRASKFSSASKYAALSVDGEDEDEGDDCTE"
     exon            27..164
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     exon            165..373
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     exon            374..490
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     exon            491..545
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     exon            546..680
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     exon            681..818
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     exon            819..992
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1221
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1319
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1533
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1589
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1695
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1768
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..3659
                     /gene="Eif4b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccctctccc aacatggcgg cctcagcaaa aaagaagaat aagaagggga agaccatctc
       61 cctaacagac tttctagctg aggatggggg aactggtgga ggaagcacct atgtccccaa
      121 accagtcagc tgggctgatg aaacagacga tctggaagga gatgtgtcaa caacttggca
      181 tagtaacgat gacgatgtgt acagggcacc tcctattgac cgttccatcc ttcccactgc
      241 tccacgggct gctcgggaac ccaatattga tcggagccgt cttcccaagt caccacccta
      301 cactgctttc ctagggaatc tgccctatga tgtgacagaa gactctatta aggatttctt
      361 tagaggatta aatatcagcg ctgtacgctt gccgcgtgag cccagcaatc cagacaggtt
      421 gaaaggtttt ggctatgccg aatttgagga tctggattct ctgctcagtg ctctgagtct
      481 caatgaagag tctctaggta acaggagaat tcgggtggat gttgctgatc aagcacagga
      541 taaagacagg gatgaccgtt cttttggtcg agatagaaat cgggattctg acaagacaga
      601 cacagactgg agggcccgtc ctgccacaga cagctttgat gactacccac ctagacgagg
      661 tgatgacagc ttcggagaca agtatcgaga tcgttacgag tcagaccggt atcgggatgg
      721 gtatagggac ggatatcggg acggcccacg cagagacatg gaccgctatg ggggccggga
      781 tcgctatgat gaccgaggca gcagagacta tgaccgaggc tatgactcca ggataggcag
      841 tggcagaaga gcatttggaa gtgggtaccg gagggatgac gactacagag gaggtgggga
      901 ccgctatgaa gatcgctatg acagacggga cgatcggtca tggagctcca gggacgatta
      961 ctctcgggac gattacaggc gtgatgacag aggtcccccc caaagaccca aactgaatct
     1021 aaagcctcgg agtactccta aagaagatga ttcctctgct agcacctccc agtccagccg
     1081 agcggcttct atctttggag gggcgaagcc tgttgacaca gctgctagag aaagagaagt
     1141 agaggagcgg ctacagaagg agcaggagaa gctgcagcgt cagctggatg agccaaaact
     1201 agaccgccgg ccccgggaga gacacccaag ttggcgaagt gaagaaactc aggaaagaga
     1261 acggtcgagg acaggaagtg agtcatcgca gactgggacc tcagccacat ctggcagaaa
     1321 tacacgaagg agagagagtg agaagtctct agaaaatgaa accctcaata aagaagaaga
     1381 ctgtcactct ccaacctcta agcctcctaa acctgaccag cctctaaagg taatgccagc
     1441 ccctccacca aaggagaatg cgtgggtgaa gcgaagctct aaccctcctg ctcgatctca
     1501 gagctcagac acagagcagc cgtcccctac aagtggtgga gggaaagttg ctccagctca
     1561 gccctctgag gaaggaccat caaggaaaga tgaaactaaa gtggatgggg tgagcaccac
     1621 caaaggccag actggacact ccagccgtgg tcctggggat ggagggagca gagaccactg
     1681 gaaggagttg gataggaagg acggcaaaaa agatcaagac tccagatctg cacctgagcc
     1741 aaagaaatct gaggagaacc gagcctctaa gttcagttct gcaagcaagt acgctgctct
     1801 gtctgtggac ggtgaggatg aggatgaggg agacgactgc actgagtaga cctccacacc
     1861 tgtgctttct ccttgtctcc accctggaac attcaagagc aaatcaaacc tctatccaga
     1921 caagacaaaa taaactcacc atctcctgaa gacctttcta aacttttttt ttaatgaaat
     1981 gaaattcttt tgcatgctgc tgcagccttt taaagtattg gagtaactgg agaatcacca
     2041 ttgtagccag agatgcggct accgcttctg aacagggaag ttgtgtctga tgataccaag
     2101 cagttacctg tgtgaatagt gcctggggct ccattcagca gaaatgcagt gacagagagg
     2161 cagtcacacc agttaggcag tagagaacgc agggagaagt gagatttcca ccttctaatt
     2221 cttatcctaa ggtggcacct gtgaaccccc acacattacc tgaacaaact tcccatcctt
     2281 aggtagctct agtctctcaa gctgttttag tctccaggag gctgccaacc cctctacttt
     2341 agttctgact tcagtggggc cagcctaggg agaattgttt tttgttttgt tttttttttt
     2401 accccccaag ggggtagttg ggagtgagtc tacaggccac taacagtagc accgcttggg
     2461 gaccaaaatg aatgggaaat tcaatcgtgg tttgaaaagc tttggggagg tgatcgatta
     2521 tattttatac caggtagtaa gggaaatggt gtgacctcca gtaactacat gaatagagtg
     2581 gtcgtttctg gatgaggaag cacttacagg tcgtgggaag ttctagtctt gtgtgtcctg
     2641 gttttgcccc ttctaaactg tcctctctag aggtttgagc atatccacat tctttgaaaa
     2701 ccttgtcact ctggccatct catgttctcc atgacactta gactcccaga gctgtctctg
     2761 agtcacacac ctccacagac attgtatctt ggccacaaga gcagggcctg aggactcact
     2821 gcttttccag gcagaccagc tctgtgcttt ctttatcttt tgattcctgc cctatctgct
     2881 gctgtcatcc ctgactgatg ggcttgggtg gggaatgggg tgtagacggg gtgagttgga
     2941 gccttcagcc ttcgagtgtt taaaggtttc tgtctataag tttccttcac tgaaccccac
     3001 accggtgctt gagttgtcac tgcttttctg cctaggaggg ctggcgtctt tactcccctc
     3061 cagagtaaag gaggatgcaa agaactgttg gccagggtcc gagttcctcg tgcagcgctg
     3121 tagcctgtct tgatgtgcac ctttgtagct cagctccgag gatggcaagc ttccctgttg
     3181 tgggtagtca ggtacctgca gacagatgag accttggttt tagcacaagt tcctaggcct
     3241 gctgtgcagg agcattgacg tcacgtgctg cagcagtagg cacagcaaat ttcttcggtg
     3301 gatttgattg gctagtagct aggagggctt ttgcagagat acccaggttg aatgggtttt
     3361 taaaccattg ttgtagacag tgagaaggta gtttgccctc ttcatgtcta tttcccttcc
     3421 agatagttgc atccaaaaga cagctgtttt gtcccactct cctactttcc tctgttaaaa
     3481 taagaacagg ggttgactta tgtcccgctc ctgaatacat gtaaaatttg tacaaaaata
     3541 tcttctatga aaatgatttg taatctgtag acattacttg ggagatgtct tgagatgtaa
     3601 aatcccatcc tttgggttga gggttttttg tttttctcca aataaatcca gtctttaaa
//
