LOCUS       NM_001100158            1515 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 4A3
            (Eif4a3), mRNA.
ACCESSION   NM_001100158 XM_001081786
VERSION     NM_001100158.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1515)
  AUTHORS   Wang,Y., Zhang,Y., Qu,Y., Li,S., Xi,W., Liu,B. and Ye,L.
  TITLE     eIF4A3-mediated circEHMT1 regulation in retinal microvascular
            endothelial dysfunction in diabetic retinopathy
  JOURNAL   Microvasc Res 151, 104612 (2024)
   PUBMED   37839527
  REMARK    GeneRIF: eIF4A3-mediated circEHMT1 regulation in retinal
            microvascular endothelial dysfunction in diabetic retinopathy.
REFERENCE   2  (bases 1 to 1515)
  AUTHORS   Zhan,X., Yan,C., Zhang,X., Lei,J. and Shi,Y.
  TITLE     Structure of a human catalytic step I spliceosome
  JOURNAL   Science 359 (6375), 537-545 (2018)
   PUBMED   29301961
REFERENCE   3  (bases 1 to 1515)
  AUTHORS   Favaro,F.P., Alvizi,L., Zechi-Ceide,R.M., Bertola,D., Felix,T.M.,
            de Souza,J., Raskin,S., Twigg,S.R., Weiner,A.M., Armas,P.,
            Margarit,E., Calcaterra,N.B., Andersen,G.R., McGowan,S.J.,
            Wilkie,A.O., Richieri-Costa,A., de Almeida,M.L. and
            Passos-Bueno,M.R.
  TITLE     A noncoding expansion in EIF4A3 causes Richieri-Costa-Pereira
            syndrome, a craniofacial disorder associated with limb defects
  JOURNAL   Am J Hum Genet 94 (1), 120-128 (2014)
   PUBMED   24360810
REFERENCE   4  (bases 1 to 1515)
  AUTHORS   Nguyen,L.S., Kim,H.G., Rosenfeld,J.A., Shen,Y., Gusella,J.F.,
            Lacassie,Y., Layman,L.C., Shaffer,L.G. and Gecz,J.
  TITLE     Contribution of copy number variants involving nonsense-mediated
            mRNA decay pathway genes to neuro-developmental disorders
  JOURNAL   Hum Mol Genet 22 (9), 1816-1825 (2013)
   PUBMED   23376982
REFERENCE   5  (bases 1 to 1515)
  AUTHORS   Barker-Haliski,M.L., Pastuzyn,E.D. and Keefe,K.A.
  TITLE     Expression of the core exon-junction complex factor eukaryotic
            initiation factor 4A3 is increased during spatial exploration and
            striatally-mediated learning
  JOURNAL   Neuroscience 226, 51-61 (2012)
   PUBMED   22982623
  REMARK    GeneRIF: These findings thus further implicate eIF4A3 as a key
            mediator of Arc protein mRNA availability underlying learning and
            memory processes in vivo
REFERENCE   6  (bases 1 to 1515)
  AUTHORS   Xia,Q., Kong,X.T., Zhang,G.A., Hou,X.J., Qiang,H. and Zhong,R.Q.
  TITLE     Proteomics-based identification of DEAD-box protein 48 as a novel
            autoantigen, a prospective serum marker for pancreatic cancer
  JOURNAL   Biochem Biophys Res Commun 330 (2), 526-532 (2005)
   PUBMED   15796914
REFERENCE   7  (bases 1 to 1515)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   8  (bases 1 to 1515)
  AUTHORS   Tange,T.O., Nott,A. and Moore,M.J.
  TITLE     The ever-increasing complexities of the exon junction complex
  JOURNAL   Curr Opin Cell Biol 16 (3), 279-284 (2004)
   PUBMED   15145352
  REMARK    Review article
REFERENCE   9  (bases 1 to 1515)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   10 (bases 1 to 1515)
  AUTHORS   Li,Q., Imataka,H., Morino,S., Rogers,G.W. Jr., Richter-Cook,N.J.,
            Merrick,W.C. and Sonenberg,N.
  TITLE     Eukaryotic translation initiation factor 4AIII (eIF4AIII) is
            functionally distinct from eIF4AI and eIF4AII
  JOURNAL   Mol Cell Biol 19 (11), 7336-7346 (1999)
   PUBMED   10523622
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CO559861.1 and
            BC105875.1.
            
            On Jan 22, 2011 this sequence version replaced NM_001100158.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105875.1, SRR8487230.55187.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                CO559861.1         1-55
            56-1515             BC105875.1         1-1460
FEATURES             Location/Qualifiers
     source          1..1515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1515
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /note="eukaryotic translation initiation factor 4A3"
                     /db_xref="GeneID:688288"
                     /db_xref="RGD:1591139"
     exon            1..229
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1296
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /EC_number="3.6.4.13"
                     /note="DEAD box protein 48; ATP-dependent RNA helicase
                     DDX48; ATP-dependent RNA helicase eIF4A-3; eIF-4A-III"
                     /codon_start=1
                     /product="eukaryotic initiation factor 4A-III"
                     /protein_id="NP_001093628.1"
                     /db_xref="GeneID:688288"
                     /db_xref="RGD:1591139"
                     /translation="MAATATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMG
                     LREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDI
                     QVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVV
                     AGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLIS
                     ATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLT
                     ITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLIST
                     DVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDI
                     EQYYSTQIDEMPMNVADLI"
     exon            230..302
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /inference="alignment:Splign:2.1.0"
     exon            303..369
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /inference="alignment:Splign:2.1.0"
     exon            370..432
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /inference="alignment:Splign:2.1.0"
     exon            433..565
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /inference="alignment:Splign:2.1.0"
     exon            566..646
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /inference="alignment:Splign:2.1.0"
     exon            647..788
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /inference="alignment:Splign:2.1.0"
     exon            789..927
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1043
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1151
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1279
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1490
                     /gene="Eif4a3"
                     /gene_synonym="eIF4A-III"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgagccttg tttccggttc ccgccgcagc tcgcagttgt ctattagtgg ggtcgggatc
       61 atggcggcca cggccacgat ggcgacgtcg ggctccgcgc ggaagcggct gctcaaagag
      121 gaggacatga ccaaagtgga gttcgagacc agcgaggagg tggacgtgac ccccacgttc
      181 gacaccatgg gccttcggga ggacctgctg cgcggcatct acgcctacgg ttttgaaaaa
      241 ccttctgcga tccaacagcg tgctatcaag cagataatta aagggagaga tgtcattgca
      301 cagtctcagt ctggcacagg caagacggcc accttcagta tttcagtcct tcagtgcttg
      361 gatatccagg ttcgagaaac ccaagctttg atattggctc caacaagaga gttagcagtg
      421 cagattcaga agggtctgct tgctttgggg gattacatga acgtgcagtg ccatgcctgc
      481 attggtggca ccaatgtcgg ggaggacatc cggaagctgg actatgggca gcatgttgtg
      541 gcgggcacac caggacgagt ctttgatatg atccgccgta gaagtttaag gacacgggca
      601 atcaagatgt tggttttgga tgaagctgat gaaatgttga acaaaggttt caaggagcag
      661 atctatgacg tgtacaggta cttgccacca gccactcagg ttgttctcat cagcgccacg
      721 ctgccccatg agatcctgga gatgaccaac aagttcatga ccgaccccat ccgcatcttg
      781 gtgaagcgtg atgagttgac tctggaaggc atcaaacagt tcttcgtggc cgtggaaaga
      841 gaggaatgga agttcgacac tctctgtgat ctctacgaca cgctgaccat cacccaggct
      901 gtcatcttct gcaacaccaa gaggaaggtt gactggctga cagagaaaat gagagaagcc
      961 aatttcacag tgtcgtccat gcacggagac atgccccaga aagagcgtga gtccatcatg
     1021 aaggagttcc ggtcaggtgc cagccgagtg ctcatctcca cagatgtctg ggcgcggggc
     1081 ctcgatgtcc ctcaggtgtc cctcatcatt aactatgacc tgcccaacaa cagagaactg
     1141 tacattcaca gaatcgggag atcaggtcga tatggacgca aaggtgtggc catcaatttt
     1201 gtgaagaatg atgacatccg catcctcagg gacattgagc agtactactc cacccagata
     1261 gatgagatgc ctatgaatgt ggctgacctc atctgaagct ggtgctggta caccaagggc
     1321 ctgtttggag ctcctctttg gacatggaag cttctattta atggggttta tatgaactgt
     1381 cttctcatag ccctcaggag gaccctcggc ctctgccatc ttttctaatg cacgtgtaaa
     1441 taatccaatg cgctaaatct tttacattaa acatggaaat tttcccacga aaaaaaaaaa
     1501 aaaaaaaaaa aaaaa
//
