LOCUS       NM_001008335            1912 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 4A2
            (Eif4a2), mRNA.
ACCESSION   NM_001008335 XM_221325
VERSION     NM_001008335.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1912)
  AUTHORS   Lu,W.T., Wilczynska,A., Smith,E. and Bushell,M.
  TITLE     The diverse roles of the eIF4A family: you are the company you keep
  JOURNAL   Biochem Soc Trans 42 (1), 166-172 (2014)
   PUBMED   24450646
  REMARK    Review article
REFERENCE   2  (bases 1 to 1912)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1912)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1912)
  AUTHORS   Parsyan,A., Svitkin,Y., Shahbazian,D., Gkogkas,C., Lasko,P.,
            Merrick,W.C. and Sonenberg,N.
  TITLE     mRNA helicases: the tacticians of translational control
  JOURNAL   Nat Rev Mol Cell Biol 12 (4), 235-245 (2011)
   PUBMED   21427765
  REMARK    Review article
REFERENCE   5  (bases 1 to 1912)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   6  (bases 1 to 1912)
  AUTHORS   Kyono,K., Miyashiro,M. and Taguchi,I.
  TITLE     Human eukaryotic initiation factor 4AII associates with hepatitis C
            virus NS5B protein in vitro
  JOURNAL   Biochem Biophys Res Commun 292 (3), 659-666 (2002)
   PUBMED   11922617
REFERENCE   7  (bases 1 to 1912)
  AUTHORS   Selvamurugan,N., Joost,O.H., Haas,E.S., Brown,J.W., Galvin,N.J. and
            Eliceiri,G.L.
  TITLE     Intracellular localization and unique conserved sequences of three
            small nucleolar RNAs
  JOURNAL   Nucleic Acids Res 25 (8), 1591-1596 (1997)
   PUBMED   9092667
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085859.1.
            
            On Dec 16, 2004 this sequence version replaced XM_221325.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085859.1, SRR8487230.144060.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1912
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1912
                     /gene="Eif4a2"
                     /note="eukaryotic translation initiation factor 4A2"
                     /db_xref="GeneID:303831"
                     /db_xref="RGD:1309225"
     exon            1..50
                     /gene="Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1245
                     /gene="Eif4a2"
                     /EC_number="3.6.4.13"
                     /note="protein synthesis initiation factor 4AII; eIF4A-II;
                     eIF-4A-II; ATP-dependent RNA helicase eIF4A-2; eukaryotic
                     translation initiation factor 4A"
                     /codon_start=1
                     /product="eukaryotic initiation factor 4A-II"
                     /protein_id="NP_001008336.1"
                     /db_xref="GeneID:303831"
                     /db_xref="RGD:1309225"
                     /translation="MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESL
                     LRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKET
                     QALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTP
                     GRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMP
                     TDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQA
                     VIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLA
                     RGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFY
                     NTTVEEMPMNVADLI"
     exon            51..96
                     /gene="Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            97..229
                     /gene="Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            230..369
                     /gene="Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            370..538
                     /gene="Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..648
                     /gene="Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..792
                     /gene="Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..930
                     /gene="Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1020
                     /gene="Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1100
                     /gene="Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1880
                     /gene="Eif4a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgagtgg gttttcggat catgtctggt ggctccgcgg attacaacag agaacatggc
       61 ggcccagagg gaatggaccc cgatggtgtc atcgagagca actggaatga aattgttgat
      121 aactttgatg atatgaattt aaaggagtcc cttcttcgag gcatctatgc ttatggtttt
      181 gagaagcctt cagctattca gcagagagct ataatcccat gtattaaagg atatgatgtg
      241 attgctcaag ctcagtcagg tactggcaag acagccacat ttgctatttc catcctgcaa
      301 cagttggaga ttgagttcaa ggagacccaa gcactagtat tggcccccac cagagaactg
      361 gctcaacaga tccaaaaggt cattttggct cttggagatt atatgggagc aacttgtcat
      421 gcttgcattg gaggaacaaa tgttcgaaat gaaatgcaga agttgcaggc tgaagcccct
      481 catattgttg ttggcactcc tgggagagta tttgatatgc taaacagaag atacctttct
      541 ccaaaatgga tcaaaatgtt tgttttggat gaagcagatg aaatgttgag ccgagggttt
      601 aaggatcaga tctatgagat tttccaaaaa ttaaatacaa gcattcaggt tgtgttactt
      661 tctgccacaa tgccaactga tgtcctagaa gtgaccaaga aattcatgag agatccaatt
      721 cgaattctgg tgaagaagga agaattgacc cttgaaggaa ttaaacaatt ttatattaat
      781 gttgagcgag aggagtggaa gctggacact ctttgtgact tgtatgagac tttgactatc
      841 acacaagcag ttatttttct caatacaagg cgcaaggtgg actggctcac ggagaaaatg
      901 catgccaggg acttcacagt ttctgctctg catggtgaca tggaccagaa ggaaagagat
      961 gtcatcatga gggaattccg atcagggtca agccgtgttc tgatcactac tgacttgttg
     1021 gctcgtggga ttgatgtgca acaagtgtcc ttggttataa actatgatct acctaccaat
     1081 cgtgaaaact atattcacag aattggcaga gggggtcgat ttgggaggaa aggtgtggct
     1141 ataaactttg ttactgaaga agacaagagg attcttcgtg acattgagac tttctacaat
     1201 actacagtgg aggaaatgcc catgaatgtg gctgacctaa tttaattcct gggatgagat
     1261 agtttggaat gcagtgctcg ctgttgctga ataggcgatc acaacgtgca ttgtgcttct
     1321 ttgagaatat ttgaatcttg tctcaatgct cataacggat cacaaataca gattctgata
     1381 gcaaagcgac tttagtcctg agctcttgtg aggaaaggca ttggctttat cctctttaga
     1441 gttagactgt tgggggtggg tataaaagat ggggtctgta aaatcttttt ttcttagaaa
     1501 ttcatttact agttatgtag aaatggttgt attagatgtt ctctatcatt taataatata
     1561 cttgtggact aaaagatata agtgctgtat aaaatcagcc aattatgtta aactagcata
     1621 tctgccttta ttgtgtttgt cattagcctg actagaaagg cctttaaagt gatctttttt
     1681 tagagaaaat ttgaatgcat tttgtttatt gtatttattc aataaagtat ttaattagtg
     1741 ctaagtgtga actggaccct gttgctaagc ctcagcaagc aatcatccta ggtagggtta
     1801 acaacccccc agtaaaattg ccatattgca catgtcttaa tgaagtttga atgttaaata
     1861 aaaattgtat attcacttta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
