LOCUS       NM_199372               1772 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 4A1
            (Eif4a1), mRNA.
ACCESSION   NM_199372 XM_213364
VERSION     NM_199372.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1772)
  AUTHORS   Lu,W.T., Wilczynska,A., Smith,E. and Bushell,M.
  TITLE     The diverse roles of the eIF4A family: you are the company you keep
  JOURNAL   Biochem Soc Trans 42 (1), 166-172 (2014)
   PUBMED   24450646
  REMARK    Review article
REFERENCE   2  (bases 1 to 1772)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   3  (bases 1 to 1772)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 1772)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 1772)
  AUTHORS   Parsyan,A., Svitkin,Y., Shahbazian,D., Gkogkas,C., Lasko,P.,
            Merrick,W.C. and Sonenberg,N.
  TITLE     mRNA helicases: the tacticians of translational control
  JOURNAL   Nat Rev Mol Cell Biol 12 (4), 235-245 (2011)
   PUBMED   21427765
  REMARK    Review article
REFERENCE   6  (bases 1 to 1772)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   7  (bases 1 to 1772)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 1772)
  AUTHORS   Bohnsack,M.T., Regener,K., Schwappach,B., Saffrich,R.,
            Paraskeva,E., Hartmann,E. and Gorlich,D.
  TITLE     Exp5 exports eEF1A via tRNA from nuclei and synergizes with other
            transport pathways to confine translation to the cytoplasm
  JOURNAL   EMBO J 21 (22), 6205-6215 (2002)
   PUBMED   12426392
REFERENCE   9  (bases 1 to 1772)
  AUTHORS   Aloni,R., Peleg,D. and Meyuhas,O.
  TITLE     Selective translational control and nonspecific posttranscriptional
            regulation of ribosomal protein gene expression during development
            and regeneration of rat liver
  JOURNAL   Mol Cell Biol 12 (5), 2203-2212 (1992)
   PUBMED   1373810
REFERENCE   10 (bases 1 to 1772)
  AUTHORS   Nielsen,P.J., McMaster,G.K. and Trachsel,H.
  TITLE     Cloning of eukaryotic protein synthesis initiation factor genes:
            isolation and characterization of cDNA clones encoding factor
            eIF-4A
  JOURNAL   Nucleic Acids Res 13 (19), 6867-6880 (1985)
   PUBMED   3840589
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 29, 2021 this sequence version replaced NM_199372.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063812.1, FQ228869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                JAXUCZ010000010.1  54888564-54888602   c
            40-88               JAXUCZ010000010.1  54887239-54887287   c
            89-221              JAXUCZ010000010.1  54886946-54887078   c
            222-361             JAXUCZ010000010.1  54886465-54886604   c
            362-530             JAXUCZ010000010.1  54885260-54885428   c
            531-640             JAXUCZ010000010.1  54884829-54884938   c
            641-784             JAXUCZ010000010.1  54884595-54884738   c
            785-922             JAXUCZ010000010.1  54884381-54884518   c
            923-1012            JAXUCZ010000010.1  54884206-54884295   c
            1013-1092           JAXUCZ010000010.1  54883884-54883963   c
            1093-1772           JAXUCZ010000010.1  54883093-54883772   c
FEATURES             Location/Qualifiers
     source          1..1772
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1772
                     /gene="Eif4a1"
                     /note="eukaryotic translation initiation factor 4A1"
                     /db_xref="GeneID:287436"
                     /db_xref="RGD:735141"
     exon            1..39
                     /gene="Eif4a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1237
                     /gene="Eif4a1"
                     /EC_number="3.6.4.13"
                     /note="eukaryotic translation initiation factor 4A"
                     /codon_start=1
                     /product="eukaryotic initiation factor 4A-I"
                     /protein_id="NP_955404.1"
                     /db_xref="GeneID:287436"
                     /db_xref="RGD:735141"
                     /translation="MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLL
                     RGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQ
                     ALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPG
                     RVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPS
                     DVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAV
                     IFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLAR
                     GIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYN
                     TSIEEMPLNVADLI"
     exon            40..88
                     /gene="Eif4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            89..221
                     /gene="Eif4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            222..361
                     /gene="Eif4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..530
                     /gene="Eif4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..640
                     /gene="Eif4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            641..784
                     /gene="Eif4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..922
                     /gene="Eif4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1012
                     /gene="Eif4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1092
                     /gene="Eif4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1772
                     /gene="Eif4a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagattcta aggatcatgt ctgcgagtca ggattctcga tccagagaca atggccccga
       61 tgggatggag ccggaaggcg tcatcgagag taactggaat gagattgtgg atagcttcga
      121 tgacatgaat ctctcagaat ccctcctccg tggtatttat gcctatggtt ttgagaagcc
      181 ctctgccatc cagcagcgag ctattcttcc ttgtatcaag ggttatgatg tgattgctca
      241 agcccagtct gggactggga aaacagctac atttgccata tccattctgc agcagattga
      301 attagatcta aaggccactc aggctttggt tctggcaccc actcgtgaat tggctcagca
      361 gattcaaaag gtggttatgg cactgggaga ctacatgggt gcctcttgtc atgcctgtat
      421 tgggggcacc aacgtgcgtg ctgaggtgca gaagctgcaa atggaagctc cccatatcat
      481 cgtgggcacc cctggccggg tgttcgatat gcttaaccgg agatacctgt cacccaaata
      541 catcaagatg ttcgtcctgg atgaagcaga tgaaatgcta agccgtgggt tcaaggatca
      601 gatctatgat atattccaaa agctcaacag caacacacag gtagttttgc tgtctgccac
      661 aatgccttct gatgtccttg aggtgactaa gaagttcatg agagacccta ttcggattct
      721 tgtcaagaag gaagagttga ccctggaggg tatccgccaa ttctacatca atgtggaacg
      781 agaggagtgg aagctcgaca cattgtgtga cttgtatgaa acactgacca tcacccaggc
      841 agtaatcttt attaatacca gaaggaaggt ggactggctc actgagaaga tgcatgcccg
      901 ggatttcaca gtttctgcca tgcatggaga tatggaccaa aaggaacgag acgtgatcat
      961 gagggagttc cggtctggct ctagcagagt attaattacc actgacctgt tggccagagg
     1021 cattgatgtg cagcaggtct ccctagtcat caattatgac cttcccacca acagggaaaa
     1081 ctacatccac agaattggtc gaggtggtcg gtttggccgg aaaggtgtgg ctattaacat
     1141 ggtgacagaa gaagacaaga ggactcttcg agacattgag actttctaca acacctccat
     1201 tgaagagatg cccctcaacg ttgctgacct catttgaggg gctgtcctgc tacctggccc
     1261 tagcccaggg ttcagtcctg ggggcagggc tgaggaacag ctggaggggg gagggaaggg
     1321 agccaaggga tggacatctt gtttttgttt ttttgttttg tttttttttt ctctctctct
     1381 ctctctttga ataaatgtca ctttttgagg caaaaagaag gaaccgtgaa cattttagac
     1441 acccttttct ttggggtagg ctctgcccca ggcgccgtct ccttcccccc caaacactaa
     1501 tgcatttccc taacctaatc acctcattcc taaaggcttt cctaccccag ccaaatctcc
     1561 aaaagtgagt caaggggcta aaacatggct ggcctcattt gctggaccaa atctacaggg
     1621 agaaccccct gaatgaggtt gtccagggac ttgtccccag gtgaggggag caggggagag
     1681 aaaatggtag ccatttttac attgttttgt atagtattta ttgattcagg aaacaaacac
     1741 aaaattctga ataaaattac ttggaaactg cc
//
