LOCUS       NM_001168523            1259 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 3,
            subunit M (Eif3m), transcript variant 1, mRNA.
ACCESSION   NM_001168523 XM_001079651 XM_215794
VERSION     NM_001168523.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1259)
  AUTHORS   Lee,A.S., Kranzusch,P.J. and Cate,J.H.
  TITLE     eIF3 targets cell-proliferation messenger RNAs for translational
            activation or repression
  JOURNAL   Nature 522 (7554), 111-114 (2015)
   PUBMED   25849773
REFERENCE   2  (bases 1 to 1259)
  AUTHORS   Hinnebusch,A.G.
  TITLE     The scanning mechanism of eukaryotic translation initiation
  JOURNAL   Annu Rev Biochem 83, 779-812 (2014)
   PUBMED   24499181
  REMARK    Review article
REFERENCE   3  (bases 1 to 1259)
  AUTHORS   Zeng,L., Wan,Y., Li,D., Wu,J., Shao,M., Chen,J., Hui,L., Ji,H. and
            Zhu,X.
  TITLE     The m subunit of murine translation initiation factor eIF3
            maintains the integrity of the eIF3 complex and is required for
            embryonic development, homeostasis, and organ size control
  JOURNAL   J Biol Chem 288 (42), 30087-30093 (2013)
   PUBMED   24003236
REFERENCE   4  (bases 1 to 1259)
  AUTHORS   Zhou,M., Sandercock,A.M., Fraser,C.S., Ridlova,G., Stephens,E.,
            Schenauer,M.R., Yokoi-Fong,T., Barsky,D., Leary,J.A., Hershey,J.W.,
            Doudna,J.A. and Robinson,C.V.
  TITLE     Mass spectrometry reveals modularity and a complete subunit
            interaction map of the eukaryotic translation factor eIF3
  JOURNAL   Proc Natl Acad Sci U S A 105 (47), 18139-18144 (2008)
   PUBMED   18599441
REFERENCE   5  (bases 1 to 1259)
  AUTHORS   Damoc,E., Fraser,C.S., Zhou,M., Videler,H., Mayeur,G.L.,
            Hershey,J.W., Doudna,J.A., Robinson,C.V. and Leary,J.A.
  TITLE     Structural characterization of the human eukaryotic initiation
            factor 3 protein complex by mass spectrometry
  JOURNAL   Mol Cell Proteomics 6 (7), 1135-1146 (2007)
   PUBMED   17322308
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Dec 12, 2009 this sequence version replaced
            XM_215794.4, XM_001079651.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220907.1, FQ229811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806, SAMN16676811
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               JAXUCZ010000003.1  111897088-111897193 c
            107-239             JAXUCZ010000003.1  111894695-111894827 c
            240-378             JAXUCZ010000003.1  111893690-111893828 c
            379-502             JAXUCZ010000003.1  111892913-111893036 c
            503-597             JAXUCZ010000003.1  111892569-111892663 c
            598-681             JAXUCZ010000003.1  111886253-111886336 c
            682-781             JAXUCZ010000003.1  111885381-111885480 c
            782-863             JAXUCZ010000003.1  111884675-111884756 c
            864-1007            JAXUCZ010000003.1  111881205-111881348 c
            1008-1068           JAXUCZ010000003.1  111880205-111880265 c
            1069-1259           JAXUCZ010000003.1  111879589-111879779 c
FEATURES             Location/Qualifiers
     source          1..1259
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q33"
     gene            1..1259
                     /gene="Eif3m"
                     /gene_synonym="RGD1565840"
                     /note="eukaryotic translation initiation factor 3, subunit
                     M"
                     /db_xref="GeneID:295975"
                     /db_xref="RGD:1565840"
     exon            1..106
                     /gene="Eif3m"
                     /gene_synonym="RGD1565840"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1189
                     /gene="Eif3m"
                     /gene_synonym="RGD1565840"
                     /EC_number="3.6.5.3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit M isoform 1"
                     /protein_id="NP_001161995.1"
                     /db_xref="GeneID:295975"
                     /db_xref="RGD:1565840"
                     /translation="MSVPAFIDISEEDQAAELRAYLKSKGAEISEENSEGGLHVDLAQ
                     IIEACDVCLKEDDKDVESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLR
                     LQLLSNLFHGMDKNTPVRYTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWKLTTEK
                     KHTLLRLLYEALVDCKKSDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAF
                     LFDHLLTLKPVKFLEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAK
                     MRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVV
                     SHSTHRTFGKQQWQQLYDTLNAWKQNLNKVKNSLLSLSDT"
     exon            107..239
                     /gene="Eif3m"
                     /gene_synonym="RGD1565840"
                     /inference="alignment:Splign:2.1.0"
     exon            240..378
                     /gene="Eif3m"
                     /gene_synonym="RGD1565840"
                     /inference="alignment:Splign:2.1.0"
     exon            379..502
                     /gene="Eif3m"
                     /gene_synonym="RGD1565840"
                     /inference="alignment:Splign:2.1.0"
     exon            503..597
                     /gene="Eif3m"
                     /gene_synonym="RGD1565840"
                     /inference="alignment:Splign:2.1.0"
     exon            598..681
                     /gene="Eif3m"
                     /gene_synonym="RGD1565840"
                     /inference="alignment:Splign:2.1.0"
     exon            682..781
                     /gene="Eif3m"
                     /gene_synonym="RGD1565840"
                     /inference="alignment:Splign:2.1.0"
     exon            782..863
                     /gene="Eif3m"
                     /gene_synonym="RGD1565840"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1007
                     /gene="Eif3m"
                     /gene_synonym="RGD1565840"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1068
                     /gene="Eif3m"
                     /gene_synonym="RGD1565840"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1259
                     /gene="Eif3m"
                     /gene_synonym="RGD1565840"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taccgctcct tttccggtcg gcgtggttct ggagcggagc gtcttccgca gccaggcctt
       61 caccatgagc gtcccggcct tcatcgatat cagcgaggaa gaccaggccg ctgaacttcg
      121 cgcttatctg aaatcaaaag gagctgagat ctcagaagag aactcggaag gtggacttca
      181 tgtagactta gctcagatta ttgaagcctg tgatgtgtgt ctgaaggaag atgataaaga
      241 tgttgaaagt gtgatgaaca gtgtggtgtc cctcctgttg atcctggaac cagacaagca
      301 agaagcattg attgaaagtc tgtgtgaaaa gttggtcaag ttccgggaag gcgaacgccc
      361 atctctgaga ctacaattgc tcagcaatct tttccatggg atggacaaga atactcctgt
      421 aaggtacaca gtgtactgca gcctcatcaa agtggcggca tcatgtgggg ccatccagta
      481 catcccaacg gaactggacc aagtgagaaa gtggatctct gactggaagc tcaccactga
      541 aaagaaacac accctcttaa gacttctcta tgaggcgctc gtggattgta agaaaagtga
      601 tgctgcttca aaggtcatgg tggaattgct tgggagttac acagaagaca atgcttccca
      661 ggctcgagtt gatgcccaca ggtgtattgt gcgggcactg aaggatccaa atgcctttct
      721 ttttgaccat cttcttactc tgaagccagt caaatttttg gaaggcgagc ttatccatga
      781 tttattgacc attttcgtga gtgctaaatt ggcatcatat gtcaagttct atcagaataa
      841 caaagacttc atagattcac ttggcttgtt acatgagcaa aatatggcga aaatgagact
      901 cctcaccttt atgggaatgg cagtggaaaa caaagagatt tcttttgata caatgcagca
      961 agagctacag attggagctg atgatgttga agcatttgtt attgatgctg taagaactaa
     1021 aatggtctac tgcaaaatcg atcagacaca aagaaaagta gttgtcagtc acagcacaca
     1081 tcggacattt ggaaaacagc agtggcaaca actgtacgac actcttaatg cctggaagca
     1141 gaacttgaac aaagtgaaaa atagcctttt gagtctttca gatacctgaa tttttatgca
     1201 aataattttg ttcttggggg aaaaagttct aagtcatagt aaaacattat caactgaaa
//
