LOCUS       NM_001100662            3061 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 3,
            subunit C (Eif3c), mRNA.
ACCESSION   NM_001100662 XM_001079906 XM_215080
VERSION     NM_001100662.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3061)
  AUTHORS   Lee,A.S., Kranzusch,P.J. and Cate,J.H.
  TITLE     eIF3 targets cell-proliferation messenger RNAs for translational
            activation or repression
  JOURNAL   Nature 522 (7554), 111-114 (2015)
   PUBMED   25849773
REFERENCE   2  (bases 1 to 3061)
  AUTHORS   Hinnebusch,A.G.
  TITLE     The scanning mechanism of eukaryotic translation initiation
  JOURNAL   Annu Rev Biochem 83, 779-812 (2014)
   PUBMED   24499181
  REMARK    Review article
REFERENCE   3  (bases 1 to 3061)
  AUTHORS   Villa,N., Do,A., Hershey,J.W. and Fraser,C.S.
  TITLE     Human eukaryotic initiation factor 4G (eIF4G) protein binds to
            eIF3c, -d, and -e to promote mRNA recruitment to the ribosome
  JOURNAL   J Biol Chem 288 (46), 32932-32940 (2013)
   PUBMED   24092755
REFERENCE   4  (bases 1 to 3061)
  AUTHORS   Zeng,L., Wan,Y., Li,D., Wu,J., Shao,M., Chen,J., Hui,L., Ji,H. and
            Zhu,X.
  TITLE     The m subunit of murine translation initiation factor eIF3
            maintains the integrity of the eIF3 complex and is required for
            embryonic development, homeostasis, and organ size control
  JOURNAL   J Biol Chem 288 (42), 30087-30093 (2013)
   PUBMED   24003236
REFERENCE   5  (bases 1 to 3061)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3061)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 3061)
  AUTHORS   Zhou,M., Sandercock,A.M., Fraser,C.S., Ridlova,G., Stephens,E.,
            Schenauer,M.R., Yokoi-Fong,T., Barsky,D., Leary,J.A., Hershey,J.W.,
            Doudna,J.A. and Robinson,C.V.
  TITLE     Mass spectrometry reveals modularity and a complete subunit
            interaction map of the eukaryotic translation factor eIF3
  JOURNAL   Proc Natl Acad Sci U S A 105 (47), 18139-18144 (2008)
   PUBMED   18599441
REFERENCE   8  (bases 1 to 3061)
  AUTHORS   Masutani,M., Sonenberg,N., Yokoyama,S. and Imataka,H.
  TITLE     Reconstitution reveals the functional core of mammalian eIF3
  JOURNAL   EMBO J 26 (14), 3373-3383 (2007)
   PUBMED   17581632
REFERENCE   9  (bases 1 to 3061)
  AUTHORS   Damoc,E., Fraser,C.S., Zhou,M., Videler,H., Mayeur,G.L.,
            Hershey,J.W., Doudna,J.A., Robinson,C.V. and Leary,J.A.
  TITLE     Structural characterization of the human eukaryotic initiation
            factor 3 protein complex by mass spectrometry
  JOURNAL   Mol Cell Proteomics 6 (7), 1135-1146 (2007)
   PUBMED   17322308
REFERENCE   10 (bases 1 to 3061)
  AUTHORS   Asano,K., Kinzy,T.G., Merrick,W.C. and Hershey,J.W.
  TITLE     Conservation and diversity of eukaryotic translation initiation
            factor eIF3
  JOURNAL   J Biol Chem 272 (2), 1101-1109 (1997)
   PUBMED   8995409
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169011.1.
            
            On or before Sep 10, 2008 this sequence version replaced
            XM_001079906.1, XM_215080.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169011.1, SRR8487227.102853.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3061
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..3061
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /note="eukaryotic translation initiation factor 3, subunit
                     C"
                     /db_xref="GeneID:293484"
                     /db_xref="RGD:1308871"
     exon            1..171
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            172..312
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2947
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /note="eukaryotic translation initiation factor 3, subunit
                     8, 110kDa; eukaryotic translation initiation factor 3
                     subunit 8"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit C"
                     /protein_id="NP_001094132.1"
                     /db_xref="GeneID:293484"
                     /db_xref="RGD:1308871"
                     /translation="MSRFFTTGSDSESESSLSGEELVTKPVSGNYGKQPLLLSEDEED
                     TKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGV
                     PRFYVRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITNYK
                     QNPEQSADEDAEKNEEDSEGSSDEDEDDDGVSGTAFLKKKPDSSGESRKFHKKMEDDD
                     EDSEDSEDEEWDTSSTSSDSDSEEEEGKQTVLASKFLKKAPTTEEDKKAAEKKREDKA
                     KKKHDRKSKRMDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEI
                     LQVRGKKGTDRATQIELLQLLVQIASENNLGVGVIVKIKFNIIASLYDYNPNLATYMK
                     PEMWQMCLDCINELMDTLVAHSNIFVGENILEESENLHNFDQPLRVRGCILTLVERMD
                     EEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEICQIYLRRILHT
                     YYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCA
                     ILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLT
                     KDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELLEC
                     VYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASK
                     AMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYD
                     SISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQ
                     LAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMRRGGYRQQQSQTAY"
     exon            313..378
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            379..568
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            569..694
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            695..749
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            750..856
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            857..981
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1141
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1245
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1387
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1513
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1607
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1798
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..2023
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2387
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2547
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2613
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2701
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2864
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3037
                     /gene="Eif3c"
                     /gene_synonym="eIF3 p110; Eif3s8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggctttc ggggggatct cgctcggctt tcgggccgat ctgctcggtt ttcgggcgga
       61 tctgctcggc tttcgggcgg atctcgcctt tcgggccgcc ggctcggctt tcgggcccgt
      121 ctcggccgtc gctcctgtct cgcccgttct cgagactcgg gagctcagct gcttcgggcc
      181 acgagcgcct caacccttca gcaccgtcgc catgtcccgg tttttcacca ccggctcgga
      241 cagtgagtcg gagtcgtccc tgtccgggga ggagctcgtc accaaaccag tctccgggaa
      301 ctatggcaaa cagcctttgt tactgagcga ggatgaagag gatacaaaga gagttgttcg
      361 aagtgccaag gacaagaggt ttgaggagct gaccaacctt atacgaacca tccgtaatgc
      421 catgaagatt cgagatgtca ccaagtgtct agaagagttt gaactcctgg gaaaagccta
      481 tgggaaagcc aagagtattg tggataagga gggtgtcccc cgattctatg tccggatatt
      541 ggctgacctg gaggactatc ttaatgagct ttgggaagat aaggaaggga aaaagaagat
      601 gaataaaaac aatgccaagg ctctgagtac attgcgccag aagatccgaa aatacaaccg
      661 agattttgag tctcacatca ccaactataa gcagaaccct gaacaatctg cagatgaaga
      721 tgcagaaaag aatgaggaag actcagaagg ctcttcagat gaggatgaag atgacgatgg
      781 agtcagtggt acagccttct tgaagaagaa accagactct tctggggaga gtcgaaagtt
      841 ccacaaaaag atggaggatg atgatgagga ctctgaagat tctgaggatg aagaatggga
      901 caccagttcc acatcttctg attcagactc cgaagaagaa gaaggaaaac aaactgttct
      961 ggcctcaaag ttccttaaaa aggcacccac cacagaggag gacaaaaagg cagctgaaaa
     1021 gaaacgggaa gacaaagcca agaagaagca cgataggaag tctaagcgca tggatgagga
     1081 agaggaggac aatgaaggcg gggagtggga acgggtccga ggcggcgtac cacttgttaa
     1141 ggagaaacca aaaatgtttg ccaagggaac agagatcact catgctgttg tcatcaagaa
     1201 gctgaatgag attctacagg tcagaggcaa gaagggaaca gaccgtgcta cccagattga
     1261 attgctccag ctgctggttc agattgcttc tgaaaacaac ctgggggtgg gtgtcattgt
     1321 caagatcaag ttcaatatca ttgcctctct ctacgattac aaccctaacc tggccacgta
     1381 catgaagcca gagatgtggc agatgtgcct ggactgtatc aatgagttga tggatacctt
     1441 ggttgcacat tccaacatct ttgttggaga gaacattttg gaagagagtg agaacttaca
     1501 caattttgat cagccactgc gtgtacgagg ctgcatccta actctggtgg agcgaatgga
     1561 tgaagaattt accaaaataa tgcaaaatac tgatcctcac tcccaagagt atgtggaaca
     1621 tctgaaggat gaggcacaag tatgtgccat cattgagcgt gtacagcgct acctggagga
     1681 gaaaggtacc actgaggaga tctgccagat ctacttgagg cgcatcctgc acacttacta
     1741 caagtttgat tacaaggccc atcagcgtca gcttactcct ccggaagggt cctcaaagtc
     1801 tgagcaagac caggcagaaa atgagggtga ggactcagct gtgctaatgg aaagactgtg
     1861 caaatacatc tatgccaagg accgtacaga ccgcatccgt acctgtgcca tcctctgcca
     1921 tatctaccat catgcgctcc actcccgctg gtatcaggcc cgtgacctca tgctcatgag
     1981 ccacctacaa gacaacatcc agcacgcaga cccgccagta cagatcctgt ataaccgtac
     2041 catggtgcaa ctgggcatct gtgctttccg ccaaggcctg acaaaggatg cacacaatgc
     2101 acttctggat attcagtcaa gtggtcgtgc caaggagctt ctgggccagg gtctgctgct
     2161 gcgcagcctc caggagcgca accaggaaca ggagaaggta gagcgacgcc ggcaggtgcc
     2221 ctttcacctg cacatcaacc tggaactgct ggagtgtgtg tatctggtgt ctgctatgct
     2281 cctggagatc ccctacatgg ctgcccatga gagtgatgcc cgccgacgca tgatcagcaa
     2341 gcagttccat caccaactgc gggtgggcga gcggcagccc ctgctaggtc ctcctgagtc
     2401 aatgagggag catgtggttg ctgcctccaa ggccatgaag atgggtgact ggaagacctg
     2461 ccacagtttc atcattaatg aaaagatgaa tgggaaagtg tgggaccttt tccctgaggc
     2521 tgacaaagtt cgcaccatgc tagttcggaa gatccaggaa gagtctctga ggacctacct
     2581 ttttacctat agcagtgtct atgactcaat cagtatggag acactctcag atatgtttga
     2641 gctggatctg cccactgttc actccatcat cagcaagatg atcattaatg aagaattgat
     2701 ggcttccctg gaccagccaa cgcagacggt agtgatgcac cgtactgagc ccactgccca
     2761 acagaacttg gctctgcagc tggctgagaa gcttggcagc ctagtggaga ataatgaacg
     2821 tgtgtttgac cataagcaag gaacctatgg cggctatttc cgagaccaaa aggatggcta
     2881 ccgaaaaaat gaaggctata tgcgccgtgg tggctaccgc cagcagcagt ctcagacagc
     2941 ttactgaggt cctcacttct tgtcgtccct atgaccagac tatctacctt tttgttccta
     3001 aactcacccc ggtcattaaa ggtctgttga gaatgtaaaa aaaaaaaaaa aaaaaaaaaa
     3061 a
//
