LOCUS       NM_001047087            5139 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 3,
            subunit A (Eif3a), mRNA.
ACCESSION   NM_001047087 XM_001056819 XM_001073847 XM_001073873 XM_238649
VERSION     NM_001047087.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5139)
  AUTHORS   Yang,H.T., Wang,G., Zhu,P.C. and Xiao,Z.Y.
  TITLE     Silencing EIF3A ameliorates pulmonary arterial hypertension through
            HDAC1 and PTEN/PI3K/AKT pathway in vitro and in vivo
  JOURNAL   Exp Cell Res 426 (1), 113555 (2023)
   PUBMED   36921705
  REMARK    GeneRIF: Silencing EIF3A ameliorates pulmonary arterial
            hypertension through HDAC1 and PTEN/PI3K/AKT pathway in vitro and
            in vivo.
REFERENCE   2  (bases 1 to 5139)
  AUTHORS   Guo,R., Lv,Y., Ouyang,Y., Liu,S. and Li,D.
  TITLE     The Role of miR-497/EIF3A Axis in TGFbeta1-Induced
            Epithelial-Mesenchymal Transition and Extracellular Matrix in Rat
            Alveolar Epithelial Cells and Pulmonary Fibroblasts
  JOURNAL   J Cell Biochem 118 (10), 3401-3408 (2017)
   PUBMED   28322466
  REMARK    GeneRIF: miR-497 could suppress TGFbeta1-induced pulmonary
            fibroblast proliferation and EIF3A, Collagen I and alpha-SMA
            protein levels.
REFERENCE   3  (bases 1 to 5139)
  AUTHORS   Lee,A.S., Kranzusch,P.J., Doudna,J.A. and Cate,J.H.
  TITLE     eIF3d is an mRNA cap-binding protein that is required for
            specialized translation initiation
  JOURNAL   Nature 536 (7614), 96-99 (2016)
   PUBMED   27462815
REFERENCE   4  (bases 1 to 5139)
  AUTHORS   Li,B., Chen,H., Yang,X., Wang,Y., Qin,L. and Chu,Y.
  TITLE     Knockdown of eIF3a ameliorates cardiac fibrosis by inhibiting the
            TGF-beta1/Smad3 signaling pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 62 (7), 97-101 (2016)
   PUBMED   27453280
  REMARK    GeneRIF: silencing eIF3a might alleviate TGF-beta1-induced cardiac
            fibrogenesis in cardiac fibroblasts by inhibiting Smad3 activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5139)
  AUTHORS   Li,W.Q., Li,X.H., Wu,Y.H., Du,J., Wang,A.P., Li,D. and Li,Y.J.
  TITLE     Role of eukaryotic translation initiation factors 3a in
            hypoxia-induced right ventricular remodeling of rats
  JOURNAL   Life Sci 144, 61-68 (2016)
   PUBMED   26612348
  REMARK    GeneRIF: The eIF3a plays a crucial role in hypoxia-induced right
            ventricular remodeling by regulating TGF-beta1-induced
            proliferation and differentiation of cardiac fibroblasts
REFERENCE   6  (bases 1 to 5139)
  AUTHORS   Masutani,M., Sonenberg,N., Yokoyama,S. and Imataka,H.
  TITLE     Reconstitution reveals the functional core of mammalian eIF3
  JOURNAL   EMBO J 26 (14), 3373-3383 (2007)
   PUBMED   17581632
REFERENCE   7  (bases 1 to 5139)
  AUTHORS   Damoc,E., Fraser,C.S., Zhou,M., Videler,H., Mayeur,G.L.,
            Hershey,J.W., Doudna,J.A., Robinson,C.V. and Leary,J.A.
  TITLE     Structural characterization of the human eukaryotic initiation
            factor 3 protein complex by mass spectrometry
  JOURNAL   Mol Cell Proteomics 6 (7), 1135-1146 (2007)
   PUBMED   17322308
REFERENCE   8  (bases 1 to 5139)
  AUTHORS   Shakib,K., Norman,J.T., Fine,L.G., Brown,L.R. and
            Godovac-Zimmermann,J.
  TITLE     Proteomics profiling of nuclear proteins for kidney fibroblasts
            suggests hypoxia, meiosis, and cancer may meet in the nucleus
  JOURNAL   Proteomics 5 (11), 2819-2838 (2005)
   PUBMED   15942958
REFERENCE   9  (bases 1 to 5139)
  AUTHORS   MacDonald,J.I., Verdi,J.M. and Meakin,S.O.
  TITLE     Activity-dependent interaction of the intracellular domain of rat
            trkA with intermediate filament proteins, the beta-6 proteasomal
            subunit, Ras-GRF1, and the p162 subunit of eIF3
  JOURNAL   J Mol Neurosci 13 (1-2), 141-158 (1999)
   PUBMED   10691301
REFERENCE   10 (bases 1 to 5139)
  AUTHORS   Sizova,D.V., Kolupaeva,V.G., Pestova,T.V., Shatsky,I.N. and
            Hellen,C.U.
  TITLE     Specific interaction of eukaryotic translation initiation factor 3
            with the 5' nontranslated regions of hepatitis C virus and
            classical swine fever virus RNAs
  JOURNAL   J Virol 72 (6), 4775-4782 (1998)
   PUBMED   9573242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB698626.1 and AB259154.1.
            
            On Oct 15, 2009 this sequence version replaced NM_001047087.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ221906.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               CB698626.1         9-355
            348-5139            AB259154.1         1-4792
FEATURES             Location/Qualifiers
     source          1..5139
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..5139
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /note="eukaryotic translation initiation factor 3, subunit
                     A"
                     /db_xref="GeneID:292148"
                     /db_xref="RGD:1307269"
     exon            1..233
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..4249
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /note="eukaryotic translation initiation factor 3, subunit
                     10 (theta); eIF-3-theta; eukaryotic translation initiation
                     factor 3 subunit 10"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit A"
                     /protein_id="NP_001040552.2"
                     /db_xref="GeneID:292148"
                     /db_xref="RGD:1307269"
                     /translation="MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQ
                     KIHEPIMLKYLELCVDLRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKLAEEKTE
                     AAKEESQQMVLDIEDLDNIQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQC
                     LDLLRNNSRVERLYHDIAQQAFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAI
                     NLNNPESQSMHLETRLVQLDSAISMELWQEAFKAVEDIHGLFSLSKKPPKPQLMANYY
                     NKVSTVFWKSGNALFHASTLHRLYHLSREMRKNLTQDEMQRMSTRVLLATLSIPITPE
                     RTDIARLLDMDGIIVEKQRRLATLLGLQAPPTRIGLINDMVRFNVLQYVVPEVKDLYN
                     WLEVEFNPLKLCERVTKVLNWVREQPEKEPELQQYVPQLQNNTILRLLQQVAQIYQSI
                     EFSRLTSLVPFVDAFQLERAIVDAARHCDLQVRIDHTSRTLSFGSDLNYATREDAPIG
                     PHLQSMPSEQIRNQLTAMSSVLAKALEVIKPAHILQEKEEQHQLAVTAYIKNSRKEHQ
                     RILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERI
                     LQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKK
                     ELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRVKDMDLWEQQEEERITTMQLER
                     EKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQR
                     KEERKITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVER
                     KKRQRELEIEERERRREEERRLGEDPLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPP
                     EKEWRRETRDDERPHRRDEDRLRRLGGDDEERESSLRPDDDRIPRRGLDDDRGPRRGP
                     DEDRFSRRGTDDDRPSWRNADDDRPPRRIGDDDRGSWRHTDDDRPPRRGLDDDRPPRR
                     GLDDERGSWRTAEEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGMDDDRG
                     PRRGLDDDRGPWRNAAEDRISRRGADDDRGPWRNMDDDRVPRRGDDARPGPWRPFVKP
                     GGWREKEKAREESWGPPRESRPPEEREWDRDKEKDRDNQDREENDKDLERDRDRERDG
                     DREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRDRDDRRDLRDLRDRRD
                     LRDDRDRRGPPLRSEREEASSWRRTDDRKDDRTEERDPPRRVPPPTLSRERERERDRE
                     GEKEKASWRAEKDRESLRRTKNETDEDGWTTVRR"
     exon            234..424
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            425..561
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            562..725
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            726..925
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1134
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1306
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1411
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1510
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1627
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1813
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2161
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2266
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2380
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2503
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2657
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2842
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2931
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3623
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3825
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..4025
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..5139
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcggcgg cgctgccgcc gcgagggaat cacgtggctc cttcctttcc gtctctggcc
       61 ggctgggcgc gggcgactgc tggcgaggcg cgtggaagct cgcgctagtt cccctccgcc
      121 tcctctcccg gtccaggcca ctagggagtt cgctgacgcc gggtgaactg agcgtaccgc
      181 caagatgccg gcctatttcc agaggccgga aaatgccctc aagcgcgcca acgaatttct
      241 tgaggttggc aaaaagcagc ctgccctgga tgttctttat gatgttatga aaagtaagaa
      301 acacagaaca tggcagaaga tacacgagcc aattatgctg aaatacttgg aactatgtgt
      361 ggatcttcgt aagagccact tggctaagga aggattatat caatataaga acatttgtca
      421 gcaggtaaac attaaatctt tagaagatgt tgttagggca tatttgaaat tagcagagga
      481 aaaaacagaa gctgctaaag aagagtccca acaaatggtg ttagacatag aagatctgga
      541 taatattcag actcctgaga gtgttctctt aagtgcagta agtggggaag acactcagga
      601 tcgtactgac agattgctac tgactccctg ggtcaagttc ctgtgggaat catacaggca
      661 gtgtttggac cttcttcgaa acaattctag agtagagcgt ctttaccatg atatcgccca
      721 acaagctttc aaattctgcc tccagtatac tcgcaaggct gagttccgca agctgtgtga
      781 caacttgcga atgcacttat cccagattca gcgccaccat aaccaaagta cagcaatcaa
      841 tcttaataat ccagagagcc agtccatgca tttggaaacc agacttgttc agctggacag
      901 tgctatcagc atggaattgt ggcaggaagc cttcaaagct gtggaagata ttcatggact
      961 attttccttg tctaaaaaac cacctaagcc tcagttgatg gcaaattact ataacaaagt
     1021 ttcaacggtg ttttggaaat ctggaaatgc tttgtttcat gcatctacac ttcatcgtct
     1081 ttatcatctg tctagagaaa tgagaaagaa tcttacacaa gatgagatgc aaagaatgtc
     1141 tactagagtc cttttggcga ctctttccat tcctattact cctgagcgaa ctgatattgc
     1201 acgacttttg gatatggatg gtattatagt tgagaagcag cggcgccttg ccacattgct
     1261 aggtcttcaa gcaccaccca cacgaattgg acttattaat gatatggtca ggtttaatgt
     1321 gctacaatat gttgtcccag aagtgaaaga cctttacaac tggttggagg tggaattcaa
     1381 cccactaaaa ctctgtgaga gagttacaaa ggtattaaat tgggttaggg aacaacctga
     1441 aaaagaacca gaattgcaac aatatgtgcc acaactacag aacaatacca tactccgtct
     1501 tctgcaacag gtggcacaga tttatcagag cattgagttt tctcgtttga cctctctggt
     1561 tccttttgtt gatgctttcc aactggaacg ggccatagta gatgcagcta ggcactgtga
     1621 cctgcaggtt cgtattgacc atacttctcg gactctgagt tttggatcag acttaaatta
     1681 tgcaactcga gaagatgccc caattggtcc tcatctgcag agcatgcctt cagaacaaat
     1741 aagaaatcaa ctgacagcca tgtcctcggt acttgcaaaa gcgcttgaag tcatcaagcc
     1801 tgctcatatt ctgcaagaga aagaagaaca gcatcagttg gcagttactg cgtatattaa
     1861 aaattcacgg aaagagcatc agaggatcct ggctcggaga cagacaattg aggagagaaa
     1921 agagcgtctt gagagtctga atattcaacg tgagaaggaa gaactagagc agagggaagc
     1981 tgaactccag aaagtacgga aggctgaaga agaaaggctg cgtcaagagg caaaggagcg
     2041 agagaaggaa cggatccttc aagaacatga acaaatcaag aagaaaactg ttcgggagcg
     2101 gttagaacag atcaagaaga cagagctggg tgccaaagca tttaaagata ttgacattga
     2161 agaccttgaa gaattggatc cagattttat tatggccaaa caagttgaac aactagaaaa
     2221 agaaaagaag gaacttcagg aacgccttaa gaatcaagaa aagaagattg actattttga
     2281 gagagctaag cgtttggaag aaattccttt aataaagagt gcttacgagg aacaaagggt
     2341 taaagacatg gacctgtggg aacaacaaga agaagaaaga attactacaa tgcagctaga
     2401 acgagaaaaa gctctggaac ataagaatcg gatgtcacga atgttggaag acagagatct
     2461 atttgtgatg cggctcaaag ctgcccggca gtctgtctat gaggagaaac tgaaacagtt
     2521 tgaagagcgt ttagcagaag aaaggcataa tcgcctggaa gaacggaaga ggcaacggaa
     2581 agaagaacgc aaaataactt actacagaga aaaggaagag gaagagcaga gaagggcaga
     2641 ggagcagatg ctcaaagagc gagaagaaag agaacgagct gagagagcaa aacgtgagga
     2701 agaacttaga gaatatcagg agcgagtcaa gaaactggaa gaagtagaaa ggaaaaagcg
     2761 gcaaagagag ctggaaattg aagaaaggga aagacgcaga gaggaagaaa ggagacttgg
     2821 tgaggatcca ctttctagga aggactctcg ttggggagat agagattcag aaggcacctg
     2881 gagaaaagga ccagaagctg actctgagtg gagaagaggc ccaccagaaa aggagtggag
     2941 acgagaaact cgggatgatg agaggcctca caggagagat gaggatcggc tgaggcgctt
     3001 ggggggggac gatgaagaga gagagtcgtc tcttagacca gatgatgatc gcatccccag
     3061 gcgtggcctg gatgatgaca gagggcctag acgtggtccc gatgaagata gattttctcg
     3121 tagaggaaca gatgatgacc gtccttcctg gcgtaatgca gatgatgacc ggcctcccag
     3181 gcgaattggt gatgatgaca ggggaagctg gcgtcacaca gatgatgaca gaccacccag
     3241 acggggactg gatgatgaca gaccacccag acggggactg gatgatgaga gaggaagctg
     3301 gcgcacagca gaagaggaca gaggacctag acgtgggatg gatgatgacc gggggccaag
     3361 acgaggaggt gctgatgatg agcggtcatc ctggcggaat gctgatgacg ataggggtcc
     3421 caggaggggg atggatgacg ataggggtcc caggcgaggg ttggatgatg atcgaggacc
     3481 ttggaggaat gctgctgaag ataggatttc caggagaggt gcagatgatg accgggggcc
     3541 ttggagaaat atggatgacg atcgggttcc tagacggggt gatgatgcaa gacctggtcc
     3601 ctggagacca tttgtcaaac caggtggatg gagagagaaa gaaaaggcta gagaagagag
     3661 ttggggtcca cctcgagaat caagaccacc agaagaacgt gaatgggata gagacaaaga
     3721 gaaggacaga gataatcaag atcgagagga gaacgacaag gaccttgaac gtgataggga
     3781 cagagagaga gatggggacc gggaggatcg tttcagaaga cccagggatg aaggtggctg
     3841 gagaagagga ccagcagaag aatcttcaag ctggagagat tcaagtcgcc gtgatgatag
     3901 ggacagggat gaccgacggc gggacagaga tgatcgtcgt gatctgagag acctgagaga
     3961 cagaagggat ttaagagatg atagagatcg gagaggccct ccccttagat cagagcgaga
     4021 agaagcaagc tcctggagac gcactgatga caggaaagat gaccggactg aagaaaggga
     4081 tccacctcgt cgtgttcctc ccccaactct ttcaagagag agagaaagag agagagatcg
     4141 agaaggtgag aaagagaaag catcttggag agctgagaaa gatagggagt cccttcgtcg
     4201 tactaagaat gaaactgatg aagatggatg gaccacagta cgacgttaaa tcacaagacg
     4261 atggagtcaa acttgtggtt cgcataggtt tgctcacatt caaggattat tatacttgtg
     4321 cttcaaccag tctaaattga attctttaat gttgtctcac cataacacaa aaagcatgaa
     4381 cttgtattaa tcatatataa tagattgatc atgcactgta ttcacaggag gttgtaaaac
     4441 catgccattt tctggaactt aaggtgttgc attatttcat caatcatttg ttaaaaaaaa
     4501 aaactaaaaa ataaaaaatg tgaacccttc aggtgtaaac accttatctt ggtatacaat
     4561 tgatcttttt tgttttgttt tgattttgaa gtatcagata ttaatttgga ataaggtaag
     4621 gttctcttga aacatttgaa aaccctttaa gacaactgat ctgtcagctt tcccatcagt
     4681 agtagtggga atataccttc ttaggtattt actgttaaat atatttaggc agtttatagc
     4741 ttctgatcag tgtggtagac attacaaaca ctggctgtaa tggggttttc tatagactta
     4801 cttgagagag gtgagtataa aagcattttt tagtcatcat catgacgatg ctgctcaagt
     4861 gcaggtccag aacagtacag ctttgggtcc ctagagcatt tggtaaactg ttgtgggttt
     4921 ctttttttct gttgccaaaa gaaaactgct tttccactaa ttcatgcctt tcaagcattt
     4981 taaatatgac aatatttata aatgtgtggt ttggaggaat tgtttaaatt ctttttccta
     5041 attttcttca ggatagatta tttcaacaag taatttgtag tgatgactgt gttgacttca
     5101 attttggagt gtgtagctgt gttttaaaaa aaaaaaaaa
//
