LOCUS       NP_001040552            1354 aa            linear   ROD 03-APR-2024
DEFINITION  eukaryotic translation initiation factor 3 subunit A [Rattus
            norvegicus].
ACCESSION   NP_001040552 XP_001056819 XP_001073847 XP_001073873 XP_238649
VERSION     NP_001040552.2
DBSOURCE    REFSEQ: accession NM_001047087.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1354)
  AUTHORS   Yang,H.T., Wang,G., Zhu,P.C. and Xiao,Z.Y.
  TITLE     Silencing EIF3A ameliorates pulmonary arterial hypertension through
            HDAC1 and PTEN/PI3K/AKT pathway in vitro and in vivo
  JOURNAL   Exp Cell Res 426 (1), 113555 (2023)
   PUBMED   36921705
  REMARK    GeneRIF: Silencing EIF3A ameliorates pulmonary arterial
            hypertension through HDAC1 and PTEN/PI3K/AKT pathway in vitro and
            in vivo.
REFERENCE   2  (residues 1 to 1354)
  AUTHORS   Guo,R., Lv,Y., Ouyang,Y., Liu,S. and Li,D.
  TITLE     The Role of miR-497/EIF3A Axis in TGFbeta1-Induced
            Epithelial-Mesenchymal Transition and Extracellular Matrix in Rat
            Alveolar Epithelial Cells and Pulmonary Fibroblasts
  JOURNAL   J Cell Biochem 118 (10), 3401-3408 (2017)
   PUBMED   28322466
  REMARK    GeneRIF: miR-497 could suppress TGFbeta1-induced pulmonary
            fibroblast proliferation and EIF3A, Collagen I and alpha-SMA
            protein levels.
REFERENCE   3  (residues 1 to 1354)
  AUTHORS   Lee,A.S., Kranzusch,P.J., Doudna,J.A. and Cate,J.H.
  TITLE     eIF3d is an mRNA cap-binding protein that is required for
            specialized translation initiation
  JOURNAL   Nature 536 (7614), 96-99 (2016)
   PUBMED   27462815
REFERENCE   4  (residues 1 to 1354)
  AUTHORS   Li,B., Chen,H., Yang,X., Wang,Y., Qin,L. and Chu,Y.
  TITLE     Knockdown of eIF3a ameliorates cardiac fibrosis by inhibiting the
            TGF-beta1/Smad3 signaling pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 62 (7), 97-101 (2016)
   PUBMED   27453280
  REMARK    GeneRIF: silencing eIF3a might alleviate TGF-beta1-induced cardiac
            fibrogenesis in cardiac fibroblasts by inhibiting Smad3 activation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1354)
  AUTHORS   Li,W.Q., Li,X.H., Wu,Y.H., Du,J., Wang,A.P., Li,D. and Li,Y.J.
  TITLE     Role of eukaryotic translation initiation factors 3a in
            hypoxia-induced right ventricular remodeling of rats
  JOURNAL   Life Sci 144, 61-68 (2016)
   PUBMED   26612348
  REMARK    GeneRIF: The eIF3a plays a crucial role in hypoxia-induced right
            ventricular remodeling by regulating TGF-beta1-induced
            proliferation and differentiation of cardiac fibroblasts
REFERENCE   6  (residues 1 to 1354)
  AUTHORS   Masutani,M., Sonenberg,N., Yokoyama,S. and Imataka,H.
  TITLE     Reconstitution reveals the functional core of mammalian eIF3
  JOURNAL   EMBO J 26 (14), 3373-3383 (2007)
   PUBMED   17581632
REFERENCE   7  (residues 1 to 1354)
  AUTHORS   Damoc,E., Fraser,C.S., Zhou,M., Videler,H., Mayeur,G.L.,
            Hershey,J.W., Doudna,J.A., Robinson,C.V. and Leary,J.A.
  TITLE     Structural characterization of the human eukaryotic initiation
            factor 3 protein complex by mass spectrometry
  JOURNAL   Mol Cell Proteomics 6 (7), 1135-1146 (2007)
   PUBMED   17322308
REFERENCE   8  (residues 1 to 1354)
  AUTHORS   Shakib,K., Norman,J.T., Fine,L.G., Brown,L.R. and
            Godovac-Zimmermann,J.
  TITLE     Proteomics profiling of nuclear proteins for kidney fibroblasts
            suggests hypoxia, meiosis, and cancer may meet in the nucleus
  JOURNAL   Proteomics 5 (11), 2819-2838 (2005)
   PUBMED   15942958
REFERENCE   9  (residues 1 to 1354)
  AUTHORS   MacDonald,J.I., Verdi,J.M. and Meakin,S.O.
  TITLE     Activity-dependent interaction of the intracellular domain of rat
            trkA with intermediate filament proteins, the beta-6 proteasomal
            subunit, Ras-GRF1, and the p162 subunit of eIF3
  JOURNAL   J Mol Neurosci 13 (1-2), 141-158 (1999)
   PUBMED   10691301
REFERENCE   10 (residues 1 to 1354)
  AUTHORS   Sizova,D.V., Kolupaeva,V.G., Pestova,T.V., Shatsky,I.N. and
            Hellen,C.U.
  TITLE     Specific interaction of eukaryotic translation initiation factor 3
            with the 5' nontranslated regions of hepatitis C virus and
            classical swine fever virus RNAs
  JOURNAL   J Virol 72 (6), 4775-4782 (1998)
   PUBMED   9573242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB698626.1 and AB259154.1.
            
            On Oct 15, 2009 this sequence version replaced NP_001040552.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ221906.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1354
                     /organism="Rattus norvegicus"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     Protein         1..1354
                     /product="eukaryotic translation initiation factor 3
                     subunit A"
                     /note="eukaryotic translation initiation factor 3, subunit
                     10 (theta); eIF-3-theta; eukaryotic translation initiation
                     factor 3 subunit 10"
                     /calculated_mol_wt=163065
     Site            68
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q14152; propagated from
                     UniProtKB/Swiss-Prot (Q1JU68.2)"
     Region          426..498
                     /region_name="PINT"
                     /note="motif in proteasome subunits, Int-6, Nip-1 and
                     TRIP-15; smart00088"
                     /db_xref="CDD:214509"
     Site            492
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14152,
                     ECO:0000255|HAMAP-Rule:MF_03000; propagated from
                     UniProtKB/Swiss-Prot (Q1JU68.2)"
     Region          <549..>803
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Site            584
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14152; propagated from
                     UniProtKB/Swiss-Prot (Q1JU68.2)"
     Region          664..835
                     /region_name="Interaction with EIF3B.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03000"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1JU68.2)"
     Region          809..844
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1JU68.2)"
     Region          866..1249
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1JU68.2)"
     Site            895
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14152; propagated from
                     UniProtKB/Swiss-Prot (Q1JU68.2)"
     Region          900..>1137
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     Region          924..1143
                     /region_name="22 X 10 AA approximate tandem repeats of
                     [DA]-[DE]-[ED]-R-[PLIGFSV]-[RPS]-[RW]-[RL]-[GNIHT]-
                     [DGLPTAM]"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1JU68.2)"
     Site            949
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14152; propagated from
                     UniProtKB/Swiss-Prot (Q1JU68.2)"
     Site            1038
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14152; propagated from
                     UniProtKB/Swiss-Prot (Q1JU68.2)"
     Site            1159
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14152; propagated from
                     UniProtKB/Swiss-Prot (Q1JU68.2)"
     Site            1233
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14152; propagated from
                     UniProtKB/Swiss-Prot (Q1JU68.2)"
     Region          1262..1354
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1JU68.2)"
     Site            1310
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14152,
                     ECO:0000255|HAMAP-Rule:MF_03000; propagated from
                     UniProtKB/Swiss-Prot (Q1JU68.2)"
     Site            1336
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14152,
                     ECO:0000255|HAMAP-Rule:MF_03000; propagated from
                     UniProtKB/Swiss-Prot (Q1JU68.2)"
     CDS             1..1354
                     /gene="Eif3a"
                     /gene_synonym="Eif3s10; ZH12"
                     /coded_by="NM_001047087.2:185..4249"
                     /db_xref="GeneID:292148"
                     /db_xref="RGD:1307269"
ORIGIN      
        1 mpayfqrpen alkranefle vgkkqpaldv lydvmkskkh rtwqkihepi mlkylelcvd
       61 lrkshlakeg lyqyknicqq vniksledvv raylklaeek teaakeesqq mvldiedldn
      121 iqtpesvlls avsgedtqdr tdrllltpwv kflwesyrqc ldllrnnsrv erlyhdiaqq
      181 afkfclqytr kaefrklcdn lrmhlsqiqr hhnqstainl nnpesqsmhl etrlvqldsa
      241 ismelwqeaf kavedihglf slskkppkpq lmanyynkvs tvfwksgnal fhastlhrly
      301 hlsremrknl tqdemqrmst rvllatlsip itpertdiar lldmdgiive kqrrlatllg
      361 lqapptrigl indmvrfnvl qyvvpevkdl ynwlevefnp lklcervtkv lnwvreqpek
      421 epelqqyvpq lqnntilrll qqvaqiyqsi efsrltslvp fvdafqlera ivdaarhcdl
      481 qvridhtsrt lsfgsdlnya tredapigph lqsmpseqir nqltamssvl akalevikpa
      541 hilqekeeqh qlavtayikn srkehqrila rrqtieerke rleslniqre keeleqreae
      601 lqkvrkaeee rlrqeakere kerilqeheq ikkktvrerl eqikktelga kafkdidied
      661 leeldpdfim akqveqleke kkelqerlkn qekkidyfer akrleeipli ksayeeqrvk
      721 dmdlweqqee erittmqler ekalehknrm srmledrdlf vmrlkaarqs vyeeklkqfe
      781 erlaeerhnr leerkrqrke erkityyrek eeeeqrraee qmlkereere raerakreee
      841 lreyqervkk leeverkkrq releieerer rreeerrlge dplsrkdsrw gdrdsegtwr
      901 kgpeadsewr rgppekewrr etrdderphr rdedrlrrlg gddeeressl rpdddriprr
      961 gldddrgprr gpdedrfsrr gtdddrpswr nadddrpprr igdddrgswr htdddrpprr
     1021 gldddrpprr glddergswr taeedrgprr gmdddrgprr ggadderssw rnadddrgpr
     1081 rgmdddrgpr rgldddrgpw rnaaedrisr rgadddrgpw rnmdddrvpr rgddarpgpw
     1141 rpfvkpggwr ekekareesw gppresrppe erewdrdkek drdnqdreen dkdlerdrdr
     1201 erdgdredrf rrprdeggwr rgpaeesssw rdssrrddrd rddrrrdrdd rrdlrdlrdr
     1261 rdlrddrdrr gpplrseree asswrrtddr kddrteerdp prrvppptls rerererdre
     1321 gekekaswra ekdreslrrt knetdedgwt tvrr
//
