LOCUS       NM_001100542            3689 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 2
            subunit gamma (Eif2s3), mRNA.
ACCESSION   NM_001100542 XM_001056580 XM_001056649 XM_216704
VERSION     NM_001100542.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3689)
  AUTHORS   Young-Baird,S.K., Lourenco,M.B., Elder,M.K., Klann,E., Liebau,S.
            and Dever,T.E.
  TITLE     Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule
            ISRIB
  JOURNAL   Mol Cell 77 (4), 875-886 (2020)
   PUBMED   31836389
REFERENCE   2  (bases 1 to 3689)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3689)
  AUTHORS   Borck,G., Shin,B.S., Stiller,B., Mimouni-Bloch,A., Thiele,H.,
            Kim,J.R., Thakur,M., Skinner,C., Aschenbach,L., Smirin-Yosef,P.,
            Har-Zahav,A., Nurnberg,G., Altmuller,J., Frommolt,P., Hofmann,K.,
            Konen,O., Nurnberg,P., Munnich,A., Schwartz,C.E., Gothelf,D.,
            Colleaux,L., Dever,T.E., Kubisch,C. and Basel-Vanagaite,L.
  TITLE     eIF2gamma mutation that disrupts eIF2 complex integrity links
            intellectual disability to impaired translation initiation
  JOURNAL   Mol Cell 48 (4), 641-646 (2012)
   PUBMED   23063529
REFERENCE   4  (bases 1 to 3689)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 3689)
  AUTHORS   Mikami,S., Masutani,M., Sonenberg,N., Yokoyama,S. and Imataka,H.
  TITLE     An efficient mammalian cell-free translation system supplemented
            with translation factors
  JOURNAL   Protein Expr Purif 46 (2), 348-357 (2006)
   PUBMED   16289705
REFERENCE   6  (bases 1 to 3689)
  AUTHORS   Bohnsack,M.T., Regener,K., Schwappach,B., Saffrich,R.,
            Paraskeva,E., Hartmann,E. and Gorlich,D.
  TITLE     Exp5 exports eEF1A via tRNA from nuclei and synergizes with other
            transport pathways to confine translation to the cytoplasm
  JOURNAL   EMBO J 21 (22), 6205-6215 (2002)
   PUBMED   12426392
REFERENCE   7  (bases 1 to 3689)
  AUTHORS   Kruger,M., Beger,C., Li,Q.X., Welch,P.J., Tritz,R., Leavitt,M.,
            Barber,J.R. and Wong-Staal,F.
  TITLE     Identification of eIF2Bgamma and eIF2gamma as cofactors of
            hepatitis C virus internal ribosome entry site-mediated translation
            using a functional genomics approach
  JOURNAL   Proc Natl Acad Sci U S A 97 (15), 8566-8571 (2000)
   PUBMED   10900014
REFERENCE   8  (bases 1 to 3689)
  AUTHORS   Gil,C., Plana,M., Riera,M. and Itarte,E.
  TITLE     Rat liver pp49, a protein that forms complexes with protein kinase
            CK2, is composed of the beta and the gamma subunits of translation
            initiation factor eIF-2
  JOURNAL   Biochem Biophys Res Commun 225 (3), 1052-1057 (1996)
   PUBMED   8780732
REFERENCE   9  (bases 1 to 3689)
  AUTHORS   Bommer,U.A., Lutsch,G., Behlke,J., Stahl,J., Nesytova,N., Henske,A.
            and Bielka,H.
  TITLE     Shape and location of eukaryotic initiation factor eIF-2 on the 40S
            ribosomal subunit of rat liver. Immunoelectron-microscopic and
            hydrodynamic investigations
  JOURNAL   Eur J Biochem 172 (3), 653-662 (1988)
   PUBMED   2450747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI029347.1, BC166783.1, BC091286.1, EV772689.1 and BM392036.1.
            
            On or before Jun 1, 2008 this sequence version replaced
            XM_216704.4, XM_001056649.1, XM_001056580.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166783.1, SRR8487230.106833.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AI029347.1         14-31
            19-1719             BC166783.1         1-1701
            1720-2695           BC091286.1         1503-2478
            2696-3221           EV772689.1         54-579
            3222-3689           BM392036.1         1-468               c
FEATURES             Location/Qualifiers
     source          1..3689
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..3689
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /note="eukaryotic translation initiation factor 2 subunit
                     gamma"
                     /db_xref="GeneID:299027"
                     /db_xref="RGD:1561279"
     exon            1..92
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1442
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /EC_number="3.6.5.3"
                     /note="eIF-2-gamma X; eukaryotic translation initiation
                     factor 2 subunit gamma, X-linked; eIF2-gamma; eIF2-gamma
                     X; eukaryotic translation initiation factor 2, subunit 3,
                     structural gene X-linked; eukaryotic translation
                     initiation factor 2, subunit 3 gamma"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 2
                     subunit 3, X-linked"
                     /protein_id="NP_001094012.1"
                     /db_xref="GeneID:299027"
                     /db_xref="RGD:1561279"
                     /translation="MAGGEAGVTLGQPHLSRQDLATLDVTKLTPLSHEVISRQATINI
                     GTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY
                     RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIA
                     GNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEG
                     APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKG
                     GVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPG
                     GLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKA
                     AKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKH
                     WRLIGWGQIRRGVTIKPTVDDD"
     exon            93..156
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /inference="alignment:Splign:2.1.0"
     exon            157..284
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /inference="alignment:Splign:2.1.0"
     exon            285..406
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /inference="alignment:Splign:2.1.0"
     exon            407..501
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /inference="alignment:Splign:2.1.0"
     exon            502..660
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /inference="alignment:Splign:2.1.0"
     exon            661..795
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /inference="alignment:Splign:2.1.0"
     exon            796..890
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1035
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1205
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1378
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..3672
                     /gene="Eif2s3"
                     /gene_synonym="Eif2g; Eif2s3x; PP42"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttcctttt ctctctgagc aagatggctg ggggtgaggc tggagtgact ctcggacagc
       61 cacatctttc ccgacaggat ctcgccacat tggatgttac caagttgaca ccactttccc
      121 atgaggttat cagcagacaa gctacaatta atattggtac aattggtcat gtagctcatg
      181 ggaagtccac cgtggtaaag gctatttctg gagttcacac tgtcagattc aaaaatgagc
      241 tagaaagaaa cattaccatc aagcttggat atgctaatgc taagatttat aaacttgatg
      301 acccaagttg tcctagacca gaatgttata gatcatgtgg aagcagtaca ccagatgagt
      361 ttcctacaga cattccaggg accaaaggga acttcaaatt agtcaggcat gtgtccttcg
      421 ttgactgtcc tggccatgat attttgatgg ctacgatgct gaacggtgca gcggtgatgg
      481 acgcagctct tctattgata gctggtaatg aatcgtgtcc tcagccccag acttcagaac
      541 acctggctgc catagaaatc atgaaactca agcatatttt gatcttacag aataaaattg
      601 atctggtaaa agaaagtcag gctaaggaac aatatgagca aattctcgca tttgtgcaag
      661 gaaccgtagc agaaggggca ccaattattc caatttctgc tcagctgaaa tacaatattg
      721 aagttgtctg tgaatacata gtaaagaaaa taccagtgcc cccaagagac tttacttcag
      781 agccacgtct tattgttatc aggtcatttg atgtcaacaa acctggctgt gaagttgatg
      841 accttaaggg aggtgtagct ggcggtagta ttctaaaagg agtgttaaag gtaggccagg
      901 agatagaagt cagacccggt attgtctcca aagacagtga aggaaaactc atgtgtaaac
      961 ccatcttttc caaaattgtg tcacttttcg ctgaacataa tgatcttcag tatgctgccc
     1021 cgggtggtct cattggagtt ggaacaaaga tcgaccccac tttgtgcaga gctgacagaa
     1081 tggtgggaca agtgcttggt gcagttggag ctttacctga aatattcaca gaactggaaa
     1141 tttcctattt cctgctcaga cgtcttctgg gcgtacgtac tgaaggagac aagaaagcag
     1201 caaaggtcca aaaactgtct aagaatgaag tgctcatggt caacatagga tccttgtcaa
     1261 caggaggaag agttagtgct gtcaaggctg atttgggcaa gattgttttg accaatcctg
     1321 tgtgcacaga agtaggagaa aaaattgccc ttagcagaag agttgaaaaa cactggcgtt
     1381 taattggttg gggtcagata agaagaggag tgaccattaa gccgactgta gatgatgact
     1441 gaagattcca cgttaaacaa tgccttggga tggagttgga atttctttta atagcctagg
     1501 ggtatatttt caaagcaata ctagaaagaa ttaatttaat agctcattac cttactagta
     1561 gctataaatt tattctttta ttttggtgtt gaaaatttaa actctacttt ttttttcttt
     1621 ttattgattc cttgtttcat atcatgtagc ccaacccact catcccctca tatctgacct
     1681 tgcaacctcc cccaaaataa ataacacaaa caaccacaac aaagcataga aagcatctca
     1741 tggtggaagc tgtagcttct gtgacaacac cagtgttggc tcctcatcag gactccctca
     1801 agttaacctg ttgctgtgct gtgtcatggg gatcctacag ctttggaaca gcaggactgg
     1861 ccctttcaca gtcccatcta ttcgaagatg atataggttt tagggtgggt caattcaaag
     1921 ccctgaaact ggactgggct ggaaactaag gtcaactgga ctgggccagc tctcccagtg
     1981 tgccttcacc atcagggcca gcttcactgt gttgcccagg tgaggtgaca ggactgctca
     2041 tactcttaag gccaggtctt cctatagaag gtagcaatgg gggagggcat cccattcaca
     2101 ccaccttata acaaaggagt ggcagggcca gctgtccaga gtgctgtatg caacaagcgg
     2161 cggggccaga tctgcacagt cctggacatt ccagtgttct ctagtggtaa taataatcca
     2221 tggacactga cccaccactg tggagccaca gactcaaaca gggccccaat ggcagggatg
     2281 cccactcata agaggctatt tctttccacc catgaccctt caattccttt tatctattgc
     2341 catgcactag agggcaggtc tgtgggtgac atggaggttt gcaagacctt gtgttcctct
     2401 tctcatgctg tgctgctgtg atttgatttt tatgatccct aggcataaga cttaagtttt
     2461 ggccatgaag ttaggatgaa caaagggctg ccatctgccc caatttagaa caataccacc
     2521 aacaaggtgt ctctgtgccc cttgctggga tttgtaatct ttctaatatg gggcctaaaa
     2581 ttaaatgtga aaattggtat actatatact acattggatc aaatctacat tttagcaaaa
     2641 gttaagcatt ccaaaataat gtctaattta tcaatgaata aaagtttgaa gtgaagatga
     2701 tctattctta tgatttacct gtgaccagct ccatactgaa gggcaattag taaaaactaa
     2761 acatctaccc ctttatttgt cctatttgag gttctgtttg aaatttgaag gaagatgaac
     2821 aaggggctca aatgagcact gctcttagaa atcgagtgcc taatccctta gcttgggtgg
     2881 atctttctta ttcagttcct gaatgggacc ttaggaatcc agtgccagaa cttctcaccg
     2941 tcttccagtg ccctgagact gtctttatca tgtatactta aaatctcagt cttctctcac
     3001 tggcagatag tataacagca ggtgattagt ggtgattgac aaggttctgt ccaggttgct
     3061 ttgttgaggt ctttatttta gtaagctatg gatggaatag tctcttgcat gatgaataaa
     3121 tagtctacca tggactccac tgcccctagc tgtagatcct ttccttagtt ggtaggatta
     3181 tggtagaaat tgtgctatta gtgatctttg agccgtggaa aagataaaaa ttgttcaaaa
     3241 acagtgtgtc ctttggtttc taaatctatt cccccacatg cctgcagttt tcttgtgctg
     3301 tgctttttaa attaatcgtg tttttactta attagatact cttctatagc aatgatttcc
     3361 aactctggct tacataagaa ttgctgggga agtttgaagg gggaaataaa agccccgagg
     3421 tgcagtccag gctttgatag tttttaaaat tcaccagtgt tgagaaagaa gtgagtttag
     3481 aaataggcat cctaaataat gacatcactg atttcagtgg ccacaattac tctgctgtgc
     3541 tcttttggat actgcagctg ccttatagag acttagtgag ttttgaggaa acctattgac
     3601 attatgtatt tgattgattc tgaaaggttg tattgtagca tgaagaaact agtaaatgtg
     3661 aaaataactg gaaaaaaaaa aaaaaaaaa
//
