LOCUS       NM_199380               1462 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 2
            subunit beta (Eif2s2), mRNA.
ACCESSION   NM_199380 XM_215895
VERSION     NM_199380.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1462)
  AUTHORS   Hinnebusch AG.
  TITLE     The scanning mechanism of eukaryotic translation initiation
  JOURNAL   Annu Rev Biochem 83, 779-812 (2014)
   PUBMED   24499181
  REMARK    Review article
REFERENCE   2  (bases 1 to 1462)
  AUTHORS   Borck G, Shin BS, Stiller B, Mimouni-Bloch A, Thiele H, Kim JR,
            Thakur M, Skinner C, Aschenbach L, Smirin-Yosef P, Har-Zahav A,
            Nurnberg G, Altmuller J, Frommolt P, Hofmann K, Konen O, Nurnberg
            P, Munnich A, Schwartz CE, Gothelf D, Colleaux L, Dever TE, Kubisch
            C and Basel-Vanagaite L.
  TITLE     eIF2gamma mutation that disrupts eIF2 complex integrity links
            intellectual disability to impaired translation initiation
  JOURNAL   Mol Cell 48 (4), 641-646 (2012)
   PUBMED   23063529
REFERENCE   3  (bases 1 to 1462)
  AUTHORS   Hinnebusch AG and Lorsch JR.
  TITLE     The mechanism of eukaryotic translation initiation: new insights
            and challenges
  JOURNAL   Cold Spring Harb Perspect Biol 4 (10), a011544 (2012)
   PUBMED   22815232
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1462)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1462)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1462)
  AUTHORS   Mikami S, Masutani M, Sonenberg N, Yokoyama S and Imataka H.
  TITLE     An efficient mammalian cell-free translation system supplemented
            with translation factors
  JOURNAL   Protein Expr Purif 46 (2), 348-357 (2006)
   PUBMED   16289705
REFERENCE   7  (bases 1 to 1462)
  AUTHORS   Bohnsack MT, Regener K, Schwappach B, Saffrich R, Paraskeva E,
            Hartmann E and Gorlich D.
  TITLE     Exp5 exports eEF1A via tRNA from nuclei and synergizes with other
            transport pathways to confine translation to the cytoplasm
  JOURNAL   EMBO J 21 (22), 6205-6215 (2002)
   PUBMED   12426392
REFERENCE   8  (bases 1 to 1462)
  AUTHORS   Kebache S, Zuo D, Chevet E and Larose L.
  TITLE     Modulation of protein translation by Nck-1
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5406-5411 (2002)
   PUBMED   11959995
REFERENCE   9  (bases 1 to 1462)
  AUTHORS   Ben-Asouli Y, Banai Y, Hauser H and Kaempfer R.
  TITLE     Recognition of 5'-terminal TAR structure in human immunodeficiency
            virus-1 mRNA by eukaryotic translation initiation factor 2
  JOURNAL   Nucleic Acids Res 28 (4), 1011-1018 (2000)
   PUBMED   10648795
REFERENCE   10 (bases 1 to 1462)
  AUTHORS   Bommer UA, Lutsch G, Behlke J, Stahl J, Nesytova N, Henske A and
            Bielka H.
  TITLE     Shape and location of eukaryotic initiation factor eIF-2 on the 40S
            ribosomal subunit of rat liver. Immunoelectron-microscopic and
            hydrodynamic investigations
  JOURNAL   Eur J Biochem 172 (3), 653-662 (1988)
   PUBMED   2450747
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062402.1.
            
            On Jan 11, 2004 this sequence version replaced XM_215895.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062402.1, FQ213305.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1462
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1462
                     /gene="Eif2s2"
                     /note="eukaryotic translation initiation factor 2 subunit
                     beta"
                     /db_xref="GeneID:296302"
                     /db_xref="RGD:735192"
     exon            1..97
                     /gene="Eif2s2"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1084
                     /gene="Eif2s2"
                     /note="eukaryotic translation initiation factor 2, subunit
                     2 beta, 38kDa"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 2
                     subunit 2"
                     /protein_id="NP_955412.1"
                     /db_xref="GeneID:296302"
                     /db_xref="RGD:735192"
                     /translation="MSGDEMIFDPTMSKKKKKKKKPFMLDEEGDAQTEETQPSETKEV
                     EPEPAEEKDVEADEEDSRKKDASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEAIKDVK
                     IESDAQEPAEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDSKKDDGISFS
                     NQTGPAWAGSERDYTYEELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTS
                     FVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIK
                     EYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAKAN"
     exon            98..275
                     /gene="Eif2s2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..379
                     /gene="Eif2s2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..515
                     /gene="Eif2s2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..616
                     /gene="Eif2s2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..765
                     /gene="Eif2s2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..822
                     /gene="Eif2s2"
                     /inference="alignment:Splign:2.1.0"
     exon            823..908
                     /gene="Eif2s2"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1439
                     /gene="Eif2s2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtaggagc tacgctgact ccggggtgtg aagccgaccg gtctgacttt tcatcactgc
       61 cgaacccact cgaaccacag ccatgtccgg ggacgagatg atttttgatc ctactatgag
      121 caaaaagaaa aagaagaaga agaagccttt tatgttagat gaagaaggtg atgcccagac
      181 agaagaaacc cagccctcag agacaaaaga agtggagcca gaaccagctg aagagaaaga
      241 tgtggaagcc gatgaagagg acagtaggaa aaaagatgct tctgatgact tagatgactt
      301 gaacttcttt aatcaaaaga aaaagaagaa aaagacaaaa aagatatttg atattgatga
      361 agctgaagaa gctataaagg atgttaagat tgaaagtgat gctcaagagc cggccgagcc
      421 ggaggacgac cttgacatta tgcttggcaa taagaagaag aaaaagaaga atgtgaaatt
      481 cccagatgaa gacgaaatac tagaaaaaga tgaagcttta gaagatgaag acagcaaaaa
      541 agatgatggc atttcattca gtaaccaaac tgggcctgct tgggcaggct cagaaagaga
      601 ctacacatat gaggagttgc tgaaccgagt gttcaacatc atgagagaaa agaatccaga
      661 tatggttgct ggcgagaaga ggaaatttgt tatgaaacct ccacaggtcg tccgagtagg
      721 aactaagaaa acttcttttg tcaattttac agatatctgt aaactattac atcgtcaacc
      781 caaacatctc cttgcatttt tattggcaga attgggtaca agtggttcta tagatggtaa
      841 taaccaactt gtaatcaaag gaagattcca acagaaacag atagaaaacg tcttgagaag
      901 atatatcaag gaatacgtca cttgtcacac atgccggtca ccggacacaa tcctacagaa
      961 ggacacccga ctctatttct tacagtgtga aacttgtcat tctcgatgct ctgtggccag
     1021 tatcaaaact ggcttccagg ctgtcacagg caagcgagca cagctccgtg ccaaagctaa
     1081 ctaatttgct aatcaccatt gattttttca aaatgtggtg gagatttggc tggacaggtt
     1141 accatcagag tggatgtacc attgagttaa aaacaagata gaaactgcca agttctttgg
     1201 cgagtgattg ttctgaaatc cttgcaagat accggtattc aagctgttga tatactcgtt
     1261 gcctacttta acaactgtca gagaaacgtg atggagtaag gaggtgcttc ttaaaatcgt
     1321 tcatagactt ctgtaaaatg caagataaat taaagttatt ataacagtaa ttctttcaat
     1381 ttgatctgtc cttcggtttt cttttctaca ataaactgct cgttaaattt agctaaaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aa
//
