LOCUS       NM_133609               1610 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 2B
            subunit gamma (Eif2b3), mRNA.
ACCESSION   NM_133609
VERSION     NM_133609.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1610)
  AUTHORS   Kashiwagi,K., Shigeta,T., Imataka,H., Ito,T. and Yokoyama,S.
  TITLE     Expression, purification, and crystallization of
            Schizosaccharomyces pombe eIF2B
  JOURNAL   J Struct Funct Genomics 17 (1), 33-38 (2016)
   PUBMED   27023709
REFERENCE   2  (bases 1 to 1610)
  AUTHORS   Hinnebusch,A.G. and Lorsch,J.R.
  TITLE     The mechanism of eukaryotic translation initiation: new insights
            and challenges
  JOURNAL   Cold Spring Harb Perspect Biol 4 (10), a011544 (2012)
   PUBMED   22815232
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1610)
  AUTHORS   Mikami,S., Masutani,M., Sonenberg,N., Yokoyama,S. and Imataka,H.
  TITLE     An efficient mammalian cell-free translation system supplemented
            with translation factors
  JOURNAL   Protein Expr Purif 46 (2), 348-357 (2006)
   PUBMED   16289705
REFERENCE   4  (bases 1 to 1610)
  AUTHORS   Van Haren,K., van der Voorn,J.P., Peterson,D.R., van der Knaap,M.S.
            and Powers,J.M.
  TITLE     The life and death of oligodendrocytes in vanishing white matter
            disease
  JOURNAL   J Neuropathol Exp Neurol 63 (6), 618-630 (2004)
   PUBMED   15217090
REFERENCE   5  (bases 1 to 1610)
  AUTHORS   Li,W., Wang,X., Van Der Knaap,M.S. and Proud,C.G.
  TITLE     Mutations linked to leukoencephalopathy with vanishing white matter
            impair the function of the eukaryotic initiation factor 2B complex
            in diverse ways
  JOURNAL   Mol Cell Biol 24 (8), 3295-3306 (2004)
   PUBMED   15060152
REFERENCE   6  (bases 1 to 1610)
  AUTHORS   Fabian,J.R., Kimball,S.R., Heinzinger,N.K. and Jefferson,L.S.
  TITLE     Subunit assembly and guanine nucleotide exchange activity of
            eukaryotic initiation factor-2B expressed in Sf9 cells
  JOURNAL   J Biol Chem 272 (19), 12359-12365 (1997)
   PUBMED   9139680
REFERENCE   7  (bases 1 to 1610)
  AUTHORS   Price,N.T., Kimball,S.R., Jefferson,L.S. and Proud,C.G.
  TITLE     Cloning of cDNA for the gamma-subunit of mammalian translation
            initiation factor 2B, the guanine nucleotide-exchange factor for
            eukaryotic initiation factor 2
  JOURNAL   Biochem J 318 (Pt 2) (Pt 2), 631-636 (1996)
   PUBMED   8809057
REFERENCE   8  (bases 1 to 1610)
  AUTHORS   Welsh,G.I., Miyamoto,S., Price,N.T., Safer,B. and Proud,C.G.
  TITLE     T-cell activation leads to rapid stimulation of translation
            initiation factor eIF2B and inactivation of glycogen synthase
            kinase-3
  JOURNAL   J Biol Chem 271 (19), 11410-11413 (1996)
   PUBMED   8626696
REFERENCE   9  (bases 1 to 1610)
  AUTHORS   Gilligan,M., Welsh,G.I., Flynn,A., Bujalska,I., Diggle,T.A.,
            Denton,R.M., Proud,C.G. and Docherty,K.
  TITLE     Glucose stimulates the activity of the guanine nucleotide-exchange
            factor eIF-2B in isolated rat islets of Langerhans
  JOURNAL   J Biol Chem 271 (4), 2121-2125 (1996)
   PUBMED   8567668
REFERENCE   10 (bases 1 to 1610)
  AUTHORS   Karinch,A.M., Kimball,S.R., Vary,T.C. and Jefferson,L.S.
  TITLE     Regulation of eukaryotic initiation factor-2B activity in muscle of
            diabetic rats
  JOURNAL   Am J Physiol 264 (1 Pt 1), E101-E108 (1993)
   PUBMED   8430778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072507.1.
            
            On Jun 13, 2004 this sequence version replaced NM_133609.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072507.1, U38253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1610
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1610
                     /gene="Eif2b3"
                     /note="eukaryotic translation initiation factor 2B subunit
                     gamma"
                     /db_xref="GeneID:171145"
                     /db_xref="RGD:620821"
     exon            1..98
                     /gene="Eif2b3"
                     /inference="alignment:Splign:2.1.0"
     exon            99..256
                     /gene="Eif2b3"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1467
                     /gene="Eif2b3"
                     /note="translation initiation factor eIF-2B subunit gamma;
                     eIF2B GDP-GTP exchange factor subunit gamma; eIF-2B
                     GDP-GTP exchange factor subunit gamma; eukaryotic
                     translation initiation factor 2B, subunit 3 (gamma, 58kD);
                     eukaryotic translation initiation factor 2B, subunit 3
                     gamma"
                     /codon_start=1
                     /product="translation initiation factor eIF2B subunit
                     gamma"
                     /protein_id="NP_598293.2"
                     /db_xref="GeneID:171145"
                     /db_xref="RGD:620821"
                     /translation="MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLE
                     RVGFEEVIVVTTKDVQKALCAEFKMKLKPDIVCIPDEADMGTADSLRHIYPKLKTDVL
                     VLGCDLITDVALHEVVDLFRAYDASLAMLMRKGQESTEPVPGQKGKKKTVEQRDFIGV
                     DSTGKRLLFMANEADLDEELVIKGSILQKHPRIHFQTGLVDAHLYCLKKYVVDFLMEN
                     KSITSIRSELIPYLVRKQFSSASSQQRQEDKEEDLKKKEPKSLDIYSFIKKDNTLTLA
                     PYDACWNAFRRDKWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLSVLC
                     PEESMIHPSAQIANKHLIGADSLIGSDTQVGEKSSIKRSVIGSSCVIRDRVTVTNCLL
                     MNSVTVEEGSSIHGSVICNNAVVEAGAEIRDCLIGSGQRIEAKAKRMNEVIVGNDQLM
                     EI"
     exon            257..402
                     /gene="Eif2b3"
                     /inference="alignment:Splign:2.1.0"
     exon            403..562
                     /gene="Eif2b3"
                     /inference="alignment:Splign:2.1.0"
     exon            563..674
                     /gene="Eif2b3"
                     /inference="alignment:Splign:2.1.0"
     exon            675..764
                     /gene="Eif2b3"
                     /inference="alignment:Splign:2.1.0"
     exon            765..892
                     /gene="Eif2b3"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1083
                     /gene="Eif2b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1161
                     /gene="Eif2b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1310
                     /gene="Eif2b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1414
                     /gene="Eif2b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1578
                     /gene="Eif2b3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgtgggg agcgctggga gcggctacgg cgtgcgggga gctgaggtaa agccggggct
       61 agtacggtac caggcggtgc acgagctggc taagcaagat ttgtaaaaat ggagtttcaa
      121 gccgtagtta tggccgtcgg tgggggatct cggatgacag acttgacttc cagcattccc
      181 aagcctctgc ttccagttgg aaacaaacct ttaatttggt acccgctgaa cctgcttgag
      241 cgagttggat ttgaagaagt catcgtggtt acaaccaaag atgtccaaaa ggctctgtgt
      301 gcagagttca agatgaaatt gaagccagat attgtgtgca ttcctgatga ggcagacatg
      361 gggactgcag attctctacg ccacatatat ccaaaactta agactgatgt gctggtcctg
      421 ggctgcgatc tgataacaga tgttgcctta cacgaggttg tggacctgtt cagagcttac
      481 gatgcatcac ttgccatgtt aatgaggaaa ggacaagaga gcacagaacc agttccaggt
      541 cagaagggga aaaaaaaaac agtggagcag cgtgacttca ttggagtgga cagcacagga
      601 aaaaggctgc tctttatggc taatgaagca gacttggatg aagagctggt cattaaggga
      661 tccatcctgc agaagcaccc taggatacat ttccagacag gccttgtgga tgctcatctc
      721 tactgcttga agaaatatgt tgtggatttc ttaatggaaa ataagtcaat cacttctatc
      781 cgaagcgaac tgattccata cctagtaaga aaacagtttt cctcagcctc ctcacagcaa
      841 aggcaggaag acaaagaaga ggatctaaag aaaaaggagc ccaagtcttt agatatttac
      901 agttttataa aaaaagacaa cactctgact ttggctccct atgatgcctg ctggaatgct
      961 tttcgaagag acaagtggga agatttgtct agatcacagg ttcgctgcta tgtccacatc
     1021 atgaaggaag gactttgctc tcgagtaagc acactgggac tctacatgga agccaacaga
     1081 caggtaccca aattgctgtc tgttctttgt cctgaggaat caatgatcca tccatcagcc
     1141 cagattgcca acaaacacct gattggagcc gacagcctta tcgggtcaga tacacaagtt
     1201 ggagagaagt catctattaa acgatctgtc attggctcat cctgtgtcat cagagacaga
     1261 gtaactgtta ccaactgcct tctcatgaac tctgtcaccg tggaagaagg gagcagcatc
     1321 catggcagcg tcatctgcaa caacgccgtg gtcgaggcgg gcgcggagat cagggactgt
     1381 ttaattggaa gtggtcagag gattgaagcc aaagctaaac gcatgaacga ggtgatcgtg
     1441 ggaaatgacc agctcatgga gatctgaatc ctgaacaagt ctgacccctt ccttttggcc
     1501 ccaaaactac agatgttggc tggcccacct gtttgactct gtatttattt ttcaataaag
     1561 aagaatttcc aggctgtaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
